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| 1 | Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow显示文摘肺的动脉的背景反常 apoptosis 光滑的肌肉房间(PASMC ) 是在肺的动脉的一个重要 pathophysiological 过程结构的改变和肺的高血压。我们在 39 只男 Sprague-Dawley 老鼠随机被分到4星期的控制的高肺的血 flow.Methods 导致的肺的高血压的开发期间在 PASMC 的 apoptosis 上调查了内长的氢硫化物( H_2S )的可能的效果,4星期的分流,4星期的 shunt+propargylglycine ( PPG ),11星期的控制,11星期的分流和11星期的 shunt+sodium hydrosulfide ( NaHS )组织。在 4 星期的分流, 4 星期的 shunt+PPG, 11 星期的分流和 11 星期的 shunt+NaHS 组的老鼠经历了腹的主动脉晚辈静脉 cava 分流。在 4 星期的 shunt+PPG 组的老鼠 intraperitoneally 与 PPG 被注射,内长的 H_2S 生产的一个禁止者,为 4 个星期。在 11 星期的 shunt+NaHS 组的老鼠 intraperitoneally 与 NaHS 被注射,一个 H_2S 施主,为 11 个星期。肺织物 H_2S 被硫化物敏感的电极评估。PASMC 的 Apoptosis 被终端 deoxynucleotidyl transferase 检测标记的调停的 dUTP 刻痕结束(TUNEL ) 。在 PASMC 的船边交货, bcl-2 和 caspase-3 的表情四个星期在推延的操作以后与免疫化学的 staining.Results 被分析, PASMC 的 apoptosis 和船边交货和 caspase-3 的表示显著地被减少(P < 0.01 ) ,但是 bcl-2 的表示显著地增加了(P < 0.01 ) 。PPG 管理进一步禁止了 PASMC 的 apoptosis, downregulated 船边交货和 caspase-3 的表示(P < 0.01 ) ,但是增加了 bcl-2 的表示(P < 0.01 ) 。在 11 星期推延以后操作, PASMC 的 apoptosis 和船边交货和 caspase-3 的表示显著地被减少(P < 0.01 ) ,但是 bcl-2 的表示显然增加了(P < 0.01 ) 。NaHS 管理显著地增加了 PASMC 的 apoptosis, upregulated 船边交货和 caspase-3 的表示,但是禁止了 bcl-2.Conclusions H_2S 的表示在高肺的血的发展导致 PASMC 的 apoptosis 由激活船边交货小径并且禁止 bcl-2 小径的导致流动的肺的高血压。 | LI Wei JIN Hong-fang LIU Die SUN Jing-hui JIAN Pei-jun LI Xiao-hui TANG Chao-shu DU Jun-bao | 2009 | Chinese Medical Journal2009，，24： | 26 |
| 2 | Acquisition of deleterious mutations duringpotato polyploidization显示文摘Potatoes(Solanum tuberosum L.) represent an important tuber crop, worldwide. During its prolonged clonal propagation, numerous deleterious mutations have accumulated in the potato genome,leading to severe inbreeding depression; however,the shaping of this mutation burden during polyploidization and improvement is largely unknown.Here, we sequenced 20 diploid landraces of the Stenotomum group, eight tetraploid landraces, and 20 tetraploid modern cultivars, to analyze variations in their deleterious mutations. We show that deleterious mutations accumulated rapidly during the polyploidization of tetraploid potatoes. This study provides a foundation for future potato improvement. | Qun Lian Die Tang Zhiyan Bai Jianjian Qi Fei Lu Sanwen Huang Chunzhi Zhang | 2019 | Journal of Integrative Plant Biology2019，61，1： | 8 |
| 3 | Prevalence of Opportunistic Pathogens and Diversity of Microbial Communities in the Water System of a Pulmonary Hospital显示文摘Objective Our objective was to investigate the occurrence of opportunistic pathogens and characterize the bacterial community structures in the water system of a pulmonary hospital.Methods The water samples were collected from automatic and manual faucets in the consulting room,treatment room,dressing room,respiratory ward,and other non-medical rooms in three buildings of the hospital.Quantitative polymerase chain reaction was used to quantify the load of several waterborne opportunistic pathogens and related microorganisms,including Legionella spp.,Mycobacterium spp.,and M.avium.Illumina sequencing targeting 16 S r RNA genes was performed to profile bacterial communities.Results The occurrence rates of Legionella spp.,Mycobacterium spp.,and M.avium were 100%,100%,and 76%,respectively in all samples.Higher occurrence rates of M.avium were observed in the outpatient service building(building 1,91.7%)and respiration department and wards(building 2,80%)than in the office building(building 3),where no M.avium was found.M.avium were more abundant in automatic faucets(average 2.21×10~4 gene copies/L)than in manual faucets(average 1.03×10~4 gene copies/m L)(P<0.01).Proteobacteria,Actinobacteria,Bacteroidetes,Cyanobacteria,Firmicutes,and Acidobacteria were the dominant bacterial phyla.Disinfectant residuals,nitrate,and temperature were found to be the key environmental