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| 1 | Indocyanine Green Nanoparticles for Theranostic Applications显示文摘Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that has been approved by Food and Drug Administration(FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles(NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging(fluorescent imaging and photoacoustic imaging) and therapeutics(photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics. | Zonghai Sheng Dehong Hu Miaomiao Xue Meng He Ping Gong Lintao Cai | 2013 | Nano-Micro Letters2013，5，3： | 11 |
| 2 | Recent progress in Chinese polar upper-atmospheric physics research: review of research advances supported by the Chinese Arctic and Antarctic expeditions显示文摘It has been more than 30 years since the first Chinese Antarctic Expedition took place. Polar upper atmospheric observations started at this time. First began at Great Wall Station and then at Zhongshan Station in Antarctica, and later in the Arctic at Yellow River Station, Kjell Henriksen Observatory on Svalbard, and at the China-Iceland Joint Aurora Observatory in Iceland. In this paper, we reviewed the advances in polar upper atmosphere physics(UAP) based on the Chinese national Arctic and Antarctic research over the last five years. These included newly deployed observatories and research instruments in the Arctic and Antarctic; and new research findings, from ground-based observations, about polar ionosphere dynamics, aurora and particle precipitation, polar plasma convection, geomagnetic pulsations and space plasma waves, space weather in the polar regions, simulations of the polar ionosphere-magnetosphere. In conclusion, suggestions were made for future polar upper atmosphere physics research in China. | HE Fang HU Hongqiao YANG Huigen ZHANG Beichen HUANG Dehong LIU Yonghua HU Zejun LIU Jianjun | 2016 | Advances in Polar Science2016，27，4： | 6 |
| 3 | Aptamer/graphene oxide nanocomplex for in situmolecular probing in living cells显示文摘 | Wang Y Li Z H Dehong Hu D H | 2010 | J Am Chem Soc2010，132，： | 1 |
| 4 | Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates显示文摘Fluorescence probes with aggregation-induced emission(AIE)characteristics are of great importance in biomedical imaging with superior spatial and temporal resolution.However,the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical translation.Here,we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green(ICG)during a study period of 36 days to demonstrate AIE probes are nontoxic.Furthermore,through bright and nontoxic AIE probes and fluorescence imaging in the second window(NIR-II,1,000-1,700 nm),we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates,breaking the current limitation of millimeter-deep NIR-II fluorescence imaging.Our important findings,i.e.,nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates,may facilitate successful translation of AIE probes in clinical trials. | Zonghai Sheng Yaxi Li Dehong Hu Tianliang Min Duyang Gao Jen-Shyang Ni Pengfei Zhang Yuenan Wang Xin Liu Kai Li Hairong Zheng Ben Zhong Tang | 2020 | Research2020，，1： | 1 |
| 5 | Clinical Significance and Functional Studies of Myeloid-Derived Suppressor Cells in Chronic Hepatitis C Patients显示文摘 | Weiping Cai Aiping Qin Pengle Guo Dehong Yan Fengyu Hu Qiong Yang Min Xu Yongshui Fu Jie Zhou Xiaoping Tang | 2013 | Journal of Clinical Immunology2013，，4： | 1 |
| 6 | An introduction to the riometer system deployed at China-Iceland joint Arctic observatory and its beam-forming correction method based on the preliminary data显示文摘The China-Iceland joint Arctic observatory(CIAO)has formally been operating since October 18,2018,and an imaging riometer system was deployed at CIAO in August 2019 for the conjunction observation purpose with the co-located ground-based all sky imager auroral observation system.The features of the riometer and antenna system are presented.The riometer’s beam-forming performance were evaluated with the analysis method introduced in detail.The analysis results showed that the mapping of beams was incorrectly ordered,and the correction has been made.The revised ordering result was reasonably verified and the analysis method was proved to be effective. | HE Fang HU Zejun HU Hongqiao HUANG Dehong YU Yao | 2021 | Advances in Polar Science2021，32，3： | 0 |
