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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 3 | Differen-tial effects of tumor necrosis factor-a and interleukin-lp on celldeath in human articular chondrocytes 显示文摘 | Carames B Lopez Armada MJ Cillero Pastor B | 2008 | Osteoarthritis andCartilage2008，16，6： | 1 |
| 4 | 'If there wasn't the technology then I would probably be out everyday' : a qualitative study of children's strategies to reduce their screen viewing 显示文摘 | Sebire S J Jago R Gorely T Hoyos Cillero I Biddle SJH | 2011 | Prev Med2011，，53： | 1 |
| 5 | Prospective and randomized study on the usefulness of octreotide in the prevention of complications after cephalic duodenopancreatectomy显示文摘 | Briceno Delgado FJ Lopez Cillero P Rufian Pena S | | 0，，10： | 1 |
| 6 | Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal hu- man chondrocytes 显示文摘 | Cillero - Pastor B Carames B Lires - Dean M | 2008 | Arthritis Rheum2008，58，8： | 1 |
| 7 | Differential effects of tumor necrosis factor2 alpha and interteu kin21 beta on cell death in human articular chondrocytes显示文摘 | Carames B Lopez Armada MJ Cillero Pastor B | 2008 | Osteoarthri tis and Cartilage2008，16，6： | 1 |
| 8 | Influence of KRAS p.G13D Mutation in Patients With Metastatic Colorectal Cancer Treated With Cetuximab显示文摘 | Pablo Gajate Javier Sastre Inmaculada Bando Teresa Alonso Lourdes Cillero Julian Sanz Trinidad Caldés Eduardo Díaz-Rubio | 2012 | Clinical Colorectal Cancer2012，，4： | 1 |
| 9 | Mitoehondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes 显示文摘 | Cillero - Pastor B Carames B Lires - Dean M | 2008 | Arthritis Rheumatism2008，58，8： | 1 |
| 10 | Differential effects of tumor necrosis factor - otand intedeukin - 1βon cell death in human articular chondrocytes显示文摘 | Carames B Lopez - Armada M j Cillero - Pastor B | 2008 | Osteoarthritis and Cartilage2008，16，6： | 1 |
| 11 | Prospective and randomized study on the usefulness of octreotide in the prevention of complications after cephalic duodeno-pancreatec- tomy显示文摘 | Briceno Delgado FJ L6pez Cillero P Rufi6n Pena S | 1998 | Rev Esp Enferm Dig1998，90，10： | 1 |
| 12 | Differential effects of tumor necrosis factor - α and interleukin - 1β on cell death in human articular chondrocytes 显示文摘 | Carames B Lopez - Armada M J Cillero - Pastor B | 2008 | Osteoarthritis and Cartilage2008，6，： | 1 |
| 13 | Differential effects of tumor necrosis factor - α and inter- leukin- 1β on cell death in human articular ehondrocytes 显示文摘 | Carames B Lopez - Armada MJ Cillero - Pastor B | 2008 | Osteoarthritis and Cartilage2008，6，： | 1 |
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