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| 1 | YODA-HSP90 Module Regulates Phosphorylation-Dependent Inactivation of SPEECHLESS to Control Stomatal Development under Acute Heat Stress in Arabidopsis显示文摘Stomatal ontogenesis,patterning,and function are hallmarks of environmental plant adaptation,especially to conditions limiting plant growth,such as elevated temperatures and reduced water availability.The specification and distribution of a stomatal cell lineage and its terminal differentiation into guard cells require a master regulatory protein phosphorylation cascade involving the YODA mitogen-activated protein kinase kinase kinase.YODA signaling results in the activation of MITOGEN-ACTIVATED PROTEIN KINASEs(MPK3 and MPK6),which regulate transcription factors,including SPEECHLESS(SPCH).Here,we report that acute heat stress affects the phosphorylation and deactivation of SPCH and modulates stomatal density.By using complem entary molecular,genetic,biochemical,and cell biology approaches,we provide solid evidence that HEAT SHOCK PROTEINS 90(HSP90s)play a crucial role in transducing heat-stress response through the YODA cascade.Genetic studies revealed that YODA and HSP90.1 are epistatic,and they likely function linearly in the same developmental pathway regulating stomata formation.HSP90s interact with YODA,affectits cellular polarization,and modulate the phosphorylation of downstream targets,such as MPK6 and SPCH,under both normal and heat-stress conditions.Thus,HSP90-mediated specification and differentiation of the stomatal cell lineage couples stomatal development to environmental cues,providing an adaptive heat stress response mechanism in plants. | Despina Samakovli Tereza Ticha Tereza Vavrdova Miroslav Ovecka Ivan Luptovciak Veronika Zapletalova Anna Kucharova Pavel Krenek Yuliya Krasylenko Theoni Margaritopoulou Loukia Roka Dimitra Milioni George Komis Polydefkis Hatzopoulos Jozef Samaj | 2020 | Molecular Plant2020，13，4： | 9 |
| 2 | Apolipoprotein J as a predictive biomarker for restenosis after carotid endarterectomy: a retrospective study显示文摘颈动脉 endarterectomy (CEA ) 是为在大多数病人的击预防的一种有效外科的选择。在 CEA 以后的狭窄能导致重新干预和不利事件,但是预言狭窄的因素糟糕被理解。Apolipoprotein J (ApoJ ) 被认为是脉管的狭窄的一个新奇预兆的因素并且与与动脉粥样硬化和房间周期阶段有关的很多过程被联系。这研究的目的是阐明在内部颈动脉动脉(集成通信适配器) 的 Apo J 的预兆的价值狭窄追随者 CEA。都检验的这回顾的研究有希望地为在一个 2 年的时期上在我们的外科的部门经历了 CEA 的病人收集了数据。100 个病人的浆液 ApoJ 层次被检验;经历了 CEA 的 56 个病人包括了脉管的组(VG ) ,并且经历了次要的外科的 44 个病人包括了控制组(CG ) 。ApoJ 样品外科手术前地被获得,在外科的过程以后并且在 1, 6 和 12 个月的 24 h 此后在后续期间。在在 CG 和 VG 之间的 ApoJ 层次的外科手术前的差别是统计上 signifcant;吝啬的价值是 39.11 并且每个方法的能力在正常之间区别吗?? | Anastasios MASKANAKIS Nikolaos PATELIS Georgios KARAOLANIS Spyridon DAVAKIS Dimitrios SCHIZAS Despina PERREA Chris KLONARIS Sotirios GEORGOPOULOS Theodoros LIAKAKOS Chris BAKOYIANNIS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 6 |
| 3 | Albuminuria as a marker of arterial stiffness in chronic kidney disease patients显示文摘AIM:To access the association between albuminuria levels and arterial stiffness in non-diabetic patients with hypertension and chronic kidney disease(CKD) stages 1-2,treated with renin angiotensin blockade agents plus other hypertensive drugs when needed.METHODS:One hundred fifteen patients [median age 52 years(68% males)] were consequently enrolled in the study.For each patient,we recorded gender,age,body mass index(BMI),peripheral systolic blood pressure(p SBP),peripheral diastolic blood pressure,peripheral pulse pressure,central systolic blood pressure(c SBP),central diastolic blood pressure(c DBP),central pulse pressure(c