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| 1 | Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film显示文摘一个新奇电气化学的脱氧核糖核酸生物传感器基于氧化锌(ZnO ) ,为脱氧核糖核酸固定和提高的杂交察觉的 nanoparticles 和多围的碳 nanotubes (MWNT ) 被介绍。MWNTs/nano ZnO/chitosan 合成电影修改了玻璃化炭黑电极(MWNTs/ZnO/CHIT/GCE ) 被制作,脱氧核糖核酸探针在电极表面上被使不能调动。杂交事件被微分脉搏 voltammetry (DPV ) 作为指示物用亚甲蓝(MB ) 监视。传感器能有效地区别不同脱氧核糖核酸序列与有关在转基因的玉米轻拍基因,与 2.8 ×的检测极限 10 ? 目标顺序的 12 mol/L。 | Wei Zhang Tao Yang Da Ming Huang Kui Jiao | 2008 | Chinese Chemical Letters2008，19，5： | 8 |
| 2 | Strain Softening and Hardening Behavior in AZ61 Magnesium Alloy显示文摘The deformation behavior of AZ61 Mg alloy during hot deformation has been investigated in wide temperature and strain rate range by a Gleeble simulator. Specimens are deformed in compression in the temperature range of 523~673 K and at strain rates of 0.001~1 s-1. It is found that the flow curves exhibit a peak and then decrease towards steady-state of classical DRX, which decrease with rising temperature and decreasing strain rate. The deformation behavior of the specimens can be attributed to the occurrence of strain hardening and softening. As stress decreases, the strain hardening rate declines at a fast rate when temperature rises or strain rate decreases. The shapes of θ-σ curves indicate some important features such as subgrain formation, the critical stress, the peak stress and steady stress. The onset of DRX can be determined by the point of inflection on θ-σ or Inθ-σ curves. | Haitao ZHOU, Liufa LIU, Qudong WANG, Da LU, Xiaoqin ZENG and Wenjiang DINGNational Engineering Research Center of Light Alloys Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200030, China | 2004 | Journal of Materials Science & Technology2004，20，6： | 7 |
| 3 | Effects of Bacterial-Feeding Nematode Grazing and Tea Saponin Addition on the Enhanced Bioremediation of Pyrene-Contaminated Soil Using Polycyclic Aromatic Hydrocarbon-Degrading Bacterial Strain显示文摘As one of the most widely distributed bacterial predators in the soil, the role of bacterivorous nematodes on the enhanced bioremediation of polycyclic aromatic hydrocarbon-contaminated soils is crucial, but remains to be investigated.A microcosm-level study was conducted to examine the effects of bacterial-feeding nematode grazing and tea saponin(TS) addition on bioremediation of a pyrene-contaminated soil enhanced by the polycyclic aromatic hydrocarbon(PAH)-degrading bacterial strain Sphingobium sp.PHE9.After 180 d of incubation, the highest pyrene dissipation(71.3%) was achieved through a combination of Sphingobium sp.PHE9 inoculation with nematode and TS addition.Meanwhile, high counts of culturable PAH-degrading bacteria, soil enzyme activity, and biodiversity indices were observed under the combined treatment, implying that the microbiological function of the contaminated soil was significantly restored.Additionally, the results of Tenax~ extraction with the first-order three-compartment model indicated that rate-limiting factors varied among treatments.The lack of degrading microorganisms was the main rate-limiting factor for the treatments involving TS/nematode addition, and inadequate bioaccessible pyrene was the vital rate-limiting factor in the treatments involving Sphingobium sp.PHE9 inoculation.The proposed combined clean-up strategy proved to be a promising bioremediation technology for aged pyrene-contaminated soils. | SUN Mingming LIU Kuan ZHAO Yuanchao TIAN Da YE Mao LIU Manqiang JIAO Jiaguo JIANG Xin | 2017 | Pedosphere2017，27，6： | 7 |
| 4 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 5 | Ice-templated porous tungsten and tungsten carbide inspired by natural wood显示文摘The structures of tungsten and tungsten carbide scaffolds play a key role in determining the properties of their infiltrated composites for multifunctional applications.However,it is challenging to construct and control the architectures by means of self-assembly in W/WC systems because of their large densities.Here we present the development of unidirectionally porous architectures,with high porosities exceeding 65 vol.%,for W and WC scaffolds which in many respects reproduce the design motif of natural wood using a direct ice-templating technique.This was achieved by adjusting the viscosities of suspensions to retard sedimentation during freezing.The processing,structural characteristics and mechanical properties of the resulting scaffolds were investigated with the correlations between them explored.Quantitative relationships were established to describe their strengths based on the mechanics of cellular solids by taking into account both inter-and intra-lamellar pores.The fracture mechanisms were also identified,especially in light of the porosity.This study extends the effectiveness of the ice-templating technique for systems with large densities or particle sizes.It further provides preforms for developing new natureinspired multifunctional materials,as represented by W/WC-Cu composites. | Yuan Zhang Guoqi Tan Da Jiao Jian Zhang Shaogang Wang Feng Liu Zengqian Liu Longchao Zhuo Zhefeng Zhang Sylvain Deville Robert O.Ritchie | 2020 | Journal of Materials Science & Technology2020，42，10： | 4 |
