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| 1 | Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?显示文摘AIM:To determine whether acoustic radiation force impulse(ARFI) elastography is a reliable method for predicting fibrosis severity in patients with chronic hepatitis C virus(HCV) hepatitis.METHODS:We performed a multicenter study including 274 subjects with HCV chronic hepatitis in which we compared ARFI with liver biopsy(LB).In each patient we performed LB(evaluated according to the Metavir score) and ARFI measurements(using a Siemens Acuson S2000TM ultrasound system:10 valid measurements were performed and median values were calculated and expressed in meters/second(m/s).RESULTS:A direct,strong,correlation(Spearman r = 0.707) was found between ARFI measurements and fibrosis(P < 0.0001).For predicting the presence of fibrosis(F ≥ 1 Metavir),significant fibrosis(F ≥ 2),severe fibrosis(F ≥ 3) and cirrhosis(F = 4),the cutoff values of 1.19,1.21,1.58 and 1.82 m/s were determined,respectively,liver stiffness measurements had 73%,84%,84% and 91% Se respectively;93%,91%,94%,90% Sp,respectively;with AUROCs of 0.880,0.893,0.908 and 0.937,respectively.CONCLUSION:ARFI measurement is a reliable method for predicting the severity of fibrosis in HCV | Ioan Sporea Roxana Sirli Simona Bota Carmen Fierbinteanu-Braticevici Alina Popescu Radu Badea Monica Lupsor Ana Petrisor Mirela Dnil | 2011 | World Journal of Radiology2011，3，7： | 24 |
| 2 | Diagnosis and treatment of diabetes mellitus in chronic pancreatitis显示文摘Diabetes secondary to pancreatic diseases is commonly referred to as pancreatogenic diabetes or type 3c diabetes mellitus.It is a clinically relevant condition with a prevalence of 5%-10%among all diabetic subjects in Western populations.In nearly 80%of all type 3c diabetes mellitus cases,chronic pancreatitis seems to be the underlying disease.The prevalence and clinical importance of diabetes secondary to chronic pancreatitis has certainly been underestimated and underappreciated so far.In contrast to the management of type 1 or type2 diabetes mellitus,the endocrinopathy in type 3c is very complex.The course of the disease is complicated by additional present comorbidities such as maldigestion and concomitant qualitative malnutrition.General awareness that patients with known and/or clinically overt chronic pancreatitis will develop type 3c diabetes mellitus(up to 90%of all cases)is rather good.However,in a patient first presenting with diabetes mellitus,chronic pancreatitis as a potential causative condition is seldom considered.Thus many patients are misdiagnosed.The failure to correctly diagnose type 3 diabetes mellitus leads to a failure to implement an appropriate medical therapy.In patients with type 3c diabetes mellitus treating exocrine pancreatic insufficiency,preventing or treating a lack of fat-soluble vitamins(especially vitamin D)and restoring impaired fat hydrolysis and incretin secretion are key-features of medical therapy. | Nils Ewald Philip D Hardt | 2013 | World Journal of Gastroenterology2013，19，42： | 23 |
| 3 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 4 | Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: A systematic review显示文摘AIM: To identify severe adverse events (SAEs) leading to treatment discontinuation that occur during antiviral therapy in hepatitis C virus (HCV)-infected cirrhotic patients. METHODS: We identified all the articles published prior to December 2011 in the PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases that presented these data in cirrhotic patients. These studies evaluated the rate of SAEs leading to discontinuation of standard care treatment: Pegylated interferon (PegIFN) alpha 2a (135-180 