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| 1 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 2 | A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns显示文摘AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B vaccine.METHODS In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 to1998.Their serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA Kits.The annual HBsAgpositive conversion rate was counted by life-table method.RESULTS①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year respectively.GMT valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year respectively.Therewas a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic carriers.Compared with the baselinebefore immunization,the protective rates were97.19% and 95.32% respectively.CONCLUSION The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers. | Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 3 | Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells显示文摘In order to study the mechanism of the effect of heparin on apoptosis in carcinoma cells, the nasopharyngeal carcinoma cell line CNE2 was used to identify the effect of heparin on apoptosis associated with the expression of c-myc, bax, bcl-2 proteins by use of Hoechst 33258 staining, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), agarose gel electrophoresis, and flow cytometry, as well as Western blot analysis. The results showed that heparin induced apoptosis of CNE2 cells including the morphologic changes such as reduction in the volume, and the nuclear chromatin condensation, as well as the “ladder pattern” revealed by agarose gel electrophoresis of DNA in a concentration-dependent manner.The number of TUNEL-positive cells was dramatically increased to 33.6±1.2% from 2.8±0.3% by treat ment with heparin in different concentrations (10~40 kU/L). The apoptotic index was increased to 32.5% from 3.5% by detecting SubG1 peaks on flow cytometry. Western blot analysis showed that levels of bcl-2,bax and c-myc were significantly overexpressed by treatment with the increase of heparin concentrations.These results suggest that heparin induces apoptosis of CNE2 cells, which may be regulated by differential expression of apoptosis-related genes. | LI HONG LIANG , KAI HE YE , HAI WEI ZHANG , YING RU LUO , XIAN DA REN, AI HUA XIONG, RUI SITU Department of Pharmacology ,Pharmacy College, Department of Pathology Medical College, Jinan University, Guangzhou 510632, China | 2001 | Cell Research2001，11，4： | 9 |
| 4 | Mechanism of exogenous nucleic acids and their precursors improving the repair of intestinal epithelium after 7-irradiation in mice显示文摘AIM To clone expressed genes associated withrepair of irradiation-damaged mice intestinalgland cells treated by small intestinal RNA,andto explore the molecular mechanism ofexogenous nucleic acids improving repair ofintestinal crypt.METHODS The animal mode of test group andcontrol group was established,forty-five micebeing irradiated by γ ray were treated with smallintestinal RNA as test group,forty mice beingirradiated by γ ray were treated withphysiological saline as control group,five micewithout irradiation were used as normal control,their jejunal specimens were collectedrespectively at 6h,12h,24h,4d and 8d afterirradiation.Then by using LD-PCR based onsubtractive hybridization,these gene fragmentsdifferentially expressed between test group andcontrol group were obtained,and then werecloned into T vectors as well as beingsequenced.Obtained sequences were screenedagainst.GeneBank,if being new sequences,they were submitted to GeneBank.RESULTS Ninety clones were associated withrepair of irradiation-damaged intestinal glandcells treated by intestinal RNA.These clonesfrom test group of 6h,12h,24h,4d and 8dwere respectively 18,22,25,13,12.By screening against GeneBank,18 of which werenew