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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Inactivation of myelin-associated glycoprotein enhances optic nerve regeneration显示文摘 | Wong EV David S Jacob MH | 2003 | J Neurosci2003，23，8： | 1 |
| 3 | Inactivation of myelin-associated glycoprotein enhances optic nerve regeneration显示文摘 | Wong EV David S Jacob MH | 2003 | J Neurosci2003，23，8： | 1 |
| 4 | Inactivation of myelin-as- sociat- edgly coproteinenhances optic nerve regeneration 显示文摘 | Wong-EV David S Jacob MH Jay DG | 2003 | J Neurosci2003，23，8： | 1 |
| 5 | Dietary carbohydrate, glycemic index, and glyeemie load and the risk of coloreetal cancer in the BCDDP cohort显示文摘 | LORI S DAVID R JACOBS J R | 2007 | Cancer Causes Control2007，18，8： | 1 |
| 6 | Recognition of speech signals,an experimental comparison of linear predictive coding and discrete wavelet transforms显示文摘 | Sonia Sunny David Peter S K Poulose Jacob | | 0，，4： | 1 |
| 7 | Temporary internal distraction as an aid to correction of severe scoliosis显示文摘 | Jacob M B David L S Paul D S | 2007 | J Bone Joint Surg2007，89，2： | 1 |
| 8 | Synthesis of one-dimensional structured metal phthalocyanine in an ionic liquid 显示文摘 | David S Jacob Aharon Gedanken Leonid A Solovyov | 2007 | Journal of Porphyrins and Phthalocyanines2007，11，10： | 1 |
| 9 | A Prospective Study of the Diagnostic Accuracy of PillCam ESO Esophageal Capsule Endoscopy Versus Conventional Upper Endoscopy in Patients With Chronic Gastroesophageal Reflux Diseases显示文摘 | Rami Eliakim Virender K Sharma Kamel Yassin Samuel N Adler Harold Jacob David R Cave Ritu Sachdev Roger D Mitty Dirk Hartmann Dieter Schilling Jurgen F Riemann Simon Bar-Meir Eytan Bardan Brian Fennerty Glenn Eisen Douglas Faigel Blair S Lewis David E Fle | 2005 | Journal of Clinical Gastroenterology2005，，7： | 1 |
| 10 | Synthesis and characterization of TiO2 @ C coreshell composite nanoparticles and evaluation of their photocatalytic activities显示文摘 | Sangaraju Shanmugam Alexandra Gabashvili David S Jacob | 2006 | Chem Mater2006，18，9： | 1 |
| 11 | The Influence of Antenna Pattern on Faraday Rotation in Remote Sensing at L-Band 显示文摘 | Le Vine David M Jacob S Daniel Dinnat Emmanuel P | 2007 | IEEE Transactions on Geoscience and Remote Sensing2007，45，9： | 1 |
| 12 | Polyanalgesic Consensus Conference 2012: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel显示文摘 | Timothy R. Deer Joshua Prager Robert Levy James Rathmell Eric Buchser Allen Burton David Caraway Michael Cousins José De Andrés Sudhir Diwan Michael Erdek Eric Grigsby Marc Huntoon Marilyn S. Jacobs Philip Kim Krishna Kumar Michael Leong Liong Liem Gladst | 2012 | Neuromodulation: Technology at the Neural Interface2012，，5： | 1 |
| 13 | Molecular phylgenetics and historical biogeography of Rhi- nolophus bats显示文摘 | SAMANTHA Stoffberg DAVID S Jacobs IAIN J Mackie | 2010 | Molecular Phylogenetics and Evolution2010，54，1： | 1 |
| 14 | Seismic activity,polar tides and the chandler wobble显示文摘 | David P Jacob S | 1973 | Nature1973，245，： | 1 |
| 15 | Inactivation of myelinas- soi-ciated glycoprotein enhancesoptic nerve regeneration 显示文摘 | Wong EV David S Jacob MH | 2003 | J Neurosci2003，23，8： | 1 |
| 16 | The influence of antenna pattern on faraday rotation in remote sensing at L-Band 显示文摘 | Le Vine David M Jacob S Daniel Dinnat Emmanuel P | 2007 | IEEE Transactions On Geoscience and Remote Sensing2007，45，9： | 1 |
| 17 | Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration显示文摘 | Hamdi K Hamdi Jacob Reznik Raquel Castellon Shari R Atilano John M Ong Nitin Udar Jeffrey H Tavis Annette M Aoki Anthony B Nesburn David S Boyer Kent W Small Donald J Brown M Cristina Kenney | 2002 | Biochemical and Biophysical Research Communications2002，，3： | 1 |
| 18 | Dendritic cells in hepatitis C virus infection:Key players in the IFNL3-genotype response显示文摘Recently,single nucleotide polymorphisms,in the vicinity of the interferon lambda 3(IFNL3)gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus(HCV)infection.Since then,increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype effect.Dendritic cells(DCs)are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is emerging.Reports have identified subclasses of DCs,particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV infection.Given the complexities of dendritic cell biology and the conflicting current available data,this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to placeit into context of what is know about lambda interferons and dendritic cells in general. | Kate S O'Connor Jacob George David Booth Golo Ahlenstiel | 2014 | World Journal of Gastroenterology2014，20，47： | 0 |
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