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| 1 | Active power regulation of wind power systems through demand response显示文摘With the specific characteristics of low-carbon intensity and economy,wind power has been widely promoted around the world.Due to the variable and intermittent nature of wind power production,the system has to frequently redispatch generators in order to ensure the effective use of wind power whilst maintaining system security.In this way,traditional generation costs are increased and the social benefit of wind power decreases indirectly.In this paper,a new regulation strategy based on power flow tracing was proposed,taking advantage of a comfort-constrained demand response strategy to follow the fluctuations of wind farm output,with the remaining imbalance of active power compensated by traditional generators.Examples showed that compared with conventional regulation,demand response could reduce the gross operating costs of the system,and the rapid response could help maintaining system stability in case of contingency.The strategy in this paper also applies to other large-scale integration problems associated with renewable energy resources which display short-term production variability. | MIAO WeiWei JIA HongJie WANG Dan PARKINSON Simon CRAWFORD Curran DJILALI Ned | 2012 | Science China(Technological Sciences)2012，55，6： | 24 |
| 2 | Enhancing photocatalytic performance by constructing ultrafine TiO2 nanorods/g-C3N4 nanosheets heterojunction for water treatment显示文摘Photocatalysis is considered to be a clean, green and efficient method to purify water. In this report, we first developed a highly efficient ultrafine TiO_2 nanorods/g-C3 N4 nanosheets(TiO_2 NR/CN NS) composites via a simple hydrothermal method. Tiny TiO_2 nanorods(diameter:~1.5 nm and length:~8.3 nm) were first loaded in situ on the CN NS by adding graphitic carbon nitride(g-C3 N4) to the reaction solution.The TiO_2 NR/CN NS composites present high charge separation efficiency and broader light absorbance than P25 TiO_2. Furthermore, we illustrate that the Ti0_2 NR/CN NS catalyst possesses high performance for the photocatalytic degradation of the common and stubborn pollutants in water, such as the rhodamine B(RhB) dye and phenol. Under visible light(λ> 420 nm) irradiation, the apparent rate of the TiO_2 NR/CN NR is 172 and 41 times higher than that of the P25 TiO_2 and TiO_2 NR, respectively.Additionally, we speculated that the heterojunction formed between TiO_2 NR and CN NS, which is the basis for the experiments we have designed and the corresponding results. We demonstrated that reactive oxidative species such as superoxide anion radical and holes play critical roles in the degradation,and the hydroxyl radical contributes nothing to the degradation. | Shiliang Luan Dan Qu Li An Wenshuai Jiang xiang Gao Shixin Hua Xiang Miao Yuanjing Wen Zaicheng Sun | 2018 | Science Bulletin2018，63，11： | 16 |
| 3 | Effect of defects on photocatalytic activity of rutile TiO2 nanorods显示文摘进一步理解结构的缺点的效果在上电气化学并且 TiO 2, 的 photocatalytic 性质二条合成途径此处基于热水的合成和 synthetic 以后化学药品减小被开发完成氧 defectimplantation。这些途径在体积或在两个的表面,或联合上与一致地分布式的缺点导致了 TiO 2 nanorods 的形成,在形成的 TiO 2 nanorods (NR ) 。两条途径作为反应先锋利用唯一的听 nanoparticles。电子显微镜学和 Brunauer-Emmett-Teller (赌注) 分析显示所有学习样品展出类似的形态学和类似的特定的表面区域。X 光检查光电子光谱学(XPS ) 和电子顺磁的回声(EPR ) 数据证实氧缺点(VO ) 的存在。有植入的 VO 的不同类型的 TiO 2 的 photocatalytic 性质基于 photocatalytic H 2 生产被评估。由在受到不同处理的 TiO 2 NR 之中优化 VO 的集中,显著地更高的 photocatalytic 活动比 stoichiometric TiO 2 NR 的被完成。事件 photon-to-current 效率(IPCE ) 数据显示提高的 photocatalytic 活动主要从帮助缺点的费用分离产生,它暗示产生相片的电子或洞能被 VO 捕获并且压制费用再结合进程。结果证明联合二条途径获得的有缺点的 TiO 2 在所有样品之中展出最大的 photocatalytic 活动改进。 | Zhao Zhao Xiaoyan Zhang Guoqiang Zhang Zhenyu Liu Dan Qu Xiang Miao Pingyun Feng Zaicheng Sun | 2015 | Nano Research2015，8，12： | 8 |
