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| 1 | A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein显示文摘Baicalein(BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide(BE-NCT) nanococrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0-t of BE-NCT nano-cocrystals(6.02-fold) was significantly higher than BE coarse powder(1-fold), BE-NCT cocrystals(2.87-fold) and BE nanocrystals(3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BENCT nano-cocrystals possessed excellent performance both in vitro and in vivo evaluations.Thus, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE. | Jiaxin Pi Shuya Wang Wen Li Dereje Kebebe Ying Zhang Bing Zhang Dongli Qi Pan Guo Nan Li Zhidong Liu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 12 |
| 2 | Research progress of in-situ gelling ophthalmic drug delivery system显示文摘Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden.Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system.Drug administration to the eye by conventional delivery systems results in poor ocular bioavailability(<5%).The designing of a novel approach for a safe,simple,and effective ocular drug delivery is a major concern and requires innovative strategies to combat the problem.Over the past decades,several novel approaches involving different strategies have been developed to improve the ocular delivery system.Among these,the ophthalmic in-situ gel has attained a great attention over the past few years.This review discussed and summarized the recent and the promising research progress of in-situ gelling in ocular drug delivery system. | Yumei Wu Yuanyuan Liu Xinyue Li Dereje Kebebe Bing Zhang Jing Ren Jun Lu Jiawei Li Shouying Du Zhidong Liu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 7 |
| 3 | 单克隆抗体OX26修饰的丹酚酸B/黄芩苷纳米结构脂质载体研究显示文摘目的制备转铁蛋白受体单克隆抗体OX26修饰的丹酚酸B/黄芩苷纳米结构脂质载体(Sal B/BA-NLC),并对其进行表征和细胞摄入研究。方法采用乳化-固化法制备Sal B/BA-NLC,用2-亚氨基硫烷盐酸盐(2-iminothiolane hydrochloride)将OX26进行硫醇化后连接于Sal B/BA-NLC表面,以形态、粒径、Zeta电位及包封率等为评价指标考察其理化性质,并用差示扫描量热法(DSC)与核磁共振波谱(NMR)进行验证。以香豆素-6(coumarin-6,C6)为荧光探针,代替黄芩苷和丹酚酸B制备制剂,利用高内涵成像仪考察脑微血管内皮细胞bEnd.3对其的摄入情况。结果所制备的OX26修饰的Sal B/BA-NLC粒径为(27.50±3.37)nm,PDI为0.39±0.04,Zeta电位为(-7.06±1.85)m V。DSC与NMR结果表明,药物是以无定形的形式存在于纳米结构脂质载体中。细胞摄入结果显示,当考察时间一致时,bEnd.3细胞摄入3组溶液体系的荧光强度为OX26-C6-NLC>C6-NLC>C6-SL。结论所制备的OX26修饰的Sal B/BA-NLC粒径较小、分布均匀,且包封率高。与溶液组和未修饰的NLC组相比,OX26修饰的NLC组具有更高的摄入量。 | 吴玉梅 李新悦 张谦 刘静静 Dereje KEBEBE 郭盼 刘志东 | 2018 | 中草药2018，49，12： | 5 |
| 4 | Effects of soil and water conservation practices on soil physicochemical properties in Gumara watershed, Upper Blue Nile Basin, Ethiopia显示文摘Background:Soil erosion is among the foremost causes of declining soil resources in Ethiopia,which in turn affect agricultural productivity.To limit this problem,for the last two decades in Gumara watershed,soil and water conservation measures have been practiced through free labor community mass-mobilization.However,their effect on soil fertility has not been evaluated.This study investigated the impact of implemented soil and water conservation measures on fertility improvement in the Gumara watershed.Both composite and core soil samples were taken from upstream,midstream,and downstream adjacent conserved and non-conserved cultivated and grazing plots.Selected soil fertility indicators were analyzed using standard laboratory procedures.Results:Soil and water conservation practices have resulted in a statistically significantly higher mean values of total nitrogen,exchangeable Na+and Mg2+at p<0.01,and of soil organic carbon and organic matter at p<0.05 in the watershed.The clay content,soil reaction,cation exchange capacity,and exchangeable K+showed nonsignificant,but higher mean values in conserved plots.Furthermore,the effects of conservation practices on soil properties were found more effective in cultivated land uses as compared to that of grazing land uses.This is because conservation treatments had significant effects on organic carbon,total nitrogen,exchangeable Na+and Mg2+in cultivated land uses but only on exchangeable Na+in grazing land uses.The interaction effect of treatments and land uses did not reach a statistically significant result for any of the soil properties considered in this study.Conclusion:Conservation measures have important implications for improving soil fertility in the Gumara watershed.Therefore,proper guidance and follow-up,use of agro-forestry and grass strips,and maintenance are required for the watershed’s sustainability and good soil conditions. | Mengie Belayneh Teshome Yirgu Dereje Tsegaye | 2019 | Ecological Processes2019，8，1： | 3 |
