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| 1 | Approaches to establish Q-markers for the quality standards of traditional Chinese medicines显示文摘Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic 'multicomponent and multitarget' feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as'herbal medicine' or 'natural product', and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of 'quality marker'(Q-marker), following the 'property-effect-component' theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM.This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples. | Wenzhi Yang Yibei Zhang Wanying Wu Luqi Huang Dean Guo Changxiao Liu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 51 |
| 2 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 3 | Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling fourdimensional separation and characterization of the multicomponents from white ginseng and red ginseng显示文摘Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification.A dimension-enhanced strategy,by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(2 D-LC/IM-QTOF-MS)enabling four-dimensional separations(2 D-LC,IM,and MS),is proposed.In combination with in-house database-driven automated peak annotation,this strategy was utilized to characterize ginsenosides simultaneously from white ginseng(WG)and red ginseng(RG).An offline 2 DLC system configuring an Xbridge Amide column and an HSS T3 column showed orthogonality 0.76 in the resolution of ginsenosides.Ginsenoside analysis was performed by data-independent high-definition MSE(HDMSE)in the negative ESI mode on a Vion?IMS-QTOF hybrid high-resolution mass spectrometer,which could better resolve ginsenosides than MSEand directly give the CCS information.An in-house ginsenoside database recording 504 known ginsenosides and 58 reference compounds,was established to assist the identification of ginsenosides.Streamlined workflows,by applying UNIFI?to automatedly annotate the HDMSEdata,were proposed.We could separate and characterize 323 ginsenosides(including 286 from WG and 306 from RG),and 125 thereof may have not been isolated from the Panax genus.The established 2 D-LC/IM-QTOF-HDMSEapproach could also act as a magnifier to probe differentiated components between WG and RG.Compared with conventional approaches,this dimensionenhanced strategy could better resolve coeluting herbal components and more efficiently,more reliably identify the multicomponents,which,we believe,offers more possibilities for the systematic exposure and confirmative identification of plant metabolites. | Tiantian Zuo Chunxia Zhang Weiwei Li Hongda Wang Ying Hu Wenzhi Yang Li Jia Xiaoyan Wang Xiumei Gao Dean Guo | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 9 |
| 4 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 5 | MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation显示文摘 | Ruirui Ji Yunhui Cheng Junming Yue Jian Yang Xiaojun Liu He Chen David B. Dean Chunxiang Zhang | 2007 | Circulation Research2007，，11： | 4 |
| 6 | Uniformly dispersed FeOx atomic clusters by pulsed arc plasma deposition: An efficient electrocatalyst for improving the performance of Li-O2 battery显示文摘现在的学习探索了一个新方法改进非宝贵的金属的催化活动,特别在电气化学的反应。弧分泌物生产的高度电离的 Fe 血浆一致地在多孔的碳底层上被扔并且在碳表面上形成了原子簇。同样准备的 FeO x /C 材料在不同的当前的率下面在一节可充电的 Li-O 2 电池作为阴极材料被测试。结果以周期生活和反应率在电池性能显示出重要改进。而且, X 光检查衍射(XRD ) 和扫描电子显微镜学(SEM ) 结果证明同样准备的阴极材料稳定了阴极并且减少了方面反应并且当前的率是在分泌物产品的成核的一个关键因素。 | Xiangyi Luo Jun Lu Evan Sohm Lu Ma Tianpin Wu Jianguo Wen Dantong Qiu YunKai Xu Yang Ren Dean J. Miller Khalil Amine | 2016 | Nano Research2016，9，7： | 3 |
| 7 | Deep reinforcement with spectrum series learning control for a mode-locked fiber laser显示文摘A spectrum series learning-based model is presented for mode-locked fiber laser state searching and switching.The mode-locked operation search policy is obtained by our proposed algorithm that combines deep reinforcement learning and long short-term memory networks.Numerical simulations show that the dynamic features of the laser cavity can be obtained from spectrum series.Compared with the traditional evolutionary search algorithm that only uses the current state,this model greatly improves the efficiency of the mode-locked search.The switch of the mode-locked state is realized by a predictive neural network that controls the pump power.In the experiments,the proposed algorithm uses an average of only 690 ms to obtain a stable mode-locked state,which is one order of magnitude less than that of the traditional method.The maximum number of search steps in the algorithm is 47 in the 16°C–30°C temperature environment.The pump power prediction error is less than 2 mW,which ensures precise laser locking on multiple operating states.This proposed technique paves the way for a variety of optical systems that require fast and robust control. | ZHAN LI SHUAISHUAI YANG QI XIAO TIANYU ZHANG YONG LI LU HAN DEAN LIU XIAOPING OUYANG JIANQIANG ZHU | 2022 | Photonics Research2022，10，6： | 2 |