| 4 | TiO2 sensitized by red-, green-, blue-emissive carbon dots for enhanced H2 production显示文摘Carbon dots(Cdots)with a broad light absorption range could be a potential stable sensitizer for TiO2,which is an excellent ultraviolet(UV)response photocatalyst.Herein,we systematically investigated the different color emissive Cdots-sensitized TiO2 for H2 production.Firstly,all kinds of Cdots enhanced the photocatalytic properties of TiO2.All the Cdots-sensitized TiO2 exhibits visible light H2 production due to their absorption in the visible light region.The photocurrent and H2 production amount display strong dependence on the light absorption range of Cdots.The blue-emissive Cdots endow the weak H2 production rate due to its weak absorption in the visible light.The enhanced photocatalytic activities are mainly contributed to the strong light absorbance and high-efficient charge separation.The light absorption of green-and red-emissive Cdots is another main factor for the high catalytic activities besides charge separation. | Dong-Xue Yang Dan Qu Xiang Miao Wen-Shuai Jiang Li An Yuan-Jing Wen Dan-Dan Wu Zai-Cheng Sun | 2019 | Rare Metals2019，38，5： | 8 |
| 5 | Development and Validation of a Model for Predicting Diabetic Nephropathy in Chinese People显示文摘Objective To develop a risk model for predicting later development of diabetic nephropathy(DN)in Chinese people with type 2 diabetes mellitus(T2DM)and evaluate its performance with independent validation.Methods We used data collected from the project‘Comprehensive Research on the Prevention and Control of Diabetes’,which was a community-based study conducted by the Jiangsu Center for Disease Control and Prevention in 2013.A total of 11,771 eligible participants were included in our study.The endpoint was a clear diagnosis of DN.Data was divided into two components:a training set for model development and a test set for validation.The Cox proportional hazard regression was used for survival analysis in men and women.The model’s performance was evaluated by discrimination and calibration.Results The incidence(cases per 10,000 person-years)of DN was 9.95(95%CI;8.66-11.43)in women and 11.28(95%CI;9.77-13.03)in men.Factors including diagnosis age,location,body mass index,high-density-lipoprotein cholesterol,creatinine,hypertension,dyslipidemia,retinopathy,diet control,and physical activity were significant in the final model.The model showed high discrimination and good calibration.Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention. | MIAO Dan Dan PAN En Chun ZHANG Qin SUN Zhong Ming QIN Yu WU Ming | 2017 | Biomedical and Environmental Sciences2017，30，2： | 8 |
| 6 | Contrasting Characteristics of the Surface Energy Balance between the Urban and Rural Areas of Beijing显示文摘A direct comparison of urban and rural surface energy balances, as well as a variety of other variables including incoming shortwave/longwave radiation and aerosol optical depth, is conducted for the Beijing metropolitan area. The results indicate that, overall, the urban area receives a smaller amount of incoming shortwave radiation but a larger amount of incoming longwave radiation. However, comparisons in the aerosol optical depth and cloud fraction at the two locations suggest that neither aerosol optical depth nor cloud fraction alone can explain the difference in the incoming shortwave radiation. The urban–rural differences in the incoming longwave radiation are unlikely to be caused by the presence of more