| 5 | Pharmacokinetic study of ginsenoside Re after vaginal administration in rabbits by UPLC-MS/MS determination显示文摘Objective: A selective and sensitive ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method was employed to study the pharmacokinetics of ginsenoside Re(GRe) in rabbits after vaginal administration of Xiaomi suppository to evaluate the systemic exposure of the suppository for the local treatment.Methods: Chromatographic separation was on an ACQUITY UPLC?BEH C18 column, and acetonitrile-0.1%formic acid was used as mobile phase in gradient elution. The plasma samples were deproteinized by acetonitrile, and the pharmacokinetic parameters were calculated by Winnonlin 6.4.Results: Calibration curve of GRe showed a good linearity over the concentration range from 5 ng/mL to500 ng/mL(r = 0.9999). The low limit of quantification of 5 ng/m L could satisfy the experimental requirement. The intra-day and inter-day precision of GRe at three concentrations were less than 1.96%, and the average recoveries of GRe were more than 64.0%. The pharmacokinetic parameters for vaginal administration were as follows: Tm ax, 0.5 h; C max, 20.88 ng/mL; AUC0-t, 64.71 h · ng/mL and the residence time was3.06 h. By using deconvolution calculation method, the cumulative absorption fraction of GRe was about0.89%.Conclusion: The systemic exposure of GRe was minimal after vaginal administration of Xiaomi suppository. | Xu Han Ying Zhang Jia-xin Pi Dereje Kebebe Bing Zhang Shu-ya Wang Bo-ying Liu Jing Ren Zhi-dong Liu | 2018 | Chinese Herbal Medicines2018，10，3： | 2 |
| 6 | Improving immunization capacity in Ethiopia through continuous quality improvement interventions:a prospective quasi-experimental study显示文摘Background:Strong scientific evidence is needed to support low-income countries in building effective and sustainable immunization programs and proactively engaging in global vaccine development and implementation initiatives.This study aimed to implement and evaluate the effectiveness of system-wide continuous quality improvement(CQI)interventions to improve national immunization programme performance in Ethiopia.Methods:The study used a prospective,quasi-experimental design with an interrupted time-series analysis to collect data from 781 government health sectors(556 healthcare facilities,196 district health offices,and 29 zonal health departments)selected from developing and emerging regions in Ethiopia.Procedures included baseline quality assessment of immunization programme and services using structured checklists;immunization systems strengthening using onsite technical support,training,and supportive supervision interventions in a Plan-Do-Check-Act cycle over 12 months;and collection and analysis of data at baseline and at the 6th and 12th month of interventions using statistical process control and the t-test.Outcome measures were the coverage of the vaccines pentavalent 3,measles,Bacillus Calmette-Guérin vaccine(BCG),Pneumococcal Conjugate Vaccine(PCV),as well as full vaccination status;while process measures were changes in human resources,planning,service delivery,logistics and supply,documentation,coordination and collaboration,and monitoring and evaluation.Analysis and interpretation of data adhered to SQUIRE 2.0 guidelines.Results:Prior to the interventions,vaccination coverage was low and all seven process indicators had an aggregate score of below 50%,with significant differences in performance at healthcare facility level between developing and emerging regions(P=0.0001).Following the interventions,vaccination coverage improved significantly from 63.6%at baseline to 79.3%for pentavalent(P=0.0001),62.5 to 72.8%for measles(P=0.009),62.4 to 73.5%for BCG(P=0.0001),65.3 to 81.0%for PCV(P=0.02),and insignificantly from 56.2 to 74.2%for full vaccination.All seven process indicators scored above 75%in all regions,with no significant differences found in performance between developing and emerging regions.Conclusions:The CQI interventions improved immunization capacity and vaccination coverage in Ethiopia,where the unstable transmission patterns and intensity of infectious diseases necessitate for a state of readiness of the health system at all times.The approach was found to empower zone,district,and facility-level health sectors to exercise accountability and share ownership of immunization outcomes.While universal approaches can improve routine immunization,local innovative interventions that target local problems and dynamics are also necessary to achieve optimal coverage. | Tsegahun Manyazewal Alemayehu Mekonnen Tesfa Demelew Semegnew Mengestu Yusuf Abdu Dereje Mammo Workeabeba Abebe Belay Haffa Daniel Zenebe Bogale Worku Amir Aman Setegn Tigabu | 2018 | Infectious Diseases of Poverty2018，7，1： | 1 |
| 7 | Design optimization and reliability of PWB level electronic package显示文摘 | Mohammad M H Sudhakar G J Dereje A | 2007 | Journal of Electronic Packaging2007，129，1： | 1 |