μg/wk) or PegIFN alpha 2b (1 or 1.5 μg/kg per week) and ribavirin (800-1200 mg/d). Patients with genotype 1 + 4 underwent treatment for 48 wk, whereas those with genotypes 2 + 3 were treated for 24 wk.RESULTS: We included 17 papers in this review, comprising of 1133 patients. Treatment was discontinued due to SAEs in 14.5% of the patients. The most common SAEs were: severe thrombocytopenia and/or neutropenia (23.2%), psychiatric disorders (15.5%), decompensation of liver cirrhosis (12.1%) and severe anemia (11.2%). The proportion of patients who needed to discontinue their therapy due to SAEs was significantly higher in patients with Child-Pugh class B and Cvs those with Child-Pugh class A: 22%vs 11.4% (P = 0.003). A similar discontinuation rate was found in cirrhotic patients treated with PegIFN alpha 2a and those treated with PegIFN alpha 2b, in combination with ribavirin: 14.2%vs 13.7% (P = 0.96). The overall sustained virological response rate in cirrhotic patients was 37% (95%CI: 33.5-43.1) but was significantly lower in patients with genotype 1 + 4 than in those with genotype 2 + 3: 20.5% (95%CI: 17.9-24.8) vs 56.5% (95%CI: 51.5-63.2), (P < 0.0001). CONCLUSION: Fourteen point five percent of HCV cirrhotic patients treated with PegIFN and ribavirin needed early discontinuation of therapy due to SAEs, the most common cause being hematological disorders. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Adriana Maria Neghinǎ Mirela Dǎnilǎ Mihnea Strǎin | 2013 | World Journal of Hepatology2013，5，3： | 6 |
| 5 | Pegylated-interferon alpha 2a treatment for chronic hepatitis C in patients on chronic haemodialysis显示文摘瞄准:评估反应到 pegylated 干扰素高山哈在长期的血液透析上的长期的丙肝病人的 2a。方法:有长期的 C 肝炎的十个病人在这研究被注册。所有为超过 6 瞬间,积极 antiHCV 抗体和积极 PCR HCV-RNA 增加了 aminotransferases。我们管理了木钉干扰素高山哈 2a 为 48 wk 的 180 microg/wk。在治疗的 12 wk 以后,我们评估了生物化学、早的 virological 反应(EVR ) 。在治疗的结束,我们在我们评估了的治疗的结束以后评估了生物化学的反应和 24 wk 持续 virological 反应(SVR ) 。我们在治疗期间监视了副作用。结果:二个病人在治疗的开始的 12 wk 放弃了并且 2 在治疗的开始的 12 wk 以后。在治疗的 12 wk 以后, 7 从 8 个病人有生物化学的反应和 EVR, 1 有生物化学的反应但是坚持的病毒血。我们不得不在 2 种情况中把 pegylated 干扰素的剂量归结为 135 mug/wk。三(50%) 从 6,病人们在治疗的结束以后有 SVR 24 wk。Intention-to-treat 分析证明 3 从 10 个病人(30%) 有 SVR。副作用发生在大多数病人(像流感的症候群,血小板减少或 leucopoenia ) ,但是他们没强加治疗的中止。结论:在有木钉干扰素高山的治疗的 12 wk 以后哈在有长期的 C 肝炎的长期的血液透析上的病人的 2a (40 ku ) , EVR 在 87.5% 被获得(7/8 ) 盒子。SVR 在完成了治疗的 48 wk 的 50% 盒子(3/6 病人) 中被完成。 | Ioan Sporea Alina Popescu Roxana ■irli Ovidiu Golea CameliaTotolici Mirela Dǎnilǎ Corina Vernic | 2006 | World Journal of Gastroenterology2006，12，26： | 2 |
| 6 | Value of acoustic radiation force impulse elastography for the assessment of ascites syndrome显示文摘AIM:To assess the feasibility of performing acoustic radiation force impulse(ARFI) elastography in patients with ascites and its predictive value for the cirrhotic or non-cirrhotic etiology of ascites.METHODS:Our study included 153 patients with ascites,mean age 58.8 ± 13.1 years.One hundred and fifteen(75.2%) patients had ascites in the context of cirrhosis,29(18.9%) had non-cirrhotic ascites(diagnosed by clinical,ultrasound,endoscopic and/or laparoscopic criteria) and in 9(5.9%) cases we could not establish the etiology of ascites.We performed 10 ARFI measurements and the median value was calculated and expressed in meters/second(m/s).Among the 29 patients with non-cirrhotic ascites were included:20 laparoscopically demonstrated peritoneal carcinomatosis with histological confirmation,7 acute pancreatitis with ascites which later resolved,and one case each of lymphatic ascites and ascites in the context of a liver abscess.In 11 of the 20 patients with peritoneal carcinomatosis,the liver structure was homogenous in the ultrasound examination and in 9 patients the ultrasound exam revealed liver