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| 1 | 短暂性脑缺血发作的定义和评价:美国心脏协会/美国卒中协会卒中委员会、心血管外科和麻醉委员会、心血管放射学和介入委员会、心血管护理委员会和外周血管病跨学科委员会对医疗卫生专业人员发布的科学声明:美国神经病学学会确认该声明作为神经科医生继续教育工具的价值显示文摘本科学声明面向为短暂性脑缺血发作(transient ischemic attacks,TIA)患者提供医疗诊治的临床医生和相关医疗卫生人员。采用正规的证据复习方法对1990-2007年7月期间Medline数据库进行系统的文献检索,并运用证据表、汇总分析和病例资料的合并分析,对数据进行综合处理。本文支持以下基于组织学的TIA定义:局灶性脑、脊髓或视网膜缺血引起的短暂性神经功能障碍发作,且无急性脑梗死。TIA患者的近期卒中风险较高,可根据临床量表、血管影像学和磁共振弥散加权成像进行风险分层。诊断推荐包括:TIA患者应在发病24h内接受神经影像学评价,最好是应用包括弥散序列在内的MRI;应进行无创性颈部血管成像检查,最好是无创性颅内血管成像;对于未能确定血管病因的患者,TIA发病后应尽快进行心电图检查,也应考虑持续心电监测和超声心动图检查;应进行常规血液化验;对于发病72h内就诊并且ABCD^2评分≥3分(提示近期复发风险较高)或在门诊不能迅速完成诊断评价的TIA患者,应收入院治疗。 | J. Donald Easton Jeffrey L. Saver Gregory W. Albers Mark J. Alberts Seemant Chaturvedi Edward Feldmann Thomas S. Hatsukami Randall T. Higashida S. Claibome Johnston Chelsea S. Kidwell Helmi L. Lutsep Elaine Miller Ralph L. Sacco 李海峰 高翔(译) | 2009 | 国际脑血管病杂志2009，，9： | 86 |
| 2 | Biochar compost blends facilitate switchgrass growth in mine soils by reducing Cd and Zn bioavailability显示文摘Biochars have the potential to reclaim mine-impacted soils;however,their variable physico-chemical properties incite specu-lation about their successful remediation performance.This investigation examined the capability of biochars produced from three different feedstocks along with a compost blend to improve switchgrass growth conditions in a mine-impacted soil by examining influences on soil pH,grass metal contents,and soil-extractable metal concentrations.Cadmium(Cd)-and zinc(Zn)-contaminated mine soil was collected from a site near Webb City,Missouri,USA-a location within the Tri-State Min-ing District.In a full factorial design,soil was treated with a 0%,2.5%,and 5%(w/w)compost mixture(wood chips+beef cattle manure),and 0%,2.5%and 5%of each biochar pyrolyzed from beef cattle manure,poultry litter,and lodgepole pine feedstocks.Switchgrass(Panicum virgatum,‘Cave-In-Rock’variety)was grown in a greenhouse for 50 days and the mass of shoots(above-ground biomass)and roots was assessed,while soil pH,deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations were measured.Poultry litter biochar and compost had the greatest ability to raise soil pH(from 4.40 to 6.61),beef cattle manure biochar and compost moderately raised pH(from 4.4 to 5.92),and lodgepole pine biochar and compost weakly raised pH(from 4.40 to 5.05).Soils treated with beef cattle manure biochar,poultry litter biochar signifi-cantly reduced deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations,while lodgepole pine biochar-treated soils showed mixed results.Switchgrass shoot and root masses were greatest in soil treated with compost in combination with either beef cattle manure biochar or poultry litter biochar.Soils treated with 5%beef cattle manure biochar+5%compost had greater reductions in total Cd and Zn concentrations measured in switchgrass shoots and roots compared to the other two treatments.The three biochars and compost mixtures applied to heavy metal,mine-impacted soil had considerable performance dissimilarities for improving switchgrass productivity.Switchgrass growth was noticeably improved after treatment with the compost in combination with biochar from beef cattle manure or poultry litter.This may be explained by the increased soil pH that promoted Zn and Cd precipitation and organic functional groups that reduced soil-available heavy metal concentrations.Our results imply that creating designer biochars is an important management component in developing successful mine-site phytostabilization programs. | Jeffrey M.Novak James A.Ippolito Donald W.Watts Gilbert C.Sigua Thomas F.Ducey Mark G.Johnson | 2019 | Biochar2019，1，1： | 8 |
| 3 | Efficacy of Linaclotide for Patients With Chronic Constipation显示文摘 | Anthony J. Lembo Caroline B. Kurtz James E. MacDougall B.J. Lavins Mark G. Currie Donald A. Fitch Brenda I. Jeglinski Jeffrey M. Johnston | 2010 | Gastroenterology2010，，3： | 3 |
| 4 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 5 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 6 | 2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Clyde W. Yancy Mariell Jessup Biykem Bozkurt Javed Butler Donald E. Casey Mark H. Drazner Gregg C. Fonarow Stephen A. Geraci Tamara Horwich James L. Januzzi Maryl R. Johnson Edward K. Kasper Wayne C. Levy Frederick A. Masoudi Patrick E. McBride John J.V. | 2013 | Circulation2013，，16： | 2 |
