|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | Androgen receptors are expressed in a variety of human fetal extragenital tissues: an immunohistochemical study显示文摘瞄准:在开发人的胚胎的额外的生殖器的纸巾调查雄激素受体的表示。方法:用免疫组织化学,我们在第一个三个月(8-12 星期怀孕期) 的嵌入石蜡的织物节的额外的生殖器的纸巾调查了雄激素受体(AR ) 的分发人的胚胎。性被 polymerized 链反应决定。结果:在在在怀孕期的任何阶段的男、女的胚胎的 AR 的表示和分发没有差别。AR 表示在胸腺腺被看见。肺的支气管的上皮显示出与包围基质的强烈积极染色否定。而且,为雄激素受体的积极染色在包围纸巾与一些积极房间在针的绳索被展出。心脏的阀门也显示出强壮的积极染色但是与包围心肌的微弱反应。在肾没有染色,肾,肝或肠。结论:这研究表明反应 AR 蛋白质是的那免疫在许多人第一三个月在场胎儿的纸巾和表演为影响纸巾的雄激素的潜力,它主要没被认为是雄激素依赖者。而且,它暗示那雄激素可能充当一个营养的因素并且影响这些机关而非简单地的早发展性区别。 | Yasmin Sajjad Siobhan Quenby Paul Nickson David Iwan Lewis-Jones Gill Vince | 2007 | Asian Journal of Andrology2007，9，6： | 4 |
| 3 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 4 | Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography显示文摘 | Robert P. Myers Aaron Pollett Richard Kirsch Gilles Pomier‐Layrargues Melanie Beaton Mark Levstik Andres Duarte‐Rojo David Wong Pam Crotty Magdy Elkashab | 2012 | Liver Int2012，，6： | 4 |
| 5 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 6 | On 2-Site Voronoi Diagrams Under Geometric Distance Functions显示文摘We revisit a new type of Voronoi diagram, in which distance is measured from a point to a pair of points. We consider a few more such distance functions, based on geometric primitives, namely, circles and triangles, and analyze the structure and complexity of the nearest- and furthest-neighbor 2-site Voronoi diagrams of a point set in the plane with respect to these distance functions. In addition, we bring to notice that 2-point site Voronoi diagrams can be alternatively interpreted as 1-site Voronoi diagrams of segments, and thus, our results also enhance the knowledge on the latter. | Gill Barequet Matthew Dickerson David Eppstein David Hodorkovsky Kira Vyatkina | 2013 | Journal of Computer Science & Technology2013，28，2： | 2 |
| 7 | International study group on rectal cancer regression grading: interobserver variability with commonly used regression grading systems显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang Vikram Deshpande David Driman Marisa Gomez Godman Greywoode Eleanor Jaynes C. Soon Lee Michael Locketz Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Ra | 2012 | Human Pathology2012，，11： | 2 |
| 8 | A Prospective Multicenter Registry of Patients with Chronic Gastroesophageal Reflux Disease Receiving Transoral Incisionless Fundoplication显示文摘 | Reginald C.W. Bell Peter G. Mavrelis William E. Barnes David Dargis Bart J. Carter Kevin M. Hoddinott Robert W. Sewell Karim S. Trad Brian DaCosta Gill Glenn M. Ihde | 2012 | Journal of the American College of Surgeons2012，，6： | 2 |
| 9 | Changes in efficiency and resource utilization after increasing experience with double balloon enteroscopy显示文摘AIM:To investigate changes in efficiency and resource utilization as a single endoscopist's experience increased with each subsequent 100 double balloon enteroscopy(DBE) procedures.METHODS:We reviewed consecutive DBE procedures performed by a single endoscopist at our center over 4 years.DBE was employed when the clinician deemed the procedure was needed for disease management.The approach(oral,anal or both) was chosen based on suspected location of the target lesion.All DBE was performed in a standard endoscopy room with a portable fluoroscopy unit.Fluoroscopy was used to aid in shortening the small intestine and reducing bowel loops.For oral DBE,measurements were taken from the incisors.For anal DBE,measurements were taken from the anal verge.Enteroscopy continued until the target lesion was reached,until the entire small intestine was examined,or until no further progress was deemed possible.The length of small intestine examined(cm),procedure duration(min),and fluoroscopy time(s) were analyzed for sequential groups of 100 DBE.Sub-groups of diagnostic and therapeutic procedures were analyzed using multivariable linear regression.RESULTS:802 consecutive DBE procedures were analyzed.For oral DBE,median [interquartile range(IQR)] length of small bowel examined was 230.8 cm(range:210-248 cm) and for anal DBE was 143.5 cm(range:100-180 cm).No significant increase in length examined was noted for either the oral or anal approach with advancing position in series.In terms of duration of procedure,the median(IQR) for oral DBE was 