| 8 | In vitro anthelmintic activity of crude extracts of five medicinal plants against egg-hatching and larval development of Haemonchus contortus显示文摘 | Tadesse Eguale Dereje Tadesse Mirutse Giday | 2011 | Journal of Ethnopharmacology2011，，1： | 1 |
| 9 | Multilocus genotyping and molecular phylogenetics resolve a novel head blight pathogen within the Fusarium graminearum species complex from Ethiopia显示文摘 | Kerry O’Donnell Todd J. Ward Dereje Aberra H. Corby Kistler Takayuki Aoki Nathane Orwig Makoto Kimura ?smund Bj?rnstad Sonja S. Klemsdal | 2008 | Fungal Genetics and Biology2008，，11： | 1 |
| 10 | A HACCP plan for mycotoxigenic hazards associ- ated with Dry-cured meat production process显示文摘 | DEREJE T ASEFA CATHRINE F KURE RAGNHILD O GJERDE | 2011 | Food Control2011，22，83： | 1 |
| 11 | Tropical forest canopies and their relationships with climate and disturbance: results from a global dataset of consistent field-based measurements显示文摘Background: Canopy structure, defined by leaf area index(LAI), fractional vegetation cover(FCover) and fraction of absorbed photosynthetically active radiation(f APAR), regulates a wide range of forest functions and ecosystem services. Spatially consistent field-measurements of canopy structure are however lacking, particularly for the tropics.Methods: Here, we introduce the Global LAI database: a global dataset of field-based canopy structure measurements spanning tropical forests in four continents(Africa, Asia, Australia and the Americas). We use these measurements to test for climate dependencies within and across continents, and to test for the potential of anthropogenic disturbance and forest protection to modulate those dependences.Results: Using data collected from 887 tropical forest plots, we show that maximum water deficit, defined across the most arid months of the year, is an important predictor of canopy structure, with all three canopy attributes declining significantly with increasing water deficit. Canopy attributes also increase with minimum temperature, and with the protection of forests according to both active(within protected areas) and passive measures(through topography). Once protection and continent effects are accounted for, other anthropogenic measures(e.g. human population) do not improve the model.Conclusions: We conclude that canopy structure in the tropics is primarily a consequence of forest adaptation to the maximum water deficits historically experienced within a given region. Climate change, and in particular changes in drought regimes may thus affect forest structure and function, but forest protection may offer some resilience against this effect. | marion pfeifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.paine rob marchant andrew burt kim calders colin courtney-mustaphi aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía pieter i.olivier petri pellikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler pantaleo k.t.munishi thomas martin abdul mustari philip j.platts | 2018 | Forest Ecosystems2018，5，1： | 1 |
| 12 | Putative drug and vaccine target protein identification using comparative genomic analysis of KEGG annotated metabolic pathways of Mycoplasma hyopneumoniae显示文摘 | Dereje Damte Joo-Won Suh Seung-Jin Lee Sileshi Belew Yohannes Md. Akil Hossain Seung-Chun Park | 2013 | Genomics2013，，1： | 1 |
| 13 | Urban agriculture in Mekelle, Tigray state, Ethiopia: Principal characteristics, opportunities and constraints for further research and development 显示文摘 | Dereje Ashebir Margaret Pasquini Wubetu Bihon | 2007 | Cities2007，24，3： | 1 |
| 14 | The Nile basin cooperative framework agreement negotiations and the adoption of a 'Water Security' paradigm: Flight into obscurity or a logical cul-de-sac?显示文摘 | Dereje Zeleke Mekonnen | 2010 | The European Journal of International Law2010，21，2： | 1 |
| 15 | Optimization of data center room layout to minimize rack inlet air temperature 显示文摘 | Siddharth Bhopte Dereje Agonafer Roger Schmidt | 2006 | Journal of Electronic Packaging2006，128，： | 1 |
| 16 | Optimization of data center room layout to minimize rack inlet air temperature 显示文摘 | Siddharth Bhopte Dereje Agonafer Roger Schmidt | 2006 | Journal of Electronic Packaging2006，128，： | 1 |
| 17 | 用于眼后段持续给药的原位pH触发凝胶系统中三七总皂苷的研制与评价显示文摘目的:为三七总皂苷(PNS)在pH敏感型原位凝胶中的研究及相关制剂的开发和改进奠定基础。方法:我们使用Carbopol■940(一种常用的pH敏感聚合物)和增稠剂羟丙基甲基纤维素(HPMC E4M)作为眼用凝胶基质来制备PNS眼用原位凝胶。此外,通过评估凝胶能力和体外释放研究结果进行配方优化。还进行了体外(角膜渗透、流变学和稳定性)和体内(眼部刺激和玻璃体的初步药代动力学)研究。结果:研究表明,含有三七总皂苷的原位凝胶系统显示出药物的缓释性,使其成为改善眼后生物利用度的理想眼部给药系统。结论:本研究为原位pH触发凝胶中PNS的研究及相关制剂的开发和改进奠定了基础。同时,它将传统中药与现代原位凝胶技术相结合,为糖尿病视网膜病变等后眼病的治疗提供了新的方向。 | 卢鹏 王仁兴 岳兴 高艳泉 张清清 邢斌 张颖 于昌祥 蔡新富 尚强 Dereje Kebebe 皮嘉欣 刘志东 | 2021 | Acupuncture and Herbal Medicine2021，1，2： | 1 |
