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| 1 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 2 | A Footpad Structure with Reusable Energy Absorption Capability for Deep Space Exploration Lander:Design and Analysis显示文摘The footpad structure of a deep space exploration lander is a critical system that makes the initial contact with the ground,and thereby plays a crucial role in determining the stability and energy absorption characteristics during the impact process.The conventional footpad is typically designed with an aluminum honeycomb structure that dissipates energy through plastic deformation.Nevertheless,its effectiveness in providing cushioning and energy absorption becomes significantly compromised when the structure is crushed,rendering it unusable for reusable landers in the future.This study presents a methodology for designing and evaluating structural energy absorption systems incorporating recoverable strain constraints of shape memory alloys(SMA).The topological configuration of the energy absorbing structure is derived using an equivalent static load method(ESL),and three lightweight footpad designs featuring honeycomb-like Ni-Ti shape memory alloys structures and having variable stiffness skins are proposed.To verify the accuracy of the numerical modelling,a honeycomb-like structure subjected to compression load is modeled and then compared with experimental results.Moreover,the influence of the configurations and thickness distribution of the proposed structures on their energy absorption performance is comprehensively evaluated using finite element simulations.The results demonstrate that the proposed design approach effectively regulates the strain threshold to maintain the SMA within the constraint of maximum recoverable strain,resulting in a structural energy absorption capacity of 362 J/kg with a crushing force efficiency greater than 63%. | Weiyuan Dou Xiaohang Qiu Zhiwei Xiong Yanzhao Guo Lele Zhang | 2023 | Chinese Journal of Mechanical Engineering2023，36，4： | 0 |
| 3 | The Impact of Population Aging on the Expenditure of Medical Insurance Fund for Urban Workers in China显示文摘Objective To explore the impact of population aging on the expenditures of medical insurance funds against the background that great changes in population structure influences economic development.Methods Through analyzing the impact of the population aging,the income and accumulated balance of the medical insurance fund,and other related factors on the expenditure of the medical insurance fund,development status of the medical insurance fund for urban employees in China since 2003 was obtained.Stata 16.0 was used to perform multiple linear regression analysis on related factors to determine the correlation between population aging and the change in medical insurance expenditures.Results and Conclusion The factors that have a greater impact on the expenditure of the medical insurance fund are the amount of income from the medical insurance,followed by the number of people over the age of 65 in China and the urban retired employees participating in medical insurance.We should focus on the sustainable development of the urban employee medical insurance fund to deal with the threat of aging. | Wang Shuling Dou Lele Shi Hui Huang Zhe | 2023 | Asian Journal of Social Pharmacy2023，18，3： | 0 |
| 4 | Investigation on the Current Situation of China’s DTP Pharmacy and Suggestions for Its Development显示文摘Objective To summarize the main characteristics and development approaches of direct-to-patient(DTP)pharmacies,and to explore its future development trend.Methods Firstly,relevant policies of DTP pharmacies were sorted out based on some documents on the government website,and related articles were studied.Secondly,499 DTP pharmacies were investigated.Finally,the current status of the industry was summarized and analyzed.Results and Conclusion Policies on China’s DTP pharmacy have been constantly improved.According to industry standards,the current compliance rate of DTP pharmacies is about 46.09%.In terms of varieties,the market share concentration rate of biological products is higher than that of chemical drugs.The regional distribution of these drugs is mainly concentrated in the central and eastern provinces.However,63.45%of DTP pharmacies have less than 50 product specifications.DTP pharmacies have an average of 7.3 pharmacy technicians and 2.3 licensed pharmacists,which is higher than that of ordinary pharmacies.Due to the policy promotion,DTP pharmacies will be paid more attention by the public and the government,and the market share will become larger than before.Patients shifting from hospitals to drug-to-pharmacies can make them better layout.Besides,pharmaceutical services will become more specialized,and disease division will be more detailed.With the deepening of medical reform and the continuous improvement of national medical security as well as drug procurement and medical insurance payment methods,DTP pharmacies can play an important role in the national basic medical security system. | Wen Dong Dou Lele Sun Yuyuan Wang Shuling | 2023 | Asian Journal of Social Pharmacy2023，18，2： | 0 |
| 5 | Comparative Analysis of Social Forces Participating in Emergency Management of Public Health Events in China, Australia, Germany and the United States显示文摘Objective To provide a reference and suggestions for Chinese social forces to participate in the emergency management of public health events.Methods Through literature research method,comparative research method and SWOT matrix analysis,four aspects of prevention,early warning,response and recovery of the social forces in China,Germany,Australia and the United States participating in emergency management were studied comparatively.Results and Conclusion In the emergency management of public health events,China’s social forces play greater role in the response and recovery phase than that in the prevention and response phase.As to its shortcomings,the following suggestions are made,such as incorporating social forces into the national emergency management system,strengthening the construction and training of social forces,popularizing public health knowledge and awareness,clarifying property rights and using incentives and punishment together. | Wang Shuling Dou Lele Lin Xiangpeng Liu Liang Chen Hui | 2022 | Asian Journal of Social Pharmacy2022，17，2： | 0 |