PP),hematocrit,hemoglobin,hs CRP,total cholesterol triglycerides,high-density lipoprotein-C,low-density lipoprotein-C,calcium,phosphorus,parathormone,and albumin,as well as 24 h urine albumin excretion.According to 24-h urine albumin collection,patients were then classified as those with moderately increased albuminuria(formerly called macroalbuminuria)(≤ 300 mg/d) and those with severely increased albuminuria(formerly called macroaluminuria(> 300 mg/d).We considered aortic stiffness(AS) indices [carotid femoral pulse wave velocity(PWVc-f) and augmentation index(AIx)] as primary outcomes ofthe study.We explored potential correlations between severely increased albuminuria and AS indices using a multiple linear regression model.RESULTS:Fifty-eight patients were included in the moderately increased albuminuria group and 57 in the severely increased albuminuria.Blood pressure measurements of the study population were 138 ± 14/82 ± 1.3 mm Hg(systolic/diastolic).There were no significant differences in age,sex,and BP measurements between the two groups.Patients with severely increased albuminuria had higher PWV and AIx than patients with moderately increased albuminuria(P < 0.02,P < 0.004,respectively).In addition these patients exhibited higher BMI(P < 0.03),hs CRP(P < 0.001),and fibrinogen levels(P < 0.02) compared to patients with moderately increased albuminuria.In multivariate linear regression analysis,severely increased albuminuria(β = 1.038,P < 0.010) p SBP(β = 0.028,P < 0.034) and Ht(β = 0.171,P = 0.001) remained independent determinants of the increased PWVc-f.Similarly,severely increased albuminuria(β = 4.385,P < 0.012),c SBP(β = 0.242,P < 0.001),c PP(β = 0.147,P < 0.01) and Ht levels(β = 0.591,P < 0.013) remained independent determinants of increased AIx.CONCLUSION:These findings demonstrate an independent association between AS indices and severely increased albuminuria in non-diabetic,hypertensive patients with CKD stages 1-2 treated with renin angiotensin aldosterone system blockers. | Rigas G Kalaitzidis Despina P Karasavvidou Athina Tatsioni Kosmas Pappas Giorgos Katatsis Angelos Liontos Moses S Elisaf | 2015 | World Journal of Nephrology2015，4，3： | 5 |
| 4 | Chylorrhea complicating D2+a gastrectomy: review of the literature and clarification of terminology apropos one case显示文摘 | John Griniatsos Nikoletta Dimitriou Despina Kyriaki Antigoni Velidaki Stavros Sougioultzis Paris Pappas | 2010 | Chinese Medical Journal2010，，16： | 4 |
| 5 | Gastric signet-ring adenocarcinoma presenting with breast metastasis显示文摘从胃的癌症的胸转移是极其稀罕的。有胸的 37 岁的女性的一份病案报告煽动性的侵略和腹水被描述。胸活体检视与图章戒指特征从腺癌房间揭示了 lymphatics 的癌的侵略。雌激素(嗯) 并且孕酮受体(PR ) 和 c-erb-B2 是否定的。上面的胃肠的内视镜检查法揭示了一个幽门前溃疡的团。损害的组织病理学说的检查从高级腺癌显示出渗入,与胸的相同。Immunostaining 为 cytokeratins CK-7 和 CK-20 和 CEA 和 negative 是积极的为嗯并且 PR。腹水细胞学为腺癌房间是积极的。早期胸部肿瘤Ⅹ射线测定法不是诊断的。扫描的腹的 CT 揭示了转移(Krukenberg 的肿瘤) 暗示的大卵巢的群众。基于 cisplatin 的政体被给,但是没有客观反应被观察。病人死了在起始的诊断以后的六个月。文学的评论被执行。 | Anastasios L Boutis Charalambos Andreadis Frideriki Patakiouta Despina Mouratidou | 2006 | World Journal of Gastroenterology2006，12，18： | 4 |
| 6 | Resurgence of the cotton bollworm Helicoverpa armigera in northern Greece associated with insecticide resistance显示文摘Helicoverpa armigera 在北希腊的主要棉花庄稼生产区域与化学杀虫药剂有效地被控制许多年了。然而,害虫的苏醒在 2010 被观察,它显著地影响了庄稼生产。在 4 年的调查(20072010 ) 期间,我们检验了 H 的杀虫药剂抵抗地位。来自在对七杀虫药剂(chlorpyrifos, diazinon, methomyl, alpha-cypermethrin, cypermethrin, gamma-cyhalothrin 和 endosulfan ) 的北希腊的二个主要、代表性的棉花生产区域的 armigera 人口。第三个中间形态幼虫上的完整的剂量反应生物鉴定被热门申请执行。在 50% 点的致命的剂量被概率单位分析估计,抵抗因素(RF ) 是计算的,与易受影响的实验室参考紧张相比。抵抗层次是相对中等的直到 2009,与在为 organophosphates 和氨基甲酸酯并且直到为 pyrethroid alpha-cypermethrin 的 16 褶层的 10 褶层下面的抵抗比率。然而,抵抗为 chlorpyrifos 和 alpha-cypermethrin 升起了到 46 褶层和 81 褶层,分别地在 2010,当害虫的苏醒被观察时。任何一个都没在 pyrethroid 抵抗的昆虫已知的 pyrethroid 抵抗变化被发现。在抵抗和 H 之间的可能的协会。在希腊的 armigera 苏醒被讨论。 | George K. Mironidis Despina Kapantaidaki Maria Bentila Evangelia Morou M. Savopoulou-Soultani John Vontas | 2013 | Insect Science2013，20，4： | 3 |
