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| 1 | Role of surgery in severe ulcerative colitis in the era of medical rescue therapy显示文摘Despite the growing use of medical salvage therapy,colectomy has remained a cornerstone in managing acute severe ulcerative colitis(ASC) both in children and in adults.Colectomy should be regarded as a life saving procedure in ASC,and must be seriously considered in any steroid-refractory patient.However,colectomy is not a cure for the disease but rather the substitution of a large problem with smaller problems,including fecal incontinence,pouchitis,irritable pouch syndrome,cuffitis,anastomotic ulcer and stenosis,missed or de-novo Crohn's disease and,in young females,reduced fecundity.This notion has led to the widespread practice of offering medical salvage therapy before colectomy in most patients without surgical abdomen or toxic megacolon.Medical salvage therapies which have proved effective in the clinical trial setting include cyclosporine,tacrolimus and infliximab,which seem equally effective in the short term.Validated predictive rules can identify a subset of patients who will eventually fail corticosteroid therapy after only 3-5 d of steroid therapy with an accuracy of 85%-95%.This accuracy is sufficiently high for initiat-ing medical therapy,but usually not colectomy,early in the admission without delaying colectomy if required.This approach has reduced the colectomy rate in ASC from 30%-70% in the past to 10%-20% nowadays,and the mortality rate from over 70% in the 1930s to about 1%.In general,restorative proctocolectomy(ileoanal pouch or ileal pouch-anal anastomosis),especially the J-pouch,is preferred over straight pullthrough(ileo-anal) or ileo-rectal anastomosis,which may still be considered in young females concerned about infertility.Colectomy in the acute severe colitis setting,is usually performed in three steps due to the severity of the inflammation,concurrent steroid treatment and the generally reduced clinical condition.The first surgical step involves colectomy and constructing an ileal stoma,the second-constructing the pouch and the third-closing the stoma.This review focuses on the role of surgical treatment in ulcerative colitis in the era of medical rescue therapy. | Bosmat Dayan Dan Turner | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 2 | The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease显示文摘 | Holm H. Uhlig Tobias Schwerd Sibylle Koletzko Neil Shah Jochen Kammermeier Abdul Elkadri Jodie Ouahed David C. Wilson Simon P. Travis Dan Turner Christoph Klein Scott B. Snapper Aleixo M. Muise | 2014 | Gastroenterology2014，，： | 3 |
| 3 | Removal of roosters alters the domestic phenotype and microbial and genetic profile of hens显示文摘Hens are raised apart from roosters in modern poultry production, a substantial change from their natural social structure. We compared productivity, injuries, behavior, physiology, microbiome and transcriptome of hens housed with(R+) or without(R–)roosters to quantify the effects of this change in social structure. Hens were raised free-range from 70 to 280 days when 30 birds per treatment were assigned to battery cages until Day 315(R+C vs. R–C), while 30 birds per treatment remained in free-range pens(R+F vs. R–F). Response to a novel environment and object, behavioral time budgets, cecum microbiome, blood composition and transcriptomic sequencing of thigh muscle and spleen were analyzed. Hens housed without roosters showed better survival, consumed less food, produced more eggs and had better feed conversion. R+F hens clustered around the rooster and were less mobile in the novel environment and object tests. R+F hens displayed the richest microbiome, and the presence of roosters resulted in differentially expressed genes related to muscle development, cellular processes, environmental information processing and immune function. Removing roosters from housed hens intensified desirable characteristics favored by domestication probably operating by deprivation of mating behavior and reduced fear, along with altered microbial and genetic function. | Hai Xiang Siyu Chen Hui Zhang Xu Zhu Dan Wang Huagui Liu Jikun Wang Tao Yin Langqing Liu Minghua Kong Jian Zhang Hua Li Simon Turner Xingbo Zhao | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 4 | Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study显示文摘 | Dan Turner Anthony R. Otley David Mack Jeffrey Hyams J. de Bruijne Krista Uusoue Thomas D. Walters Mary Zachos Petar Mamula Dorcas E. Beaton A. Hillary Steinhart Anne M. Griffiths | 2007 | Gastroenterology2007，，2： | 1 |
