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| 1 | A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood显示文摘新复合 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl )-5,6,7,8-tetrahydro-4H-chromen-4-one (1 ) 从中国沉香被孤立[Aquilaria sinensis (愁相) Gilg ] 。它的结构被阐明根据光谱数据。与 14.6 渭 g /mL 的 IC50 价值由 MTT 方法在 vitro 对人的胃的癌症房间线(SGC-7901 ) 加重 1 显示出的 cytotoxicity。 | Jun Liu Jiao Wu You Xing Zhao Yuan Yuan Deng Wen Li Mei Hao Fu Dai | 2008 | Chinese Chemical Letters2008，19，8： | 25 |
| 2 | CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target显示文摘The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in TME.Over-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer patients.In TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and metastasis.The CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in TME.Blocking the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor progression.CXCL5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the treatment.In this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in TME.The possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed. | Wen Zhang Huishan Wang Mingyang Sun Xueting Deng Xueru Wu Yilan Ma Mengjing Li Said Maisam Shuoa Qiang You Lin Miao | 2020 | Cancer Communications2020，40，2： | 19 |
| 3 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 4 | A new type of leak-floor flip bucket显示文摘Flip buckets are commonly used to discharge flow away from a hydraulic structure into the downstream to dissipate energy.A new leak-floor flip bucket is presented,making the ski-jump water jet a typical long-narrow nappe.Based on the model experiments and numerical simulation,the flow pattern,formation process and mechanism of the leak-floor flip bucket are studied.The results show that cross section flow shape develops from the'Y-type'to'|-type',and this is because the natural pressure difference is generated when water flows through the leak-floor area and moves transversely from both sides to the center.Different from the slit-type flip bucket with sidewall contraction,the leak-floor flit bucket makes the water jet narrow and long without high pressure on the side walls of the flip bucket.Under the same jet length condition,the maximum sidewall pressure of the slit-type is 4.67 times that of the leak-floor flip bucket.The effects of flow discharge on the jet length are less significant for the leak-floor bucket than for the slit-type bucket. | DENG Jun YANG ZhengLi TIAN Zhong ZHANG FaXing WEI WangRu YOU Xiang XU WeiLin | 2016 | Science China(Technological Sciences)2016，59，4： | 15 |
| 5 | Investigation of mental health and its influence on Chinese cancer patients using a multidisciplinary screening flow: an epidemiological survey in the west of China显示文摘 | SONG Huan LI Jin LU You DENG Lei SUN Xue-li | 2013 | Chinese Medical Journal2013，，1： | 14 |
| 6 | Measuring Conflict Functions in Generalized Power Space显示文摘One of the most important open issues is that the classical conflict coefficient in D-S evidence theory (DST) cannot correctly determine the conflict degree between two pieces of evidence. This drawback greatly limits the use of DST in real application systems. Early researches mainly focused on the improvement of Dempster’s rule of combination (DRC). However, the current research shows it is very important to define new conflict coefficients to determine the conflict degree between two or more pieces of evidence. The evidential sources of information are considered in this work and the definition of a conflict measure function (CMF) is proposed for selecting some useful CMFs in the next fusion work when sources are available at each instant. Firstly, the definition and theorems of CMF are put forward. Secondly, some typical CMFs are extended and then new CMFs are put forward. Finally, experiments illustrate that the CMF based on Jousselme and its similar ones are the best suited ones. | HU Lifang GUAN Xin DENG Yong HAN Deqiang HE You | 2011 | Chinese Journal of Aeronautics2011，24，1： | 11 |
| 7 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 8 | A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var.beijingensis显示文摘The protein synthesis inhibitor anisomycin features a unique benzylpyrrolidine system and exhibits potent selective activity against pathogenic protozoa and fungi.It is one of the important effective components in Agricultural Antibiotic120,which has been widely used as naturally-originated agents for treatment of crop decay in China.The chemical synthesis of anisomycin has recently been reported,but the complex process with low productivity made the biosynthesis still to be a vital mainstay in efforts.The biosynthetic gene cluster(BGC)of anisomycin in Streptomyces hygrospinosus var.beijingensis has been identified in our previous work,while poor understanding of the regulatory mechanism limited the yield enhancement via regulation engineering of S.hygrospinosus var.beijingensis.In this study here,we characterized AniF as an indispensable LuxR family transcriptional regulator for the activation of anisomycin biosynthesis.The genetic manipulations of aniF and the real-time quantitative PCR(RT-qPCR)revealed that it positively regulated the