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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Origin of the high pie- zoelectric response in PbZr1-xTixO3 显示文摘 | Guo R Cross L E Park DE | 2000 | Phys Rev B2000，84，23： | 1 |
| 3 | A low temperature combination method for the production of ZnO nanowires显示文摘 | CROSS R B M DE SOUZA M M NARAYANAN E M S | 2005 | Nanotechnology2005，16，： | 1 |
| 4 | Molecular analysis of aldolase B genes in hereditary fructose intol- erance 显示文摘 | Cross N C de Franchis R Sebastio G | 1990 | The Lancet1990，335，8685： | 1 |
| 5 | A meta-analysis to review organizational outcomes related to charismatic leadership显示文摘 | de Groot Timothy Kiker D Scott and Cross Thomas C | 2000 | Canadian Journal of Administrative Sciences2000，17，4： | 1 |
| 6 | A low Temperature Combination Method for the Production of ZnO Nanowire显示文摘 | Cross R B M De Souza M M Sankara Narayanan E M | 2005 | Nanotechnolosy2005，16，： | 1 |
| 7 | The effect of gate-bias stress and temperature on the performance of ZnO thin-film tran- sistors显示文摘 | Cross R B M De Souza M M | 2008 | IEEE Transactions on Device and Materials Relia- bility2008，8，2： | 1 |
| 8 | 查看详情显示文摘 | Cross R B M De Souza M M Sankara Narayanan E M | | 0，，： | 1 |
| 9 | 显示文摘 | Melo JV Gordon DE Cross NC | 1993 | Blood1993，81，： | 1 |
| 10 | Importance of the autoeontrol crossmatch in human renal transplantation 显示文摘 | Cross DE Greiner R Whittier FC | 1976 | Transplantation1976，21，4： | 1 |
| 11 | Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study显示文摘 | G. Buckland N. Travier J.M. Huerta H.B(as) Bueno‐de‐Mesquita P.D. Siersema G. Skeie E. Weiderpass D. Engeset U. Ericson B. Ohlsson A. Agudo I. Romieu P. Ferrari H. Freisling S. Colorado‐Yohar K. Li R. Kaaks V. Pala A.J. Cross E. Riboli A. Trichopoulou P. | 2015 | Cancer2015，，3： | 1 |
| 12 | Climate suitability forEuropean ticks : assessing species distribution models against nullmodels and projection under AR5 climate 显示文摘 | Williams HW Cross DE Crump HL | 2014 | Parasit Vectors2014，8，440： | 1 |
| 13 | Investigating the stability of zinc oxide thin film transistors 显示文摘 | CROSS R B M DE SOUZA M M | 2006 | Appl Phys Lett2006，89，26： | 1 |
| 14 | The effect of gate-bias stress and temperature on the performance of ZnO thin-film transistors 显示文摘 | CROSS R B M DE SOUZA M M | 2008 | Dev Mater Reliab2008，8，2： | 1 |
| 15 | A comparison of the performance and stability of ZnO-TFTs with silicon dioxide and nitride as gate insulators 显示文摘 | CROSS R B M DE SOUZA M M DEANE S C | 2008 | Elec Dev Lett2008，55，5： | 1 |
| 16 | Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva显示文摘 | Silvia de Sanjosé Laia Alemany Jaume Ordi Sara Tous Maria Alejo Susan M. Bigby Elmar Armin Joura Paula Maldonado Jan Laco Ignacio G. Bravo August Vidal Núria Guimerà Paul Cross Gerard V. Wain Karl Ulrich Petry Luciano Mariani Christine Bergeron Václav Man | 2013 | European Journal of Cancer2013，，16： | 1 |
| 17 | A meta-analysis to review organizational outcomes related to charismatic le- adership显示文摘 | De Groot T Kiker D S Cross T C | 2000 | Canadian Journal of Administrative Sciences2000，17，4： | 1 |
| 18 | Quality Of Life Researeh : An International Journal Of Quality Of Life Aspects Of Treatment显示文摘 | de la Loge C Cross - cultural development and validation of a patient self - administered questionnaire to assess quality of life in upper gastrointestinal disorders: the PAGI - QOL | 2004 | Care And Rehabilitation[ Qual Life Res]2004，13，10： | 1 |
| 19 | The ABL-BCR fusion gene is expressed in chronic myeloid leukemia显示文摘 | MELO JV GORDON DE CROSS NC | 1993 | Blood1993，81，1： | 1 |
| 20 | The ABL-BCR fusion gene is expressed in chronic myeloid leukemia 显示文摘 | Melo JV Gordon DE Cross NC | 1993 | Blood1993，81，1： | 1 |
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