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| 1 | Durable, superhydrophobic, antireflection, and low haze glass surfaces using scalable metal dewetting nanostructuring显示文摘在这份报纸,我们在第一次,联合的玻璃上报导多功能的 nanostructured 表面大量光,弄湿并且耐久性性质,包括的低全向的反射率,低薄雾,高传播, superhydrophobicity, oleophobicity,和高度机械抵抗。Nanostructures 被反应离子通过 nanomask 蚀刻在玻璃表面上制作了,它被 dewetting ultrathin 金属电影形成(< 10 nm 厚度) 使遭到了到快速的热退火(RTA ) 。nanostructures 强烈减少起始的表面反射率(4%) ,当在低价值保留薄雾时,在 390800 nm 波长变化到不到 0.4%(<0.9%) 。相应的水接触角度(c ) 是 24.5 敶愠朠晩吗?? | Daniel Infante Karl W. Koch Prantik Mazumder Lili Tian Albert Carrilero Domenico Tullit David Baker Valerio Pruneri | 2013 | Nano Research2013，6，6： | 6 |
| 2 | Fourteen‐year oncological and functional outcomes of high‐intensity focused ultrasound in localized prostate cancer显示文摘 | Roman Ganzer Hans‐Martin Fritsche Andreas Brandtner Johannes Bründl Daniel Koch Wolf F. Wieland Andreas Blana | 2013 | BJU Int2013，，3： | 1 |
| 3 | Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease显示文摘 | Cynthia A. Moylan Herbert Pang Andrew Dellinger Ayako Suzuki Melanie E. Garrett Cynthia D. Guy Susan K. Murphy Allison E. Ashley‐Koch Steve S. Choi Gregory A. Michelotti Daniel D. Hampton Yuping Chen Hans L. Tillmann Michael A. Hauser Manal F. Abdelmalek | 2014 | Hepatology2014，，2： | 1 |
| 4 | Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer显示文摘Objective: Patients with BRAF-mutant colorectal cancer(CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with known BRAF status.Methods: We screened 298 oncological drugs with and without ionising radiation in colorectal cancer cells isogenic for BRAF. Hits from rank product analysis were validated in a 16-cell line panel of human CRC cell lines, using clonogenic survival assays and xenograft models in vivo.Results: Most consistently identified hits were drugs targeting cell growth/proliferation or DNA damage repair. The most effective class of drugs that radiosensitised wild-type and mutant cell lines was PARP inhibitors. In clonogenic survival assays, talazoparib produced a radiation enhancement ratio of 1.9 in DLD1(BRAF-wildtype) cells and 1.8 in RKO(BRAF V600 E) cells. In DLD1 xenografts, talazoparib significantly increased the inhibitory effect of radiation on tumour growth(P ≤ 0.01).Conclusions: Our method for screening large drug libraries for radiosensitisation has identified PARP inhibitors as promising radiosensitisers of colorectal cancer cells with wild-type and mutant BRAF backgrounds. | Rebecca Carter Azadeh Cheraghchi-Bashi Adam Westhorpe Sheng Yu Yasmin Shanneik Elena Seraia Djamila Ouaret Yasuhiro Inoue Catherine Koch Jenny Wilding Daniel Ebner Anderson J. Ryan Francesca M. Buffa Ricky A. Sharma | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 5 | Tumor Infiltrating T Lymphocytes in Colorectal Cancer: Tumor-Selective Activation and Cytotoxic Activity In Situ显示文摘 | Moritz Koch Philipp Beckhove Jan op den Winkel Daniel Autenrieth Philipp Wagner Daniel Nummer Sebastian Specht Dalibor Antolovic Luis Galindo Friedrich H. Schmitz-Winnenthal Volker Schirrmacher Markus W. Büchler Jürgen Weitz | 2006 | Annals of Surgery2006，，6： | 1 |
| 6 | Distribution Control Centers in the US and Europe:Commonalities,Differences,and Lessons显示文摘The distribution control center(DCC)has evolved from a sideshow in the traditional distribution service center to a major centerpiece of the utility moving into the decentralized world.Mostly,this is the place where much of the action is happening due to new forms of energy that are coining into the distribution system.This creates the flexibility of operation and in-creased complexity due to the need for increased coordination between the transmission control center and DCC.However,the US and European utilities have adapted to this change in very different ways.Firstly,we describe the research works done in a DCC and their evolutions from the perspectives of major US utilities,and those enhanced by the European perspective focusing on the coordination of distribution system operator and transmission system operator(DSO-TSO).We pres-ent the insights into the systems used in these control centers and the role of vendors in their evolution.Throughout this paper,we present the perspectives of challenges,operational capabilities,and the involvement of various parties who will be re-sponsible to make the transition successful.Key differences are pointed out on how distribution operations are conducted between the US and Europe. | Subramanian Vadari Izudin Dzafic Dan'l Koch Ryan Murphy Daniel Hayes Jr. Tarik Donlagic | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，2： | 0 |