abundant greenhouse gases over the urban area, as suggested by some previous studies, given that water vapor is the most dominant greenhouse gas and precipitable water is found to be less in urban areas. The higher incoming longwave radiation observed over the urban area is mostly likely due to the higher temperatures of the ambient air. The urban area is also found to always produce higher sensible heat fluxes and lower latent heat fluxes in the growing season. Furthermore, the urban area is associated with a larger amount of available energy(the sum of sensible and latent heat fluxes) than the rural area, except in May and October when evapotranspiration in the rural area significantly exceeds that in the urban area. This study provides observational evidence of urban–rural contrasts in relevant energy-balance components that plausibly arise from urban–rural differences in atmospheric and land-surface conditions. | WANG Linlin GAO Zhiqiu MIAO Shiguang GUO Xiaofeng SUN Ting Maofeng LIU Dan LI | 2015 | Advances in Atmospheric Sciences2015，32，4： | 7 |
| 7 | N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys显示文摘瞄准:为了在血管收缩素 II (Ang II ) 上调查 ROS scavenger N-acetylcysteine (NAC ) 的效果,调停了在 vivo 并且在 vitro.Methods 的肾的纤维变性:老鼠受到单方的 ureteral 阻塞(UUO ) ,然后与车辆或 NAC 对待(250 mg/kg, ip ) 为 7 天。妨碍的肾的组织学的变化与 Massons 被观察三色的染色。ROS 层次被检测, DHE 染色。在妨碍的肾的相关蛋白质的表示用西方的弄污的试金被估计。肾的成纤维细胞 NRK-49F 房间在 vitro experiments.Results 被用于的有教养的老鼠:在妨碍的肾, Ang II 层次显著地被提高,并且骨胶原我在空隙的空格被积累。而且, ROS 生产和 p47 (NADPH oxidase 建筑群的一个关键子单元) 的表示以一种时间依赖者方式被增加;fibronectin 的表示, α -SMA 和 TGF-β是 upregulated。NAC 的管理显著地在妨碍的肾减轻了 fibrotic 回答。在有教养的 NRK-49F 房间,有 Ang II 的处理(0.001-10 μ mol/L ) 增加了 fibronectin 的表示,骨胶原我, α -SMA 和 TGF-β在剂量依赖者和时间依赖者礼貌。Ang II 也增加了 ROS 生产和 Smad3 的 phosphorylation。有 NAC 的预告的处理(5 μ mol/L ) 在 cells.Conclusion 的堵住的 Ang 导致 II 的氧化压力和 ECM 生产:在老鼠妨碍了肾,从 Ang II upregulation 的 fibrotic 回答结果能被 ROS scavenger N-acetylcysteine 减轻。 | Yang SHEN Nai-jun MIAO Jin-lan XU Xin-xin GAN Dan XU Li ZHOU Hong XUE Wei ZHANG Li-min LU | 2016 | Acta Pharmacologica Sinica2016，37，5： | 7 |
| 8 | Inactivation, reactivation and regrowth of indigenous bacteria in reclaimed water after chlorine disinfection of a municipal wastewater treatment plant显示文摘Disinfection of reclaimed water prior to reuse is important to prevent the transmission of pathogens. Chlorine is a widely utilized disinfectant and as such is a leading contender for disinfection of reclaimed water. To understand the risks of chlorination resulting from the potential selection of pathogenic bacteria, the inactivation, reactivation and regrowth rates of indigenous bacteria were investigated in reclaimed water after chlorine disinfection. Inactivation of total coliforms, Enterococcus and Salmonella showed linear correlations, with constants of 0.1384, 0.1624 and 0.057 L/(mg·min) and R 2 of 0.7617, 0.8316 and 0.845, respectively. However, inactivation of total viable cells by measurement of metabolic activity typically showed a linear correlation at lower chlorine dose (0-22 (mg·min)/L), and a trailing region with chlorine dose increasing from 22 to 69 (mg·min)/L. Reactivation and regrowth of bacteria were most likely to occur after exposure to lower chlorine doses, and extents of reactivation decreased gradually with increasing chlorine dose. In contrast to total coliforms and Enterococcus, Salmonella had a high level of regrowth and reactivation, and still had 2% regrowth even after chlorination of 69 (mg·min)/L and 24 hr storage. The bacterial compositions were also significantly altered by chlorination and storage of reclaimed water, and the ratio of Salmonella was significantly increased from 0.001% to 0.045% after chlorination of 69 (mg·min)/L and 24 hr storage. These trends indicated that chlorination contributes to the selection of chlorine-resistant pathogenic bacteria, and regrowth of pathogenic bacteria after chlorination in reclaimed water with a long retention time could threaten public health security during wastewater reuse. | Dan Li Siyu Zeng April Z. Gu Miao He Hanchang Shi | 2013 | Journal of Environmental Sciences2013，25，7： | 7 |