sequences,the others were dramaticallysimilar to the known sequences,mainly similarto hsp,Nmi,Dutt1,alkaline phosphatase,homeobox,anti-CEA ScFv antibody,arginine/serine kinase and BMP-4,repA.Eighteen genefragments were new sequences,their acceptnumbers in GeneBank were respectivelyAF240164-AF240181.CONCLUSION Ninety clones were obtained tobe associated with repair of irradiation-damagedmice intestinal gland cells treated by smallintestinal RNA,which may be related toabnormal expression of genes and matchedproteins of hsp,Nmi,Duttl,Na,K-ATPase,alkalineph-osphatase,glkA,single strandedreplicative centromeric gene as well as 18 newsequences. | Da Xiang Cui~1 Guei Ying Zeng~2 Feng Wang~1 Jun Rong Xu~1 Dong Qing Ren~2 Yan Hai Guo~1 Fu Rong Tian~2 Xiao Jun Yan~1 Yu Hou~1 Cheng Zhi Su~1 1 Institute of Genetic Diagnosis of the Fourth Military Medical University,Xi’an 710032,China 2 Department of Irradiation Medicine of the Fourth Military Medical University,Xi’an 710032,China | 2000 | World Journal of Gastroenterology2000，6，5： | 8 |
| 5 | The promoter analysis of the human C17orf25 gene, a novel chromosome 17pl3.3 gene显示文摘The human C17orf25 gene (Accession No. AF177342) is one of thirteen genes cloned from a region displaying a high score of loss of heterozygosity within chromosome 17p13.3 in human hepatocellular car-cinoma in China[l]. To unveil the underlying mechanisms for the transcription regulation of this gene and understand its implication to the hepatocellular carcinogenesis, we looked into the relevant aspects by both bioinformatic and experimental executions. We found: 1, The abundant expression of the C17orf25 gene was evident in all the cell lines and tissue samples tested, showing little hepatoma-selectivity; 2, Its tran-scription starts at a single site, locating at -60 from the translation initiation codon; 3, A 58 bp fragment containing the transcription start, extending from -112 to -55, represents the minimal promoter; 4, The consensus sequence within this fragment recognized by SP1 contributes predominantly to the activity of the minimal promoter; 5, The bioinformatic analysis suggests that the C17ort25 gene may encode a protein in the family of the glyoxalase. Our data has provided some deep insight into both function and regulation of the C17orf25 gene in the context of the normal liver and hepatocellular carcinoma. | JIAN YING GUO, JIAN XU, DA QIN MAO, LI LI FU, JIAN REN GU, JING DE ZHUThe State-Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ln 2200/25, Xie-Tu Road, Shanghai 200032, China | 2002 | Cell Research2002，12，5： | 7 |
| 6 | A Method for the Environmental Quality Assessment of Surface Water Based on Artificial Neural Networks | YANG Guo\|dong\+1,\ PAN Da\|feng\+2,\ FAN Ying\|fang\+3 1.Dep. of Environmental Science, Shanxi Uni., Taiyuan 030006, China 2.Shanxi Academy of Agriculture Science, Taiyuan 030031, China 3.Institute of Molecular Science, Shanxi Uni., Taiyuan 030006, C | 2000 | Systems Science and Systems Engineering2000，10，1： | 7 |
| 7 | The combination of PD-1 blockade with interferon-αhas a synergistic effect on hepatocellular carcinoma显示文摘Background The efficacy of immune checkpoint inhibitors(ICIs),such as programmed cell death protein-1(PD-1)or its ligand 1(PD-L1)antibody,in hepatocellular carcinoma(HCC)is limited,and it is recommended that they be combined with other therapies.We evaluated the combination of pegylated interferon-α(Peg-IFNα)with PD-1 blockade in HCC mouse models.Methods We analyzed the effects of Peg-IFNαon tumor-infiltrating immune cells and PD-1 expression in the HCC immune microenvironment and examined the underlying mechanism of its unique effect on the PD-1 pathway.The in vivo efficacy of anti-PD-1 and Peg-IFNαwas evaluated in both subcutaneous and orthotopic mouse models of HCC.Results The combination of Peg-IFNαwith PD-1 