| 7 | Silver impregnated carbon for adsorption and desorption of elemental mercury vapors显示文摘The Hg 0 vapor adsorption experimental results on a novel sorbent obtained by impregnating a commercially available activated carbon (Darco G60 from BDH) with silver nitrate were reported.The study was performed by using a fundamental approach,in an apparatus at laboratory scale in which a synthetic flue gas,formed by Hg 0 vapors in a nitrogen gas stream,at a given temperature and mercury concentration,was flowed through a fixed bed of adsorbent material.Breakthrough curves and adsorption isotherms were obtained for bed temperatures of 90,120 and 150°C and for Hg 0 concentrations in the gas varying in the range of 0.8–5.0 mg/m 3 .The experimental gas-solid equilibrium data were used to evaluate the Langmuir parameters and the heat of adsorption.The experimental results showed that silver impregnated carbon was very effective to capture elemental mercury and the amount of mercury adsorbed by the carbon decreased as the bed temperature increased.In addition,to evaluate the possibility of adsorbent recovery,desorption was also studied.Desorption runs showed that both the adsorbing material and the mercury could be easily recovered,since at the end of desorption the residue on solid was almost negligible.The material balance on mercury and the constitutive equations of the adsorption phenomenon were integrated,leading to the evaluation of only one kinetic parameter which fits well both the experimentally determined breakthrough and desorption curves. | Despina Karatza Marina Prisciandaro Amedeo Lancia Dino Musmarra | 2011 | Journal of Environmental Sciences2011，23，9： | 3 |
| 8 | Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity显示文摘AIM: Acute hepatitis may seldom have a fulminant course.In the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl4).METHODS: After CCl4 intoxication, 84 male Wistar rats used as recipients were divided in to four experimental groups accordingly to their treatment: Group A (n=24): intrasplenic transplantation of 10±10^6 isolated hepatoo/tes, Group B (n=24):intrapedtoneal transplantation of 20×10^6 isolated hepatocytes attached on plastic microcarriers, Group C (n= 18): intrasplenic injection of 1 mL normal saline (sham-operated controls),Group D (n=18): intraperitoneal injection of 2.5 mL normal saline (sham-operated controls). Survival, liver function tests (LIT) and histology were studied in all four groups, on d 2,5 and 10 post-HCTx.RESULTS: The ten-day survival (and mean survival) in the 4 groups was 72.2% (8.1±3.1), 33.3% (5.4±3.4), 0%(3.1±1.3) and 33.3% (5.4±3.6) in groups A, B, C, D,respectively (PAB<0.05, PAc<0.05, P80=NS). In the final survivors, LIT (except alkaline phosphatase) and hepatic histology retumed to normal, independently of their previous therapy. Viable hepatocytes were identified within splenic parenchyma (in group A on d 2) and both in the native liver and the fatty tissue of abdominal wall (in group B on d 5).CONCLUSION: A significantly better survival of the intrasplenically transplanted animals has been demonstrated,Intraperitoneal hepatocytes failed to promptly engraft. A different timing between liver injury and intraperitoneal HCTx may give better results and merits further investigation. | Charalampos Pilichos Despina Perrea Maria Demonakou Athena Preza Ismini Donta | 2004 | World Journal of Gastroenterology2004，10，14： | 2 |