| 7 | Towards a business model for second-life batteries: Barriers,opportunities, uncertainties, and technologies显示文摘Electric vehicles(EVs) and the recent pandemic outbreak give cities a new trend to primarily private and shared mobility with low noise and less air pollution.Crucial factors for the widespread of EVs are the electrical charging infrastructure,driving range,and the reduction of the cost of battery packets.For this reason,there is a massive effort from manufacturers,governments,and the scientific community to reduce battery costs and boost sustainable electrical production and distribution.Battery reuse is an alternative to reduce batteries’ costs and environmental impacts.Second-life batteries can be used in a wide variety of secondary applications.Second-life batteries can be connected with off-grid or on-grid photovoltaic and wind systems,vehicle charging stations,forklifts,and frequency control.The present work aims to analyze the main challenges imposed on the reuse of batteries,the leading technologies for their reuse,and the different types of batteries in terms of their feasibility for second-life use.The main novelty of this work is the discussion about the barriers,opportunities,uncertainties,and technologies for the second life market.Here we summarize the present state of the art in reusing lithium-ion batteries discussing technical and economic feasibility,environmental impacts,and perspectives.The results show five business models that have been proposed in the literature,three types of markets for trading second-life batteries,and the main opportunities and barriers for each actor in the battery supply chain. | Carlos Antônio Rufino Júnior Eleonora Riva Sanseverino Pierluigi Gallo Daniel Koch Yash Kotak Hans-Georg Schweiger Hudson Zanin | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 8 | One year experience with computer-assisted propofol sedation for colonoscopy显示文摘AIM To report our one-year experience with computer assisted propofol sedation(CAPS) for colonoscopy as the first United States Medical Center to adopt CAPS technology for routine clinical use.METHODS Between September 2014 and August 2015, 2677 patients underwent elective outpatient colonoscopy with CAPS at our center. All colonoscopies were performed by 1 of 17 gastroenterologists certified in the use of the CAPS system, with the assistance of a specially trained nurse. Procedural success rates, polyp detection rates, procedure times and recovery times were recorded and compared against corresponding historical measuresfrom 2286 colonoscopies done with midazolam and fentanyl from September 2013 to August 2014. Adverse events in the CAPS group were recorded.RESULTS The mean age of the CAPS cohort was 59.9 years(48.7% male); 31.3% were ASA?Ⅰ, 67.3% ASA Ⅱ and 1.4% ASA Ⅲ. 45.1% of the colonoscopies were for screening, 31.5% for surveillance, and 23.4% for symptoms. The mean propofol dose administered was 250.7 mg(range 16-1470 mg), with a mean fentanyl dose of 34.1 mcg(0-100 mcg). The colonoscopy completion and polyp detection rates were similar to that of historical measures. Recovery times were markedly shorter(31 min vs 45.6 min, P < 0.001). In CAPS patients, there were 20(0.7%) cases of mild desaturation(< 90%) treated with a chin lift and reduction or temporary discontinuation of the propofol infusion, 21(0.8%) cases of asymptomatic hypotension(< 90 systolic blood pressure) treated with a reduction in the propofol rate, 4(0.1%) cases of marked agitation or discomfort due to undersedation, and 2 cases of pronounced transient desaturation requiring brief(< 1 min) mask ventilation. There were no sedation-related serious adverse events such as emergent intubation, unanticipated hospitalization or permanent injury. CONCLUSION CAPS appears to be a safe, effective and efficient means of providing moderate sedation for colonoscopy in relatively healthy patients. Recovery times were much shorter than historical measures. There were few adverse events, and no serious adverse events, related to CAPS. | Otto S Lin Danielle La Selva Richard A Kozarek Deborah Tombs Wade Weigel Ryan Beecher Johannes Koch Susan Mc Cormick Michael Chiorean Fred Drennan Michael Gluck Nanda Venu Michael Larsen Andrew Ross | 2017 | World Journal of Gastroenterology2017，23，16： | 0 |
