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| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial显示文摘 | Thomas E Hutson Vladimir Lesovoy Salman Al-Shukri Viktor P Stus Oleg N Lipatov Angel H Bair Brad Rosbrook Connie Chen Sinil Kim Nicholas J Vogelzang | 2013 | Lancet Oncology2013，，13： | 2 |
| 3 | Macrophage Migration Inhibitory Factor Is an Important Mediator in the Pathogenesis of Gastric Inflammation in Rats显示文摘 | Xiao Ru Huang Connie Wun Chun Hui Yong-Xiong Chen Benjamin Chun Yu Wong Peter C.W. Fung Christine Metz Chi Hin Cho Wai Mo Hui Richard Bucala Shiu-Kum Lam Hui Y. Lan | 2001 | Gastroenterology2001，，3： | 2 |
| 4 | EWMA forecast of normal system activity for computer intrusion detection显示文摘 | YE N CHEN Q CONNIE M B | 2011 | IEEE Transac- tions on Reliability2011，53，4： | 1 |
| 5 | Postoperative Analgesia: Economics, Resource Use, and Patient Satisfaction in an Urban Teaching Hospital显示文摘 | Scott A. Strassels Connie Chen Daniel B. Carr | 2002 | Anesthesia & Analgesia2002，，1： | 1 |
| 6 | Urban recreational water – potential breeding ground for antibiotic resistant bacteria?显示文摘The emergence of multidrug-resistant bacteria, or'superbugs,' has become an urgent and worldwide concern.Antibiotic-resistant bacteria (ARB) cause significant morbidity and mortality (O’Neill, 2016). It has been estimated that ARB cause at least 23,000 deaths annually in the United States alone and hundreds of thousands of deaths in developing countries (Bougnom and Piddock, 2017). | Jing Yang Xu Connie Le Baowei Chen Hongquan Zhang | 2019 | Journal of Environmental Sciences2019，31，7： | 1 |
| 7 | EWMA Forecast of Normal System Activity for Computer Intrusion Detection 显示文摘 | YE Nong CHEN Qiang Connie M Borror | 2004 | IEEE Transactions on Reliability2004，53，4： | 1 |
| 8 | 显示文摘 | Miao Jing Chen Guohua Gao ConNie | 2006 | Journal of Menbrane Science2006，280，： | 1 |
| 9 | Postoperative Pain Experience: Results from a National Survey Suggest Postoperative Pain Continues to Be Undermanaged显示文摘 | Jeffrey L. Apfelbaum Connie Chen Shilpa S. Mehta and Tong J. Gan | 2003 | Anesthesia & Analgesia2003，，2： | 1 |
| 10 | Argonaute(AGO)proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells(MSCs)显示文摘As multipotent progenitor cells,mesenchymal stem cells(MSCs)can renew themselves and give rise to multiple lineages including osteoblastic,chondrogenic and adipogenic lineages.It’s previously shown that BMP9 is the most potent BMP and induces osteogenic and adipogenic differentiation of MSCs.However,the molecular mechanism through which BMP9 regulates MSC differentiation remains poorly understood.Emerging evidence indicates that noncoding RNAs,especially microRNAs,may play important roles in regulating MSC differentiation and bone formation.As highly conserved RNA binding proteins,Argonaute(AGO)proteins are essential components of the multi-protein RNA-induced silencing complexes(RISCs),which are critical for small RNA biogenesis.Here,we investigate possible roles of AGO proteins in BMP9-induced lineage-specific differentiation of MSCs.We first found that BMP9 upregulated the expression of Ago1,Ago2 and Ago3 in MSCs.By engineering multiplex siRNA vectors that express multiple siRNAs targeting individual Ago genes or all four Ago genes,we found that silencing individual Ago expression led to a decrease in BMP9-induced early osteogenic marker alkaline phosphatase(ALP)activity in MSCs.Furthermore,we demonstrated that simultaneously silencing all four Ago genes significantly diminished BMP9-induced osteogenic and adipogenic differentiation of MSCs and matrix mineralization,and ectopic bone formation.Collectively,our findings strongly indicate that AGO proteins and associated small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs. | Yukun Mao Na Ni Linjuan Huang Jiaming Fan Hao Wang Fang He Qing Liu Deyao Shi Kai Fu Mikhail Pakvasa William Wagstaff Andrew Blake Tucker Connie Chen Russell R.Reid Rex C.Haydon Sherwin H.Ho Michael J.Lee Tong-Chuan He Jian Yang Le Shen Lin Cai Hue H.Luu | 2021 | Genes & Diseases2021，8，6： | 1 |