| 9 | Weekly Gemcitabine for the Treatment of Biliary Tract and Gallbladder Cancer显示文摘 | Nikolas Tsavaris Christos Kosmas Panagiotis Gouveris Kostadinos Gennatas Aris Polyzos Despina Mouratidou Heracles Tsipras Helias Margaris George Papastratis Evanthia Tzima Nikitas Papadoniou Gavrilos Karatzas Efstathios Papalambros | 2004 | Investigational New Drugs2004，，2： | 2 |
| 10 | Biomechanical characteristics of bone in streptozotocin-induced diabetic rats:An in-vivo randomized controlled experimental study显示文摘AIM: To investigate the in vivo effects of type Ⅰdiabetes on the mechanical strength of tibial bone in a rodent model.METHODS: The biomechanical effect of diabetes on the structural integrity of the tibia in streptozotocin induced diabetic Wistar rats was analysed. Induction of diabetes was achieved by an intra-peritoneal injection and confirmed by measuring serial blood glucose levels(> 150 mg/d L). After 8 wk the tibiae were harvested and compared to a control group. Biomechanical analysis of harvested tibiae was performed using a threepoint bending technique on a servo hydraulic MTS 858 MiniB ionix frame. Maximum force applied to failure(N), stiffness(N × mm) and energy absorbed(N/mm) were recorded and plotted on load displacement curves. A displacement control loading mode of 1 mm/min was selected to simulate quasi-static loading conditions. Measurements from load-displacement curves were directly compared between groups.RESULTS: Fourteen streptozotocin induced diabetic Wistar rats were compared against nineteen non-diabetic controls. An average increase of 155.2 g in body weight was observed in the control group compared with only 5 g in the diabetic group during the experimental study period. Levels of blood glucose increased to 440.25 mg/d L in the diabetic group compared to 116.62 mg/d L in the control group.The biomechanical results demonstrate a highly significant reduction in the maximum load to failure from 69.5 N to 58 N in diabetic group compared to control(P = 0.011). Energy absorption to fracture was reduced from 28.2 N in the control group to 23.5 N in the diabetic group(P = 0.082). No significant differences were observed between the groups for bending stiffness.CONCLUSION: Streptozotocin-induced diabetes in rodents reduces the maximum force and energy absorption to failure of bone, suggesting a predisposition for fracture risk. | Nektarios Korres Eleftherios Tsiridis George Pavlou Athanasios Mitsoudis Despina N Perrea Aristedes B Zoumbos | 2013 | World Journal of Orthopedics2013，4，3： | 2 |
| 11 | Visitor Motivations and Barriers for Sustainable Music Festival Tourism: The Case of Street Mode & Reworks Festivals显示文摘During the last decade, music festivals are increasingly used as an important motivator to attract visitors, giving riseto a more sustainable tourism growth in hand with cultural stimulation for the cities. This research paper aims toaddress the motives and barriers of music festival visitors travelling to attend two music events in the second largestGreek city of Thessaloniki in Northern Greece. The main objective of the research paper is to determine the visitors’motivation for choosing to attend each festival and