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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | 用熔解曲线法分析插入/缺失多态性和Y染色体SNPs多态性显示文摘随着单核苷酸多态性SNPs (SingleNucleotidePolymorphisms)及插入 /缺失多态性Indels (Insertion/Dele tion)的分型技术研究的深入 ,SNPs和Indels在法医学上的应用将受到深刻的影响。本文研究和探讨Indels的分型方法 ,通过测定扩增DNA片段在溶液中的溶解曲线图确定每个样品的基因型 ,称为溶解曲线Indels基因分型方法(McI/D)。溶解曲线图由被测样品DNA片段的特殊溶解温度组成 ,扩增结果直接由仪器分析不需要繁杂的PCR后期操作。 | 叶健 郑秀芬 季安全 Esteban J Parra Donna M Sosnoski Mark D Shriver | 2001 | 中国法医学杂志2001，16，4： | 3 |
| 3 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 4 | Toward a Theory of Stakeholder Identification And Salience:Defining The Principle of Who and What Really Counts显示文摘 | RONALD K MITCHELL BRADLEY R AGLE DONNA J WOOD | 1997 | Academy of Management Review1997，22，4： | 1 |
| 5 | Root planing fllowing short-term pocket distertion显示文摘 | Donna M Peter J | 1997 | J Periodontol1997，68，7： | 1 |
| 6 | To- ward a Theory of Stakeholder Identification and Salience: Defining the Principle of Who and What Really Counts 显示文摘 | Ronald K Mitchell Bradley R Agle Donna J Wood | 1997 | Academy of Management Review1997，，： | 1 |
| 7 | Clinical relevance of transmembrane drug as a mechanism of multidrug resistance显示文摘 | Donna M Bradshaw Robert J | 1998 | Journal of Clinical Oncology1998，16，11： | 1 |
| 8 | Customer complaints by e-rrmil:a exploratory investication of corporate responses and customer reaetion显示文摘 | Judy Strauss Donna J Hill | 2001 | Journal of Interactive Marketing2001，15，11： | 1 |
| 9 | Adverse effects of semen processing on human spem DNA integrity显示文摘 | Victor M Keith J Donna P | 1999 | J Urol1999，161，282： | 1 |
| 10 | Current Issues and Conceptualizations of Service Quality in the Recreation Sport Industry显示文摘 | Yong J K Donna L P | 2004 | Sport Marketing Quarterly2004，13，3： | 1 |
| 11 | Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract显示文摘 | KENNETH M HUTTNER K M DONNA J | 1998 | American Society for Nutritional Sciences1998，128，2： | 1 |
| 12 | Neuropsychological assessment of learning and memory显示文摘 | Donna E Kalyna Z Buter J | 2003 | Jclin psychinatry2003，64，： | 1 |
| 13 | Effects of nutrition education progranms on anthropometric measurements and pregnancy outconme of adolescents显示文摘 | Donna Jean arbara J Janice R | 2002 | Am Diet Assoc2002，102，3： | 1 |
| 14 | Immunophenotypic markers and antiretroviral therapy (IMART):T cell activation and maturation help predict treatment response显示文摘 | Donna M Ronald J B Ryung S K | 2004 | JID2004，189，15： | 1 |
| 15 | Corporate Social Performance Revisited显示文摘 | Wood Donna J | 1991 | Academy of Management Review1991，16，4： | 1 |
| 16 | An event-based spatio temporal data model ( ESTDM ) for temporal analysis of geo- graphical data 显示文摘 | Donna J Peuquet Niu Duan | 1995 | IntJ Geographical Info Sys1995，9，1： | 1 |
| 17 | Experimen -tal and analytical efforts to characterize cutting fluid mist forma-tion and behavior in machining 显示文摘 | Donna J Michalek Wilson W S Hii Jichao Sun | 2003 | Applied Occupational & Envi -ronmental Hygiene2003，18，11： | 1 |
| 18 | Unrelated umbilical cord blood transplantation in adult patients显示文摘 | Gwynn D Long Mary Laughlin Bella Madan Joanne Kurtzberg Cristina Gasparetto Ashley Morris David Rizzieri Clayton Smith James Vredenburgh Edward C Halperin Gloria Broadwater Donna Niedzwiecki Nelson J Chao | 2003 | Biology of Blood and Marrow Transplantation2003，，： | 1 |
| 19 | Making space for time:issues in space-time data representation显示文摘 | DONNA J P | 2001 | Geolnformatiea2001，5，1： | 1 |
| 20 | Cancer proteomics: flom signaling networks to tumor markers显示文摘 | Richard J S Donna S D | 2001 | Trends in Biotechnology2001，19，10： | 1 |
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