| 6 | Static strength and crashworthiness analysis of a train cowcatcher at a running speed of 160 km/h显示文摘The cowcatcher is one of the unique devices at the front end of the train, which can remove obstacles on the track by crashing before the vehicle body to ensure the safety of the train. When a collision accident happens, the cowcatcher serves as the first energy-absorbing structure to dissipate and guide the collision energy. The design of the existing cowcatcher of multiple units generally focuses on the good ability to remove obstacles, while the secondary function, the crashworthiness of orderly deformation under collision, still needs further research. In this study, a finite element model of structural static load and collision analysis was established under standard EN 15227, with the cowcatcher for 160 km/h train as the prototype. Then the solution and simulation process was accomplished under the environment of ANSYS and LS-DYNA. The analysis results showed that the structural static strength of the current cowcatcher met the requirements of the standard EN 15227, and the longitudinal stiffness was evenly distributed. When removing the obstacles with low mass, the impact force was small and the structure would not produce obvious deformation;when removing the obstacles with large mass, the impact force was large and the shear fracture might occur at the connection of the cowcatcher. | Yanzhao Guo Lele Zhang Weiyuan Dou Yu Zhu Haifeng Zhang | 2023 | High-Speed Railway2023，1，4： | 0 |
| 7 | Reflections on the Participation of Social Organizations in the Prevention of COVID-19显示文摘Objective To study the problems of Chinese social organizations in participating in the prevention and control of the COVID-19 pandemic so that we can standardize the participation mechanism,improve the collaborative management mechanism,and promote the development of social organizations.Methods Through the analysis of CNKI,news reports,industry conferences and other data,combined with the current situation,the participation of social organizations in public health emergencies were investigated.Results and Conclusion The coordination between government and social organizations is not good.Social organizations in the field of public health are unable to stand out in a timely manner.The public do not have self-management ability.Some of the media spread rumors.Besides,most social organizations are highly dependent on the government and they are ack supervision.Social organizations should be incorporated into the emergency management system and national hub-based social organizations must be established.In addition,supervision should be strengthened to increase the credibility of social organizations.The responsibilities of community and emergency management at the grassroots level should be enhanced.The public opinion response and disposal system should be improved.Lastly,the responsibility of social organizations in the field of public health must be fulfilled. | Liao Wenjing Lin Xiangpeng Liu Liang Dou Lele Wang Shuling | 2022 | Asian Journal of Social Pharmacy2022，17，4： | 0 |
| 8 | A Compensation Algorithm for Large Element Characterizing the Damage Evolution Process and Its Application to Structure Collisions显示文摘When simulating the process from elastic–plastic deformation,damage to failure in a metal structure collision,it is necessary to use the large shell element due to the calculation efficiency,but this would affect the accuracy of damage evolution simulation.The compensation algorithm adjusting failure strain according to element size is usually used in the damage model to deal with the problem.In this paper,a new nonlinear compensation algorithm between failure strain and element size was proposed,which was incorporated in the damage model GISSMO(Generalized incremental stress state dependent damage model)to characterize ductile fracture.And associated material parameters were calibrated based on tensile experiments of aluminum alloy specimens with notches.Simulation and experimental results show that the new compensation algorithm significantly reduces the dependence of element size compared with the constant failure strain model and the damage model with the linear compensation algorithm.During the axial splitting process of a circular tubular structure,the new compensation algorithm keeps the failure prediction errors low over the stress states ranging from shear to biaxial tension,and achieves the objective prediction of the damage evolution process.This study demonstrates how the compensation algorithm resolves the contradiction between large element size and fracture prediction accuracy,and this facilitates the use of the damage model in ductile fracture prediction for engineering structures. | Wen Liu Lele Zhang Yifan Ru Geng Chen Weiyuan Dou | 2023 | Chinese Journal of Mechanical Engineering2023，36，1： | 0 |
| 9 | Study of the Impact of the COVID-19 Pandemic on Health Insurance Fund of Hubei Province in 2020显示文摘Objective To provide a reference for future budget of health insurance fund for the COVID-19 pandemic in other parts of China or other major public health events.Meanwhile,it also offers a reference for the government to introduce and adjust the policy of health insurance funds after the pandemic.Methods Models of the income,expenditure and cumulative balance of health insurance fund in Hubei Province in 2020 were established and compared.The former was mainly established and tested using SPSS 26.0 and Excel,while the latter was obtained by inferential analysis.Results and Conclusion The COVID-19 pandemic reduced the income and increased expenditure of the health insurance fund in Hubei Province in 2020,resulting in a deficit.The COVID-19 outbreak has caused a deficit in health insurance fund of Hubei Province in the short term,but in the long term,the outbreak will not have a major impact on the health insurance fund. | Zhi Yuanyuan Dou Lele Xing Miaomiao Wang Shuling | 2021 | Asian Journal of Social Pharmacy2021，16，4： | 0 |
| 10 | Fatigue Characterization on a Cast Aluminum Beam of a High-Speed Train Through Numerical Simulation and Experiments显示文摘The cast aluminum beam is a key structure for carrying the body-hung traction motor of a high-speed train;its fatigue property is fundamental for predicting the residual life and service mileage of the structure.To characterize the structural fatigue property,a finite element-based method is developed to compute the stress concentration factor,which is used to obtain the structural fatigue strength reduction factors.A full-scale fatigue test on the cast aluminum beam is designed and implemented for up to ten million cycles,and the corresponding finite element model of the beam is validated using the measured data of the gauges.The results show that the maximum stress concentration occurs at the fillet of the supporting seat,where the structural fatigue strength reduction factor is 2.45 and the calculated fatigue limit is 35.4 MPa.Moreover,no surface cracks are detected using the liquid penetrant test.Both the experimental and simulation results indicate that the cast aluminum beam can satisfy the service life requirements under the designed loading conditions. | Weiyuan Dou Lele Zhang Haifeng Chang Haifeng Zhang Changqing Liu | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 0 |
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