| 7 | FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation显示文摘Tyrosine kinase inhibitors(TKIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other drugs.We investigated the combination of FLT3 TKIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia cells.The combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML samples.Venetoclax also re-sensitized FLT3 TKI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPK pathway inhibition.Gilteritinib treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to BCL-2.Venetoclax treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from BCL-2.Treatment with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased apoptosis.These findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TKI mainly through the dissociation of BIM and BCL-2 and also decreased BIM expression.This study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TKI therapy in FLT3/ITD AML treatment. | Ruiqi Zhu Li Li Bao Nguyen Jaesung Seo Min Wu Tessa Seale Mark Levis Amy Duffield Yu Hu Donald Small | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 8 | PARALLEL ADAPTIVE SIMULATION OF A PLUNGING LIQUID JET显示文摘This paper is concerned with three-dimensional numerical simulation of a plunging liquid jet.The transient processes of forming an air cavity around the jet,capturing an initially large air bubble,and the break-up of this large toroidal-shaped bubble into smaller bubbles were analyzed.A stabilized finite element method(FEM)was employed under parallel numerical simulations based on adaptive,unstructured grid and coupled with a level-set method to track the interface between air and liquid.These simulations show that the inertia of the liquid jet initially depresses the pool's surface,forming an annular air cavity which surrounds the liquid jet.A toroidal liquid eddy which is subsequently formed in the liquid pool results in air cavity collapse,and in turn entrains air into the liquid pool from the unstable annular air gap region around the liquid jet. | Azat Yu.Galimov Onkar Sahni Richard T.Lahey Jr. Mark S.Shephard Donald A.Drew Kenneth E.Jansen | 2010 | Acta Mathematica Scientia2010，30，2： | 2 |
| 9 | Practice Parameters for the Treatment of Perianal Abscess and Fistula-in-Ano ?(Revised)显示文摘 | Mark H. Whiteford M.D. John Kilkenny M.D. Neil Hyman M.D. W. Donald Buie M.D. Jeffrey Cohen M.D. Charles Orsay M.D. Gary Dunn M.D. W. Brian Perry M.D. C. Neal Ellis M.D. Jan Rakinic M.D. Sharon Gregorcyk M.D. Paul Shellito M.D. Richard Nelson M.D. Joe J. | 2005 | Diseases of the Colon & Rectum2005，，7： | 2 |
| 10 | Towards an explanatory and computational theory of scientific discovery显示文摘 | Chaomei Chen Yue Chen Mark Horowitz Haiyan Hou Zeyuan Liu Donald Pellegrino | 2009 | Journal of Informetrics2009，，3： | 2 |
| 11 | Understanding the relationship of perceived social support to post-trauma cognitions and posttraumatic stress disorder显示文摘 | Donald J. Robinaugh Luana Marques Lara N. Traeger Elizabeth H. Marks Sharon C. Sung J. Gayle Beck Mark H. Pollack Naomi M. Simon | 2011 | Journal of Anxiety Disorders2011，，8： | 1 |
| 12 | A denial-of-service resistant intrusion detection architecture 显示文摘 | Peter Mell Donald Marks Mark McLarnon | 2000 | Computer Security Division National Institute of Standards and Technology Elsevier Computer Networks 20002000，34，4： | 1 |
| 13 | Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture:bioenergetic and functional implications显示文摘 | Guy A Mark H Donald A | 2003 | Molecular Vision2003，9，： | 1 |
| 14 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 15 | The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by fungal pathogens and responds to methyl jasmonate but not to salicylic acid显示文摘 | John M. Manners Iris A.M.A. Penninckx Katrien Vermaere Kemal Kazan Rebecca L. Brown Andrew Morgan Donald J. Maclean Mark D. Curtis Bruno P.A. Cammue Willem F. Broekaert | 1998 | Plant Molecular Biology1998，，6： | 1 |
| 16 | Clinical and Angiographic Results With the Next-Generation Resolute Stent System显示文摘 | Ian T. Meredith Stephen Worthley Robert Whitbourn Darren L. Walters Dougal McClean Mark Horrigan Jeffrey J. Popma Donald E. Cutlip Ann DePaoli Manuela Negoita Peter J. Fitzgerald | 2009 | JACC: Cardiovascular Interventions2009，，10： | 1 |
| 17 | Mixed orthogonal frequen-cy coded SAW RFID tags 显示文摘 | Gallagher Mark W Malocha Donald C | 2013 | IEEE Trans on Ultrasonics Ferro-electrics and Frequency Control2013，60，3： | 1 |
| 18 | A passivewireless multi-sensor SAW technology device and system per-spectives 显示文摘 | Malocha Donald C Gallagher Mark Fisher Brian | 2013 | Sensors2013，13，5： | 1 |
| 19 | Migration of mesenchymal stem cells to heart allografts during chronic rejection显示文摘 | Gordon D. Wu Jan A. Nolta Yang-Sun Jin Mark L. Barr Hong Yu Vaughn A. Starnes Donald V. Cramer | 2003 | Transplantation2003，，5： | 1 |
| 20 | Obesity-induced hypertension : new concepts from the emerging biology of obesity显示文摘 | Mark AL Marcelo Correia Donald A | 1999 | Hypertension1999，33，： | 1 |
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