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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19显示文摘Coronavirus disease 2019(COVID-19)is a pandemic with no specific drugs and high fatality.The most urgent need is to find effective treatments.We sought to determine whether hydroxychloroquine(HCQ)application may reduce the death risk of critically ill COVID-19 patients.In this retrospective study,we included 550 critically ill COVID-19 patients who need mechanical ventilation in Tongji Hospital,Wuhan,from February 1,2020 to April 4,2020.All 550 patients received comparable basic treatments including antiviral drugs and antibiotics,and 48 of them were treated with oral HCQ treatment(200 mg twice a day for 7–10 days)in addition to the basic treatments.Primary endpoint is fatality of patients,and inflammatory cytokine levels were compared between HCQ and non-hydroxychloroquine(NHCQ)treatments.We found that fatalities are 18.8%(9/48)in HCQ group,which is significantly lower than 47.4%(238/502)in the NHCQ group(P<0.001).The time of hospital stay before patient death is 15(10–21)days and 8(4–14)days for the HCQ and NHCQ groups,respectively(P<0.05).The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2(8.3–118.9)pg mL–1 at the beginning of the treatment to 5.2(3.0–23.4)pg mL–1(P<0.05)at the end of the treatment in the HCQ group but there is no change in the NHCQ group.These data demonstrate that addition of HCQ on top of the basic treatments is highly effective in reducing the fatality of critically ill patients of COVID-19 through attenuation of inflammatory cytokine storm.Therefore,HCQ should be prescribed as a part of treatment for critically ill COVID-19 patients,with possible outcome of saving lives. | Bo Yu Chenze Li Peng Chen Ning Zhou Luyun Wang Jia Li Hualiang Jiang Dao-Wen Wang | 2020 | Science China(Life Sciences)2020，63，10： | 7 |
| 3 | Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases显示文摘Coronavirus disease 2019(COVID-19) is a global pandemic which has caused numerous deaths worldwide. The present study investigated the roles of hypoproteinemia in the clinical outcome and liver dysfunction of COVID-19 patients. In this retrospective study, we extracted data from 2,623 clinically confirmed adult COVID-19 patients(≥18 years old) between January 29,2020 and March 6, 2020 in Tongji Hospital, Wuhan, China. The patients were divided into three groups—non-critically ill,critically ill, and death groups—in accordance with the Chinese Clinical Guideline for COVID-19. Serum albumin, low-density lipoproteins cholesterol(LDL-C), and high-density lipoproteins cholesterol(HDL-C) concentrations and inflammatory cytokines levels were measured and compared among these three groups. The median age of these 2,623 patients was 64 years old(interquartile range(IQR), 52–71). Among the patients enrolled in the study, 2,008(76.6%) were diagnosed as non-critically ill and 615(23.4%) were critically ill patients, including 383(14.6%) critically ill survivors and 232(8.8%) critically ill deaths in the hospital. Marked hypoalbuminemia occurred in 38.2%, 71.2%, and 82.4% patients in non-critically ill, critically ill, and death groups, respectively, on admission and 45.9%, 77.7%, and 95.6% of these three groups, respectively, during hospitalization. We also discovered that serum low-density lipoprotein(LDL) and HDL levels were significantly lower in critically ill and death groups compared to non-critically ill group. Meanwhile, the patients displayed dramatically elevated levels of serum inflammatory factors, while a markedly prolonged activated partial thromboplastin time(APTT) in critically ill patients reflected coagulopathy. This study suggests that COVID-19-induced cytokine storm causes hepatotoxicity and subsequently critical hypoalbuminemia, which are associated with exacerbation of disease-associated inflammatory responses and progression of the disease and ultimately leads to death for some critically ill patients. | Wei Huang Chenze Li Zhiquan Wang Hong Wang Ning Zhou Jiangang Jiang Li Ni Xin A.Zhang Dao-Wen Wang | 2020 | Science China(Life Sciences)2020，63，11： | 7 |
