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| 1 | Current aging research in China显示文摘微型评论在中国在国家老化研究策略上源自一个最近的会议在中国讨论老化研究的部件和挑战。加亮,资助状况和很多个研究队的主要努力研究的最近的专业的突出的例子是成就。最后,作者们在中国讨论老化研究的潜在的目标和策略。 | Ruijuan Sun Heqi Cao Xudong Zhu Jun-Ping Liu Erdan Dong | 2015 | Protein & Cell2015，6，5： | 12 |
| 2 | Achievements in cancer research supported by National Natural Science Foundation of China显示文摘For the past two decades,great achievements have been made in cancer research of China and the majority of them were supported by the National Natural Science Foundation of China(NSFC).In this article,we reviewed the funding history of NSFC including the number of proposals,the amount of grants,distribution of supported program categories during the period of 1987 to 2012 and the representative achievements made by continuous support of NSFC.Also,the impacts of NSFC support on discipline development and talent fostering were analyzed.From 1987 to 2012,a total of 8738 proposals related to cancer research were funded by NSFC.The percentages of the Research Program,Talent-Training Program,and the Research Environment Program were 61.19%,36.32%,and 2.49%,respectively.Under the support of NSFC,cancer research in China has achieved a significantly rapid and balanced development in both disciplines and scientist resources. | HONG Wei LI Cui ZHANG LiPing XU YanYing ZHANG Jun HU Hai DONG ErDan | 2013 | Chinese Science Bulletin2013，58，1： | 5 |
| 3 | New insight into vascular homeostasis and injury-reconstruction显示文摘Acquired vascular abnormalities are a pivotal part of the pathophysiology of multiple cardiovascular and metabolic diseases.Complications of various types of vascular pathology,for example,stroke,myocardial infarction and aortic dissection constitute most common causes of disability and deaths worldwide[1].Ageing per se is also associated with significant remodeling of vasculatures that exacerbates concomitant cardiovascular or metabolic diseases[2].Important discoveries in the field of vascular biology | ZHANG YouYi DONG ErDan | 2014 | Science China(Life Sciences)2014，57，8： | 4 |
| 4 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 5 | Heart failure research in China: current status and future direction显示文摘Heart failure is a major public health problem worldwide. Despite advances in the therapy and care of heart failure, morbidity and mortality remain persistently high. Recent years have witnessed major breakthroughs in the investigations of pathogenesis, prevention, and treatment of heart failure in China. It is noteworthy that the continuing and growing support from funding agencies in China including the National Natural Science Foundation of China has yielded substantial effects on the basic and clinical research in heart failure in the last decade. In this review, we provide an update on the current status of heart failure research, both basic and translational/clinical, in China, including funding and publications. We also discuss the future challenges and possible strategies in improving our understanding and management of heart failure in China. | Yuangui Zhu Ruijuan Sun Erdan Dong | 2016 | Science Bulletin2016，61，23： | 3 |
| 6 | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway显示文摘Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)stiffness.The increased stiffness further promotes CF differentiation and fibrosis.However,the molecular mechanism is still unclear.We used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer substrate.Immunofluorescent staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and TGIF2.The expression of these fibrosis repressors was inhibited on pathological substrate stiffness.Knockdown of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF differentiation.In conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis repressors.Our work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment. | Mingzhe Li Jimin Wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 7 | Extracting and Measuring Uncertain Biomedical Knowledge from Scientific Statements显示文摘Purpose:Given the information overload of scientific literature,there is an increasing need for computable biomedical knowledge buried in free text.This study aimed to develop a novel approach to extracting and measuring uncertain biomedical knowledge from scientific statements.Design/methodology/approach:Taking cardiovascular research publications in China as a sample,we extracted subject-predicate-object triples(SPO triples)as knowledge units and unknown/hedging/conflicting uncertainties as the knowledge context.We introduced information entropy(IE)as potential metric to quantify the uncertainty of