| 11 | Postoperative pain expe- rience:results from a national survey suggest postoperative pain contin- ues to be undermanaged显示文摘 | Jeffrey L Apfelbaum MD Connie Chen | 2003 | Anesth Analg2003，97，3： | 1 |
| 12 | Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial显示文摘 | Robert J Motzer Bernard Escudier Piotr Tomczak Thomas E Hutson M Dror Michaelson Sylvie Negrier Stephane Oudard Martin E Gore Jamal Tarazi Subramanian Hariharan Connie Chen Brad Rosbrook Sinil Kim Brian I Rini | 2013 | Lancet Oncology2013，，： | 1 |
| 13 | Reversibly immortalized keratinocytes(iKera)facilitate re-epithelization and skin wound healing:Potential applications in cell-based skin tissue engineering显示文摘Skin injury is repaired through a multi-phase wound healing process of tissue granulation and re-epithelialization.Any failure in the healing process may lead to chronic non-healing wounds or abnormal scar formation.Although significant progress has been made in developing novel scaffolds and/or cell-based therapeutic strategies to promote wound healing,effective management of large chronic skin wounds remains a clinical challenge.Keratinocytes are critical to re-epithelialization and wound healing.Here,we investigated whether exogenous keratinocytes,in combination with a citrate-based scaffold,enhanced skin wound healing.We first established reversibly immortalized mouse keratinocytes(iKera),and confirmed that the iKera cells expressed keratinocyte markers,and were responsive to UVB treatment,and were non-tumorigenic.In a proof-of-principle experiment,we demonstrated that iKera cells embedded in citrate-based scaffold PPCN provided more effective re-epithelialization and cutaneous wound healing than that of either PPCN or iKera cells alone,in a mouse skin wound model.Thus,these results demonstrate that iKera cells may serve as a valuable skin epithelial source when,combining with appropriate biocompatible scaffolds,to investigate cutaneous wound healing and skin regeneration. | Jiamin Zhong Hao Wang Ke Yang Huifeng Wang Chongwen Duan Na Ni Liqin An Yetao Luo Piao Zhao Yannian Gou Shiyan Sheng Deyao Shi Connie Chen William Wagstaff b Bryce Hendren-Santiago b Rex C.Haydon b Hue H.Luu b Russell R.Reid Sherwin HHo Guillermo A.Ameer Le Shen Tong-Chuan He Jiaming Fan | 2022 | Bioactive Materials2022，7，3： | 0 |
| 14 | SV40 large T antigen-induced immortalization reprograms mouse cardiomyocyte progenitors with mesenchymal stem cell characteristics and osteogenic potential显示文摘While progenitor cell-based cardiomyocyte regeneration holds great promise of repairing an injured heart,primary cardiomyogenic progenitors(CPs)have a limited life span in culture,hampering the use of CPs for in vitro and in vivo studies.We previously isolated primary CPs from mouse E15.5 fetal heart,and reversibly immortalized them with SV40 large T antigen(SV40 LTA),resulting in immortalized CPs(iCPs),which maintain long-term proliferation and ex-press cardiomyogenic markers and retain differentiation potential under appropriate differentiation conditions. | Yichun Yu Jiamin Zhong Connie Chen Yannian Gou Guozhi Zhao Piao Zhao Yonghui Wang Wei Zeng Annie Wang William D.Wagstaff Jr Rex C.Haydon Tong-Chuan He Russell R.Reid Michael J.Lee Hue H.Luu Jiaming Fan | 2023 | Genes & Diseases2023，10，4： | 0 |