| 4 | Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection显示文摘Aortic dissection(AD) is a devastating,heterogeneous condition of aorta.The homeostasis between collagens and matrix metalloproteases(MMPs)/tissue inhibitors of MMPs(TIMPs) system in the extracellular matrix plays an important role for structure and functions of aorta.However,our knowledge on association between variants of genes in this system and pathogenesis of AD is very limited.We analyzed all yet known coding human genes of collagens(45 genes),MMPs/TIMPs(27genes) in 702 sporadic AD patients and in 163 matched healthy controls,by using massively targeted next-generation and Sanger sequencing.To define the pathogenesis of potential disease-causing candidate genes,we performed transcriptome sequencing and pedigree co-segregation analysis in some genes and generated Col5a2 knockout rats.We identified 257 pathogenic or likely pathogenic variants which involved 88.89%(64/72) genes in collagens-MMPs/TIMPs system and accounted for 31.05%(218/702) sporadic AD patients.In them,84.86%patients(185/218) carried one variant,12.84%two variants and 2.30%more than two variants.Importantly,we identified 52 novel probably pathogenic loss-of-function(LOF) variants(20 nonsense,16 frameshift,14 splice sites,one stop-loss,one initiation codon) in 11.06%(50/452) AD patients,which were absent in 163controls(P=2.5×10^(-5)).Transcriptome sequencing revealed that identified variants induced dyshomeostasis in expression of collagens-TIMPs/MMPs systems.The Col5α2^(-/-) rats manifested growth retardation and aortic dysplasia.Our study provides a first comprehensive map of genetic alterations in collagens-MMPs/TIMPs system in sporadic AD patients and suggests that variants of these genes contribute largely to AD pathogenesis. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Chenze Li Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2017 | Science China(Life Sciences)2017，60，1： | 4 |
| 5 | Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs显示文摘Dear Editor.The coronavirus disease 2019(COVID-19)pandemic caused by widespread infection with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)(Chen et al.,2020;Guan et al.,2020)has led to a global health crisis.More than 3.5 million infections and 246,838 deaths have occurred as of May 4,2020(Saqrane and El Mhammedi,2020),with a rapid upward trend.Many CO VID-19 patients suffer from complicated systemic injuries such as cardiac(Chen et al.,2020)and hepatic(Huang et al.,2020)damages. | Bo Yu Chenze Li Peng Chen Jia Li Hualiang Jiang Dao-Wen Wang | 2021 | Science China(Life Sciences)2021，64，2： | 2 |
| 6 | Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients显示文摘到在急性冠的症候群(交流) 以后的病人的第二等的预防药(ATM ) 的低坚持与差的临床的结果被联系。然而,文学在对与交流在中国病人与穷人联系的 ATM 和风险的评价以后提供有限数据。在当前的工作, ATM 在 Tongji 与交流在连续地招募的病人被估计从 2013 年 11 月 5 日的医院到 2014 年 12 月 31 日。2126 个病人的一个总数在低坚持下面被分类(盖住的天(PDC ) 分配 C <50%) 并且高坚持(PDC >50%) 在分泌物以后基于他们的表演组织。所有病人被跟随在上面在第一,第 6,和第 12 月当记录 ATM 和主要不利心脏的事件(向) 时,排出。Bivariate 逻辑回归被用来识别与 ATM 联系的因素。考克斯回归被用来在分泌物以后在一年以内分析在 ATM 和向之间的协会。结果证明冠的动脉独自绕过 grafting (CABG ) 到 P2Y12 对手的高坚持的有的显著地更低的比例(83.0% 对 90.7% , P < 0.01 ) 比仅仅与经皮的冠的干预(一种总线标准) 对待的病人。而且在经历一种总线标准的病人,到 P2Y12 对手的高坚持减少了向的风险(危险比率 = 0.172, 95% 信心间隔:0.039-0.763;P = 0.021 ) 。在结论,对待一种总线标准的病人是对比对待 CABG 的病人仍然是支持者到药敏感的更多。到 P2Y12 对手的高坚持与向的更低的风险被联系。 | Yang Sun Chenze Li Lina Zhang Dong Hu Xudong Zhang Ting Yu Min Tao Dao Wen Wang Xiaoqing Shen | 2017 | Frontiers of Medicine2017，11，1： | 2 |
| 7 | Biotransformation of 14-deoxy-14- methylenetriptolide into a novel hydroxylation product by Neurospora crassa 显示文摘 | ChenZ Li JA Lin H | 2013 | J Biosei Bioeng2013，116，2： | 1 |
| 8 | Novel carbon-based strong acid catalyst from starch and its catalytic ac-tivities for acetalization 显示文摘 | Liang Xuezheng Li Chunqing Qi Chenze | 2010 | J Mater Sci2010，46，： | 1 |