epistemic status of scientific knowledge represented at subject-object pairs(SO pairs)levels.Findings:The results indicated an extraordinary growth of cardiovascular publications in China while only a modest growth of the novel SPO triples.After evaluating the uncertainty of biomedical knowledge with IE,we identified the Top 10 SO pairs with highest IE,which implied the epistemic status pluralism.Visual presentation of the SO pairs overlaid with uncertainty provided a comprehensive overview of clusters of biomedical knowledge and contending topics in cardiovascular research.Research limitations:The current methods didn’t distinguish the specificity and probabilities of uncertainty cue words.The number of sentences surrounding a given triple may also influence the value of IE.Practical implications:Our approach identified major uncertain knowledge areas such as diagnostic biomarkers,genetic polymorphism and co-existing risk factors related to cardiovascular diseases in China.These areas are suggested to be prioritized;new hypotheses need to be verified,while disputes,conflicts,and contradictions need to be settled.Originality/value:We provided a novel approach by combining natural language processing and computational linguistics with informetric methods to extract and measure uncertain knowledge from scientific statements. | Xin Guo Yuming Chen Jian Du Erdan Dong | 2022 | Journal of Data and Information Science2022，7，2： | 3 |
| 8 | Progress of basic research in Parkinson’s disease in China: data mini-review from the National Natural Science Foundation显示文摘This review is to analyze the role of National Natural Science Foundation of China(NSFC)on the development of basic research of Parkinson’s disease from 1990 to 2012.Data on the total number of projects and funding of NSFC allocated to Parkinson’s disease,as well as hotspots in western countries,papers published,awards,personnel training,subject construction were collected,and the role of NSFC on other sources of funding was evaluated.Over the past 23 years,a full range of continuous funding from NSFC has led to fruitful results and a strong impetus to the progress of basic research of Parkinson’s disease. | Heqi Cao Gang Chen Erdan Dong | 2013 | Translational Neurodegeneration2013，2，1： | 2 |
| 9 | Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension显示文摘Consecutively hospitalized patients with confirmed coronavirus disease 2019(COVID-19)in Wuhan,China were retrospectively enrolled from January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitor(RAS-I)and the outcome of this disease.Associations between the use of RAS-I(angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor blocker(ARB)),ACEI,and ARB and in-hospital mortality were analyzed using multivariate Cox proportional hazards regression models in overall and subgroup of hypertension status.A total of 2771 patients with COVID-19 were included,with moderate and severe cases accounting for 45.0%and 36.5%,respectively.A total of 195(7.0%)patients died.RAS-I(hazard ratio(HR)=0.499,95%confidence interval(CI)0.325–0.767)and ARB(HR=0.410,95%CI 0.240–0.700)use was associated with a reduced risk of all-cause mortality among patients with COVID-19.For patients with hypertension,RAS-I and ARB applications were also associated with a reduced risk of mortality with HR of 0.352(95%CI 0.162–0.764)and 0.279(95%CI 0.115–0.677),respectively.RAS-I exhibited protective effects on the survival outcome of COVID-19.ARB use was associated with a reduced risk of all-cause mortality among patients with COVID-19. | Huai-yu Wang Suyuan Peng Zhanghui Ye Pengfei Li Qing Li Xuanyu Shi Rui Zeng Ying Yao Fan He Junhua Li Liu Liu Shuwang Ge Xianjun Ke Zhibin Zhou Gang Xu Ming-hui Zhao Haibo Wang Luxia Zhang Erdan Dong | 2022 | Frontiers of Medicine2022，16，1： | 0 |
| 10 | Patients' Attitudes to Unproven Therapies in Treating COVID-19 Merit Evaluation显示文摘(The Innovation 1,100028-1–100028-2;August 28,2020)In the initially published article,the term“COVID-19”was written as“Covid-19”in the title and throughout the manuscript.The authors apologize for this error,and this has since been corrected online. | Hong-tian Li Zhi-hao Cheng Yong-ying Huang Xi-lin Lv Yu-bo Zhou Erdan Dong Jian-meng Liu | 2020 | The Innovation2020，1，3： | 0 |
| 11 | Single-Chain Fragmented Antibodies Guided SiRNA Delivery in Breast Cancer显示文摘Over the past ten years,the enthusiasm to harness small RNA molecules,mainly small interfering RNAs(siRNAs) and microRNA mimics,into therapeutic weapons has never been quenched.However,a major obstacle hindering the clinical application of these small molecules is how to efficiently and precisely deliver siRNAs in vivo into target cells to silence target genes.An international collaborative study led by Song Erwei from the Memorial Hospital of Sun-YatSen University and Wang Jun from Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences of University of Science and Tech- | Hong Wei Li Cui Dong Erdan | 2012 | Science Foundation in China2012，20，1： | 0 |