transcription of the anisomycin BGC.Moreover,the overexpression of aniF contributed to the improvement of the production of anisomycin and its derivatives.Dissection of the mechanism underlying the function of AniF revealed that it directly activated the transcription of the genes aniR-G involved in anisomycin biosynthesis.Especially,one AniF-binding site in the promoter region of aniR was identified by DNase I footprinting assay and an inverted repeat sequence(5′-GGGC-3′)composed of two 4-nt half sites in the protected region was found.Taken together,our systematic study confirmed the positive regulatory role of AniF and might facilitate the future construction of engineering strains with high productivity of anisomycin and its derivatives. | Jufang Shen Lingxin Kong Yan Li Xiaoqing Zheng Qing Wang Weinan Yang Zixin Deng Delin You | 2019 | Synthetic and Systems Biotechnology2019，4，1： | 10 |
| 9 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 10 | Juvenile hominoid cranium from the terminal Miocene of Yunnan,China显示文摘Fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of Lufengpithecus.They mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from Yuanmou.Here we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in Yunnan.It is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus lufengensis.Lufengpithecus has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is unlikely.The new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape lineage.It substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene. | JI XuePing JABLONSKI Nina G SU Denise F DENG ChengLong FLYNN Lawrence J YOU YouShan KELLEY Jay | 2013 | Chinese Science Bulletin2013，58，31： | 8 |
| 11 | New method for measuring the degree of conflict among general basic probability assignments显示文摘There is doubt about Dempster's rule of combination because of counter-intuitive results when dealing with conflict information in intelligent reasoning.Therefore,many modified combination rules have been presented in the literature on multi-source information fusion and reasoning with uncertainty.However,the issue of identifying conflict among evidence has been ignored.A new parameter measuring conflict evidence called the conflict distance parameter is defined to determine whether there are conflicts in evidence based on the analysis of existing conflict parameters.At the same time,a decisive rule,which a reasonable conflict measure function should satisfy,is put forward.Finally,an analysis of two typical counter-intuitive situations is given,showing that the new parameter can not only satisfy the decisive rule,but can also attain the same effect as a two-dimensional measure when deciding whether to use the Dempster's rule of combination,and can exceed its effect when deciding whether to use Dezert-Smarandache theory. | HE You HU LiFang GUAN Xin DENG Yong HAN DeQiang | 2012 | Science China(Information Sciences)2012，55，2： | 7 |
| 12 | Fiber Bragg grating monitors for thermal and stress of the composite insulators in transmission lines显示文摘Running composite insulators are prone to failure due to their harsh surrounding work environment, which directly affects the safe operation of transmission lines. This paper puts forward the method of using fiber Bragg grating(FBG) as the monitors to parameters correlated with thermal and stress of the composite insulators in transmission lines at working status. Firstly, monitoring points are found out by the mechanical test on composite insulator samples. Secondly, based on the monitoring theory, this paper introduces the feasibility design frame of the composite insulator with FBG implanted in the rod and the online monitor system. At last, it describes applications of this monitor system in the field of transmission lines. | Heming Deng Wei Cai You Song Jinsong Liu Christopher Redman Qiandong Zhuang | 2018 | Global Energy Interconnection2018，1，3： | 6 |
| 13 | Characterization of ornidazole metabolites in human bile after intraveneous doses by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry显示文摘Ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry(UPLC/Q-TOF MS)was used to characterize ornidazole metabolites in human bile after intravenous doses.A liquid chromatography tandem mass spectrometry(LC–MS/MS)assay was developed for the determination of the bile level of ornidazole.Bile samples,collected from four patients with T-tube drainage after biliary tract surgery,were prepared by protein precipitation with acetonitrile before analysis.A total of 12 metabolites,including 10 novel metabolites,were detected and characterized.The metabolites of ornidazole in human bile were the products of hydrochloride(HCl)elimination,oxidative dechlorination,hydroxylation,sulfation,diastereoisomeric glucuronation,and substitution of NO_(2) or Cl atom by cysteine or N-acetylcysteine,and oxidative dechlorination followed by further carboxylation.The bile levels of ornidazole at 12 h after multiple intravenous infusions were well above its minimal inhibitory concentration for common strains of anaerobic bacteria. | Jiangbo Du Pan Deng Xiaoyan Chen Haidong Wang Tiangeng You Dafang Zhong | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 5 |