| 9 | Gd-doped CuBi_(2)O_(4)/CuO heterojunction film photocathodes for photoelectrochemical H_(2)O_(2)production through oxygen reduction显示文摘Photoelectrochemical oxygen reduction reaction(ORR)toward H_(2)O_(2)is highly desirable because only sunlight,O_(2)and water are required in the process.However,the corresponding studies are still at its infancy because of the lack of suitable photocathodes,especially inorganic semiconductor photocathodes.In this work,we report CuBi_(2)O_(4)/CuO(CBO/CuO)heterojunction submicrocrystalline film photocathodes with efficient ORR activity for H_(2)O_(2)production.The heterojunction film photocathodes were prepared through thermal evaporation of Cu and Bi metals under vacuum and subsequent annealing treatment.Furthermore,the doping of Gd^(3+)ions into CBO/CuO could significantly enhance the yield of H_(2)O_(2).As a result,the concentration of H_(2)O_(2)could reach 1.3 mM within 30 min,which is 6 times higher than that obtained on the pristine CBO/CuO photocathode.The theoretical calculations suggested that the introduction of Gd could adjust the electronic structure of CBO surface and promote 2e ORR pathway for selective production of H_(2)O_(2).Our work not only provides a new strategy for designing highly efficient photocathode for H_(2)O_(2)production but also will evoke more interest in photoelectrocatalytic ORR through inorganic semiconductor photocathode. | Zixin Li Quanlong Xu Faliang Gou Bing He Wei Chen Weiwei Zheng Xu Jiang Kai Chen Chenze Qi Dekun Ma | 2021 | Nano Research2021，14，10： | 1 |
| 10 | FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population显示文摘The association among plasma trimethylamine-N-oxide(TMAO),FMO3 polymorphisms,and chronic heart failure(CHF)remains to be elucidated.TMAO is a microbiota-dependent metabolite from dietary choline and carnitine.A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction,with the longest follow-up of 7 years.The concentrations of plasma TMAO and its precursors,namely,choline and carnitine,were determined by liquid chromatography-mass spectrometry,and the FMO3 E158K polymorphisms(rs2266782)were genotyped.The top tertile of plasma TMAO was associated with a significant increment in hazard ratio(HR)for the composite outcome of cardiovascular death or heart transplantation(HR=1.47,95%CI=1.13-1.91,P=0.004)compared with the lowest tertile.After adjustments of the potential confounders,higher TMAO could still be used to predict the risk of the primary endpoint(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).This result was also obtained after further adjustment for carnitine(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).The FM03 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort,and lower TMAO levels were found in the AA-genotype.Thus,higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders,and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels. | Haoran Wei Mingming Zhao Man Huang Chenze Li Jianing Gao Ting Yu Qi Zhang Xiaoqing Shen Liang Ji Li Ni Chunxia Zhao Zeneng Wang Erdan Dong Lemin Zheng Dao Wen Wang | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 11 | Erratum to:Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19显示文摘1.In the abstract,we missed a piece of information.The correct sentence should be“In this retrospective study,we included 550 critically ill COVID-19 patients who need mechanical ventilation(63.5%)and oxygen therapy(35.6%)in Tongji Hospital,Wuhan,from February 1,2020 to April 4,2020.” | Bo Yu Chenze Li Peng Chen Ning Zhou Luyun Wang Jia Li Hualiang Jiang Dao-Wen Wang | 2020 | Science China(Life Sciences)2020，63，10： | 0 |