| 12 | Cell-cell crosstalk in the heart显示文摘Cardiovascular disease remains the top threat to human health.As the prevalence and mortality of cardiovascular diseases have been persistently increasing in China,the cardiovascular disease becomes the leading cause of death,accounting for nearly half of all deaths in China[1].In order to improve the situation,many basic cardiovascular studies have been conducted and have obtained great achievement,which is fundamental to the future advance in clinical practice[2].In the current issue,several excellent cardiovascular scientists summarize the advance of basic cardiovascular research from different perspectives,from particular critical molecules to cellular function and animal models,as well as the advanced technology.These reviews collaboratively bring us an overall vision of the frontiers and trends of cardiovascular research. | Erdan Dong | 2021 | Medical Review2021，1，1： | 0 |
| 13 | FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population显示文摘The association among plasma trimethylamine-N-oxide(TMAO),FMO3 polymorphisms,and chronic heart failure(CHF)remains to be elucidated.TMAO is a microbiota-dependent metabolite from dietary choline and carnitine.A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction,with the longest follow-up of 7 years.The concentrations of plasma TMAO and its precursors,namely,choline and carnitine,were determined by liquid chromatography-mass spectrometry,and the FMO3 E158K polymorphisms(rs2266782)were genotyped.The top tertile of plasma TMAO was associated with a significant increment in hazard ratio(HR)for the composite outcome of cardiovascular death or heart transplantation(HR=1.47,95%CI=1.13-1.91,P=0.004)compared with the lowest tertile.After adjustments of the potential confounders,higher TMAO could still be used to predict the risk of the primary endpoint(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).This result was also obtained after further adjustment for carnitine(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).The FM03 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort,and lower TMAO levels were found in the AA-genotype.Thus,higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders,and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels. | Haoran Wei Mingming Zhao Man Huang Chenze Li Jianing Gao Ting Yu Qi Zhang Xiaoqing Shen Liang Ji Li Ni Chunxia Zhao Zeneng Wang Erdan Dong Lemin Zheng Dao Wen Wang | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 14 | A novel β_(2)-AR agonist,Higenamine,induces β-arrestin-biased signaling显示文摘The biased ligands in G protein-coupled receptors(GPCRs)have opened new avenues for developing safer and more effective drugs.However,the identification of such biased ligands as drug candidates is highly desirable.Here,we report that Higenamine,a compound isolated from a Chinese herb,functions as a novel β-arrestin-biased ligand of the β_(2)-adrenergic receptor(β_(2)-AR).The radioligand binding assays demonstrated that Higenamine was the ligand of β_(2)-AR.Higenamine induced phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2),which can be blocked by propranolol,an inhibitor of β_(2)-AR.The Gi protein inhibitor,pertussis toxin,had no effect on the phosphorylation of ERK1/2 induced by Higenamine.Furthermore,Higenamine induced ERK1/2 phosphorylation through transactivation of Epithelial growth factor receptor(EGFR).We also found that Higenamine-induced-ERK1/2 phosphorylation is dependent on β-arrestin1/2,and HG inhibits Doxorubicin-induced cardiomyocyte apoptosis.Our results identify Higenamine as a novel biased ligand via the β-arrestin-dependent pathway.These findings give us a better understanding of Higenamine’s potential role in designing diagnostic and therapeutic strategies. | Nana Zhang Haibo Zhu Zijian Li Erdan Dong | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 15 | Src mediatesβ-adrenergic receptor induced YAP tyrosine phosphorylation显示文摘The Hippo pathway is a newly identified pathway and evolutionarily conserved from flies to humans mainly regulating cell proliferation.Transcriptional co-activator Yes-associated protein(YAP)functions as a major downstream effector and key node of the Hippo pathway.Phosphorylation of YAP is critical to regulate YAP activity and its corresponding functions.