factors driving microbial community structure shifts in water systems.Conclusion This study revealed a high level of colonization of water faucets by opportunistic pathogens and provided insight into the characteristics of microbial communities in a hospital water system and approaches to reduce risks of microbial contamination. | TANG Wei MAO Yu LI Qiu Yan MENG Die CHEN Ling WANG Hong ZHU Ren ZHANG Wei Xian | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 4 | Construction of homozygous diploid potato through maternal haploid induction显示文摘Reinventing the tetraploid potato into a seed-propagated,diploid,hybrid potato would significantly accelerate potato breeding.In this regard,the development of highly homozygous inbred lines is a prerequisite for breeding hybrid potatoes,but self-incompatibility and inbreeding depression present challenges for developing pure inbred lines.To resolve this impediment,we developed a doubled haploid(DH)technology,based on mutagenesis of the potato DOMAIN OF UNKNOWN FUNCTION 679 membrane protein(StDMP)gene.Here,we show that a deficiency in StDMP allows the generation of maternal haploids for generating diploid potato lines.An exercisable protocol,involving hybridization,fluorescent marker screening,molecular and flow cytometric identification,and doubling with colchicine generates nearly 100%homozygous diploid potato lines.This dmp-triggered haploid induction(HI)system greatly shortens the breeding process and offers a robust method for generating diploid potato inbred lines with high purity. | Jinzhe Zhang Jian Yin Jiayi Luo Die Tang Xijian Zhu Jie Wang Zhihong Liu Pei Wang Yu Zhong Chenxu Liu Canhui Li Shaojiang Chen Sanwen Huang | 2022 | aBIOTECH2022，3，3： | 2 |
| 5 | Using echocardiography in newborn screening for congenital heart disease may reduce missed diagnoses显示文摘Congenital heart disease(CHD)is the most common type of birth defect in China.According to a national study,the overall prevalences of CHD and critical CHD were 8.98 per 1000 live births and 1.46 per 1000 live births,respectively,in China[1].CHD,particularly critical CHD,not only seri-ously affects the quality of life of patients and their family,but creates huge economic and mental burdens on the fam-ily and on society as a whole[2].Early diagnosis of CHD is imperative for early intervention and treatment.For early diagnosis of CHD,CHD screening in all newborns was first initiated in Shanghai,China on June 1,2016[3].Since July 30,2018,the China National Health Commission initiated newborn screening program for CHD;'double index meth-ods'(cardiac auscultation plus pulse oximetry)were used to screen CHD for newborns 6 hours and 72 hours after birth. | Yun-Xiang Qiu Wei Jiang Jia-Yu Zhang Die Li Kai Yu Cang-Cang Fu Xiao-Min Tang Wei-Ze Xu | 2022 | World Journal of Pediatrics2022，18，9： | 2 |
| 6 | Postural Orthostatic Tachycardia Syndrome with Increased Erythrocytic Hydrogen Sulfide and Response to Midodrine Hydrochloride显示文摘 | Jinyan Yang Juan Zhao Shuxu Du Die Liu Chunhin Fu Xueying Li Stella Chen Chaoshu Tang Junbao Du Hongfang Jin | 2013 | The Journal of Pediatrics2013，，： | 1 |
| 7 | Polydopamine-coated metal-organic framework-based composite phase change materials for photothermal conversion and storage显示文摘The liquid leakage and weak solar absorption capacity of organic phase change materials(PCMs)seriously hinder the efficient utilization of solar energy and thermal energy storage.To address these issues,we prepared nanoporous metal organic framework(Ni-MOF)for the vacuum infiltration of paraffin wax(PW),followed by the coating of solar-absorbing functional polydopamine(PDA)on the surface of PW@MOF for photothermal conversion and storage.As an efficient photon harvester,PDA coating endows PW@MOF/PDA composite PCMs with excellent photothermal conversion and