| 18 | Precise Electro-thermal Power Loss Model of a Three-level ANPC Inverter with Hybrid Si/SiC Switches显示文摘Hybrid Si/SiC switches constituting a parallel connection of a lower current rated SiC MOSFET and a higher current rated Si IGBT are becoming very attractive solution for designing high frequency and high-power density power electronic converters.Due to the complementary nature of Si IGBT devices(smaller inverter cost and smaller conduction loss)and SiC devices(smaller switching loss and higher junction temperature capability),these novel switch device configurations enable a good tradeoff between cost and efficiency for high power converter applications.One such recent application of hybrid Si/SiC switches for efficiency-cost optimization is an Si/SiC hybrid switch based ANPC inverter proposed in Ref.[30].In Ref.[30]the topology structure,modulation strategy and the efficiency-cost benefits of the proposed ANPC inverter is presented.In this paper a precise electro-thermal power loss model for this ANPC inverter topology will be presented based on the modulation strategy of the inverter and the operating characteristics of the Si/SiC hybrid switches.The power loss model development takes into account how the current sharing between the two internal devices of the Si/SiC hybrid switches and their corresponding gate control method affects their power loss.A brief introduction to the topology structure and operation principle of the Si/SiC based ANPC inverter is first highlighted to provide context for readers and then a detailed description of the proposed electro-thermal power loss model is presented.The precision of the electro-thermal power loss model introduced in this paper is then validated using experimentally measured energy loss,device temperature and inverter efficiency data. | Dereje Woldegiorgis H.Alan Mantooth | 2022 | Chinese Journal of Electrical Engineering2022，8，3： | 0 |
| 19 | A Modified Neutral-point Voltage Control Strategy for Three-level Inverters Based on Decomposition of Space Vector Diagram显示文摘Capacitor voltage imbalance is a significant problem for three-level inverters.Due to the mid-point modulation of these inverter topologies,the neutral point potential moves up or down depending on the neutral point current direction creating imbalanced voltages among the two capacitors.This imbalanced capacitor voltage causes imbalanced voltage stress among the semiconductor devices and causes increase output voltage and current harmonics.This paper introduces a modified voltage balancing strategy using two-level space vector modulation.By decomposing the three-level space vector diagram into two-level space vector diagram and redistributing the dwell times of the two-level zero space vectors,the modified voltage balancing method ensures minimal NP voltage ripple.Compared to the commonly used NP voltage control method(using 3L SVM[9]),the proposed modified NP voltage control method offers a slightly higher neutral-point voltage ripple and output voltage harmonics but,it has much lower switching loss,code size and execution time. | Dereje Woldegiorgis H.Alan Mantooth | 2022 | CES Transactions on Electrical Machines and Systems2022，6，2： | 0 |
| 20 | Construction of curcumin-loaded micelles and evaluation of the anti-tumor effect based on angiogenesis显示文摘Objective:Inhibition of tumor angiogenesis has become a new targeted tumor therapy.In this study,we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-targeting peptide NGR.Methods:The targeted polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide)(PEG-PLGA)modified with Asn–Gly–Arg(NGR)peptide was prepared and characterized by 1H nuclear magnetic resonance and Fourier-transform infrared spectrometry.NGR-PEG-PLGA was used to construct curcumin(Cur)-loaded micelles by the solvent evaporation method.The physicochemical properties of the micelles were also investigated.Additionally,we evaluated the antitumor efficacy of the polymer micelles(PM)using in vitro cytology experiments and in vivo animal studies.Results:The particle size of Cur-NGR-PM was 139.70±2.51 nm,and the drug-loading capacity was 14.37±0.06%.In vitro cytological evaluation showed that NGR-modified micelles showed higher cellular uptake through receptor-mediated endocytosis pathways than did unmodified micelles,leading to the apoptosis of tumor cells.Then,in vivo antitumor experiments showed that the modified micelles significantly inhibited tumor growth and were safe.Conclusions:NGR-modified micelles significantly optimized the therapeutic efficacy of Cur.This strategy offers a viable avenue for cancer treatment. | Rui Liu Zhongyan Liu Xueli Guo Dereje Kebebe Jiaxin Pi Pan Guo | 2023 | Acupuncture and Herbal Medicine2023，3，4： | 0 |
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