blockade dramatically enhanced T-cell infiltration,improved the efficacy of PD-1 antibody and prolonged mouse survival compared with PD-1 antibody monotherapy.Mechanistically,Peg-IFNαcould recruit cytotoxic CD8+T cells to infiltrate the HCC microenvironment by inducing tumor cells to secrete the chemokine CCL4.Nevertheless,the HCC microenvironment quickly overcame the immune responses by upregulating PD-1 expression in CD8+T cells via the IFNα-IFNAR1-JAK1-STAT3 signaling pathway.The combination of PD-1 blockade with Peg-IFNαcould restore the cytotoxic capacity of CD8+T cells and exerted a significant synergistic effect on HCC.Conclusion These results indicate that in addition to initiating the antitumor immune response itself,Peg-IFNαcan also generate a microenvironment favoring PD-1 blockade.Thus,the combination of Peg-IFNαand PD-1 blockade can be a promising strategy for HCC. | Ying Zhu Mo Chen Da Xu Tian-En Li Ze Zhang Jian-Hua Li Xiang-Yu Wang Xin Yang Lu Lu Hu-Liang Jia Qiong-Zhu Dong Lun-Xiu Qin | 2022 | Cellular & Molecular Immunology2022，19，6： | 6 |
| 8 | Inflammation inhibitory effects of sirolimus and paclitaxel-eluting stents on interleukin-1β-induced coronary artery in-stent restenosis in pigs显示文摘背景冠的动脉 in-stent 狭窄(ISR ) 和迟了的 stent 血栓作为 stenting 的重要复杂并发症留下。对 sirolimus 和 paclitaxel-eluting stents 的发炎反应在 interleukin (IL ) 劝诱的一个猪狭窄模特儿被调查 -1.Methods 微型猪(n=12;2-3 月旧、称的 25-30 kg ) 受到 thoracotomy。中间的左前面的下降冠的动脉和左降声调符号的片断(10 公里) 冠的动脉被暴露并且无菌地包了,一个棉花网孔与 IL-1 (5 g ) 浸泡了。在 2 个星期以后,动物是 anesthetized,量的冠的动脉 X 线摄影法(QCA ) 被执行。狭窄地点为 stent 插入被使随机化进三个组:一个 sirolimus-eluting stent (SES ) 组(FirebirdTM, n=7 ) ,一个 paclitaxel-eluting stent (足) 组(TAXUSTM, n=9 ) ,并且一个赤裸金属的 stent (BMS ) 组(YINYITM, Dalian Yinyi Biomaterials 发展有限公司,中国, n=8 ) 。三不同 stents 随机被植入进狭窄片断。单核白血球 chemoattractant protein-1 (MCP-1 ) 的表示,肿瘤坏死 factor-alpha (TNF-) , P-selectin 和脉管的房间粘附 molecule-1 (VCAM-1 ) 被 .Results QCA 显示出的反向的联合抄写的聚合酶链反应(RT-PCR ) 决定在 IL-1 的严重狭窄对待片断。SES 和足组晚显示出更低的 1 月的 angiographic 在 stent 和损害以内的腔损失(LLL ) 与由后续 QCA 的 BMS (P 0.05 ) 相比。SES 在由后续 QCA 在猪减少 1 月的发炎损害比足的显示出更低的 LLL ((0. | ZHOU Xu-chen HUANG Rong-chong ZHANG Bo YIN Da LIANG Bin WANG Shao-peng GUAN Qi-gang SUN Xi-zhuo MIAO Zhi-lin HE Xue-zhi HAN Feng-tong CHENG Ying ZHANG Li ZENG Ding-yin | 2010 | Chinese Medical Journal2010，，17： | 6 |
| 9 | Near-Real-Time Carbon Emission Accounting Technology Toward Carbon Neutrality显示文摘Climate change is the greatest environmental threat to humans and the planet in the 21st century.Global anthropogenic greenhouse gas emissions are one of the main causes of the increasing number of extreme climate events.Cumulative carbon dioxide(CO_(2))emissions showed a linear relationship with cumulative temperature rise since the pre-industrial stage,and this accounts for approximately 80%of the total anthropogenic greenhouse gases.Therefore,accurate and reliable carbon emission data are the foundation and scientific basis for most emission reduction policymaking and target setting.Currently,China has made clear the ambitious goal of achieving the peak of carbon emissions by 2030 and achieving carbon neutrality by 2060.The development of a finer-grained spatiotemporal carbon emission database is urgently needed to achieve more accurate carbon emission monitoring for continuous implementation and the iterative improvement of emission reduction policies.Near-real-time carbon emission monitoring is not only a major national demand but also a scientific question at the frontier of this discipline.This article reviews existing annual-based carbon accounting methods,with a focus on the newly developed real-time carbon emission technology and its current application trends.We also present a framework for the latest near-real-time carbon emission accounting technology that can be widely used.The development of relevant data and methods will provide strong database support to the policymaking for China’s“carbon neutrality”strategy.Finally,this article provides an outlook on the future of real-time carbon emission monitoring technology. | Zhu Liu Taochun Sun Ying Yu Piyu Ke Zhu Deng Chenxi Lu Da Huo Xiang Ding | 2022 | Engineering2022，8，7： | 5 |
