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| 1 | A precise velocity field of tectonic deformation in China as inferred from intensive GPS observations显示文摘Active tectonics, e.g., faulting, folding, and rifting are clearly manifested over the vast territory of China. The in-tensive crustal deformation with long-lived structures has given rise to numerous highly-elevated mountains in the western China with the Yangtze and Yellow rivers downstreaming to the east, | LI Qiang YOU XinZhao YANG ShaoMin DU RuiLin QIAO XueJun ZOU Rong WANG Qi | 2012 | Science China Earth Sciences2012，55，5： | 23 |
| 2 | CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target显示文摘The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in TME.Over-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer patients.In TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and metastasis.The CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in TME.Blocking the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor progression.CXCL5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the treatment.In this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in TME.The possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed. | Wen Zhang Huishan Wang Mingyang Sun Xueting Deng Xueru Wu Yilan Ma Mengjing Li Said Maisam Shuoa Qiang You Lin Miao | 2020 | Cancer Communications2020，40，2： | 19 |
| 3 | Chemokine SR-PSOX/CXCL16 expression in peripheral blood of patients with acute coronary syndrome显示文摘背景:绑 phosphatidylserine 和氧化 lipoprotein/CXC chemokine ligand 的清道工人受体(SR-PSOX/CXCL16 ) 16 通过肿瘤坏死因素(TNF ) 支持泡沫房间形成 -alpha 调停了机制。因为 chemokine CXCL16 能在动脉粥样硬化患者损害和 induce 平滑肌房间(SMC ) 增长被表示,我们想在病人的外部血的单核白血球 SR-PSOX/CXCL16 察觉将为动脉粥样硬化的早诊断和预后是重要的(作为) 。方法:在这注册了学习是有急性冠的症候群(交流) 的 40 个病人,包括有尖锐心肌的梗塞(AMI ) 的 20 个病人和有不稳定的心绞痛(UAP ) 的 20 个病人,并且 20 正常控制。在外部血的单核白血球被孤立,并且 CXCL16/SR-PSOX mRNA 的表示的变化用反向的抄写聚合酶链反应(RT-PCR ) 被比较,与象内部控制的贝它肌动朊。我们在 ACS 亚群比较了 CXCL16/SR-PSOX 的表示,用对分析蛋白质表示层次西方污点。组织节由象正常控制一样与易传染的心内膜炎,肝肝硬化,和肺癌症从病人拿的活体检视标本制造了。并且 CXCL16/SR-PSOX 的表示与一台共焦的显微镜被分析。结果:在外部血的单核白血球的 CXCL16/SR-PSOX mRNA 和蛋白质的表示比在正常控制在交流病人是显著地更高的(P <
0.05 ) ;然而,在在 UAP 组和 AMI 组之间的 CXCL16/SR-PSOX 表示没有有效差量(P >
0.05 ) 。Immunofluorescence 证明有在正常脉管的 endothelial 的 SR-PSOX 的低表示并且在感染的容器的每层提高了表示,当从 endothelial 传播到包围感染变得更坏的纸巾时。共焦的显微镜学证明 SR-PSOX 的表示在肝肝硬化在渗入的淋巴细胞被提高,并且表示铺平,这对在门 hepatis 和叶的发炎的度相称。结论:在外部血的单核白血球的 CXCL16/SR-PSOX 的表达式比在控制在交流病人是显著地更高的。CXCL16/SR-PSOX-mediated 发炎可以贡献交流的致病,并且 CXCL16 可以在致病和发展起一个重要作用是在人。 | YANG Hui-ling XU Yang-yan DU Li-fen LIU Chang-hui ZHAO Qiang WEI Wu-jie YOU Yong QUAN Zhi-hua | 2008 | Chinese Medical Journal2008，，2： | 17 |
| 4 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 5 | Modeling and Operation of the Power-to-Gas System for Renewables Integration: A Review显示文摘Power-to-Gas(P2G)plays an important role in enhancing large-scale renewable energy integration in power systems.As an emerging inter-disciplinary subject,P2G technology requires knowledge in electrochemistry,electrical engineering,thermodynamic engineering,chemical engineering and system engineering.Aiming at P2G modeling and operational problems concerning the research field of power systems and the energy internet,this paper briefly reviews the main technologies and application potentials of the P2G system,and makes systematic summaries of major progresses related to P2G’s integration into the power grid in a bottom-top manner,including the modeling of high/room-temperature electrolysis cells,steady-state/dynamic optimization control of the P2G system,P2G’s integrated model and operational strategies at the grid level.In the final part of this paper,suggestions are put forward on future research directions of P2G systems from the aspects of modeling and operational optimization. | Xuetao Xing Jin Lin Yonghua Song You Zhou Shujun Mu Qiang Hu | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 15 |