metastases.RESULTS:We could not obtain valid ARFI measurements in 5 patients(3.2%).The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites:3.04 ± 0.70 vs 1.45 ± 0.59 m/s(P < 0.001).For a cut-off value of 1.8 m/s for predicting cirrhosis(and ascites in the context of cirrhosis),as obtained in a previous study,ARFI had 98.1% sensitivity,86.2% specificity,96.4% positive predictive value,92.5% negative predictive value and 95.6% accuracy for predicting cirrhotic ascites.For a cut-off value of 1.9 m/s the accuracy was 94.9% and for a 2 m/s cut-off value it was 92.8%.CONCLUSION:ARFI elastography is feasible in most patients with ascites and has a very good predictive value for the cirrhotic or non-cirrhotic etiology of ascites. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Mirela Dǎnilǎ Mǎdǎlina Sendroiu | 2011 | World Journal of Radiology2011，3，8： | 2 |
| 7 | Modification of the molar anionic charge density of acetone-formaldehyde-sulfite dispersant to improve adsorption behavior and effectiveness in the presence of cement fluid loss polymer 显示文摘 | Plank J Fatima D B Nils Recalde L | 2009 | Journal of Applied Polymer Science2009，111，4： | 1 |
| 8 | Measufing accessibility and utilization of public spaces in famagusta显示文摘 | Nil P Naciye D | | 0，，03： | 1 |
| 9 | Responses of photosynthetic efficincy, cell shape and motility in Euglena gracilis (Euglenophyceae) to short-term exponsure to heavy metals and pentachlorophenol显示文摘 | Roman A D Nils G A | 2001 | Water Air and Soil Pollution2001，132，： | 1 |
| 10 | Effects of cyclic freezing and thawing on mechanical properties of Qinghai-Tibet clay 显示文摘 | WANG D Y MA W NIL/Y H | 2007 | Cold Regions Science and Technology2007，48，： | 1 |
| 11 | A new experimental model for cryptorchidism: inguinoscrotal approach显示文摘 | Mehmet Dündar Izzet Ko?ak Nil ?ulhaci | 2001 | Urological Research2001，，3： | 1 |
| 12 | Synthesis and Photodynamic Potential of Tetra- and octa-trieth- ylencoxysalfonyl Substituted Zinc Phthalocyanines显示文摘 | Devrim A Nil S Mahmut D | 2007 | Journal of Photochemistry and Photobiology A: Chemistry( S 1010-6030)2007，186，： | 1 |
| 13 | Overexpression of G protein- coupled receptor 87 correlates with poorer tumor differentiation and higher tumor proliferation in nonsmaUceU lung cancer 显示文摘 | Nil K TOKUNAGA Y LIU D | 2014 | Molecular and clinical oncology2014，2，4： | 1 |
| 14 | Biodegradable fixation of rabbit osteotomies显示文摘 | Torbjorm A Nils D Lundberg A | 1994 | Acta Orthop Scand1994，65，2： | 1 |
| 15 | Reproducibility of peripheralarterial tonometry measurements in male cardiovascular patients显示文摘 | Nil M Schafer D Radtke T | 2014 | Eur J Clin Invest2014，44，11： | 1 |
| 16 | Coupling remote sensing with computational fluid dynamics modelling to estimate lake chlorophyll-a concentration 显示文摘 | Richard D H Nils R B O Malthus T J | 2002 | Remote Sensing of Environment2002，79，： | 1 |
| 17 | Return distributions of equity-linked retirement plans under jump and interest rate risk 显示文摘 | D NILS A WEBER U WYSTUP | 2013 | European Actuarial Journal2013，3，1： | 1 |
| 18 | X-ray structure of human proMMP-1: New insights into procollagenase activation and collagen binding显示文摘 | Jozic D Bourenkov G Lim NIL | 2005 | J Biol Chem2005，280，10： | 1 |
| 19 | Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat显示文摘 | Nils Henninger Kenneth M. Sicard Zhixin Li Praveen Kulkarni Stephan Dützmann Christian Urbanek Stefan Schwab Marc Fisher | 2007 | Critical Care Medicine2007，，11： | 1 |
| 20 | A new method for bromination of carbazoles, β-carbolines and iminkodibenzyls by use of N- bromosuccinimide and silica gel显示文摘 | Keith S D M art in J A nil GM | 1992 | T etrahed ron1992，48，36： | 1 |
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