| 9 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 10 | Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1显示文摘Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and development of renal interstitial fibrosis in vivo and in vitro. Mice were subjected to unilateral ureteral obstruction (UUO). The mice were treated with either caspase-11 inhibitor wedelolactone (Wed, 30 mg/kg/day, ig) for 7 days or caspase-11 siRNA (10 nmol/20 g body weight per day, iv) for 14 days. The mice were euthanized on day 14, their renal tissue and blood sample were collected. We found that the obstructed kidney had significantly higher caspase-11 levels and obvious tubular injury and interstitial fibrosis. Treatment with Wed or caspase-11 siRNA significantly mitigated renal fibrosis in UUO mice, evidenced by the improved histological changes. Furthermore, caspase-11 inhibition significantly blunted caspase-1 activation, IL-ip maturation, transforming growth factor-p (TGF-P), fibronectin, and collagen I expressions in the obstructed kidney. Renal tubular epithelial NRK-52E cells were treated in vitro with angiotensin (Ang, 1 pmol/L), which stimulated caspase-11 activation and IL-ip maturation. Treatment with IL-1β (20ng/ml) significantly increased the expression of TGF-β, fibronectin, and collagen I in the cells. Ang ll-induced expression of TGF-β, fibronectin, and collagen I were suppressed by caspase-11 siRNA or Wed. Finally, we revealed using co-immunoprecipitation that caspase-11 was able to interact with caspase-1 in NRK-52E cells. These results suggest that caspase-11 is involved in UUO-induced renal fibrosis. Elevation of caspase-11 in the obstructed kidney promotes renal fibrosis by stimulating caspase-1 activation and IL-1β maturation. | Nai-jun Miao Hong-yan Xie Dan Xu Jian-yong Yin Yan-zhe Wang Bao Wang Fan Yin Zhuan-li Zhou Qian Cheng Pan-pan Chen Li Zhou Hong Xue Wei Zhang Xiao-xia Wang Jun Liu Li-min Lu | 2019 | Acta Pharmacologica Sinica2019，40，6： | 5 |
| 11 | Changes of microbial composition during wastewater reclamation and distribution systems revealed by high- throughput sequencing analyses显示文摘这研究采用了 454-pyrosequencing 在二废水开垦和分发系统调查微生物引起、病原的社区。11972 个有效 16S rRNA 序列的一个总数从这二个开垦系统被获得,然后由使用 RDP 分类器指明了到相关分类等级。Chao 索引和香农差异索引证明微生物引起的社区的差异沿着废水开垦过程减少了。Proteobacteria 是在消毒以后的回收的水里的最主导的门,它分别地在二个系统占了 83% 和 88% 。包括 Clostridium, Escherichia, Shigella, Pseudomonas 和 Mycobacterium,人的机会主义的病原体被消毒过程选择并且充实。全部的氯和营养素(TOC, NH 3-N 和没有 3-N) 显著地在回收的水期间影响了微生物引起、病原的社区存储和分发过程。我们的结果显示消毒抵抗的病原体应该在回收的水里被控制,自从相对许多的增加在消毒以后的病原的细菌含有与回收的水联系的潜在的公共健康。 | Yiwen LIN Dan LI Siyu ZENG Miao HE | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 5 |
| 12 | SND p102 promotes extracellular matrix accumulation and cell proliferation in rat glomerular mesangial cells via the ATIR/ERK/Smad3 pathway显示文摘 | Jin-lan XU Xin-xin GAN Jun NI De-cui SHAO Yang SHEN Nai-jun MIAO Dan XU Li ZHOU Wei ZHANG Li- min LU | 2018 | Acta Pharmacologica Sinica2018，39，9： | 5 |