| 6 | Population pharmacokinetics of the anti-PD-1 antibody camrelizumab in patients with multiple tumor types and model-informed dosing strategy显示文摘Camrelizumab,a programmed cell death 1(PD-1)inhibitor,has been approved for the treatment of patients with relapsed or refractory classical Hodgkin lymphoma,nasopharyngeal cancer and non-small cell lung cancer.The aim of this study was to perform a population pharmacokinetic(PK)analysis of camrelizumab to quantify the impact of patient characteristics and to investigate the appropriateness of a flat dose in the dosing regimen.A total of 3092 camrelizumab concentrations from 133 patients in four clinical trials with advanced melanoma,relapsed or refractory classical Hodgkin lymphoma and other solid tumor types were analyzed using nonlinear mixed effects modeling.The PKs of camrelizumab were properly described using a two-compartment model with parallel linear and nonlinear clearance.Then,covariate model building was conducted using stepwise forward addition and backward elimination.The results showed that baseline albumin had significant effects on linear clearance,while actual body weight affected intercompartmental clearance.However,their impacts were limited,and no dose adjustments were required.The final model was further evaluated by goodness-of-fit plots,bootstrap procedures,and visual predictive checks and showed satisfactory model performance.Moreover,dosing regimens of 200 mg every 2 weeks and 3 mg/kg every 2 weeks provided similar exposure distributions by model-based Monte Carlo simulation.The population analyses demonstrated that patient characteristics have no clinically meaningful impact on the PKs of camrelizumab and present evidence for no advantage of either the flat dose or weight-based dose regimen for most patients with advanced solid tumors. | Chen-yu Wang Chang-cheng Sheng Guang-li Ma Da Xu Xiao-qin Liu Yu-ya Wang Li Zhang Chuan-liang Cui Bing-he Xu Yu-qin Song Jun Zhu Zheng Jiao | 2021 | Acta Pharmacologica Sinica2021，42，8： | 3 |
| 7 | Bioinspired tungsten-copper composites with Bouligand-type architectures mimicking fish scales显示文摘The microscopic Bouligand-type architectures of fish scales demonstrate a notable efficiency in enhancing the damage tolerance of materials;nevertheless,it is challenging to reproduce in metals.Here bioinspired tungsten-copper composites with different Bouligand-type architectures mimicking fish scales were fabricated by infiltrating a copper melt into woven contextures of tungsten fibers.These composites exhibit a synergetic enhancement in both strength and ductility at room temperature along with an improved resistance to high-temperature oxidization.The strengths were interpreted by adapting the classical laminate theory to incorporate the characteristics of Bouligand-type architectures.In particular,under load the tungsten fibers can reorient adaptively within the copper matrix by their straightening,stretching,interfacial sliding with the matrix,and the cooperative kinking deformation of fiber grids,representing a successful implementation of the optimizing mechanisms of the Bouligand-type architectures to enhance strength and toughness.This study may serve to promote the development of new high-performance tungsten-copper composites for applications,e.g.,as electrical contacts or heat sinks,and offer a viable approach for constructing bioinspired architectures in metallic materials. | Yuan Zhang Guoqi Tan Mingyang Zhang Qin Yu Zengqian Liu Yanyan Liu Jian Zhang Da Jiao Faheng Wang Longchao Zhuo Zhefeng Zhang Robert O.Ritchie | 2022 | Journal of Materials Science & Technology2022，，1： | 3 |