| 15 | Niclosamide(NA)overcomes cisplatin resistance in human ovarian cancer显示文摘Ovarian cancer(OC)is one of the most lethal malignancies of the female reproduc-tive system.OC patients are usually diagnosed at advanced stages due to the lack of early diag-nosis.The standard treatment for OC includes a combination of debulking surgery and platinum-taxane chemotherapy,while several targeted therapies have recently been approved for maintenance treatment.The vast majority of OC patients relapse with chemoresistant tu-mors after an initial response.Thus,there is an unmet clinical need to develop new therapeu-tic agents to overcome the chemoresistance of OC.The anti-parasite agent niclosamide(NA)has been repurposed as an anti-cancer agent and exerts potent anti-cancer activities in human cancers including OC.Here,we investigated whether NA could be repurposed as a therapeutic agent to overcome cisplatin-resistant(CR)in human OC cells.To this end,we first established two CR lines SKOV3CR and OVCAR8CR that exhibit the essential biological characteristics of cisplatin resistance in human cancer.We showed that NA inhibited cell proliferation,sup-pressed cell migration,and induced cell apoptosis in both CR lines at a low micromole range.Mechanistically,NA inhibited multiple cancer-related pathways including AP1,ELK/SRF,HIF1,and TCF/LEF,in SKOV3CR and OVCAR8CR cells.NA was further shown to effectively inhibit xenograft tumor growth of SKOV3CR cells.Collectively,our findings strongly suggest that NA may be repurposed as an efficacious agent to combat cisplatin resistance in chemoresistant hu-man OC,and further clinical trials are highly warranted. | Linjuan Huang Jing Zhang Youling Deng Hao Wang Piao Zhao Guozhi Zhao Wei Zeng Yonghui Wang Connie Chen William Wagstaff Rex C.Haydon Russell R.Reid Tong-Chuan He Le Shen Hue H.Luu Ling Zhao | 2023 | Genes & Diseases2023，10，4： | 0 |
| 16 | A Pilot Study of Singapore's Young Chinese Parent'sPerceptions, Attitude and Behaviours Towards Bilingual Learning显示文摘This study aims to study parents' attitude, perceptions, and behaviours towards bilingual education in Singapore'sbilingual social context. The study involves 78 young Singapore's Chinese parents, using mixed methodologiesincluding multiple choice questionnaire, interview, checklist, and focus group discussion to collect data. Qualitativeand quantitative researches have shown four important findings. First, young parents acknowledge the importanceof learning mother tongue to maintain cultural heritage. They also realize that Chinese could become their nextgeneration's crucial social capital in the future. Those families have great potential in raising bilingual children.Second, more attention should be paid to the gap between young parents' positive attitude and passive behaviourin supporting children's bilingual learning. Third, there are some misunderstandings about bilingual learning. | Aw GuatPoh Connie Lum PENG Xuan-hui CHEN Yuan TONG Qi-ying | 2017 | Sino-US English Teaching2017，14，9： | 0 |
| 17 | Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin-CD34* cord blood cells显示文摘 | Fanyi Zeng Shu-Zhen Huang Zhi-Juan Gong Mei-Jue Chen Don A Baldwin Wei Hu Hui Qian Jing-bin Yan Juan Wang Yan Ping Xiao Yves Chalandon Ashley Ringrose Zhao-Rui Ren Allen Eaves Connie Eaves Xiaoyan Jiang | 2013 | Cell Research2013，23，6： | 0 |
| 18 | Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk显示文摘Wnt signaling plays a major role in regulating cell proliferation and differentiation.The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical pathway.Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling pathways.This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes.Dys-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic lethality.The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments.However,both stimulatory and inhibitory treatments come with potential risks that need to be addressed.This review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt signaling.It thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+pathway.Further description involved each of its components and their involvement in other cellular processes.Finally,this review explained the various other pathways and processes that crosstalk with Wnt signaling. | Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi | 2024 | Genes & Diseases2024，11，1： | 0 |
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