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| 1 | A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living cells and tissues显示文摘Uridine diphosphate(UDP)-glucuronosyltransferases(UGTs)are enzymes involved in the biotransformation of important endogenous compounds such as steroids,bile acids,and hormones as well as exogenous substances including drugs,environmental toxicants,and carcinogens.Here,a novel fluorescent probe BDMP was developed based on boron-dipyrromethene(BODIPY)with high sensitivity for the detection of UGT1A8.The glucuronidation of BDMP not only exhibited a redemission wavelength(lex/lem=500/580 nm),but also displayed an excellent UGT1A8-dependent fluorescence signal with a good linear relationship with UGT1A8 concentration.Based on this perfect biocompatibility and cell permeability,BDMP was successfully used to image endogenous UGT1A8 in human cancer cell lines(LoVo and HCT15)in real time.In addition,BDMP could also be used to visualize UGT1A8 in tumor tissues.These results suggested that BDMP is a promising molecular tool for the investigation of UGT1A8-mediated physiological function in humans. | Mingyue Zhu Zhenhao Tian Lingling Jin Xiaokui Huo Chao Wang Jingnan Cui Yan Tian Xiangge Tian Lei Feng | 2022 | Frontiers of Chemical Science and Engineering2022，16，1： | 3 |
| 2 | Role,path,and vision of“5G+BDS/GNSS”显示文摘Communication,positioning,navigation,and decision-making abilities have evolved into Positioning,Navigation,and Timing(PNT)intelligence during the long process of human migration and hence promoted human evolution.This article defines intelligence and smartness from the perspective of biological intelligence.New requirements as a result of the development of communication,navigation,time service,and decision making are identified in this study.The article points out that there are many radio PNT service methods,such as 5G,the new-generation high-speed communication networks and the low-latency and ubiquitous mobile communication networks as well as Global Navigation Satellite System(GNSS),but the integrated application is especially important in providing technical support for the adjustment and control of the physical world by intelligent sensing,cognition,decision-making,and precise coordination.The fusion of 5G and GNSS[including BeiDou Navigation Satellite System(BDS)]information with the corresponding equipment can be embedded into a machine to make it intelligent.Furthermore,the fused information of 5G and GNSS together with the environment information may extend human perception and physical world control ability in terms of time and space scale.It will help to develop critical information infrastructure in the age of intelligence,which will also extend the definition of artificial intelligence.Additionally,the“5G+BDS/GNSS”fusion path is analyzed explicitly herein in terms of realization methods,information processing,and new application services.On the whole,the application of“5G+BDS/GNSS+satellite-based communication”as a critical infrastructure for land,sea,air,space and network spatiotemporal control rights is proposed. | Jingnan Liu Kefu Gao Wenfei Guo Jingsong Cui Chi Guo | 2020 | Satellite Navigation2020，1，1： | 2 |
| 3 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 4 | Colorimetric and Ratiometric Fluorescent Chemosensor with a Large Red-Shift in Emission:Cu(Ⅱ)-Only Sensing by Deprotonation of Secondary Amines as Receptor Conjugated to Naphthalimide Fluorophore显示文摘 | Xu Zhaochao Qian Xuhong Cui Jingnan | 2005 | Org Lett2005，7，： | 1 |
| 5 | Colorimetric and ratiometrie fluorescent chemosensor with a large red-shift in emission: Cu (Ⅱ)-only sensing by deprotonation of secondary amines as receptor conjugated to naphthalimide fluorophore 显示文摘 | Xu Zhaochao Qian Xuhong Cui Jingnan | 2005 | Organic Letters2005，7，14： | 1 |
| 6 | A NIR fluorescent probe for Vanin-1 and its applications in imaging, kidney injury diagnosis,and the development of inhibitor显示文摘Vanin-1 is an amidohydrolase that catalyses the conversion of pantetheine into the aminothiol cysteamine and pantothenic acid(coenzyme A precursor), which plays a vital role in multiple physiological and pathological processes. In this study, an enzyme-activated near-infrared(NIR) fluorescent probe(DDAV) has been constructed for sensitively detecting Vanin-1 activity in complicated biosamples on the basis of its catalytic characteristics. DDAV exhibited a high selectivity and sensitivity toward Vanin-1 and was successfully applied to the early diagnosis of kidney injury in cisplatin-induced kidney injury model. In addition, DDAV could serve as a visual tool for in situ imaging endogenous Vanin-1 in vivo. More importantly, Enterococcus faecalis 20247 which possessed high expression of Vanin-1 was screened out from intestinal bacteria using DDAV, provided useful guidance for the rational use of NSAIDs in clinic. Finally, oleuropein as a potent natural inhibitor for Vanin-1 was discovered fromherbal medicines library using a high-throughput screening method using DDAV, which held great promise for clinical therapy of inflammatory bowel disease. | Zhenhao Tian Fei Yan Xiangge Tian Lei Feng Jingnan Cui Sa Deng Baojing Zhang Tian Xie Shanshan Huang Xiaochi Ma | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