β-adrenergic receptor(β-AR),a typical G protein coupled receptor(GPCR),mediates proliferation in various cell types and regulates multiple physical and pathological processes.However,the role ofβ-AR in regulating YAP remains elusive.Here,we report thatβ-AR can obviously stimulate YAP tyrosine phosphorylation.The mechanism is thatβ-AR stimulation results in tyrosine kinase Src activation and Src phosphorylates YAP tyrosine at Y357.Further studies demonstrate that inhibition of Src kinase activity can obviously alleviateβ-AR induced YAP tyrosine phosphorylation and cell proliferation.We conclude thatβ-AR can induce YAP tyrosine phosphorylation and also establish the Src/YAP pathway as a critical signaling branch downstream of GPCR. | Wenjing Wang Wenqi Li Kai Liu Xiaodou Niu Kaihang Guan Yunqi Jiang Zijian Li Erdan Dong | 2020 | Science China(Life Sciences)2020，63，5： | 0 |
| 16 | Patients'Attitudes to Unproven Therapies in Treating COVID-19 Merit Evaluation显示文摘Since the outbreak of COVID-19,many randomized controlled trials have been launched to test the efficacy of promising treatments.These trials will offer great promise for future treatment.However,a public health emergency calls for a balance between gathering sound evidence and granting therapeutic access to promising trial drugs as widely as possible.In an electronic survey,we found that 3.9%of the participants preferred to receive an unproven trial drug directly in the hypothetical scenario of mild COVID-19 infection.This percentage increased drastically to 31.1%and 54.2%in the hypothetical scenario of severe and extremely severe infection,respectively.Our survey indicates a likelihood of substantial receptivity of trial drugs among actual patients in severe conditions.From the perspective of deontological ethics,a trial can only be approved when potential benefits of the investigational treatment are presumed to outweigh risks,so compassionate or off-label use of investigational therapies merits evaluation. | Hong-tian Li Zhi-hao Cheng Yong-ying Huang Xi-lin Lv Yu-bo Zhou Erdan Dong Jian-meng Liu | 2020 | The Innovation2020，1，2： | 0 |
| 17 | A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation显示文摘Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and pathogenesis.The immature phenotypes of stem cell-differentiated cells deposit a major bottleneck in regenerative medicine. | Yuxuan Guo Yangpo Cao Blake D.Jardin Neil Mazumdar Congting Guo Luzi Yang Junsen Lin Zhan Chen Qing Ma Mingming Zhao Erdan Dong William T.Pu | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
| 18 | Building a Chronic Diseases Prevention and Rehabilitation System Throughout the Life Span to Proactively Respond to the Challenges of Accelerated Population Aging显示文摘Population aging has emerged as one of the most pressing global demographic issues.Rapid population aging is being caused by a sharp drop in fertility rates over time,as well as a significant increase in life expectancy in the past decades.The World Health Organization(WHO)estimates that the proportion of those aged 60 years and older in the world’s population will almost double from approximately 12%in 2015 to 22%in 2050,with an absolute increase of 900 million to a total of 2 billion older adults(1).At the same time,the burden of global disease has changed greatly and the main diseases affecting human health have switched from acute and chronic infectious diseases to chronic non-communicable diseases(NCDs)(2).Such changing demographics and disease spectrum will profoundly affect all aspects of human society. | Erdan Dong Xiaoying Zheng | 2022 | China CDC weekly2022，4，39： | 0 |
| 19 | Current State and Challenges of Rehabilitation Needs Among Elderly-China,1990-2019显示文摘Summary What is already known about this topic?Rehabilitation is an essential part of achieving health for all,whereas the estimates of rehabilitation needs,especially for elderly individuals in China,are not clear.What is added by this report?Compared with 1990,the prevalence and years of life lived with disability for health conditions in need of rehabilitation in China increased by 71.3%and 77.0%in 2019,respectively,at a rate much higher than the global average.What are the implications for public health practices?This study mainly presents scientific data and a systematic analysis of the current state and challenges of rehabilitation needs for elderly individuals(aged 60 and above)in China based on the World Health Organization Rehabilitation Need Estimator. | Xin Guo Jiakang Huo Wanwei Dai Zhongyan Wang Jian Du Xiaoying Zheng Erdan Dong | 2022 | China CDC weekly2022，4，39： | 0 |
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