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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 5 | Creation and judicious application of a wheat resistance gene atlas显示文摘Disease-resistance(R)gene cloning in wheat(Triticum aestivum)has been accelerated by the recent surge of genomic resources,facilitated by advances in sequencing technologies and bioinformatics.However,with the challenges of population growth and climate change,it is vital not only to clone and functionally characterize a few handfuls of R genes,but also to do so at a scale that would facilitate the breeding and deployment of crops that can recognize the wide range of pathogen effectors that threaten agroecosystems.Pathogen populations are continually changing,and breeders must have tools and resources available to rapidly respond to those changes if we are to safeguard our daily bread.To meet this challenge,we propose the creation of a wheat R-gene atlas by an international community of researchers and breeders.The atlas would consist of an online directory from which sources of resistance could be identified and deployed to achieve more durable resistance to the major wheat pathogens,such as wheat rusts,blotch diseases,powdery mildew,and wheat blast.We present a costed proposal detailing how the inter-acting molecular components governing disease resistance could be captured from both the host and the pathogen through biparental mapping,mutational genomics,and whole-genome association genetics.We explore options for the configuration and genotyping of diversity panels of hexaploid and tetraploid wheat,as well as their wild relatives and major pathogens,and discuss how the atlas could inform a dynamic,durable approach to R-gene deployment.Set against the current magnitude of wheat yield losses worldwide,recently estimated at 21%,this endeavor presents one route for bringing R genes from the lab to the field at a considerable speed and quantity. | Amber N.Hafeez Sanu Arora Sreya Ghosh David Gilbert Robert L.Bowden Brande B.H.Wulff | 2021 | Molecular Plant2021，14，7： | 3 |
| 6 | Phenotypic and functional characteristic of a newly dentified CDS+Foxp3-CDI03+ regulatory T cells显示文摘 | Ya Liu Qin Lan Ling Lu Maogen Chen Zanxian Xia Jilin Ma Julie Wang Huimin Fan Yi Shen Bernhard Ryffel David Brand Francisco Quismorio Zhongmin Liu David A. Horwitz Anping Xu Song Guo Zheng | 2014 | Journal of Molecular Cell Biology2014，8，1： | 2 |
| 7 | Adoptive Transfer of Human Gingiva‐Derived Mesenchymal Stem Cells Ameliorates Collagen‐Induced Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of Regulatory T Cell Differentiation显示文摘 | Maogen Chen Wenru Su Xiaohong Lin Zhiyong Guo Julie Wang Qunzhou Zhang David Brand Bernhard Ryffel Jiefu Huang Zhongmin Liu Xiaoshun He Anh D. Le Song Guo Zheng | 2013 | Arthritis & Rheumatism2013，，5： | 1 |
| 8 | Consensus-Derived Practice Standards Plan for Complicated Kaposiform Hemangioendothelioma显示文摘 | Beth A. Drolet Cameron C. Trenor Leonardo R. Brand?o Yvonne E. Chiu Robert H. Chun Roshni Dasgupta Maria C. Garzon Adrienne M. Hammill Craig M. Johnson Brook Tlougan Francine Blei Michèle David Ravindhra Elluru Ilona J. Frieden Sheila F. Friedlander Ionel | 2013 | The Journal of Pediatrics2013，，1： | 1 |
| 9 | Improved Fecal DNA Test for Colorectal Cancer Screening显示文摘 | Steven H. Itzkowitz Lina Jandorf Randall Brand Linda Rabeneck Paul C. Schroy Stephen Sontag David Johnson Joel Skoletsky Kris Durkee Sanford Markowitz Anthony Shuber | 2007 | Clinical Gastroenterology and Hepatology2007，，1： | 1 |
| 10 | Unexpected right colon mucosal bleeding on colonoscopy显示文摘 | David M. Felig Myron H. Brand Ronald J. Vender | 1996 | Gastrointestinal Endoscopy1996，，4： | 1 |
| 11 | Interactive effects of carbon dioxide, low temperature, and ultrav|olet-B radiation on cotton seedling root and shoot morphology and growth显示文摘 | David BRAND Chathurika WIJEWARDANA Wei GAO K. Raja REDDY | 2016 | Frontiers of Earth Science2016，10，4： | 1 |