| 6 | On a New Genus of Basal Neoceratopsian Dinosaur from the Early Cretaceous of Gansu Province, China显示文摘A new genus and species of basal neoceratopsian dinosaur, Auroraceratops rugosus, is reported based on material from the Early Cretaceous Xinminpu Group in the Gongpoquan Basin of Gansu Province, China. Auroraceratops is represented by a nearly complete skull and low jaws, and different greatly from all other neoceratopsians by its considerable breadth of the nasals, fungiform expansion of the dorsal end of the lacrimal, highly developed rugosity of the jugal, dentary and surangular, and inflated, striated premaxillary teeth. The finding of Auroraceratops adds diversity and helps elucidate the evolution of basal neoceratopsian dinosaurs. | YOU Hailu LI Daqing JI Qiang Matthew C. LAMANNA Peter DODSON | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 13 |
| 7 | Gene expression profiling reveals Ki-67 associated proliferation signature in human glioblastoma显示文摘背景永久细胞的增长在 gliomagenesis 期间是基本特征, Ki-67 是在人的 glioblastoma multiforme ( GBM )的古典增长标记之一 .However ,为在 GBM 的细胞的增长的驱动程序基因或核心小径一直不是我们由 immunohistochemistry 评估了的阐明的 systematically.Methods 在有 GBM 和 64 件 GBM 样品的一个总数的 156 个中国病人的临床的结果的 Ki-67 表示的预示的值为进一步的 Agilent | JIN Qiang ZHANG Wei QIU Xiao-guang YAN Wei YOU Gan LIU Yan-wei JIANG Tao WANG Lei | 2011 | Chinese Medical Journal2011，，17： | 12 |
| 8 | Salvianolate increases heat shock protein expression in a cerebral ischemia-reperfusion injury model显示文摘Stroke remains a worldwide health problem.Salvianolate exerts a protective effect in various microcirculatory disturbance-related diseases,but studies of the mechanisms underlying its protective action have mainly focused on the myocardium,whereas little research has been carried out in brain tissue following ischemia-reperfusion.We assessed the neuroprotective effects of salvianolate in a rat model of cerebral ischemia-reperfusion injury induced using the suture method At onset and 24 and 48 hours after reperfusion,rats were intraperitoneally injected with salvianolate(18 mg/kg)or saline.Neurological deficit scores at 72 hours showed that the neurological functions of rats that had received salvianolate were significantly better than those of the rats that had received saline.2,3,5-Triphenyltetrazolium chloride was used to stain cerebral tissue to determine the extent of the infarct area.A significantly smaller infarct area and a significantly lower number of apoptotic cells were observed after treatment with salvianolate compared with the saline treatment Expression of heat shock protein 22 and phosphorylated protein kinase B in ischemic brain tissue was significantly greater in rats treated with salvianolate compared with rats treated with saline.Ou findings suggest that salvianolate provides neuroprotective effects against cerebra ischemia-reperfusion injury by upregulating heat shock protein 22 and phosphorylated protein kinase B expression. | Jinnan Zhang Wei Lu Qiang Lei Xi Tao Hong You Pinghui Xie | 2013 | Neural Regeneration Research2013，8，25： | 12 |
| 9 | Study of the varve record from Erlongwan maar lake, NE China, over the last 13 ka BP显示文摘在来自跨越最后 13 ka BP 的 Erlongwan maar 湖的一个沉积序列,二种主要纹泥类型能被认出:源於生物的纹泥(从礼品到 -11.2 ka BP, 0-632 厘米) 并且碎屑状的纹泥(从 -11.2 到 -12.7 ka BP, 632-700 厘米) 。基于在沉积包含的水藻的主导的类型,源於生物的纹泥能被分类进 dinocyst 源於生物的纹泥(0-63 厘米) 并且混合(dinocyst 和硅藻) 源於生物的纹泥(214-632 厘米) 。在这篇论文,纹泥的形成过程和部件被描述,为纹泥在整个记录变化的类型的可能的原因被讨论,一张高分辨率的纹泥年表被建立跨越最后 13 ka BP。尽管进一步的纹泥数和错误评价被需要,这里介绍的结果为学习 Erlongwan maar 湖的 palaeoclimate 记录代表一个稳固的基础。 | YOU HaiTao LIU JiaQi LIU Qiang CHU GuoQiang Patrick RIOUAL HAN JingTai | 2008 | Chinese Science Bulletin2008，53，2： | 9 |