| 13 | Expression Patterns of Cytochrome P450 Aromatase Genes During Ovary Development and Their Responses to Temperature Stress in Female Yellow Catfish (Pelteobagrus fulvidraco)显示文摘Cytochrome P450 aromatase(P450arom)plays a pivotal role in ovary development.In this study,we used semi-quanti-tative reverse transcription PCR(RT-PCR)to analyze spatiotemporal expressions of two P450arom genes(CYP19A and CYP19B)and their responses to temperature stress in female yellow catfish(Pelteobagrus fulvidraco).Tissue distribution pattern of CYP19 showed that CYP19B was abundantly expressed in fish brain and ovary(brain > ovary),but weakly in intestines,whereas CYP19A was exclusively expressed in ovary.Semi-quantitative RT-PCR analyses showed high transcript abundance of both CYP19A and CYP19B in the ovarian reproductive cycle,corresponding with serum estradiol-17β(E2)levels.Increases in aromatases,serum E2 and testosterone(T)levels in fish exposed to higher temperature indicated stimulation of ovarian maturation and recrudescence by heat stress in stages Ⅱ and Ⅴ during the ovarian cycle,whereas associated decreases in stage Ⅲ suggested vitellogenesis inhibition by heat stress.Gene expression of CYP19 was closely related to levels of serum E2.Results demonstrated CYP19 played a crucial role in the reproductive cycle of female yellow catfish.Different temperature stress affected CYP19 gene expression in the fish ovarian re-productive cycle.Associated P450arom genes could be useful for studying physiological aspects of yellow catfish. | LIU Miao WEN Haishen HE Feng LI Jifang SHI Dan HU Jian ZHANG Yuanqing MA Ruiqin MU Weijie QI Baoxia | 2011 | Journal of Ocean University of China2011，10，4： | 5 |
| 14 | Quantification of viable bacteria in wastewater treatment plants by using propidium monoazide combined with quantitative PCR(PMA-qPCR)显示文摘The detection of viable bacteria in wastewater treatment plants(WWTPs) is very important for public health, as WWTPs are a medium with a high potential for waterborne disease transmission. The aim of this study was to use propidium monoazide(PMA) combined with the quantitative polymerase chain reaction(PMA-qPCR) to selectively detect and quantify viable bacteria cells in full-scale WWTPs in China. PMA was added to the concentrated WWTP samples at a final concentration of 100 μmol/L and the samples were incubated in the dark for 5 min, and then lighted for 4 min prior to DNA extraction and qPCR with specific primers for Escherichia coli and Enterococci, respectively. The results showed that PMA treatment removed more than 99% of DNA from non-viable cells in all the WWTP samples, while matrices in sludge samples markedly reduced the effectiveness of PMA treatment. Compared to qPCR, PMA-qPCR results were similar and highly linearly correlated to those obtained by culture assay, indicating that DNA from non-viable cells present in WWTP samples can be eliminated by PMA treatment, and that PMA-qPCR is a reliable method for detection of viable bacteria in environmental samples. This study demonstrated that PMA-qPCR is a rapid and selective detection method for viable bacteria in WWTP samples, and that WWTPs have an obvious function in removing both viable and non-viable bacteria. The results proved that PMA-qPCR is a promising detection method that has a high potential for application as a complementary method to the standard culture-based method in the future. | Dan Li Tiezheng Tong Siyu Zeng Yiwen Lin Shuxu Wu Miao He | 2014 | Journal of Environmental Sciences2014，26，2： | 4 |
