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| 1 | Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis显示文摘AIM:To evaluate the effect of exogenous recombinant human bone morphogenic protein-7(rhBMP-7)on transforming growth factor-β(TGF-β)-induced epithelial mesenchymal cell transition(EMT)and assessed its antifibrotic effect via topical application.METHODS:The cytotoxic effect of rhBMP-7 was evaluated and the EMT of human corneal epithelial cells(HECEs)was induced by TGF-β. HECEs were then cultured in the presence of rhBMP-7 and/or hyaluronic acid(HA). EMT markers,fibronectin,E-cadherin,α-smooth muscle actin(α-SMA),and matrix metaloproteinase-9(MMP-9),were evaluated. The level of corneal fibrosis and the reepithelization rate were evaluated using a rabbit keratectomy model. Expression of α-SMA in keratocytes were quantified following treatment with different concentrations of rhBMP-7.RESULTS:Treatment with rhBMP-7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion(31.6%; P<0.05),the α-SMA protein level(72.2%; P<0.01),and MMP-9 expression(23.6%,P<0.05)in HECEs compared with cells grown in the presence of TGF-β alone. E-cadherin expression was significantly enhanced(289.7%; P<0.01)in the presence of rhBMP-7. Topical application of rhBMP-7 combined with 0.1% HA significantly reduced the amount of α-SMA^+ cells by 43.18%(P<0.05)at a concentration of 2.5 μg/mL and by 47.73%(P<0.05)at 25 μg/mL,compared with the control group,without disturbing corneal reepithelization.CONCLUSION:rhBMP-7 attenuates TGF-β-induced EMT in vitro,and topical application of rhBMP-7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reepithelization. Topical rhBMP-7 application as biological eye drops seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reepithelization disorders. | Jin Kwon Chung Shin Ae Park Hee Sun Hwang Kwang Sung Kim Yang Je Cho Yong Sung You Young Sik Kim Ju Woong Jang Sung Jin Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 3 |
| 2 | Risk factors for tuberculosis after gastrectomy in gastric cancer显示文摘AIM: To examine incidence of tuberculosis(TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric cancer.METHODS: A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios(SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were analyzed.RESULTS: Among the 1776 gastrectomy patients, 0.9%(16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher thanthat in the general population(SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio(OR) = 7.1, P < 0.001], lower body mass index(BMI)(kg/m2; OR = 1.21, P = 0.043) and gastrectomy extent(total gastrectomy vs subtotal gastrectomy)(OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate analysis.CONCLUSION: TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer. | Won Jai Jung Young Mok Park Joo Han Song Kyung Soo Chung Song Yee Kim Eun Young Kim Ji Ye Jung Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Sung Hoon Noh Ji Yeong An Young Ae Kang | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 3 | New techniques for laser prostatectomy: an update 显示文摘 | Chung DE Te AE | 2009 | Therapeutic Advaneesin Urology2009，1，2： | 1 |
| 4 | Whole breast irradiation for small-sized breasts after conserving surgery: is the field-in-field technique optimal?显示文摘 | Dae Sik Yang Jung Ae Lee Won Sup Yoon Se Young Chung Suk Lee Chul Yong Kim Young Je Park Gil Soo Son | 2014 | Breast Cancer2014，，2： | 1 |
| 5 | Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity显示文摘 | King AE Chung RS Viekers JC | 2006 | J Comp Neurol2006，498，2： | 1 |
| 6 | New techniques for laser prostatectomy : an up- date 显示文摘 | Chung DE Te AE | 2009 | Ther Adv Urol2009，1，2： | 1 |
| 7 | TGF-beta receptor types I and II are differentially expressed during cor- neal epithelial wound repair 显示文摘 | Zieske JD Hutcheon AE Guo X Chung EH Joyce NC | 2001 | Invest Ophthalmol Vis Sci2001，42，7： | 1 |
| 8 | TGF-beta receptor types Ⅰ and Ⅱ are differentially expressed during comeal epithelial wound repair显示文摘 | Zieske JD Hutcheon AE Guo X Chung EH Joyce NC | 2001 | Invest Ophthalmol Vis Sci2001，42，7： | 1 |
| 9 | Physical activity and BMI in a nationally representative sample of children and adolescents显示文摘 | Chung AE Skinner AC Steiner MJ | 2012 | Clin Pediatr (Phila)2012，51，2： | 1 |
| 10 | Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1显示文摘 | HT Orr M Chung S Banfi TJ Kwiatkowski A Servadio AL Beaudet AE McCall LA Duvick LPW Ranum HY Zoghbi | 1993 | Nature Genet1993，4，： | 1 |
| 11 | Three-dimensional CT with virtual bronchoscopy:a useful modality for bronchial foreign bodies in pediatric patients显示文摘 | Jung SY ?ae ST Chung SII | 2012 | Eur Arch Otorhino- laryngol2012，269，1： | 1 |
| 12 | Identification and characterization of the gene causing type 1 spinocerebellar ataxia显示文摘 | S Banfi A Servadio M Chung TJ Kwiatkowski AE McCall LA Duvick Y Shen EJ Roth HT Orr HY Zoghbi | 1994 | Nature Genet1994，7，： | 1 |
| 13 | Role for sentinel lymph node dissection in the management of large (> or = 5 cm) invasive breast cancer显示文摘 | Chung MH Ye W Giuliano AE | 2001 | Ann Surg Oncol2001，8，9： | 1 |
| 14 | High-power 532 nm laser prostatectomy:an update显示文摘 | Chung DE Te AE | | 0，，： | 1 |
| 15 | ProEx C :A Sensitive and specific marker of HPV-associated squamous lesions of the cervix显示文摘 | BadrR E Waltes AE Chung F | 2008 | Am J Surg Path2008，32，6： | 1 |
| 16 | Toherodine extended-release for overactive bladder显示文摘 | Chung DE Te AE | 2009 | Expert Opin Pharmacether2009，10，13： | 1 |
| 17 | Exploring practice variation in preventive pressure-ulcer care using data from a clinical data repository显示文摘 | InSook Cho Hyeoun - Ae Park Eunja Chung | 2011 | International journal of medical informa - tics2011，80，1： | 1 |
| 18 | Effect of 5' UTR introns on gene expression in Arabidopsis thaliana 显示文摘 | Chung BYW Simons C Firth AE | 2006 | BMC Genomics2006，7，1： | 1 |
| 19 | Role for sentinel lymph node dissection in the management of large( > or = 5 cm) inva- sive breast cancer 显示文摘 | Chung MH Ye W I Giuliano AE | 2001 | Ann Surg Oncol2001，8，9： | 1 |
| 20 | New techniques for laser prostatectomy: an update显示文摘 | Chung DE Te AE | 2009 | Ther Adv in Urol2009，1，2： | 1 |
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