| 10 | A novel lead-free Na_(0.5)Bi_(0.5)TiO_(3)-based ceramic with superior comprehensive energy storage and discharge properties for dielectric capacitor applications显示文摘Na_(0.5)Bi_(0.5)TiO_(3)(NBT)-based ceramics have been widely used as dielectric materials for energy storage capacitors because of their environmental friendliness and excellent ferroelectric properties.However,their energy storage performance still needs to be further improved to satisfy the increasing demand.Herein,we report a novel 0.90(Na_(0.5)Bi_(0.5))0.7Sr_(0.3)TiO_(3-0.10)Bi(Ni_(0.5)Sn_(0.5))O_(3)(0.90NBST-0.10BNS)ceramic with significantly improved energy density(5.0 J cm3),enhanced recoverable energy density(4.18 J cm^(3))and high energy efficiency(83.64%)through the incorporation of Bi(Ni0.5Sn0.5)O3(BNS),due to the increased breakdown strength and the relaxation ferroelectric(RFE)properties.The first-order reversal curve(FORC)measurements confirm that the addition of BNS improves RFE properties by breaking the order of long-range ferroelectricity.The 0.90NBST-0.10BNS ceramic also possesses an outstanding temperature and frequency stability of energy storage properties in the range of 20C e140C and 1 Hze100 Hz,respectively.More importantly,the discharge properties characterized by a preeminent power density(36.19 MW cm^(3)),transient energy release times(144.2 ns),and high discharge energy density(1.16 J cm3)also synchronously observed in 0.90NBST-0.10BNS ceramic.These results show that the 0.90NBST-0.10BNS ceramic with outstanding comprehensive performances is a promising energy storage ceramic candidate for capacitors in high power systems. | Da Li Ying Lin Qibin Yuan Miao Zhang Liang Ma Haibo Yang | 2020 | Journal of Materiomics2020，6，4： | 4 |
| 11 | Bubble Strategy—A Practical Solution to Return to Regular Life in the Intertwined Era of Vaccine Rollouts and Virus Mutation显示文摘For a long time,vaccination and herd immunity were considered to be the magic solution for controlling coronavirus disease 2019(COVID-19).However,the emergence of new variants altered people’s expectations and prolonged the pandemic duration,especially the Omicron strain with substantially increased transmissibility and decreased vaccine efficacy.Therefore,we are in urgent need of a practical solution to resume regular life to some extent,while mitigating COVID-19 risks in the tight race between vaccine rollouts and virus variation.This commentary proposed that bubble strategy(or closed loop management),utilized in Tokyo 2020 Olympic Games and to be implemented in Beijing 2022 Winter Games,could serve as a novel technique of nonpharmaceutical interventions in coping with such a situation. | Ying Shen Da Huo Tong Yu Quanyi Wang | 2022 | China CDC weekly2022，4，4： | 4 |
| 12 | The First Outbreak of Omicron Subvariant BA.5.2—Beijing Municipality,China,July 4,2022显示文摘On July 4,2022,the first case of Omicron subvariant BA.5.2 in Beijing Municipality was discovered in Yanqing District.The case was a 49-yearold Chinese male who had arrived in Shanghai Municipality via international flight DL9927 from North Carolina,U.S.on June 15.He stayed in a hotel for the 14-day arrival quarantine and was discharged on June 30.He arrived in Beijing via domestic flight MU5103 on July 1 and was transferred point-to-point from the airport to his residence community in Yanqing District.On July 3,his sample was collected through community mass screening and reported positive in the next morning.The case had received 3 doses of Moderna’s mRNA vaccines in the U.S.,with the last shot on May 26,2022. | Zhaomin Feng Ying Shen Shuang Li Jia Li Shaohua Wang Zhenquan Zhang Yunkui Shen Fu Li Yang Pan Quanyi Wang Da Huo | 2022 | China CDC weekly2022，4，30： | 4 |