| 7 | Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson’s Disease显示文摘Targeted therapy of Parkinson’s disease is an important challenge because of the blood–brain barrier limitation.Here,we propose a natural killer cell membrane biomimetic nanocomplex(named BLIPO-CUR)delivered via the meningeal lymphatic vessel(MLV)route to further the therapeutic efficacy of Parkinson’s disease.The membrane incorporation enables BLIPO-CUR to target the damaged neurons,thus improving their therapeutic efficacy through clearing reactive oxygen species,suppressing the aggregation ofα-synuclein,and inhibiting the spread of excessα-synuclein species.Compared with the conventional intravenous injection,this MLV administration can enhance the delivered efficiency of curcumin into the brain by~20 folds.The MLV route administration of BLIPO-CUR enhances the treatment efficacy of Parkinson’s disease in mouse models by improving their movement disorders and reversing neuron death.Our findings highlight the great potential of MLV route administration used as targeted delivery of drugs to the brain,holding a great promise for neurodegenerative disease therapy. | Jing Liu Duyang Gao Dehong Hu Siyi Lan Yu Liu Hairong Zheng Zhen Yuan Zonghai Sheng | 2023 | Research2023，，3： | 0 |
| 8 | Algorithm for the estimation of ionosphere parameters from ground scatter echoes of SuperDARN显示文摘The High-frequency over-the-horizon radar ground and sea backscatter echoes can be used to estimate the ionosphere critical frequency, providing the ionosphere states up to thousands of kilometers from the transmitter to receiver location. In this study,using the frequency scanning mode of super dual auroral radar network(SuperDARN), the skip distance of every frequency band can be obtained, then, the variation of maximum usable frequency with range is estimated. With the knowledge of elevation angles or an assigned virtual reflection height in ionosphere, the F-region critical frequency has been estimated. The cross correlation of these two sample populations as a function of the lag is calculated, which shows that the cross-correlation coefficients can be as high as 0.8 in all selected events at 0 lag, thus validating the rationality of the proposed algorithm.Therefore, the algorithm is suitable for application under conditions of abundant ground/sea backscatter echoes. | HUANG DeHong LIU ErXiao HU HongQiao LIU JianJun | 2018 | Science China(Technological Sciences)2018，61，11： | 0 |
| 9 | A case study based on ground observations of the conjugate ionospheric response to interplanetary shock in polar regions显示文摘Data acquired by imaging relative ionospheric opacity meters(riometers),ionospheric total electron content(TEC)monitors,and three-wavelength auroral imagers at the conjugate Zhongshan station(ZHS)in Antarctica and Yellow River station(YRS)in the Arctic were analyzed to investigate the response of the polar ionosphere to an interplanetary shock event induced by solar flare activity on July 12,2012.After the arrival of the interplanetary shock wave at the magnetosphere at approximately 18:10 UT,significantly enhanced auroral activity was observed by the auroral imagers at the ZHS.Additionally,the polar conjugate observation stations in both hemispheres recorded notable evolution in the two-dimensional movement of cosmic noise absorption.Comparison of the ionospheric TEC data acquired by the conjugate pair showed that the TEC at both sites increased considerably after the interplanetaryshock wave arrived,although the two stations featured different sunlight conditions(polar night in July in the Antarctic region and polar day in the Arctic region).However,the high-frequency(HF)coherent radar data demonstrated that different sourcesmight be responsible for the electron density enhancement in the ionosphere.During the Arctic polar day period in July,the increased electron density over YRS might have been caused by anti-sunward convection of the plasma irregularity,whereas in Antarctica during the polar night,the increased electron density over ZHS might have been caused by energetic particle precipitation from the magnetotail.These different physical processes might be responsible for the different responses of the ionosphere at the two conjugate stations in response to the same interplanetary shock event. | HE Fang HU Zejun HU Hongqiao HUANG Dehong YU Yao | 2021 | Advances in Polar Science2021，32，2： | 0 |
| 10 | An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells显示文摘Intervertebral disc degeneration(IDD)is the main cause of lower back pain.Lower back pain places a huge burden on society,and all current treatments for IDD cannot restore the original function of the intervertebral disc.Proposing new treatments for IDD requires clarifying the mechanisms of IDD.Physiological hypoxia is an important feature of the nucleus pulposus because of its special anatomical structure.Using RNA sequencing(RNA-seq),we obtained the whole transcriptome of nucleus pulposus cells(NPCs)under hypoxia and hypoxia-inducible factor(HIF1A)deletion.Results demonstrated possible effects of oxygen concentration and HIF1A on NPCs.In addition,our results showed that hypoxia can affect lipid metabolism in NPCs. | Zhicai Peng Zhuo Wang Shuaichi Guo Bing Tan Ruichao Cao Shengqiang Cheng Jun Chen Chunwang Xie Dehong Mao Zhenming Hu | 2024 | Genes & Diseases2024，11，2： | 0 |
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