| 14 | An Evaluation of the Investment for Child Development in China显示文摘Objective This study estimated the investment in child development from three aspects-public health,public education,and family investment to establish the level of investment,to provide reference information for government decision making and to provide international comparisons.Methods Public investment in health was measured with macro data related to public health spending and child development in government expenditure.Public education investment was based on basic education data.Family investment evaluation was based on per capita family consumer spending data in different age groups to estimate the input for child development.Results Both public health investment level and the proportion of GDP rose for all age groups over time,but the overall investment level was still insufficient.Public investment in children's education has increased year by year,but the trends in all age groups are unbalanced with much lower investment in early childhood education.Private investment in children has increased over the period,but has declined as a percentage of GDP.International comparisons show that China's investment in child development is much lower than OECD countries.Conclusion The private investment in child development was the main way in China,with public finance contributing only a small proportion.Given the poor international comparisons,the government needs to review the balance of public investment to redirect more towards the development of children under the age of six to their health and education. | ZHENG Xiao Ying CHEN Chun Ming HUANG Cheng Li Han You Li QIU Yue ZHANG Qian Deng CHEN He | 2012 | Biomedical and Environmental Sciences2012，25，4： | 4 |
| 15 | Keep Healthcare Workers Safe:Application of Teleoperated Robot in Isolation Ward for COVID‑19 Prevention and Control显示文摘At the time of writing,the coronavirus disease(COVID-19)has affected 212 countries and territories across the globe.According to the world health organization(WHO),a total number of 4,735,622 confirmed cases,including 316,289 deaths was reported[1].In the fight against COVID-19,nurses,doctors,and other healthcare workers are in the front line of the battle bearing the higher risk of infection[2].The International Council of Nurses(ICN)gathered further information to suggest that more than 90,000 healthcare workers have been infected worldwide[3].Personal protective equipment(PPE)shortage is one of the key factors increasing the infection risk for the medical staffs.Therefore,finding alternative ways to lower the infection risk has become an urgent problem to be solved. | Geng Yang Honghao Lv Zhiyu Zhang Liu Yang Jia Deng Siqi You Juan Du Huayong Yang | 2020 | Chinese Journal of Mechanical Engineering2020，33，3： | 4 |
| 16 | A New Probabilistic Transformation in Generalized Power Space显示文摘The mapping from the belief to the probability domain is a controversial issue, whose original purpose is to make (hard) decision, but for contrariwise to erroneous widespread idea/claim, this is not the only interest for using such mappings nowadays. Actually the probabilistic transformations of belief mass assignments are very useful in modern multitarget multisensor tracking systems where one deals with soft decisions, especially when precise belief structures are not always available due to the existence of uncertainty in human being’s subjective judgments. Therefore, a new probabilistic transformation of interval-valued belief structure is put forward in the generalized power space, in order to build a subjective probability measure from any basic belief assignment defined on any model of the frame of discernment. Several examples are given to show how the new transformation works and we compare it to the main existing transformations proposed in the literature so far. Results are provided to illustrate the rationality and efficiency of this new proposed method making the decision problem simpler. | HU Lifang HE You GUAN Xin DENG Yong HAN Deqiang | 2011 | Chinese Journal of Aeronautics2011，24，4： | 4 |
| 17 | Characterization of the positive SARP family regulator PieR for improving piericidin A1 production in Streptomyces piomogeues var.Hangzhouwanensis显示文摘Piericidin A1,a member ofɑ-pyridone antibiotic,exhibits various biological activities such as antimicrobial,antifungal,and antitumor properties and possesses potent respiration-inhibitory activity against insects due to its competitive binding capacity to mitochondrial complex I.The biosynthetic pathway of piericidin A1 has been reported in Streptomyces piomogeues var.Hangzhouwanensis,while the regulatory mechanism remains poorly understood.In this study,a Streptomyces antibiotic regulatory protein(SARP)family transcriptional regulator PieR was characterized.Genetic disruption and complementation manipulations revealed that PieR positively regulated the production of piericidin A1.Moreover,the overexpression of pieR contributed to the improvement of piericidin A1 productivity.The real-time quantitative PCR(RT-qPCR)was carried out and the data showed that pieR stimulated the transcription of all the biosynthesis-related genes for piericidin A1.In order to explore the regulatory mechanism,electrophoresis mobility shift assays(EMSA)and DNase I footprinting experiments have been conducted.A protected region covering 50 nucleotides within the upstream region of pieR was identified and two 5-nt direct repeat sequences(5′-CCGGA-3′)in the protected region were found.These findings,taken together,set stage for transcriptional control engineering in the view of optimizing piericidin A1 production and thus provide a viable potent route for the construction of strains with high productivity. | Yan Li Lingxin Kong Jufang Shen Qing Wang Qian Liu Weinan Yang Zixin Deng Delin You | 2019 | Synthetic and Systems Biotechnology2019，4，1： | 4 |
