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| 1 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 2 | Generalized convexity in multiobjective programming 显示文摘 | Osuna R Beato A Rufian A | 1999 | Journal of Mathematical Analysis and Applications1999，233，： | 1 |
| 3 | A characterization of pseudoinvexity in multiobjective programming 显示文摘 | Arana M Rufian A Osuna R | 2008 | Mathematical and Computer Modelling2008，48，： | 1 |
| 4 | Pseudoinvexity, optimality conditions and efficiency in multiobjective problems, duality 显示文摘 | Arana M Rufian A Osuna R | 2008 | Nonlinear Analysis2008，68，： | 1 |
| 5 | Pseudoinvexity, optimality conditions and efficiency in multiobjective problems; duality 显示文摘 | ARANA M RUFIAN A OSUNA R | 2008 | Nonlinear Anal TMA2008，68，1： | 1 |
| 6 | A characterization of pseudoinvexity for the efficiency in nondifferentiable multiobjective problems, duality 显示文摘 | Arana M Ruiz G Rufian A | 2010 | Nonlinear Analysis2010，73，： | 1 |
| 7 | A characterization of pseudoinvexity in multiobjective programming 显示文摘 | ARANA M RUFIAN A OSUNA R | 2008 | Math Comput Modelling2008，48，： | 1 |
| 8 | C-efficiency in nondifferentiable vector optimization 显示文摘 | Arana M Cambini R Rufian A | 2013 | Math- ematical and computer Modelling2013，57，： | 1 |
| 9 | Complications of extrahepatic echinococcosis:Fistulization of an adrenal hydatid cyst into the intestine显示文摘Echinococcal cysts are usually found in liver and lungs, but any other organ can potentially be involved. Extrahepatic disease due to hydatid cyst may develop in the abdominal and pelvic cavity, aside from in other less common locations, which may make both diagnosis and treatment more complex. We present a rare case of extrahepatic echinococcosis in a 70-year old patient with a 4-d history of dull abdominal pain, anemia within the transfusion range and fever. She underwent surgery for left renal hydatid cysts 30 years ago. After non operative treatment, imaging studies showed a calcified hydatid cyst in a retrogastric location communicating with a proximal jejunal loop. En-block resection of the mass together with the adrenal gland was performed including closure of the enteric fistula. Anatomic pathology confirmed the diagnosis of a calcified hydatid cyst of left adrenal origin. Surgery is the treatment of choice and most authors recommend removal of cyst and adrenal gland. | Juan Francisco Ruiz-Rabelo Manuel Gomez-Alvarez Joaquin Sanchez-Rodriguez Sebastian Rufian Pea | 2008 | World Journal of Gastroenterology2008，14，9： | 1 |
| 10 | A characterization of pseudoinvexity for the efficiency in non-differentiable multiobjective problems 显示文摘 | ARANA M RUIZ G RUFIAN A | 2010 | Duality Nonlinear Anal TMA2010，73，4： | 1 |
| 11 | Occurrence of acetic acid and formic acid in breakfast cereals 显示文摘 | Rufian - Henares J A Delgado - Andrade C Morales F J | 2006 | Journal of the Science of Food and Agriculture2006，86，9： | 1 |
| 12 | Radical surgeryperitonectomy and intraoperative intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis in recurrent or primary ovarian cancer显示文摘 | RUFIAN S MUNOZ-CASARES F C BRICENO J | 2006 | J Surg Oncol2006，94，4： | 1 |
| 13 | Donation after Cardiac Death: Where, When, and How?显示文摘 | R. Ciria J. Briceno S. Rufian A. Luque P. Lopez-Cillero | 2012 | Transplantation Proceedings2012，，6： | 1 |
| 14 | Prospective and randomized study on the usefulness of octreotide in the prevention of complications after cephalic duodenopancreatectomy显示文摘 | Briceno Delgado FJ Lopez Cillero P Rufian Pena S | | 0，，10： | 1 |
| 15 | Donation after Cardiac Death:Where,When,and How Transplant Proc显示文摘 | Ciria R Briceno J Rufian S | 2012 | 2012，，： | 1 |
| 16 | Prospective and random- ized study on the usefulness of octreotide in theprevention of com- plications after cephalic duodeno-pancreatectomy 显示文摘 | Briceno DFJ Lopez CP Rufian PS | 1998 | Rev Esp En- ferm Dig1998，90，10： | 1 |
| 17 | Functional properties of mel anoidins: In vitro antioxidant, antimicrobial and antihypertensive activities 显示文摘 | Rufian Henares J A Morales F J | 2007 | Food Research International2007，40，： | 1 |
| 18 | Assessing the antioxidant activity of melanoidins from coffee brews by different antioxidant methods 显示文摘 | Delgado Andrade C Rufian Henares JA Morales FJ | 2005 | J Agric FoodChem2005，53，20： | 1 |
| 19 | Radicalsurgery-peritonectomy and intraoperative intraperitonealchemotherapy for the treatment of peritoneal carcinomatos is inrecurrent orprimary ovarian cancer 显示文摘 | Rufian S Munoz-Casares F C? Briceno J? | 2012 | J Surg Oncol2012，94，4： | 1 |
| 20 | The role ofhyperthermic intraoperative intraperitoneal chemotherapy(HIPEC)in the treatment of peritoneal carcinomatosis inrecurrent ovarian cancer显示文摘 | Munoz-Casares F C Rufian S Rubio M J er al | 2011 | Clin Transl Oncol2011，11，11： | 1 |
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