| 12 | Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study显示文摘Thoracic aortic dissection(TAD)without familial clustering or syndromic features is known as sporadic TAD(STAD).So far,the genetic basis of STAD remains unknown.Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population(N=637).After population structure and genetic relationship and ancestry analyses,we used the optimal sequence kernel association test to identify the candidate genes or variants of STAD.We found that COL3A1 was significantly relevant to STAD(P=7.35×10^(−6))after 10000 times permutation test(P=2.49×10^(−3)).Moreover,another independent cohort,including 423 cases and 734 non-STAD subjects(N=1157),replicated our results(P=0.021).Further bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissues,and its expression was related to the extracellular matrix(ECM)pathway.Our study identified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1 could increase the risk of STAD through the ECM pathway.We wanted to expand the knowledge of the genetic basis and pathology of STAD,which may further help in providing better genetic counseling to the patients. | Yanghui Chen Yang Sun Zongzhe Li Chenze Li Lei Xiao Jiaqi Dai Shiyang Li Hao Liu Dong Hu Dongyang Wu Senlin Hu Bo Yu Peng Chen Ping Xu Wei Kong Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，3： | 0 |
| 13 | Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction:Evidence from Metabolomics显示文摘Epoxyeicosatrienoic acids(EETs)have pleiotropic endogenous cardiovascular protective effects and can be hydrolyzed to the corresponding dihydroxyeicosatrienoic acids by soluble epoxide hydrolase(sEH).Heart failure with preserved ejection fraction(HFpEF)has shown an increased prevalence and worse prognosis over the decades.However,the role of sEH activ-ity in HFpEF remains unclear.We enrolled 500 patients with HFpEF and 500 healthy controls between February 2010 and March 2016.Eight types of sEH-related eicosanoids were measured according to target metabolomics,and their correlation with clinical endpoints was also analyzed.The primary endpoint was cardiac mortality,and the secondary endpoint was a composite of cardiac events,including heart failure(HF)readmission,cardiogenic hospitalization,and all-cause mortal-ity.Furthermore,the effect of sEH inhibitors on cardiac diastolic function in HFpEF was investigated in vivo and in vitro.Patients with HFpEF showed significantly enhanced EET degradation by the sEH enzyme compared with healthy controls.More importantly,sEH activity was positively correlated with cardiac mortality in patients with HFpEF,especially in older patients with arrhythmia.A consistent result was obtained in the multiple adjusted models.Decreased sEH activity by the sEH inhibitor showed a significant effective effect on the improvement of cardiac diastolic function by ameliorating lipid disorders in cardiomyocytes of HFpEF mouse model.This study demonstrated that increased sEH activity was associated with cardiac mortality in patients with HFpEF and suggested that sEH inhibition could be a promising therapeutic strategy to improve diastolic cardiac function.Clinical trial identifier:NCT03461107(https://clini caltr ials.gov). | Liyuan Peng Ziping Song Chengcheng Zhao Kudusi Abuduwufuer Yanwen Wang Zheng Wen Li Ni Chenze Li Ying Yu Yi Zhu Hualiang Jiang Jinshan Shen Xiangrui Jiang Chen Chen Xu Zhang Dao Wen Wang | 2023 | Phenomics2023，3，1： | 0 |
| 14 | Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-Fluorodeoxyglucose Positron Emission Tomography显示文摘In animal experiments,ischemic stroke is usually induced through middle cerebral artery occlusion(MCAO),and quality assessment of this procedure is crucial.However,an accurate assessment method based on 18F-fluorodeoxyglucose(FDG)positron emission tomography(PET)is still lacking.The difficulty lies in the inconsistent preprocessing pipeline,biased intensity normalization,or unclear spatiotemporal uptake of FDG.Here,we propose an image feature-based protocol to assess the quality of the procedure using a 3D scale-invariant feature transform and support vector machine.This feature-based protocol provides a convenient,accurate,and reliable tool to assess the quality of the MCAO procedure in FDG PET studies.Compared with existing approaches,the proposed protocol is fully quantitative,objective,automatic,and bypasses the intensity normalization step.An online interface was constructed to check images and obtain assessment results. | Wuxian He Hongtu Tang Jia Li Chenze Hou Xiaoyan Shen Chenrui Li Huafeng Liu Weichuan Yu | 2022 | Neuroscience Bulletin2022，38，9： | 0 |
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