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| 1 | Three-dimensional endoanal ultrasound for diagnosis of perianal fistulas: reliable and objective technique显示文摘AIM: To evaluate accuracy of three-dimensional endoanal ultrasound(3D-EAUS) as compared to 2D-EAUS and physical examination(PE) in diagnosis of perianal fistulas and correlate with intraoperative findings. METHODS: A prospective observational consecutive study was performed with patients included over a two years period. All patients were studied and operated on by the Colorectal Unit surgeons. The inclusion criteria were patients over 18, diagnosed with a criptoglandular perianal fistula. The PE, 2D-EAUS and 3D-EAUS was performed preoperatively by the same colorectal surgeon at the outpatient clinic prior to surgery and the fistula anatomy was defined and they were classified in intersphincteric, high or low transsphincteric, suprasphincteric and extrasphincteric. Special attention was paid to the presence of a secondary tract, the location of the internal opening(IO) and the site of external opening. The results of these different examinations were compared to the intraoperative findings. Data regarding location of the IO, primary tract, secondary tract, and the presence of abscesses or cavities wasanalysed.RESULTS: Seventy patients with a mean age of 47years(range 21-77), 51 male were included. Low transsphincteric fistulas were the most frequent type found(33, 47.1%) followed by high transsphincteric(24,34.3%) and intersphincteric fistulas(13, 18.6%). There are no significant differences between the number of IO diagnosed by the different techniques employed and surgery(P > 0.05) and, there is a good concordance between intraoperative findings and the 2D-EAUS(k= 0.67) and 3D-EAUS(k = 0.75) for the diagnosis of the primary tract. The ROC curves for the diagnosis of transsphincteric fistulas show that both ultrasound techniques are adequate for the diagnosis of low transsphincteric fistulas, 3D-EAUS is superior for the diagnosis of high transsphincteric fistulas and PE is weak for the diagnosis of both types.CONCLUSION: 3D-EAUS shows a higher accuracy than 2D-EAUS for assessing height of primary tract in transsphincteric fistulas. Both techniques show a good concordance with intraoperative finding for diagnosis of primary tracts. | Marina Garcés-Albir Stephanie Anne García-Botello Alejandro Espi Vicente Pla-Martí Jose Martin-Arevalo David Moro-Valdezate Joaquin Ortega | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 7 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | The Lancet . 2006 (9536)2006，，9536： | 2 |
| 4 | Maintenance treatment with Pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer: GEICAM 2001-01 study显示文摘 | Emilio Alba Manuel Ruiz-Borrego Mireia Margelí álvaro Rodríguez-Lescure Pedro Sánchez-Rovira Amparo Ruiz Jose Ramón Mel-Lorenzo Manuel Ramos-Vázquez Nuria Ribelles Elisa Calvo Antonio Casado Antonia Márquez David Vicente José Angel García-Sáenz Miguel Mar | 2010 | Breast Cancer Research and Treatment2010，，1： | 2 |
| 5 | Vision-based active safety system for automatic stopping显示文摘 | VICENTE M DAVID F L JORGE V | 2012 | Expert systems with applications2012，39，11： | 1 |
| 6 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | 2006 (9536)2006，，9536： | 1 |
| 7 | Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization显示文摘 | Tatsuya Kondo David Vicent Kiyoshi Suzuma | 2003 | J Clin Invest2003，111，： | 1 |
| 8 | The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance显示文摘 | David Vicent Jacob Ilany Tatsuya Kondo | 2003 | J Clin Invest2003，111，： | 1 |
| 9 | Error induced by the estimation of the corneal power and the effective lens position with a rotationally asymmetric refractive multifocal intraocular lens显示文摘AIM : To evaluate the prediction error in intraocular lens(IOL) power calculation for a rotationally asymmetric refractive multifocal IOL and the impact on this error of the optimization of the keratometric estimation of the corneal power and the prediction of the effective lens position(ELP).METHODS: Retrospective study including a total of 25 eyes of 13 patients(age, 50 to 83y) with previous cataract surgery with implantation of the Lentis Mplus LS-312 IOL(Oculentis Gmb H, Germany). In all cases, an adjusted IOL power(P IOLadj) was calculated based on Gaussian