| 13 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 14 | Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice显示文摘Objective Interferon-induced transmembrane protein 3(IFITM3)is an important member of the IFITM family.However,the molecular mechanisms underlying its antiviral action have not been completely elucidated.Recent studies on IFITM3,particularly those focused on innate antiviral defense mechanisms,have shown that IFITM3 affects the body’s adaptive immune response.The aim of this study was to determine the contribution of IFITM3 proteins to immune control of influenza infection in vivo.Methods We performed proteomics,flow cytometry,and immunohistochemistry analysis and used bioinformatics tools to systematically compare and analyze the differences in natural killer(NK)cell numbers,their activation,and their immune function in the lungs of Ifitm3-/-and wild-type mice.Results Ifitm3-/-mice developed more severe inflammation and apoptotic responses compared to wild-type mice.Moreover,the NK cell activation was higher in the lungs of Ifitm3-/-mice during acute influenza infection.Conclusions Based on our results,we speculate that the NK cells are more readily activated in the absence of IFITM3,increasing mortality in Ifitm3-/-mice. | SUN Qiang LEI Na LU Jian GAO Rong Bao LI Zi LIU Li Qi SUN Ying GUO Jun Feng WANG Da Yan SHU Yue Long | 2020 | Biomedical and Environmental Sciences2020，33，5： | 4 |
| 15 | Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo显示文摘基因用短介入 RNA (siRNA ) 指向成为了普通策略因为它的突出的功效和特性,探索基因功能。人的 transmembrane 4 总科成员(TM4SF4 ) 4 原来作为一个房间在肠和肝被识别增长相关的基因。最近,它在 hepatocellular 癌(HCC ) 显示出增加的表情纸巾。在这研究,我们开发了怀有指向 TM4SF4 (AdSiTM4SF4 ) 的有效 siRNA 的 adenoviral 向量并且在肿瘤细胞生长的抑制识别了它的功能。TM4SF4 与它由西方的污点分析和 immunohistochemistry 的配对的非肿瘤纸巾相比是在 HCC 纸巾的 overexpressed,这被证实。显著地,它在 HCC 房间的房间表面上是更丰富的。在在血浆膜戏剧性地局部性的四根房间线的宫外地表示的 TM4SF4 的信号,稍微在里面细胞质,并且在原子核不在,表明那 TM4SF4 是膜蛋白质。成功地由 AdSiTM4SF4 指向 TM4SF4 施加了基因击倒的效果。感染 AdSiTM4SF4 显著地显示了的 QGY-7701 和 SMMC-7721 HCC 房间稀释了生长潜力。而且, AdSiTM4SF4 的 intratumoral 注射显著地用 SMMC-7721 hepatoma 细胞在一个异种皮移植老鼠模型压制了肿瘤生长。我们的结果显示那指向的 TM4SF4 可能是为 HCC 的抑制的一种有希望的形式。 | Leiming Wang Jian Feng Liang Da Ying Li Zaiping Li Mujun Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 4 |
| 16 | CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study显示文摘Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P < 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. | CHEN Li SUN Ke Xin JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 4 |
| 17 | Full-Length Genome Sequencing of SARS-CoV-2 Directly from Clinical and Environmental Samples Based on the Multiplex Polymerase Chain Reaction Method显示文摘The new coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is spreading worldwide with the number of confirmed cases increasing dramatically[1,2].Coronaviruses have the largest genome among RNA viruses and have caused two major outbreaks[3,4]. | NIU Pei Hua ZHAO Xiang LU Rou Jian ZHAO Li HUANG Bao Ying YE Fei WANG Da Yan TAN Wen Jie | 2021 | Biomedical and Environmental Sciences2021，34，9： | 3 |
| 18 | Photopromoted Carbonylation of Alkyl Bromides Catalyzed by Copper Salts under Ambient Conditions显示文摘Photopromoted carbonylation of alkyl bromides with carbon monoxide or carbon dioxide catalyzed by copper salts can be carried out under ambient conditions (atmospheric pressure and room temperature) and the corresponding ester was produced. The yield and the selectivity of the ester can be improved greatly by addition of sodium phosphate. | Tao WEN Ying Ping JIA Da Bin GAO Jing Mei YINI Guang Yun ZHOU Jing LIU Xiang Sheng WANG | 2005 | Chinese Chemical Letters2005，16，11： | 3 |
