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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 3 | Mosquito larvicidal properties of Orthosiphon thymiflorus(Roth)Sleesen.(Family:Labiatae)against mosquito vectors,Anopheles stephensi,Culex quinquefasciatus and Aedes aegypti(Diptera:Culicidae)显示文摘Objective:To determine the mosquito larvicidal activities of hexane,chloroform,ethyl acetate, acetone and methanol leaf extract of Orthosiphon thymiflorus(O.thymiflorus) against Anopheles stephensi(An.stephensi),Culex quinquefasciatus(Cx.quinquefasciatus) and Aedes aegypti (Ae.aegypti).Methods:The larvicidal activity was assayed against three mosquito species at various concentrations ranging from(50-450 ppm) under the laboratory conditions.The LC50 and LC90value of the O.thymiflorus leaf extract was determined by Probit analysis.Results:The LC50 values of hexane,chloroform,ethyl acetate,acetone and methanol extract of O.thymiflorus third instar larvae of An.stephensi were LC50= 201.39,178.76,158.06,139.22 and 118.74 ppm; Cx.quinquefasciatus were LC50=228.13,209.72.183.35,163.55 and 149.96 ppm and Ae.aegypti were LC50=215.65,197.91,175.05,154.80 and 137.26 ppm,respectively.Maximum larvicidal activity was observed in the methanolic extract followed by acetone,ethyl acetate chloroform and hexane extract.The larval mortality was observed after 24 h exposure.No mortality was observed in control.Conclusions:The present results suggest that the effective plant crude extracts have potential to be used as an ideal eco-friendly approach for the control of mosquito vectors.This study provides the first report on the larvicidal activity of this plant crude solvent extract of against An.stephensi,Cx.quinquefasciatus and Ae.aegypti mosquitoes. | K Kovendan K Murugan S Vincent Donald R Barnard | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 4 | A Model and Methodology for Hardware-software Codesign显示文摘 | Donald E T Jay K A Herman S | 1993 | IEEE Design & Test of Computers1993，10，3： | 2 |
| 5 | Reducing Nitrogen Loss during Poultry Litter Composting Using Biochar显示文摘 | Steiner Christoph Das K C Melear Nathan Lakly Donald | 2010 | Journal of Environmental Quality2010，，4： | 2 |
| 6 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 7 | An efficient algorithm for analysis of nonlinear heat transfer with phase changes显示文摘 | Donald Rolph W Bathe K J | 1982 | International Journal for Numerical Methods in Engineering1982，18，： | 2 |
| 8 | Discovery of 1- (4-methoxyphenyl) -7-oxo-6- (4- (2-oxopiperidin- 1 - yl) phenyl) -4,5,6,7-tetrahydro-1H-pyrazolo t3,4-c] pyridine- 3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa 显示文摘 | Donald J Michael JO Stephanie K | 2007 | JMed Chem2007，50，22： | 1 |
| 9 | Sedimentology and Shale Modeling of a Sandstone-Rich Fluvial Reservoir:Upper Statfjord Formation,Statfjord Field,Northern North Sea显示文摘 | Alister C Mac Donald Halland K | 1993 | AAPG1993，77，6： | 1 |
| 10 | A survey on physical delivery versus cash settlement in futures contracts显示文摘 | Donald L Yiu K T | | 0，，： | 1 |
| 11 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 12 | De- termination of undegradable intake protein digestibility of forages using the mobile nylon bag technique 显示文摘 | HAUGEN H L IVAN S K MAC DONALD J C | 2006 | J Anita Sci2006，84，： | 1 |
| 13 | The Mixing of Solids in Tumbling Mixers I 显示文摘 | Carley-Macauly K W Donald M B | 1962 | Chemical Engineering Science1962，17，7： | 1 |
| 14 | A ubiquitin-10 promoter-based vector set for fluorescent protein tagging facili- tates temporal stability and native protein distribution in transient and stable expression studies显示文摘 | GREFEN C DONALD N HASHIMOTO K | 2010 | Plant Journal2010，64，2： | 1 |
| 15 | Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure显示文摘 | Bennett-Richards K Kattenhorn M Donald A | 2002 | Circulation2002，105，3： | 1 |
| 16 | Relationship Between Satellite-derived Land Surface Temperatures,Arctic Vegetation Types,and NDVI显示文摘 | Martha K Raynolds Josefino C Comiso Donald A Walker | 2008 | Remote Sensing of Environment2008，112，4： | 1 |
| 17 | Characterization of a chitinase gene from Stenotrophomonas maltophilia strain 34S1 and its involvement in biological control显示文摘 | DONALD Y K RALPH M R JULIE ANN B | 2002 | Appl Environ Microbiol2002，68，： | 1 |
| 18 | Accruals and the Prediction of Future Cash Flows 显示文摘 | MARY E B DONALD P C KAREN K N | 2001 | The Accounting Re- view2001，76，1： | 1 |
| 19 | The Role of Leucine in Weight Loss Diets and Glucose Homeostasis显示文摘 | Donald K Layman | 2003 | Journal of Nutrition2003，133，： | 1 |
| 20 | Physical delivery versus cash settlement:an empirical study on the feeder cattle contract显示文摘 | Donald L Yiu K T | | 0，，： | 1 |
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