thereafter the challenges they face during their visit in the city.This exploratory research study focuses on two distinct and popular music festivals namely Reworks Festival andStreet Mode Festival. Both events share three main characteristics: (1) They host both international & Greekprofessional artists;(2) they are primarily privately funded;and (3) they have achieved a consecutive 10 years ofsuccessful presence in the city attracting thousands of visitors each year. The research methodology is based on thecollection of qualitative data by conducting one to one interviews with festival visitors. Findings of the analysis ofthe two festivals direct at identifying the commonalities & differences in tourists’ drives and obstacles in regards totheir festival attendance and visit in the city of Thessaloniki. In both cases, it is inferred that both festivals have alot of further untapped potential, as unique city branding tools, adding value to the destinations and extending thetourism season. Conclusions can contribute to building more concise and sustainable destination tourism strategiesand, therefore, more successful and sustainable events, with long-term benefits, ranging from local to nationallevels. | Vasiliki Georgoula Despina Chrisidou Spyridoula Dimitra Souki | 2021 | Journal of Tourism and Hospitality Management2021，9，1： | 1 |
| 12 | STAT-related profiles are associated with patient response to targeted treatments in locally advanced SCCHN 显示文摘 | Vassiliki Kotoula Sofia Lambaki Despina Televantou | 2011 | Neoplasia Press2011，，： | 1 |
| 13 | A comparative reactivity and ki-netic study on the combustion of coal-biomass char blends显示文摘 | Eleni K Despina V | 2006 | Fuel2006，85，9： | 1 |
| 14 | Left Ventricular Outflow Tract Obstruction as a Risk Factor for Sudden Cardiac Death in Hypertrophic Cardiomyopathy显示文摘 | Georgios K. Efthimiadis Despina G. Parcharidou Georgios Giannakoulas Efstathios D. Pagourelias Panagiotis Charalampidis Gregorios Savvopoulos Antonios Ziakas Haralambos Karvounis Ioannis H. Styliadis Georgios E. Parcharidis | 2009 | The American Journal of Cardiology2009，，5： | 1 |
| 15 | 查看详情显示文摘 | Anastasios E Helen B Spyros A Despina T | | 0，，31： | 1 |
| 16 | Modeling of an entrained flow coal gasifier (Ⅰ):Development of the model and general predictions显示文摘 | Despina Vamvuka Woodburn Edeard T Senior Peter R | 1995 | Fuel1995，74，10： | 1 |
| 17 | Selection of aptamers with high affinity and high specificity against C595, an anti-MUC1 IgG3 monoclonal antibody, for antibody targeting显示文摘 | Sotiris Missailidis Despina Thomaidou K. Eszter Borbas Mike R. Price | 2004 | Journal of Immunological Methods2004，，1： | 1 |
| 18 | Almost all articles on cancer prognostic markers report statistically significant results显示文摘 | Panayiotis A. Kyzas Despina Denaxa-Kyza John P.A. Ioannidis | 2007 | European Journal of Cancer2007，，17： | 1 |
| 19 | Weekly Gemcitabine for the Treatment of Biliary Tract and Gallbladder Cancer显示文摘 | Nikolas Tsavaris Christos Kosmas Panagiotis Gouveris Kostadinos Gennatas Aris Polyzos Despina Mouratidou Heracles Tsipras Helias Margaris George Papastratis Evanthia Tzima Nikitas Papadoniou Gavrilos Karatzas Efstathios Papalambros | 2004 | Investigational New Drugs2004，，2： | 1 |
| 20 | Assessment of Prealbumin in Hemodialysis and Renal-Transplant Patients显示文摘 | Stavroula Chrysostomou Chalalambos Stathakis George Petrikkos George Daikos Athina Gompou Despina Perrea | 2010 | Journal of Renal Nutrition2010，，1： | 1 |
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