86 min(range:71-105 min) and for anal DBE was 81.3 min(range:67-105 min).When comparing by the position in series,there was a significant(P value < 0.001) decrease in procedure duration for both upper and lower procedures with increasing experience.Median(IQR) time of exposure to fluoroscopy for oral DBE was 190 s(114-275) compared to anal DBE which was 196.4 s(312-128).This represented a significant(P value < 0.001) decrease in the amount of fluoroscopy used with increasing position in series.For both oral and anal DBE,fluoroscopy time was reduced by greater than 50% over the course of 802 total procedures performed.Sub-group analysis was conducted on therapeutic and diagnostic groups.Out of 802 procedures,a total of 434 were considered therapeutic.Argon plasma coagulation was by far the most common therapeutic intervention performed.There was no evidence of a difference in length examined or fluoroscopy exposure among oral DBE for diagnostic and therapeutic procedures,P = 0.91 and P = 0.32 respectively.The median(IQR) for length was 235 cm(range:178-280 cm) for diagnostic vs 230 cm(range:180-275 cm) for therapeutic procedures;additionally,fluoroscopy time median(IQR) was 180 s(range:110-295 s) and 162 s(range:102-263 s) for no intervention and intervention.However,there was a significant difference in procedure duration among oral DBE(P < 0.001).The median(IQR) was 80 min(range:60-97 min) and 94 min(range:77-110 min) for diagnostic and therapeutic interventions respectively.CONCLUSION:For a single endoscopist,increased DBE experience with number of performed procedures is associated with increased efficiency and decreased resource utilization. | Neal C Patel William C Palmer Kanwar R Gill David Cangemi Nancy Diehl Mark E Stark | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 10 | Single-Port Transvesical Simple Prostatectomy: Initial Clinical Report显示文摘 | Mihir M. Desai Monish Aron David Canes Khaled Fareed Oswaldo Carmona Georges-Pascal Haber Sebastien Crouzet Juan Carlos Astigueta Roy Lopez Robert de Andrade Robert J. Stein James Ulchaker Rene Sotelo Inderbir S. Gill | 2008 | Urology2008，，5： | 1 |
| 11 | All hyped up and no place to go显示文摘 | David Bell Jon Binnie Julia Cream Gill Valentine | 1994 | Gender Place & Culture1994，，1： | 1 |
| 12 | Randomized Phase II Trial of Onartuzumab in Combination With Erlotinib in Patients With Advanced Non–Small-Cell Lung Cancer显示文摘 | David R. Spigel Thomas J. Ervin Rodryg A. Ramlau Davey B. Daniel Jerome H. Goldschmidt George R. Blumenschein Maciej J. Krzakowski Gilles Robinet Benoit Godbert Fabrice Barlesi Ramaswamy Govindan Taral Patel Sergey V. Orlov Michael S. Wertheim Wei Yu Jipi | 2013 | Journal of Clinical Oncology2013，，32： | 1 |
| 13 | A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang David Driman Fraser Duthie Marisa Gomez Eleanor Jaynes Cheok Soon Lee Michael Locketz Claudia Mescoli Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Raj | 2012 | Virchows Archiv2012，，2： | 1 |
| 14 | Feasibility of Video Capsule Endoscopy in the Management of Children With Peutz-Jeghers Syndrome: A Blinded Comparison With Barium Enterography for the Detection of Small Bowel Polyps显示文摘 | Aymer Postgate Warren Hyer Robin Phillips Arun Gupta David Burling Clive Bartram Michelle Marshall Stuart Taylor Gregor Brown Gill Schofield Paul Bassett Christine Spray Aine Fitzpatrick Chris Fraser A Latchford | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 1 |
| 15 | RETROPERITONEOSCOPIC SURGERY IS NOT ASSOCIATED WITH INCREASED CARBON DIOXIDE ABSORPTION显示文摘 | CHRISTOPHER S. NG INDERBIR S. GILL GYUNG TAK SUNG DAVID G. WHALLEY RUFFIN GRAHAM DANA SCHWEIZER | 1999 | The Journal of Urology1999，，4： | 1 |
| 16 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 17 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 18 | Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures显示文摘 | Brigitte Alliot-Licht Gilles Bluteau David Magne Serena Lopez-Cazaux Blandine Lieubeau Guy Daculsi Jerome Guicheux | 2005 | Cell and Tissue Research2005，，3： | 1 |
| 19 | Contribution of Vitreous Cytology to Final Clinical Diagnosis显示文摘 | Leah A. Wittenberg David A. Maberley Patrick E. Ma N. Kevin Wade Harpreet Gill Valerie A. White | 2008 | Ophthalmology2008，，11： | 1 |
| 20 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员