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| 1 | Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria显示文摘Infections caused by drug-resistant“superbugs”pose an urgent public health threat due to the lack of effective drugs;however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors VII, IX and X, three proteins with well-established roles in initiation of the coagulation cascade. These factors exert antibacterial function via their light chains (LCs). Unlike many antibacterial agents that target cell metabolism or the cytoplasmic membrane, the LCs act by hydrolyzing the major components of bacterial outer membrane, lipopolysaccharides, which are crucial for the survival of Gram-negative bacteria. The LC of factor VII exhibits in vitro efficacy towards all Gram-negative bacteria tested, including extensively drug-resistant (XDR) pathogens, at nanomolar concentrations. It is also highly effective in combating XDR Pseudomonas aeruginosa and Acinetobacter baumannii infections in vivo. Through decoding a unique mechanism whereby factors VII, IX and X behave as antimicrobial proteins, this study advances our understanding of the coagulation system in host defense, and suggests that these factors may participate in the pathogenesis of coagulation disorder-related diseases such as sepsis via their dual functions in blood coagulation and resistance to infection. Furthermore, this study may offer new strategies for combating Gram-negative “superbugs”. | Jinwu Chen Xiaojie Li Ling Li Ting Zhang Qing Zhang Fangming Wu Diyue Wang Hongze Hu Changlin Tian Dongsheng Liao Liang Zhao Danxia Song Yongyun Zhao Chuanfang Wu Xu Song | 2019 | Cell Research2019，29，9： | 6 |
| 2 | Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats显示文摘Voltage-dependent anion channel 1(VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2–5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4(TLR4). Intrathecal injection of minocycline, an inhibitor of microglia, also attenuated the pain hypersensitivity of rat models of bone cancer pain.These results suggest that VDAC1 plays a significant role in the development of complicated cancer pain, possibly by regulating the expression of TLR4. | Xiangpeng Kong Jinrong Wei Diyu Wang Xiaoju Zhu Youlang Zhou Shusheng Wang Guang-Yin Xu Guo-Qin Jiang | 2017 | Neuroscience Bulletin2017，33，6： | 4 |
| 3 | Routing Loop Audit Mechanism Based on SDN显示文摘Routing loops can cause packet loss and long delay problems in the traditional network. Even in future networks – Software-Defined Networks, with loop-free implementation mechanism, it still suffers loop problems. In this paper, we propose an architecture to solve the loop problem in SDN. Unlike the existing passive routing loop detection algorithm, this algorithm processes based on the SDN loop-free characteristic, by auditing third-party network forwarding rules’ modification requests to avoids loop generation, thus avoid the network loop problems. Testbed is built to simulate our proposed algorithm. The evaluation shows that the loop audit algorithm proposed in this paper has better performance in extra spatial utilization and smaller number of extra interactions between SDN controller and switches. | Tao Yu Yuchen Zhang Diyue Chen Hongyan Cui Jilong Wang | 2019 | China Communications2019，16，7： | 2 |
| 4 | An SDN Oriented Loop Detection Mechanism Based on TTL Statistics显示文摘The rise of the network has injected new impetus into the development of traditional networks.Due to the complexity of the network itself and its network programmability,there is a risk of routing loops occurring in the SDN network.This paper proposes a loop detection mechanism.According to the Time To Live(TTL)value of the loop packet,there is approximately periodicity in the same loop.We use sFlow to count the number of packets corresponding to each TTL value of a switch in the loop over a period of time,and perform discrete Fourier transform on the obtained finite-length sequence to observe its frequency domain performance and determine whether there are periodic features.By doing so,it is determined whether there is a routing loop,and the purpose of passively detecting the routing loop is achieved.Compared to existing algorithms,it has advantages in real-time,scalability and false positive rate.The experimental results show that the routing loop detection algorithm based on TTL statistics in this paper still maintains high judgment accuracy under the scenarios of lower stream sampling rate and smaller detection period. | Tao Yu Longfei Yu Diyue Chen Hongyan Cui Jilong Wang | 2020 | China Communications2020，17，6： | 2 |
| 5 | Experimental study of colonic anastomosis with a degradable stent in a porcine model显示文摘 | YiFan Wang XiuJun Cai HuanJie Cai YueLong Liang DiYu Huang Xiao Liang | 2010 | The American Journal of Surgery2010，，6： | 1 |
| 6 | Simultaneously enhanced energy storage performance and luminance resistance in (K_(0.5)Na_(0.5))NbO_(3) -based ceramics via synergistic optimization strategy显示文摘The rapidly advancing energy storage performance of dielectric ceramics capacitors has garnered significant interest for applications in fast charge/discharge and high-power electronic techniques.Exploring the exceptional electrical properties in harsh environments can further promote their practical applications.Defect carriers can be excited under luminance irradiation,thereby leading to degradation of energy storage performance.Herein,a synergic optimization strategy is proposed to enhance energy storage properties and luminance resistance of(K_(0.5)Na_(0.5))NbO_(3)-base(KNN)ceramics.First,the introduction of Bi(Zn0.5Ti0.5)O_(3) solid solution and La3+ions disrupts the long-range polar orders and enhances super paraelectric relaxation characteristics.Additionally,doping La3+ions can increase the band gap and reduce oxygen vacancy concentration,resulting in excellent luminance resistance.Finally,the viscous polymer process is employed to suppress the grain growth and promote chemical homogeneity.As a result,ultrahigh recoverable energy storage density(Wrec)of 8.11 J/cm3 and high efficiency(η)of 80.98%are achieved under an electric field of 568 kV/cm.Moreover,the variations in Wrec andηare only 12.45%and 1.75%,respectively,under 500 W xenon lamp irradiation compared to the performance under a dark environment.These findings hold great potential in facilitating the practical application of dielectric ceramic capacitors in luminance irradiation environments. | Yu Huan Diyu Gui Changxiao Li Tao Wei Lingzhi Wu Xinjian Wang Xiaozhi Wang Zhenxiang Cheng | 2024 | Journal of Advanced Ceramics2024，13，1： | 0 |
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