| 18 | Vegetable and Fruit Consumption among Chinese Adults and Associated Factors: A Nationally Representative Study of 170,847 Adults显示文摘Objective This study examined vegetable and fruit(VF) consumption rate and its associated factors among Chinese adults.Methods Nationally representative data from the 2013 China Chronic Disease Surveillance survey were used. Dietary intake data, including VF consumption during the last 12 months, were collected. All analyses were weighted to obtain nationally representative estimates. Associations between VF consumption and other factors(e.g., meal frequency and physical activity) were examined through logistic regression analysis.Results The average fruit consumption was 102.3 g/day(95% CI: 97.0‐107.6) and the average vegetable consumption was 350.6 g/day(95% CI: 339.3‐361.8). Over half(53.2%, 95% CI: 50.9‐55.4) of Chinese adults met the VF consumption of 400 g/day recommended by the World Health Organization(WHO). Rural residents had a higher prevalence of low VF consumption rate than urban residents[49.20%(95% CI: 46.2%‐52.2%) vs. 44.0%(95% CI: 41.7%‐46.3%) P < 0.01]. Old age(OR = 1.01, 95% CI:1.00‐1.01), low educational level, low income, minority ethnicity(OR = 1.41, 95% CI: 1.15‐1.74),underweight(OR = 1.17, 95% CI: 1.03‐1.33), single marital status(OR = 1.20, 95% CI: 1.08‐1.33), low health literacy, irregular breakfast(OR = 1.20, 95% CI: 1.04‐1.38) or lunch(OR = 1.58, 95% CI: 1.26‐1.99)habits, and no leisure‐time physical activity were associated with low VF consumption.Conclusion Only half of Chinese adults met the VF consumption recommended by the WHO. Low socio‐economic status, irregular diet, and poor health literacy were likely associated with low VF consumption. National efforts and programs are needed to promote VF consumption. | LI Yi Chong JIANG Bo ZHANG Mei HUANG Zheng Jing DENG Qian ZHOU Mai Geng ZHAO Zhen Ping WANG You Fa WANG Li Min | 2017 | Biomedical and Environmental Sciences2017，30，12： | 3 |
| 19 | Nitric Oxide Inducing Function and Intracellular Movement of Chicken Interleukin-18 in Cultured Cells显示文摘To evaluate the characteristics of chicken interleukin-18 (ChIL-18) in different forms in vitro,the ChIL-18 full-length gene (ChIL-18-F) and the ChIL-18 presumed mature protein gene (ChIL-18-M) werecloned and inserted into the eukaryotic expression vector pCI,to construct recombinant pCI-ChIL-18-Fand pCI-ChIL-18-M.The recombinant plasmids were then transferred into chicken splenic lymphocytes(CSLs).Western blot showed that ChIL-18-F,with a molecular weight of 23.0 kDa,was produced in CSLstransfected by pCI-ChlL-18-F;ChIL-18-M,with a molecular weight of 19.5 kDa,was produced in CSLstransfected by pCI-ChIL-18-M.The nitric oxide (NO) level in the transfected CSLs and the culture mediumat different time points was further examined under confocal microscopy using 4.5-diaminofluoresceinstaining.The results showed that both pCI-ChIL-18-F and pCI-ChIL-18-M groups showed significantincrease in intracellular and extracellular NO production compared with pCI transfected control cells.Theseresults suggest that both ChIL-18-F and ChIL-18-M could stimulate NO secretion in CSLs.To characterizethe intracellular distribution of ChIL-18,ChIL-18-F and ChIL-18-M were each fused to the enhanced greenfluorescent protein gene,and expressed in Vero cells.The results showed that the ChIL-18-F tended to themembranous region in Vero cells,while ChIL-18-M did not.This indicates that the N-terminal 27 amino acidpeptide helped ChIL-18 target to Veto cell membranes. | Jian XU Tong-Le DENG Long LI Zhen-Qiang YOU Wang-Jun WAN Lian YU | 2005 | Acta Biochimica et Biophysica Sinica2005，37，10： | 3 |
| 20 | Involvement of GABA and opioid peptide receptors in sevoflurane-induced antinociception in rat spinal cord显示文摘瞄准:脊髓在因为麻药在脊髓压抑运动神经元的活动,不稳定的麻药导致的不动是枢轴的。这研究的目的是在在针的水平处理的疼痛上观察 sevoflurane 的效果。方法:开火腓肠肌肌肉被对同侧的后部的爪的电的刺激在老鼠唤起。肌电描记法(EMG ) 的感受伤害 C 反应被选择学习。GABAA 受体对手荷包牡丹硷(0.1 mg/kg ) 和 opioid 受体对手 naloxone (0.4 mg/kg ) 静脉内地被管理,当面或当 1.0% sevoflurane 不在时。结果:在有 transected 脊髓的老鼠, sevoflurane 在一个剂量依赖者和时间依赖者举止在 C 反应生产了深刻减小。面对 1.0% sevoflurane, C 回答在荷包牡丹硷和 naloxone 的注射以后被增加。结论:Sevoflurane 是对脊髓直接起作用压制感受伤害反射的不稳定的麻药。C 反应的导致 sevoflurane 的抑制被荷包牡丹硷或 naloxone 反对。结果建议针的 GABAA 受体和 opioid 肽受体涉及针的 nociception 的导致 sevoflurane 的抑制。 | Ying-wei WANG Xiao-ming DENG Xin-min YOU Shu-xiao LIU Zhi-qi ZHAO | 2005 | Acta Pharmacologica Sinica2005，26，9： | 3 |
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