| 8 | Genetic control of compound leaf development in the mungbean(Vigna radiata L.)显示文摘Many studies suggest that there are distinct regulatory processes controlling compound leaf development in different clades of legumes.Loss of function of the LEAFY(LFY)orthologs results in a reduction of leaf complexity to different degrees in inverted repeat-lacking clade(IRLC)and non-IRLC species.To further understand the role of LFY orthologs and the molecular mechanism in compound leaf development in non-IRLC plants,we studied leaf development in unifoliate leaf(un)mutant,a classical mutant of mungbean(Vigna radiata L.),which showed a complete conversion of compound leaves into simple leaves.Our analysis revealed that UN encoded the mungbean LFY ortholog(VrLFY)and played a significant role in leaf development.In situ RNA hybridization results showed that STM-like KNOXI genes were expressed in compound leaf primordia in mungbean.Furthermore,increased leaflet number in heptafoliate leaflets1(hel1)mutants was demonstrated to depend on the function of VrLFY and KNOXI genes in mungbean.Our results suggested that HEL1 is a key factor coordinating distinct processes in the control of compound leaf development in mungbean and its related non-IRLC legumes. | Keyuan Jiao Xin Li Shihao Su Wuxiu Guo Yafang Guo Yining Guan Zhubing Hu Zhenguo Shen Da Luo | 2019 | Horticulture Research2019，6，1： | 2 |
| 9 | Pilaring of Zn_2Al Layered Double Hydroxide by Dawson Polyoxometalate Anions显示文摘PilaringofZn2AlLayeredDoubleHydroxidebyDawsonPolyoxometalateAnions**SupportedbytheNationalNaturalScienceFoundationofChinaandt... | GUO Jun, LI Yunlun, JIAO Qingze** and JIANG Dazhen(Department of Chemistry, Jilin University, Changchun, 130023)MIN Enze(Research Institute of Petroleum Processing, Beijing, 100083) | 1998 | Chemical Research in Chinese Universities1998，14，2： | 2 |
| 10 | Wavelet support vector machine 显示文摘 | Zhang Li Zhou Wei -da Jiao Li -cheng | 2004 | IEEE Transactions on systems man and cybernetics - Part B : cybernetics2004，34，1： | 1 |
| 11 | Wavelet support vector machine显示文摘 | Zhang Li Zhou Wei Da Jiao Li Cheng | 2004 | IEEE Trans on System and Cybernetics-Part B: Cybernetics2004，34，1： | 1 |
| 12 | Wavelet support vector machine 显示文摘 | Zhang Li Zhou Wei - da Jiao Li-cheng | 2004 | IEEE Transactions on systems man and cybernetics2004，34，1： | 1 |
| 13 | Microbial production of recalcitrant dissolved organic matter:long-term carbon storage in the global ocean显示文摘 | Jiao NZ Herndl G J Hansell DA | | 0，，： | 1 |
| 14 | Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system 显示文摘 | Jiao J Feldheim DA Chen DF | 2008 | Proc Natl Acad Sci USA2008，105，25： | 1 |
| 15 | Bcl-2 enhances Ca^2+ signaling to support the intrinsic regenerative capacity of CNS axons 显示文摘 | Jiao J Huang X Feit-Leithman RA Neve RL Snider W Dartt DA | 2005 | EMBO J2005，24，5： | 1 |
| 16 | Hidden space support vector machines显示文摘 | Zhang Li Zhou Wei - da Jiao Li - cheng | 2004 | IEEE Transactions on Neural Networks2004，15，6： | 1 |
| 17 | Regulation of root secondary metabolites by partial root-associated microbiotas under the shaping of licorice ecotypic differentiation in northwest China显示文摘Interactions between plant hosts and their microbiotas are becoming increasingly evident,while the effects of plant communities on microbial communities in different geographic environments are poorly understood.Here,the differentiation of licorice plant ecotypes and the distribution of rootassociated microbiotas were investigated across five sampling sites in northwest China.The interactions between the environment,plant and microbial communities,and their effects on licorice root secondary metabolites,were elucidated.The plant community was clearly differentiated into distinct ecotypes based on genotyping-by-sequencing and was primarily driven by geographic distance and available soil nitrogen.The bulk soil and rootassociated microbiotas(rhizosphere soil and root endosphere)partially correlated with plant community,but all were significantly discriminated by plant clade.Moreover,these microbiotas were explained to different extents by distinct combinations of environment,geography,and plant community.Similarly,three structural equation models showed that licorice root secondary metabolites were complicatedly modulated by multiple abiotic and biotic factors,and were mostly explained by these factors in the rhizosphere model.Collectively,the results provide novel insights into the role of environment–plant–microbiota interactions in regulating root secondary metabolites.That should be accounted for when selecting appropriate licorice planting sites and management measures. | Yang Liu Hao Wang Ziheng Peng Da Li Weimin Chen Shuo Jiao Gehong Wei | 2021 | Journal of Integrative Plant Biology2021，63，12： | 1 |
| 18 | Thermoelectric cooling for power e- lectronics circuits: modeling and active temperature control显示文摘 | CongLi Da Jiao Jizhou Jia | 2014 | IEEE Transactions on Industry Applications2014，50，6： | 1 |
| 19 | Ephnns as negahve regulators of adult neurogenesis in diverse regions of the central nervous system 显示文摘 | Jiao JW Feldheim DA Chen DF | 2008 | Proc Natl Aead Sei USA2008，105，25： | 1 |
| 20 | Ephrins as negative regulators of a- dult neurogenesis in diverse regions of the central nervous system显示文摘 | Jiao JW Feldheim DA Chen DF | 2008 | Proc Natl Acad Sci U S A2008，105，25： | 1 |
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