| 12 | Associations of individual, household and environmental characteristics with carbon dioxide emissions from motorised passenger travel显示文摘 | Christian Brand Anna Goodman Harry Rutter Yena Song David Ogilvie | 2013 | Applied Energy2013，，： | 1 |
| 13 | Targeting IL-2:an unexpected effect in treating immunological diseases显示文摘Regulatory T cells(Treg)play a crucial role in maintaining immune homeostasis since Treg dysfunction in both animals and humans is associated with multi-organ autoimmune and inflammatory disease.While IL-2 is generally considered to promote Tcell proliferation and enhance effector T-cell function,recent studies have demonstrated that treatments that utilize low-dose IL-2 unexpectedly induce immune tolerance and promote Treg development resulting in the suppression of unwanted immune responses and eventually leading to treatment of some autoimmune disorders.In the present review,we discuss the biology of IL-2 and its signaling to help define the key role played by IL-2 in the development and function of Treg cells.We also summarize proof-of-concept clinical trials which have shown that low-dose IL-2 can control autoimmune diseases safely and effectively by specifically expanding and activating Treg.However,future studies will be needed to validate a better and safer dosing strategy for low-dose IL-2 treatments utilizing well-controlled clinical trials.More studies will also be needed to validate the appropriate dose of IL-2/anti-cytokine or IL-2/anti-IL-2 complex in the experimental animal models before moving to the clinic. | Congxiu Ye David Brand Song G.Zheng | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 1 |
| 14 | Trajectory of early tidal marsh restoration: Elevation, sedimentation and colonization of breached salt ponds in the northern San Francisco Bay显示文摘 | L. Arriana Brand Lacy M. Smith John Y. Takekawa Nicole D. Athearn Karen Taylor Gregory G. Shellenbarger David H. Schoellhamer Renee Spenst | 2012 | Ecological Engineering2012，，： | 1 |
| 15 | Local intracoronary administration of antisense oligonucleotide against c-myc for the prevention of in-stent restenosis:results of the randomized investigation by the thoraxcenter of antisense dna using local delivery and ivus after coronary stenting (ITALICS) trial显示文摘 | Michael JB Kutryk David P Foley Marcel van den Brand | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 16 | The identification of auto-antibodies in pancreatic cancer patient sera using a naturally fractionated Panc-1 cell line显示文摘 | Chen Li Hye-Yeung Kim Huy Vuong Tasneem Patwa Manoj Pal Randall E. Brand Diane M. Simeone David M. Lubman | 2010 | Cancer Biomarkers2010，，1： | 1 |
| 17 | Box-Behnken design:an alternative for the optimization of analytical methods显示文摘 | Ferreira S L C Bruns R E Ferreira H S Matos G D David J M Brand(a)o G C da Silva E G P Portugal L A dos Reis P S Souza A S dos Santos W N L | | 0，，02： | 1 |
| 18 | Privacy of medical records:IT implications of HIPAA显示文摘 | David Baumer Julia Brande Earp Fay Cobb Payton | 2000 | Computers and Society2000，30，4： | 1 |
| 19 | Collagen-induced arthritis 显示文摘 | David 0 Brand Kary A Latham Edward F Rosloniec | 2007 | Nature Protocols2007，2，5： | 1 |
| 20 | A protocol to develop T helper and Treg cells in vivo显示文摘An understanding of the development and function of T helper(Th)1,Th17 and regulatory T(Treg)cells is critical toward revealing pro-inflammatory immune responses,especially in autoimmune diseases.However,there is no standard protocol to monitor the development of these cells over time in vivo.This protocol details a method to generate Th1,Th17,and Treg cells in a T cell-induced colitis model in vivo and monitor their dynamic changes,which can be used for further investigations in their development from naive CD4+T cells in specific gene knockouts and background strains. | Weiqian Chen Zhenjian Xu Yongjiang Zheng Julie Wang Wenbin Qian Nancy Olsen David Brand Jin Lin Song Guo Zheng | 2017 | Cellular & Molecular Immunology2017，14，12： | 1 |
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