| 10 | Decompressive craniectomy or not: intraoperative experience in 41 patients with severe traumatic brain injury显示文摘在场的 ObjectiveTo 我们在在严重创伤的大脑损害(TBI ) 之中使用 decompressive 部分颅骨切除术(DC ) 的经验病人在操作期间并且到讨论它的 indication.MethodsFrom 2008 年 10 月到 2009 年 5 月,与严重 TBI 在 18 和 75 年之间变老的 41 个病人在这研究被包括。他们根据他们的 intraoperative 调查结果经历了 DC 或 non-DC (NDC ) 。手术后的 intracranial 压力(ICP ) ,复杂并发症,要求第二个手术并且结果是病人们经历了的 observed.ResultsFifteen DC 和 26 个病人不。每个病人的平均手术后的 ICP 比 20 低;公里 Hg。因为病人们在后续时期收到了 DC,在操作以后的 2 有的发作和 1 发达 cerebrocele;1 个仅仅 NDC 病人有 traumatic 以后发作,但是任何一个都没他们推迟 haematoma,脑髓的液体管, cerebrocele 或感染。在后续的结束, 10 个病人死了, 6 有 2 的 GOS, 3 中的 2 个, 5 .ConclusionsDC 中的 4 个和 14 中的 9 个是必要的管理胀大的暴发性的 intracranial 高血压或 intraoperative 大脑。如果在 haematoma 和 necrotized 的移动以后没有大脑胀大神经纸巾,代替颅骨拍动是安全的。发现的 intraoperative 是一个重要因素决定是否执行 DC。 | Yang Chao-hua Li Qiang Wu Cong Ma Jun-peng You Chao | 2012 | Chinese Journal of Traumatology2012，15，3： | 9 |
| 11 | Progress in ceramic materials and structure design toward advanced thermal barrier coatings显示文摘Thermal barrier coatings(TBCs)can effectively protect the alloy substrate of hot components in aeroengines or land-based gas turbines by the thermal insulation and corrosion/erosion resistance of the ceramic top coat.However,the continuous pursuit of a higher operating temperature leads to degradation,delamination,and premature failure of the top coat.Both new ceramic materials and new coating structures must be developed to meet the demand for future advanced TBC systems.In this paper,the latest progress of some new ceramic materials is first reviewed.Then,a comprehensive spalling mechanism of the ceramic top coat is summarized to understand the dependence of lifetime on various factors such as oxidation scale growth,ceramic sintering,erosion,and calcium–magnesium–aluminium–silicate(CMAS)molten salt corrosion.Finally,new structural design methods for high-performance TBCs are discussed from the perspectives of lamellar,columnar,and nanostructure inclusions.The latest developments of ceramic top coat will be presented in terms of material selection,structural design,and failure mechanism,and the comprehensive guidance will be provided for the development of next-generation advanced TBCs with higher temperature resistance,better thermal insulation,and longer lifetime. | Zhi-Yuan WEI Guo-Hui MENG Lin CHEN Guang-Rong LI Mei-Jun LIU Wei-Xu ZHANG Li-Na ZHAO Qiang ZHANG Xiao-Dong ZHANG Chun-Lei WAN Zhi-Xue QU Lin CHEN Jing FENG Ling LIU Hui DONG Ze-Bin BAO Xiao-Feng ZHAO Xiao-Feng ZHANG Lei GUO Liang WANG Bo CHENG Wei-Wei ZHANG Peng-Yun XU Guan-Jun YANG Hong-Neng CAI Hong CUI You WANG Fu-Xing YE Zhuang MA Wei PAN Min LIU Ke-Song ZHOU Chang-Jiu LI | 2022 | Journal of Advanced Ceramics2022，11，7： | 9 |
| 12 | An Early Cretaceous Avialian Bird, Shenzhouraptor sinensis from Western Liaoning, China显示文摘This paper describes an avialian bird from the Early Cretaceous Jiufotang Formation in Yixian county,western Liaoning, China, which is named as Shenzhouraptor sinensis by Ji et al. on July 15, 2002. Shenzhouraptor sinensis is characterized by no teeth in its mouth, the forelimbs longer than the hindlimbs, a long tail with more than 23 caudal vertebrae, U-shaped wishbone, and remiges longer than the total length of ulna and manus. It is certain that the new avialian bird is really capable of powerful flight, representing a missing link between theropod dinosaurs and birds. | Ji Qiang, Ji Shu’an, You Hailu, Zhang Jianping,Zhang Hongbin, Zhang Nanjun, Yuan Chongxi and Ji XinxinDepartment of Earth Sciences, Nanjing University, Nanjing, Jiangsu 100093Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037 School of Earth and Space Sciences, Peking University, Beijing 100871China University of Geosciences, Beijing 100083 China Dinosaur Park of Changzhou, Changzhou, Jiangsu 213002 | 2003 | Acta Geologica Sinica(English Edition)2003，77，1： | 8 |