| 9 | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-a-MSH and setmelanotide显示文摘The melanocortin-4 receptor(MC4R),a hypothalamic master regulator of energy homeostasis and appetite,is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity.Here,we present cryo-electron microscopy structures of MC4R-Gs-protein complexes with two drugs recently approved by the FDA,the peptide agonists NDP-a-MSH and setmelanotide,with 2.9 A and 2.6 A resolution.Together with signaling data from structure-derived MC4R mutants,the complex structures reveal the agonist-induced origin of transmembrane helix(TM)6-regulated receptor activation.The ligand-binding modes of NDP-a-MSH,a high-affinity linear variant of the endogenous agonist a-MSH,and setmelanotide,a cyclic anti-obesity drug with biased signaling toward Gq/11,underline the key role of TM3 in ligand-specific interactions and of calcium ion as a ligand-adaptable cofactor.The agonist-specific TM3 interplay subsequently impacts receptor-Gs-protein interfaces at intracellular loop 2,which also regulates the G-protein coupling profile of this promiscuous receptor.Finally,our structures reveal mechanistic details of MC4R activation/inhibition,and provide important insights into the regulation of the receptor signaling profile which will facilitate the development of tailored anti-obesity drugs. | Nicolas A.Heyder Gunnar Kleinau David Speck Andrea Schmidt Sarah Paisdzior Michal Szczepek Brian Bauer Anja Koch Monique Gallandi Dennis Kwiatkowski Jorg Burger Thorsten Mielke Annette G.Beck-Sickinger Peter W.Hildebrand Christian M.T.Spahn Daniel Hilger Magdalena Schacherl Heike Biebermann Tarek Hilal Peter Kuhnen Brian K.Kobilka Patrick Scheerer | 2021 | Cell Research2021，31，11： | 0 |
| 10 | 集成工业以太网和互联网显示文摘信息是知识的关键亦意味着力量。包含在工业系统中的信息可转化为知识和新的服务。听众可能是人们或设备机器等。当这种活动必须由Internet Service Provider(互联网服务提供者)支持时,互联网的普通用户会面临一系列他们从未遇到但又必须面对的问题,这导致一个新的名词——iISP。 | Adrian Bachofen Daniel Koch 杨昌琨 | 2002 | 国内外机电一体化技术2002，5，5： | 0 |
| 11 | TRANSFORMATIONS FOR THE PRIZE-COLLECTING STEINER TREE PROBLEM AND THE MAXIMUM-WEIGHT CONNECTED SUBGRAPH PROBLEM TO SAP显示文摘Steiner 树问题变体的转变经常在文学被讨论了。除允许容易转移复杂性结果以外,他们在图为象 Steiner 树问题那样的著名变体组成准确最先进的解答者的一个中央支柱。在这篇文章,为到 Steiner 树状问题的收集奖金的 Steiner 树问题和最大重量的连接 subgraph 问题的转变第一次被介绍。而且,为实际解决的途径的可观的含意将被表明,包括强壮的上面、更低的界限的计算。 | Daniel Rehfeldt Thorsten Koch | 2018 | Journal of Computational Mathematics2018，36，3： | 0 |
| 12 | Interdisciplinary management of central nervous system metastasis and neoplastic meningitis:recent developments and future perspectives显示文摘The incidence of metastatic disease in the central nervous system(CNS)is rising.According to current estimates,up to a third of adult cancer patients will suffer from CNS metastasis.Clinical evidence-based data from prospective randomized trials are rare,however,because CNS metastasis patients were often excluded from clinical trial participation.The management of CNS metastasis patients is therefore rather ill-defined and an interdisciplinary challenge.Recent basic and translational science data have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into the CNS.This report reviews advances,challenges,and perspectives in this field. | Ghazaleh Tabatabai Marilin Koch Cristiana Roggia Juliane Ebert Claus Garbe Friedegund Meier Sara Brucker Eva Maria Grischke Diethelm Wallwiener Robert Möhle Lothar Kanz Walter Erich Aulitzky Ulrike Ernemann Christian laFougere Konstantin Nikolaou Bernd Pichler Jens Schittenhelm Manuela Neumann Falko Fend Stefan Czemmel Sven Nahnsen Frank Paulsen Daniel Zips Maike van Lessen Hans-Otto Karnath Ulf Ziemann Constantin Roder Marco Skardelly Jürgen Bernd Honegger Marcos Tatagiba | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
| 13 | Corrigendum to“Towards a business model for second-life batteries:Barriers,opportunities,uncertainties,and technologies”[J.Energy Chem.78(2023)507–525]显示文摘In the Acknowledgments Section,please replace“Shell oil”for“TotalEnergies”.The authors would like to apologise for any inconvenience caused.For the sake of clarity(“Shell oil”should be removed and in boldblack“TotalEnergies”inserted),this section should say:The authors would like to thank Moura Batteries for the financial support. | Carlos Antônio Rufino Júnior Eleonora Riva Sanseverino Pierluigi Gallo Daniel Koch Yash Kotak Hans-Georg Schweiger Hudson Zanin | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
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