| 8 | Shape demagnetization effect on layered magnetoelectric composites显示文摘Magnetoelectric (ME) voltage coefficient of plate layered magnetostrictive-piezoelectric composites was always considered independent of the in-plane size due to the oversimplification in ME theoretical models. Here we report that the ME voltage coefficient depends on the in-plane size owing to shape demagnetization effect on magnetostriction. Both theoretical analysis and experimental results indicate that ME voltage coefficient of layered ME composites changes with the variation in in-plane sizes (length and width). ME coefficient increases with a rise in in-plane sizes, and different aspect ratio also results in different ME coefficients. Proper design of in-plane shape will greatly promote the develop- ment of ME devices. | PAN DeAn LU Jun BAI Yang CHU WuYang QIAO LiJie | 2008 | Chinese Science Bulletin2008，53，14： | 2 |
| 9 | Effect of Laminar Cooling on Phase Transformation Evolution in Hot Rolling Process显示文摘The effect of temperature variation owing to the cooling pattern(CP)on the microstructural evolution was investigated by establishing a thermomechanical coupled FE(finite element)model.A set of constitutive equations of phase transformation was implanted into the commercial FE solver MARC through the user defined subroutine CRPLAW,and the temperature field was calculated by another user defined subroutine FILM.The results show that the final microstructure is completely bainite phase for CP one,98% of bainite phase and 2% of ferrite phase for CP two,and 55% of bainite phase,35% of pearlite phase and 10% of ferrite phase for CP three. | NING Lin-xin YANG Dai-jun J Lin T A Dean | 2010 | Journal of Iron and Steel Research(International)2010，17，10： | 2 |
| 10 | Lp-affine isoperimetric inequalities 显示文摘 | LUTWAK E YANG Deane ZHANG Gaoyong | 2000 | Differential Geom2000，56，： | 1 |
| 11 | SCUBE1,a novel developmental gene involved in renal regeneration and repair显示文摘 | Zhuang J Deane JA Yang RB | 2010 | Nephrol Dial Transplant2010，25，5： | 1 |
| 12 | Influence of apatite seeds on the synthesis of calcium phosphate cement 显示文摘 | Yang Q Z Troe Zynski T Dean Mo Liu D M | 2002 | Biomaterials2002，23，： | 1 |
| 13 | Insurance, credit, and technology adoption: Field experimental evidence from Malawi显示文摘 | Xavier Gine Dean Yang | 2009 | Journal of Development Economics2009，，89： | 1 |
| 14 | Converting ceria polyhedral nanoparfides into single-crystal nanospheres 显示文摘 | Feng Xiangdong Sayle Dean C Wang Zhonglin Paras M Sha- ron Santora Brian Sutorik Anthony C Sayle Thi X T Yang Yi Ding Yong Wang Xudong Her Yie-shein | 2006 | Science2006，312，： | 1 |
| 15 | Functionalization of Isotatic Polypropylene with Maleic Anhydride by Reactive Extrusion: Mechanism of Melt Grafting 显示文摘 | Dean Shi Jinghui Yang | 2001 | Polymer2001，，2： | 1 |
| 16 | Setup time reduction and competitive advantage in a closed manufacturing cell显示文摘 | Yang J Deane R H | 1993 | European Journal of Operational Research1993，69，： | 1 |
| 17 | Time-course analyses of abscisic acid level and the expression of genes involved in abscisic acid biosynthesis in the leaves of Betula platyphylla显示文摘 | Rongshu Zhang Chuanping Yang Chao Wang Zhigang Wei Dean Xia Yuefeng Wang Guifeng Liu Yucheng Wang | 2012 | Molecular Biology Reports2012，，3： | 1 |
| 18 | Phase characterization and tunable photoluminescence of Eu-doped strontium-substituted nanohalophosphate 显示文摘 | Yang Chih Cheng Chen San Yuan Liu Dean Mo | 2006 | Journal of Crystal Growth2006，293，： | 1 |
| 19 | Efforts to de- crease crosslinking extent of polyethylene in a reactive extru- sion grafting process显示文摘 | Yang Jinghui Yao Zhanhai Shi Dean | 2001 | Journal of Applied Polymer Science2001，79，3： | 1 |
| 20 | An Investigation on the Modification of Polypropylene by Grafting of Maleic Anhydride Based on the Aspect of maleie Adhesion显示文摘 | Shi Dean Yao Z G | 2002 | J Appl Polym Sei2002，84，22： | 1 |
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