| 13 | Effect of arsenic trioxide on human hepatoma cell line BEL-7402 cultured in vitro显示文摘AIM To study the effect of a varyingconcentrations of arsenic trioxide on humanhepatoma cell line BEL-?402 cultured in vitro andits mechanism of action.METHODS The BEL-7402 cells were treatedwith arsenic trioxide(at the concentrations of0.5,1,2 μmol/L,respectively)for 4 successivedays.The cell growth and proliferation wereobserved by cell counting and cell-growth curve.Morphologic changes were studied withelectronmicroscopy.Flow cytometry was usedto assay celI-DNA distribution and the proteinexpression of Bcl-2 and Bax detected byimmunocytochemical method.RESULTS The cell growth was significantlyinhibited by varying concentrations of arsenictrioxide as revealed by cell counting and cell-growth curve,which was dose- and time-dependent.Arsenic trioxide treatment at 0.5,1and 2 μmol/L resulted in a sub-G1 cell peak,theapoptosis rate of the control group was 9.31%and that of 0.5 μmol/L arsenic trioxide 15.53%,no significant difference was seen between thetwo.The apoptosis rates of 1,2 μmol/L arsenictrioxide were 19.10% and 21.87% respectively,which were much higher(both P<0.05).Decrease of G0/G1 phase cells and increase of Sphase cells were observed by flow cytometry,suggesting the inhibition effect of 0.5,1,2 μmol/L arsenic trioxide on BEL-7402 cell lay in the G0/G1 phase.Morphologic changes such asintact cell membrane,nucleic condensation,apoptotic body formation were seen undertransmission electronmicrescopy,whereas the0.5 mol/L arsenic trioxide-treated BEL-7402cells showed decrease of nucleocytoplasmicratio,round nucleus,well-differentiatedorganelles in the cytoplasm.The processes andmicrovilli on the cell surface of the experimentalgroups under scanning electron microscopy weresignificantly decreased.High expressions ofBcl-2 and Bax were detected in 1 and 2 μmol/Larsenic trioxide-treated cells,these were 46%,87.33% and 83.08%,95.83% respectively,among which that of Bax was more significant.Arsenic trioxide treatment at 0.5 μmol/Lresulted in a higher expression level of Bcl-2 andlower expression level of Bax,which were8.81% and 3.83% respectively,as comparedwith that of the control group(15.33%)(P1<0.01,P2<0.01).CONCLUSION Arsenic trioxide not onlyinhibited proliferation but also induced apoptosisof human hepatoma cell line BEL-7402.Theinduced-apoptosis effect of 1,2 μmol/L arsenictrioxide was related to the expression level ofBcl-2 and Bax. | Hong Yu Xu You Lin Yang Yuan Yuan Gao Qiao Li Wu Guang Qiang Gao | 2000 | World Journal of Gastroenterology2000，6，5： | 8 |
| 14 | CuFe2O4@GO nanocomposite as an effective and recoverable catalyst of peroxymonosulfate activation for degradation of aqueous dye pollutants显示文摘Recently,heterogeneous activation of peroxymonosulfate(PMS) to oxidatively degrade organic pollutants has been a hotspot.In the present work,copper ferrite-graphite oxide hybrid(CuFe2 O4@GO)was prepared and used as catalyst to activate PMS for degradation of methylene blue(MB) in aqueous solution.A high degradation efficiency(93.3%) was achieved at the experimental conditions of20 mg/L MB,200 mg/L CuFe2 O4@GO,0.8 mmol/L PMS,and 25℃temperature.Moreover,CuFe2 O4@GO showed an excellent reusability and stability.The effects of various operational parameters including pollutant type,solution pH,catalyst dosage,PMS dosage,pollutant concentration,temperature,natural organic matter(NOM),and inorganic anions on the catalytic degradation process were comprehensively investigated and elucidated.The further mechanistic study revealed the Cu(Ⅱ)/Cu(Ⅰ) redox couple on CuFe2 O4@GO played the dominant role in PMS activation,where both hydroxyl and sulfate radicals were generated and proceeded the degradation of pollutants.In general,CuFe2 O4@GO is a promising heterocatalyst for PMS-based advanced oxidation processes(AOPs) in wastewater treatment. | Xiaoman Lei Menghan You Fei Pan Min Liu Peng Yang Dongsheng Xia Qiang Li Yanting Wang Jie Fu | 2019 | Chinese Chemical Letters2019，30，12： | 8 |
