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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Adaptive robust optimization for the security constrained unit commiment problem显示文摘 | Dimitris B Eugene L Sun Xu Andy | 2013 | IEEE Transaction on Power Systems2013，28，1： | 1 |
| 3 | Optimal control of execution costs显示文摘 | Dimitris B Andrew W L | 1998 | Journal of Financial Market1998，1，1： | 1 |
| 4 | Modeling of the thermomechanical behavior of porous shape memory alloys显示文摘 | PAVLIN B E DIMITRIS C L | 2001 | International Journal of Solids and Structures2001，38，： | 1 |
| 5 | Modeling porous shape memory alloys using micromechanical averaging techniques显示文摘 | DIMITRIS C L | 2002 | Mechanics of Meterials2002，34，： | 1 |
| 6 | Impact of high cadmium and nickel soil concentration on selectedphysiological parameters of Arundo donax L 显示文摘 | Eleni G P Konstantinos G S Dimitris L B | 2007 | European Journal of Soil Biology?2007，43，4： | 1 |
| 7 | Multiple time resolution unit commitment for short-term operations scheduling under high renewable penetration 显示文摘 | EMMANOUIL A B PANDELIS N B DIMITRIS P L l | 2014 | 1EEE Transactions on Power Systems2014，29，1： | 1 |
| 8 | Chaotic behavior of local temperature fluctuations in a laboratory-scale circulating fludized bed 显示文摘 | Lu H L Dimitri G Jacques B | 2002 | Powder Technol2002，，23： | 1 |
| 9 | Adaptive robust optimization for the security constrained unit commitment problem显示文摘 | Dimitris B Eugene L Xu A S | 2013 | IEEE Transactions on Power Systems2013，28，1： | 1 |
| 10 | Impact of type 2 diabetes on adenoma detection in screening colonoscopies performed in disparate populations显示文摘BACKGROUND The Black/African Ancestry(AA)population has a higher prevalence of type 2 diabetes mellitus(T2DM)and a higher incidence and mortality rate for colorectal cancer(CRC)than all other races in the United States.T2DM has been shown to increase adenoma risk in predominantly white/European ancestry(EA)populations,but the effect of T2DM on adenoma risk in Black/AA individuals is less clear.We hypothesize that T2DM has a significant effect on adenoma risk in a predominantly Black/AA population.AIM To investigate the effect of T2DM and race on the adenoma detection rate(ADR)in screening colonoscopies in two disparate populations.METHODS A retrospective cohort study was conducted on ADR during index screening colonoscopies(age 45-75)performed at an urban public hospital serving a predominantly Black/AA population(92%)(2017-2018,n=1606).Clinical metadata collected included basic demographics,insurance,body mass index(BMI),family history of CRC,smoking,diabetes diagnosis,and aspirin use.This dataset was combined with a recently reported parallel retrospective cohort data set collected at a suburban university hospital serving a predominantly White/EA population(87%)(2012-2015,n=2882).RESULTS The ADR was higher in T2DM patients than in patients without T2DM or prediabetes(35.2%vs 27.9%,P=0.0166,n=981)at the urban public hospital.Multivariable analysis of the combined datasets showed that T2DM[odds ratio(OR)=1.29,95%confidence interval(CI):1.08-1.55,P=0.0049],smoking(current vs never OR=1.47,95%CI:1.18-1.82,current vs past OR=1.32,95%CI:1.02-1.70,P=0.0026),older age(OR=1.05 per year,95%CI:1.04-1.06,P<0.0001),higher BMI(OR=1.02 per unit,95%CI:1.01-1.03,P=0.0003),and male sex(OR=1.87,95%CI:1.62-2.15,P<0.0001)were associated with increased ADR in the combined datasets,but race,aspirin use and insurance were not.CONCLUSION T2DM,but not race,is significantly associated with increased ADR on index screening colonoscopy while controlling for other factors. | Dimitri F Joseph Ellen Li Samuel L Stanley III Yi-Cong Zhu Xiao-Ning Li Jie Yang Lorenzo F Ottaviano Juan Carlos Bucobo Jonathan M Buscaglia Joshua D Miller Rajesh Veluvolu Michele Follen Evan B Grossman | 2021 | World Journal of Clinical Cases2021，9，11： | 0 |
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