| 5 | Response to Corticosteroids in Severe Ulcerative Colitis: A Systematic Review of the Literature and a Meta-Regression显示文摘 | Dan Turner Catharine M. Walsh A. Hillary Steinhart Anne M. Griffiths | 2007 | Clinical Gastroenterology and Hepatology2007，，： | 1 |
| 6 | <ce:link locator='fx1'/> Response to Corticosteroids in Severe Ulcerative Colitis: A Systematic Review of the Literature and a Meta-Regression显示文摘 | Dan Turner Catharine M. Walsh A. Hillary Steinhart Anne M. Griffiths | 2007 | Clinical Gastroenterology and Hepatology2007，，1： | 1 |
| 7 | Endoscopic and Clinical Variables that Predict Sustained Remission in Children with Ulcerative Colitis Treated With Infliximab显示文摘 | Dan Turner Anne M. Griffiths Gigi Veerman Jewel Johanns Lakshmi Damaraju Marion Blank Jeffrey Hyams | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 8 | Tight Junction Pore and Leak Pathways: A Dynamic Duo显示文摘 | Le Shen Christopher R. Weber David R. Raleigh Dan Yu Jerrold R. Turner | 2011 | Annual Review of Physiology2011，，： | 1 |
| 9 | Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study显示文摘 | Dan Turner Anthony R. Otley David Mack Jeffrey Hyams J. de Bruijne Krista Uusoue Thomas D. Walters Mary Zachos Petar Mamula Dorcas E. Beaton A. Hillary Steinhart Anne M. Griffiths | 2007 | Gastroenterology2007，，2： | 1 |
| 10 | Long-Term Fine Particulate Matter Exposure and Mortality From Diabetes in Canada显示文摘 | Robert D. Brook Sabit Cakmak Michelle C. Turner Jeffrey R. Brook Dan L. Crouse Paul A. Peters Aaron van Donkelaar Paul J. Villeneuve Orly Brion Michael Jerrett Randall V. Martin Sanjay Rajagopalan Mark S. Goldberg C. Arden Pope Richard T. Burnett | 2013 | Diabetes Care2013，，10： | 1 |
| 11 | Severe Pediatric Ulcerative Colitis: A Prospective Multicenter Study of Outcomes and Predictors of Response显示文摘 | Dan Turner David Mack Neal Leleiko Thomas D. Walters Krista Uusoue Steven T. Leach Andrew S. Day Wallace Crandall Mark S. Silverberg James Markowitz Anthony R. Otley David Keljo Petar Mamula Subra Kugathasan Jeffrey Hyams Anne M. Griffiths | 2010 | Gastroenterology2010，，7： | 1 |
| 12 | Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report显示文摘 | Dan Turner Arie Levine Kaija-Leena Kolho Ron Shaoul Oren Ledder | 2014 | Journal of Crohn’s and Colitis2014，，： | 1 |
| 13 | Management of Pediatric Ulcerative Colitis: Joint ECCO and ESPGHAN Evidence-based Consensus Guidelines显示文摘 | Dan Turner Arie Levine Johanna C. Escher Anne M. Griffiths Richard K. Russell Axel Dignass Jorge Amil Dias Jiri Bronsky Christian P. Braegger Salvatore Cucchiara Lissy de Ridder Ulrika L. Fagerberg Séamus Hussey Jean-Pierre Hugot Sanja Kolacek Kaija Leena | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，3： | 1 |
| 14 | Structure and function of S-adenosylhomocysteine hydrolase显示文摘 | Mary A. Turner Xiaoda Yang Dan Yin Krzysztof Kuczera Ronald T. Borchardt P. Lynne Howell | 2000 | Cell Biochemistry and Biophysics2000，，2： | 1 |
| 15 | Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis显示文摘 | Eytan Wine David R. Mack Jeffrey Hyams Anthony R. Otley James Markowitz Wallace V. Crandall Neal Leleiko Aleixo M. Muise Anne M. Griffiths Dan Turner | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 16 | Response to Corticosteroids in Severe Ulcerative Colitis: A Systematic Review of the Literature and a Meta-Regression显示文摘 | Dan Turner Catharine M. Walsh A. Hillary Steinhart Anne M. Griffiths | 2007 | Clinical Gastroenterology and Hepatology2007，，1： | 1 |
| 17 | Differences in the management of pediatric and adult onset ulcerative colitis — lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis显示文摘 | Frank M. Ruemmele Dan Turner | 2014 | Journal of Crohn’s and Colitis2014，，1： | 1 |
| 18 | Large scale agent-based simulation on the grid 显示文摘 | Dan Chen Georgios K Theodoropoulos Stephen J Turner Wentong Cai | 2008 | Future Generation Computer Systems (S0167-739X)2008，24，7： | 1 |
| 19 | A decoupled federate architecture for high level architecture-based distributed simulation显示文摘 | CHEN Dan TURNER S CAI Wentong | 2008 | Parallel and Distributed Computing2008，7，： | 1 |
| 20 | Alternative Solutions for Distributed Simulation Cloning显示文摘 | Dan Chen Stephen John Turner Boon Ping Gan Wentong Cai Junhu Wei Nirupam Julka | 2003 | Simulation (S1741-3133)2003，79，56： | 1 |
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