| 15 | Chitinase-3 like-protein-1 function and its role in diseases显示文摘Non-enzymatic chitinase-3 like-protein-1(CHI3L1)belongs to glycoside hydrolase family 18.It binds to chitin,heparin,and hyaluronic acid,and is regulated by extracellular matrix changes,cytokines,growth factors,drugs,and stress.CHI3L1 is synthesized and secreted by a multitude of cells including macrophages,neutrophils,synoviocytes,chondrocytes,fibroblast-like cells,smooth muscle cells,and tumor cells.It plays a major role in tissue injury,inflammation,tissue repair,and remodeling responses.CHI3L1 has been strongly associated with diseases including asthma,arthritis,sepsis,diabetes,liver fibrosis,and coronary artery disease.Moreover,following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line,CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models.To date,interleukin-13 receptor subunit alpha-2,transmembrane protein 219,galectin-3,chemo-attractant receptor-homologous 2,and CD44 have been identified as CHI3L1 receptors.CHI3L1 signaling plays a critical role in cancer cell growth,proliferation,invasion,metastasis,angiogenesis,activation of tumor-associated macrophages,and Th2 polarization of CD4+T cells.Interestingly,CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis.This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis,then posits investigational strategies for targeted therapies. | Ting Zhao Zhongping Su Yingchang Li Xiaoren Zhang Qiang You | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 16 | THE RADIATION AND DIFFRACTION OF WATER WAVES BY A BOTTOM-MOUNTED CIRCULAR CYLINDER IN A TWO-LAYER FLUID显示文摘An analytical method was proposed to analyze the radiation and diffraction of water waves by a bottom-mounted circular cylinder in a two-layer fluid. Analytical expressions for added mass and damping coefficients, as well as the wave excitation forces of the circular cylinder were obtained by an eigenfunction expansion method. The hydrodynamic forces on the bottom-mounted circular cylinder in a two-layer fluid include not only the added mass and damping coefficients, but also the wave forces of the surface and internal-wave modes. This is different from the case of a homogenous fluid. Some examples were given, showing that density stratification can have a relative large effect on these hydrodynamic forces over a wide range of frequencies. | YOU Yun-xiang SHI Qiang MIAO Guo-ping | 2007 | Journal of Hydrodynamics2007，19，1： | 7 |
| 17 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 18 | Effect of metoprolol on myocardial apoptosis after coronary microembolization in rats显示文摘BACKGROUND:Coronary microembolization(CME) is a serious complication following percutaneous coronary intervention(PCI) in patients with acute coronary syndromes.The use of metoprolol before PCI can significantly protect ischemic myocardium from myocardial damage,but the function of metoprolol in the treatment of CME is not entirely clear.This study was to explore the effect and significance of metoprolol on myocardial apoptosis and caspase-3 activation after CME in rats.METHODS:Thirty rats were randomly divided into three groups including sham-operation(control group),CME plus saline(CME group),CME plus metoprolol(metoprolol group),10 rats for each group.The CME group was induced by injecting 3 000 polyethylene microspheres(42 urn)into the left ventricle during a 10-second occlusion of the ascending aorta;the control group was injected with physiological saline instead of microembolization ball;the metoprolol or saline group was given three intravenous bolus injections before CME.Echocardiography,TUNEL staining,and Western blotting were used to evaluate cardiac function,proportion of apoptotic cells and activation of caspase-3 respectively at 6 hours after operation.RESULTS:Echocardiography parameters displayed that the metoprolol group improved cardiac function significantly compared with the CME group(PO.05).The myocardial apoptotic rate of the CME group as well as the contents of activated caspase-3 increased significantly(P<0.05),both of which were ameliorated significantly by metoprolol treatment(P<0.05).CONCLUSIONS:This study demonstrates that metoprolol can protect the myocardium during CME in rats by inhibiting apoptosis and improving cardiac function.These results suggest that the inhibition of apoptosis can be a potential therapeutic strategy for the treatment of CME. | Qiang Su Lang Li Yang-chun Liu You Zhou Wei-ming Wen | 2013 | World Journal of Emergency Medicine2013，4，2： | 7 |