optics using a variable keratometric index value(n kadj) for the estimation of the corneal power(P kadj) and on a new value for ELP(ELP adj) obtained by multiple regression analysis.This P IOLadj was compared with the IOL power implanted(P IOLReal) and the value proposed by three conventional formulas(Haigis, Hoffer Q and Holladay Ⅰ).RESULTS: P IOLReal was not significantly different than P IOLadj and Holladay IOL power(P >0.05). In the Bland and Altman analysis, P IOLadj showed lower mean difference(-0.07 D) and limits of agreement(of 1.47 and-1.61 D)when compared to P IOLReal than the IOL power value obtained with the Holladay formula. Furthermore, ELP adj was significantly lower than ELP calculated with other conventional formulas(P <0.01) and was found to be dependent on axial length, anterior chamber depth and P kadj. CONCLUSION: Refractive outcomes after cataract surgery with implantation of the multifocal IOL Lentis Mplus LS-312 can be optimized by minimizing thekeratometric error and by estimating ELP using a mathematical expression dependent on anatomical factors. | David P.Piero Vicente J.Camps María L.Ramón Verónica Mateo Rafael J.Pérez-Cambrodí | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 1 |
| 10 | A High-Resolution Topographic Correction Method for Clear-Sky Solar Irradiance Derived with a Numerical Weather Prediction Model显示文摘 | Ruiz-Arias José A Pozo-Vázquez David Lara-Fanego Vicente Santos-Alamillos Francisco J Tovar-Pescador J | 2011 | Journal of Applied Meteorology and Climatology2011，，12： | 1 |
| 11 | Intelligent automatic overtaking system using vision for vehicle detection 显示文摘 | Vicente M David F Jorge V | 2012 | Expert Systems with Application2012，39，3： | 1 |
| 12 | Primary Prophylaxis of Spontaneous Bacterial Peritonitis Delays Hepatorenal Syndrome and Improves Survival in Cirrhosis显示文摘 | Javier Fernández Miquel Navasa Ramón Planas Silvia Montoliu David Monfort German Soriano Carmen Vila Alberto Pardo Enrique Quintero Victor Vargas Jose Such Pere Ginès Vicente Arroyo | 2007 | Gastroenterology2007，，3： | 1 |
| 13 | Vision-based active safety system for automatic stopping显示文摘 | Vicente Milanés David F. Llorca Jorge Villagrá Joshue Pérez Ignacio Parra Carlos González Miguel A. Sotelo | 2012 | Expert Systems With Applications2012，，12： | 1 |
| 14 | Alterations in carbohydrate metabolism in cirrhotic patients before and after liver transplant显示文摘 | Agustín Ramos-Prol David Hervás-Marín Beatriz Rodríguez-Medina Vicente Campos-Alborg Marina Berenguer ángel Moya-Herraiz Juan Francisco Merino-Torres | 2015 | Diabetes Research and Clinical Practice2015，，： | 1 |
| 15 | Effect of High-frequency, Low-magnitude Vibration on Bone and Muscle in Children With Cerebral Palsy显示文摘 | Tishya A. L. Wren David C. Lee Reiko Hara Susan A. Rethlefsen Robert M. Kay Frederick J. Dorey Vicente Gilsanz | 2010 | Journal of Pediatric Orthopaedics2010，，7： | 1 |
| 16 | Intelligent automatic overtaking system using vision for vehicle detection 显示文摘 | Vicente Milanes David F Llorca Jorge Villagra | 2012 | Expert Systems with Applications2012，39，3： | 1 |
| 17 | Polycystic Liver Disease: A Critical Appraisal of Hepatic Resection, Cyst Fenestration, and Liver Transplantation显示文摘 | Thomas Schnelldorfer Vicente E. Torres Shaheen Zakaria Charles B. Rosen David M. Nagorney | 2009 | Annals of Surgery2009，，1： | 1 |
| 18 | Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models显示文摘 | Vicent Silvestre Chen Ron Sayles Leanne C Lin Chenwei Walker Randal G Gillespie Anna K Subramanian Aravind Hinkle Gregory Yang Xiaoping Saif Sakina Root David E Huff Vicki Hahn William C Sweet-Cordero E Alejandro | 2010 | Journal of Clinical Investigation2010，，11： | 1 |
| 19 | Sacral Nerve Stimulation for the Treatment of Severe Faecal Incontinence: Results After 10 Years Experience显示文摘 | M. Dolores Ruiz Carmona José Martín Arévalo David Moro Valdezate Vicente Plá Martí Félix Checa Ayet | 2014 | Cirugía Espa?ola (English Edition)2014，，： | 1 |
| 20 | Cardiac benefits of exercise training in aging spontaneously hypertensive rats显示文摘 | Luciana V. Rossoni Raphael A.F. Oliveira Rene R. Caffaro Maria Miana David Sanz-Rosa Márcia K. Koike Sandra L. Do Amaral Lisete C. Michelini Vicente Lahera Victoria Cachofeiro | 2011 | Journal of Hypertension2011，，12： | 1 |
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