| 19 | Enhancing hydrothermal stability of framework Al in ZSM-5:From the view on the transformation between P and Al species by solid-state NMR spectroscopy显示文摘HZSM-5,with good surface acidity and shape selectivity,was reported as hydrocarbon cracking catalyst for multiple decades,however the hydrothermal stability,especially dealumination of tetrahedrally coordinated framework aluminum(TFAl),has been proved extensively as one of the major challenges during reactionregeneration process.Phosphorus was proposed to stabilize TFAl and indeed it enhanced the hydrothermal stability.Unfortunately,most of the phosphorus species would remain outside of the zeolite pore,mainly as polyphosphate species,and block the micropore severely,with only a limited portion introduced into the channel being able to interact with TFAl.Enlarging the pore size by alkali treatment(desilication)is one of the most convinced methods,but the details about specific P species during alkali treatment and its transformation upon hydrothermal activation is not acquired,thus the mechanism has not been fully understood.Herein,the P-containing species and its transformation during direct P modification and acid/alkali treatment followed by Pmodification have been studied,and the mechanism on the interaction between P and Al species has been investigated,using several analytical methods,especially Solid-state nuclear magnetic resonance(SSNMR)spectroscopy.It was found that the combination of desilication and subsequent phosphorus modification can enhance the activity of the ZSM-5 for the cracking of ethylcyclohexane,due to the better hydrothermal stabilization of acid sites by the enhanced interaction between phosphorus and TFAl,resulting from the improved accessibility of TFAl because of the successful generation of mesoporosity.Whereas the acid treatment followed by phosphorus modification,with declined retention of crystallinity and P/Al ratio,monoclinic/orthorhombic transition during steam activation,and the failed generation of mesopores,would cause obvious aggregation of the phosphorus species and could not improve the hydrothermal stability of the ZSM-5 effectively,and the direct phosphatation turned out much worse.Finally,a specific index that the intensity of the signal at 39 in 27Al MAS NMR spectra before steam activation was proposed as the indicator for determining the efficiency of phosphorus modification.And the proposed mechanism on the interaction between phosphorus and TFAl during the phosphorus modification could also be applicable in other zeolites. | Lei Han Ying Ouyang Enhui Xing Yibin Luo Zhijian Da | 2020 | Chinese Journal of Chemical Engineering2020，28，12： | 3 |
| 20 | Photo-promoted carbonylation of chloroalkanes with carbon monoxide by non-precious metal catalysts显示文摘The photo-promoted carbonylation of chloroalkanes with carbon monoxide was carried out under ambient conditions with copper and cadmium salts catalysts. The results indicated that the corresponding esters were produced with three salt catalysts, i.e. CuBr2, CuCl2 and CdI2. Among these catalysts, CdI2 was the most efficient in terms of ester yield and selectivity, particularly, 60% yield and 75% selectivity in the carbonylation of chlorocyclohexane were achieved. Furthermore, the yield and selectivity of the ester can be improved greatly by adding tri-n-butylamine in the CuBr2 and CuCl2 catalyst systems. On the other hand, the carbonylation did not proceed with single CdCl2, however, the catalytic activity of CdCl2 was increased greatly with NaIá2H2O as additive. As a result, we suggest that iodide ion plays an important role in the catalyst system of the cadmium salts. | Hong Wei Wang Ying Ping Jia Da Bin Gao Jing Mei Yin Guang-Yun-Zhou Shen Min Li | 2007 | Chinese Chemical Letters2007，18，7： | 3 |
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