| 19 | Relationship between single nucleotide polymorphisms in the deoxycytidine kinase gene and chemosensitivity of gemcitabine in six pancreatic cancer cell lines显示文摘在 deoxycytidine kinase (dCK ) 的背景单个核苷酸多型性(SNP ) 基因与 chemosensitivity 被联系到 nucleoside 类似物。2',2'-Difluoro 2'-deoxycytidine (gemcitabine ) 是在胰腺的癌症的治疗的首要的 nucleoside 类似物药。然而,在在到 gemcitabine 的 dCK 基因和 chemosensitivity 的 SNP 之间的协会充分没被建立。因此,现在的学习试图在人的胰腺的癌症房间 lines.Methods 在 dCKgene 和 chemosensitivity 调查在 SNP 之间的关系到 gemcitabine 在 dCK 基因的七 SNP 在六根人的胰腺的癌症房间线被定序。到 gemcitabine 的这六根房间线的 chemosensitivity 与数 Kit-8 ( CCK-8 ) test.Inhibition 率的一个房间在 vitro 被评估被用来表示胰腺的癌症房间线的 chemosensitivity 到 gemcitabine.Results 在 dCKgene 的 A9846G SNP 的遗传型在六个人的胰腺的癌症房间被决定 lines.The 房间线而房间线 AsPC-1 , Mia PaCa2 , SW1990 和 SU86.86 带了 GG 遗传型, BxPC-3 和 T3M4 带了 A9846G SNP 遗传型 AG 。有 AG 遗传型( BxPC-3 和 T3M4 )的房间线与有 GG 遗传型的房间线相比对 gemcitabine 更敏感( AsPC-1 , Mia PaCa2 , SW1990 和 SU86.86 )并且显著地不同的抑制率在带 AG 和 GG 遗传型( P 0.01 ) .Conclusions 的房间线之间被观察在 dCK 基因的 A9846G SNP 的变体在胰腺的癌症房间线与敏感被联系到 gemcitabine 。dCK A9846G SNP 可以充当一个基因标记在胰腺的癌症预言 gemcitabine 的化疗功效。 | SI Shuang LIAO Quan ZHAO Yu-pei HU Ya ZHANG Qiang YOU Li-li | 2011 | Chinese Medical Journal2011，，3： | 5 |
| 20 | Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system显示文摘The present study was conducted to clarify the therapeutic effect of cornuside on experimental autoimmune encephalomyelitis(EAE)and its influence on T helper 17(Th17)cell and regulatory T(Treg)cell infiltration into the central nervous system.Rats were randomly placed into four treatment groups:control,EAE,EAE+cornuside,and EAE+prednisolone.The neurological function scores of rats were assessed daily.On the second day after EAE rats began to show neurological deficit symptoms,the four groups were treated with normal saline,normal saline,cornuside(150 mg/kg),and prednisolone(5 mg/kg),respectively.The treatment was discontinued after two weeks,and the spinal cord was obtained for hematoxylin and eosin(H&E)and luxol fast blue staining,as well as retinoic acid receptor-related orphan receptorγ(RORγ)and forkhead box protein P3(Foxp3)immunohistochemical staining.Blood was collected for Th17 and Treg cell flow cytometry testing,and the serum levels of interleukin(IL)-17A,IL-10,transforming growth factor-β(TGF-β),IL-6,IL-23,and IL-2 were measured via enzymelinked immunosorbent assay(ELISA).Compared with rats in the EAE group,rats in the EAE+cornuside and EAE+prednisolone groups began to recover from neurological deficits earlier,and had a greater degree of improvement of symptoms.Focal inflammation,demyelination,and RORγ-positive cell infiltration were reduced by cornuside or prednisolone treatment,whereas the Foxp3-positive cell numbers were not significantly different.Meanwhile,the number of Th17 cells and the IL-17A,IL-6,and IL-23 levels were lower in the blood after cornuside or prednisolone treatment,whereas the number of Treg cells or the levels of IL-10,TGF-β,and IL-2 were not markedly different.Cornuside can alleviate symptoms of EAE neurological deficits through its anti-inflammatory and immunosuppressive effects,and Th17 cells may be one of its therapeutic targets. | Rongbo ZHANG Jin LIU Bin XU You WU Shunli LIANG Qiang YUAN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，5： | 5 |
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