| 15 | c-Myc promotes tubular cell apoptosis in ischemia-reperfusion-induced renal injury by negatively regulating c-FLIP and enhancing FasL/Fas-mediated apoptosis pathway显示文摘c-Myc plays an important role in cell proliferation, differentiation, and cell apoptosis. FasL/Fas pathway is a key regulator of cell apoptosis. This study was aimed to investigate the effects of c-Myc on the FasL/Fas pathway in ischemia-reperfusion (I/R)-induced renal injury. Rats were objected to bilateral renal ischemia for 60 min and reperfused for 24 or 48 h. NRK-52E cells were treated with hypoxia-reoxygenation (H/R) or FasL. Immunohistochemistry was used to identify the distribution of c-Myc. Cell apoptosis was assessed by TUNEL staining. Ad-c-Myc and recombinant pcDAN 3.0 were used to overexpress c-Myc and c-FLIP, respectively. ChIP assay and luciferase assay were used to detect the binding of c-Myc to c-FLIP promoter. In I/R rats, c-Myc was increased signi?cantly and mainly located in renal tubular epithelial cells;meanwhile, c-FLIP was decreased, cleaved caspase-8, cleaved caspase-3 and TUNEL-positive staining cells were increased. Treatment of I/R rats with c-Myc inhibitor 10058-F4 signi?cantly attenuated the decrease in c-FLIP, the increase in cleaved caspase-8, cleaved caspase-3, TUNEL-positive cells, Scr and BUN in I/R rats. In NRK-52E cells, hypoxia and reoxygen induced the increase in c-Myc and decrease in c-FLIP. ChIP and luciferase assay results indicated that c-Myc binds to the promoter region of c-FLIP gene. Overexpression of c-Myc markedly decreased c-FLIP. Overexpression of c-FLIP inhibited the increase in cleaved caspase-8 and caspase-3 induced by FasL. Data indicated that c-Myc is increased in kidneys of I/R rats and negatively regulates the expression of c-FLIP, then enhanced FasL-induced cell apoptosis in I/R stress. | Dan Xu Bao Wang Pan-pan Chen Yan-zhe Wang Nai-jun Miao Fan Yin Qian Cheng Zhuan-li Zhou Hong-yan Xie Li Zhou Jun Liu Xiao-xia Wang Hong Xue Wei Zhang Li-min Lu | 2019 | Acta Pharmacologica Sinica2019，40，8： | 4 |
| 16 | Association of immunophenotypic characterization of peripheral lymphocytes with different clinical phenotypes of tuberculosis in Chinese Han children显示文摘背景很少的研究人员在成年肺结核( TB )在外部淋巴细胞模式学习了变化,甚至更少的研究在小儿科的 TB.In 被进行了这研究,我们从 114 个中国小儿科的 TB 病人和 116 匹配的控制获得了血样品与 TB.Methods 的不同临床的显型学习外部淋巴细胞的 phenotypic 子集的协会这些题目作为病人们组织进一步被划分的控制组和 TB 被分类 int 例如主要肺的 TB,和 TB meningitis.These,模式可以在理解致病和疾病的预示的标记有意义,并且为开发治疗的 immunomodulatory 形式。 | Xiao Jing Sun Lin Wu Xi-rong Miao Qing Jiao Wei-wei Shen Chen Shen Dan Feng Wei-xing Liu Fang Shen A-dong | 2012 | Chinese Medical Journal2012，，2： | 4 |
| 17 | Establishment of a new acute-on-chronic liver failure model显示文摘To establish an animal model of acute-on-chronic liver failure(ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum(PS) for 11 weeks. Liver fibrosis was determined by pathological and biochemical assessments. The animals then were injected with D-galactosamine(D-gal) and lipopolysaccharide(LPS). The survival times of animals with cirrhosis and ACLF were determined over 48 h. Other animals were killed at 0, 4, 8 and 12 h after administration of D-gal/LPS. Liver injury was assessed by histopathological analysis and biochemical indices, and apoptosis was detected by Western blot and TUNEL analysis. After PS administration for 11 weeks the serum levels of hyaluronic acid and N-procollagen type III peptide increased significantly, and serious fibrosis and cirrhosis was observed at weeks 10 and 11. Cirrhotic rats were injected with D-gal/LPS to induced ACLF; the rate of mortality over 48 h was 80%. ALT and AST levels increased markedly at 4 h, but decreased significantly at8 and 12 h post-treatment. The total bilirubin, direct bilirubin, and total bile acids levels increased markedly at 8 and 12 h. Clotting times, TNF-α and IL-6 levels increased significantly, except for 12 h post-treatment.Apoptosis, inflammation and necrosis were elevated as determined by hematoxylin-eosin staining and TUNEL assays. BCL-2 levels decreased significantly, While BAX levels increased significantly.Cytochrome c expression peaked at 8 h postD-gal/LPS treatment. In conclusion, an ACLF model induced by PS and D-gal/LPS was established and the underlying mechanisms of ACLF development were explored. | Fangfang Li Luyang Miao Hua Sun Yuyang Zhang Xiuqi Bao Dan Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 4 |