storage properties due to the robust broadband solar absorption capability in the UV–vis region.Resultantly,our prepared PW@MOF/PDA composite PCMs exhibit a high photothermal conversion and storage efficiency of 91.2%,while that of PW@MOF composite PCMs is only zero.In addition,PW@MOF/PDA composite PCMs also exhibit excellent thermal stability,shape stability,energy storage stability,and photothermal conversion stability.More importantly,this coating strategy is universal by integrating different MOFs and solar absorbers,showing the potential to accelerate the major breakthroughs of high-efficiency MOF-based photothermal composite PCMs in solar energy utilization. | Ang Li Mengke Huang Die Hu Zhaodi Tang Jianhang Xu Yang Li Xiaowei Zhang Xiao Chen Ge Wang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 8 | Inheritance of steroidal glycoalkaloids in potato tuber flesh显示文摘Potato (Solanum tuberosum L.) is the third most important food crop worldwide after wheat and rice in terms of human consumption. A critical domestication trait for potato was the decrease of toxic steroidal glycoalkaloids (SGAs) in tuber flesh. Here, we used a diploid F2 segregating population derived from a cross between S. tuberosum and the wild potato species Solanum chacoense to map the quantitative trait loci (QTLs) associated with the regulation of SGAs content in tuber flesh. In a three-year study, we identified two QTLs on chromosomes 2 and 8 affecting SGAs content in tuber flesh. The QTL on chromosome 8 harbors 38 genes that are co-expressed with the GLYCOALKALOID METABOLISM genes. These findings lay the foundation for exploiting the genes controlling SGAs content in tuber flesh and they provide a theoretical basis for the use of wild germplasm in potato breeding. | PENG Zhen WANG Pei TANG Die SHANG Yi LI Can-hui HUANG San-wen ZHANG Chun-zhi | 2019 | Journal of Integrative Agriculture2019，18，10： | 0 |
| 9 | Data augmentation for bias correction in mapping PM_(2.5) based on satellite retrievals and ground observations显示文摘As most air quality monitoring sites are in urban areas worldwide,machine learning models may produce substantial estimation bias in rural areas when deriving spatiotemporal distributions of air pollutants.The bias stems from the issue of dataset shift,as the density distributions of predictor variables differ greatly between urban and rural areas.We propose a data-augmentation approach based on the multiple imputation by chained equations(MICE-DA)to remedy the dataset shift problem.Compared with the benchmark models,MICE-DA exhibits superior predictive performance in deriving the spatiotemporal distributions of hourly PM2.5 in the megacity(Chengdu)at the foot of the Tibetan Plateau,especially for correcting the estimation bias,with the mean bias decreasing from-3.4µg/m3 to-1.6µg/m3.As a complement to the holdout validation,the semi-variance results show that MICE-DA decently preserves the spatial autocorrelation pattern of PM2.5 over the study area.The essence of MICE-DA is strengthening the correlation between PM2.5 and aerosol optical depth(AOD)during the data augmentation.Consequently,the importance of AOD is largely enhanced for predicting PM2.5,and the summed relative importance value of the two satellite-retrieved AOD variables increases from 5.5%to 18.4%.This study resolved the puzzle that AOD exhibited relatively lower importance in local or regional studies.The results of this study can advance the utilization of satellite remote sensing in modeling air quality while drawing more attention to the common dataset shift problem in data-driven environmental research. | Tan Mi Die Tang Jianbo Fu Wen Zeng Michael L.Grieneisen Zihang Zhou Fengju Jia Fumo Yang Yu Zhan | 2024 | Geoscience Frontiers2024，15，1： | 0 |
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