| 18 | Pharmacological actions of miltirone in the modulation of platelet function显示文摘Salvia miltiorrhiza Bunge contains various active constituents, some of which have been developed as commercially available medicine. Moreover, some other ingredients in Salvia miltiorrhiza play roles in anti-platelet activity. The aim of the present study was to investigate the effects and the underlying mechanism of miltirone, a lipophilic compound of Salvia miltiorrhiza Bunge. The ability of miltirone to modulate platelet function was investigated by a variety of in vitro and in vivo experiments. Platelet aggregation and dense granule secretion induced by various agonists were measured with platelet aggregometer. Clot retraction and spreading were imaged by digital camera and fluorescence microscope. Ferric chloride-induced carotid injury model and pulmonary thromboembolism model were used to check miltirone antithrombotic effect in vivo. To elucidate the mechanisms of anti-platelet activity of miltirone, flow cytometry and western blotting were performed. Miltirone (2, 4, 8μM) was shown to suppress platelet aggregation, dense granule, and α granule secretion in a dose-dependent manner. Meanwhile, miltirone inhibited the clot retraction and spreading of washed platelets. It reduced the phosphorylation of PLCγ2, PKC, Akt, GSK3β and ERK1/2 in the downstream signal pathway of collagen receptor. It also reduced the phosphorylation of Src and FAK in the integrin αIIbβ3-mediated “outside-in” signaling, while it did not suppress the phosphorylation of β3. In addition, miltirone prolonged the occlusion time and reduced collagen/epinephrine-induced pulmonary thrombi. Miltirone suppresses platelet “inside-out” and “outside-in” signaling by affecting PLCγ2/PKC/ERK1/2, PI3K/Akt, and Src/FAK signaling. Therefore, miltirone might represent a potential anti-platelet candidate for the prevention of thrombotic disorders. | Wei Song Yuan-yuan Ma Shuo Miao Ru-ping Yang Ying Zhu Dan Shu Meng Lu Rong Ma Zhang-yin Ming | 2019 | Acta Pharmacologica Sinica2019，40，2： | 3 |
| 19 | Development of O-serogroup specific PCR assay for detection and identification of Vibrio parahaemolyticus显示文摘 | Min Chen Dan Guo Hin-chung Wong Xi Zhang Fenxia Liu Hongyou Chen Miao Chen Bin Liu Lei Wang Fan Wu Lu Feng | 2012 | International Journal of Food Microbiology2012，，2： | 3 |
| 20 | Norovirus Infection and Histo-blood Group Antigens in Children Hospitalized with Diarrhea in Lulong and Chenzhou in China显示文摘Norovirus(No V)is a pathogen that commonly causes viral diarrhea in children.Studies indicate that No V recognizes human histo-blood group antigens(HBGAs)as cell attachment factors.In order to explore the correlation between of No V infection and HBGAs,a cross-sectional study was conducted in children less than five years old who were hospitalized with diarrhea in two areas of China between November 2014 and February 2015. | SUN Xiao Man YAN Xiao Feng HE Zhi Gang Li Jing Xin GUO Ni Jun XU Zi Qian JIN Miao LI Dan Di ZHOU Yong Kang XIE Guang Cheng Pang Li Li ZHANG Qing LIU Na DUAN Zhao Jun | 2016 | Biomedical and Environmental Sciences2016，29，4： | 3 |
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