| 7 | Highly selective NIR fluorescent probe for acetylcholinesterase and its application in pesticide residues detection显示文摘A series of near-infrared(NIR)fluorescent substrates(NDRO-1∼8)derived from fluorophore NDRH with different volumes of ester bond as the recognition group were designed and synthesized for the detection of acetylcholinesterase(AChE),among which NDRO-1 with the smallest acetate group displayed the highest activity toward AChE.The detection limit of NDRO-1 for sensing AChE was 0.32μg/mL,and K_(m )was 6.40μmol/L,indicating ultra-sensitivity and good affinity of NDRO-1 toward AChE.NDRO-1 was used to detect the inhibitory of four kinds of pesticides including methamidophos,dichlorvos,and the detection limit was lower than 50μg/L,which was further used in pesticide residues detection. | Shengui He Shufang Zhang Xin Zhao Xinyue Zhu Lisen Chen Jingnan Cui | 2022 | Chinese Chemical Letters2022，33，9： | 1 |
| 8 | Colorimetric and Ratio-metric Fluorescent Chemosensor with a Large Red-Shift in Emission :Cu ( II) -Only Sensing by Deprotonation of Secondary Amines asReceptor Conjugated to Naphthalimide Fluorophore 显示文摘 | Zhaochao Xu Xuhong Qian Jingnan Cui | 2005 | ORGANICLETTERS2005，7，14： | 1 |
| 9 | A new class of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells显示文摘 | Kong Zhixia Zhou Huizhi Cui Jingnan | 2010 | J Photochem Photobio A :Chem2010，213，： | 1 |
| 10 | A practical strategy to develop isoform-selective near-infrared fluorescent probes for human cytochrome P450 enzymes显示文摘Currently,the development of selective fluorescent probes toward targeted enzymes is still a great challenge,due to the existence of numerous isoenzymes that share similar catalytic capacity.Herein,a double-filtering strategy was established to effectively develop isoenzyme-specific fluorescent probe(s)for cytochrome P450(CYP)which are key enzymes involving in metabolism of endogenous substances and drugs.In the first-stage of our filtering approach,near-infrared(NIR)fluorophores with alkoxyl group were prepared for the screening of CYP-activated fluorescent substrates using a CYPs-dependent incubation system.In the second stage of our filtering approach,these candidates were further screened using reverse protein-ligand docking to effectively determine CYP isoenzyme-specific probe(s).Using our double-filtering approach,probes S9 and S10 were successfully developed for the real-time and selective detection of CYP2C9 and CYP2J2,respectively,to facilitate high-throughput screening and assessment of CYP2C9-mediated clinical drug interaction risks and CYP2J2-associated disease diagnosis.These observations suggest that our strategy could be used to develop the isoform-specific probes for CYPs. | Lei Feng Xiangge Tian Dahong Yao Zhenlong Yu Xiaokui Huo Zhenhao Tian Jing Ning Jingnan Cui Tony D.James Xiaochi Ma | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 11 | Incorporation of carbazole and boron-containing dye into conjugated microporous polymers with significant aerobic oxidative photocatalysis显示文摘Carbazole-based conjugated microporous polymers(CMPs)as a new type of advanced porous material have created tremendous research curiosities in the area of photocatalysis.Besides,introducing boron-containing dyes into the CMPs framework was rare but will be rather promising due to their unique properties,including strong electron-accepting capability,efficient catalytic behaviour,significant absorption coefficient and high quantum.Herein,we rationally designed and prepared two new CMPs,i.e.Cz-BF_(2)-CMP and Cz-BPh2-CMP with the combination of carbazole and boron-containing dye as electron donor and acceptor motifs,respectively.Due to the efficient D-A effect between carbazole and boron-dye which not only accelerated the interfacial charge transfer efficiency but also improved the separation capability of photogenerated electron-hole pairs,both CMPs exhibited excellent photocatalytic performances in organic transformations such as green synthesis of benzimidazole in aqueous solution and aerobic oxidation of thioether in EtOH. | Lu Liu Kaixun Dong Mehdi Hassan Weitao Gong Jingnan Cui Guiling Ning | 2022 | Green Synthesis and Catalysis2022，3，4： | 0 |
| 12 | 肿瘤再生细胞通过犬尿氨酸转移以及芳香烃受体激活诱导CD8^+T细胞表达PD-1显示文摘文章简介肿瘤免疫治疗是当前肿瘤研究的热点领域之一,通过利用免疫细胞、免疫分子直接或间接杀伤肿瘤细胞,以控制或清除肿瘤,被认为是人类战胜癌症的希望所在。肿瘤免疫治疗主要依赖活化的T细胞杀伤肿瘤细胞. | 刘玉英 梁晓雨 董文茜 Yi Fang Jiadi Lv Tianzhen Zhang Roland Fiskesund Jing Xie Jinyan Liu Xiaonan Yin Xun Jin Degao Chen Ke Tang Jingwei Ma Huafeng Zhang Jing Yu Jun Yan Huaping Liang Siqi Mo Feiran Cheng Yabo Zhou Haizeng Zhang Jing Wang Jingnan Li Yang Chen Bing Cui Zhuo-Wei Hu Xuetao Cao F. Xiao-Feng Qin 黄波 | 2019 | 科学新闻2019，0，2： | 0 |
| 13 | Real-time quantification for sulfite using a turn-on NIR fluorescent probe equipped with a portable fluorescence detector显示文摘Sulfur dioxide and its derivative sulfite widely existed in air,water as the environment pollutant.Sulfite is also commonly used as preservative and additive in fresh fruits,vegetables,wines and pharmaceutical materials.Due to sulfite is closely related with human diseases,it is very urgent for the sensitive and rapid quantification of sulfite in various samples.In our study,a turn-on near infrared(NIR)fluorescent probe(MDQ)was developed for sulfite detection based on a Michael addition reaction,with high sensitivity(LOD 4.16 nmol/L),selectivity and fast response time(400 s).Using MDQ,a quantify method for sulfite in traditional Chinese medicines(TCMs)was developed with the advantages of high precision,accuracy and convenient operation.Furthermore,according to the photophysical property of MDQ,a portable fluorescence detector is designed to quantify sulfite for TCMs and surface water in Dalian city of China.Therefore,the developed fluorescent probe MDQ and portable fluorescent detector as a rapid inspection instrument were successfully used to real-time monitor the sulfite in various complex samples. | Fei Yan Jingnan Cui Chao Wang Xiangge Tian Dawei Li Yan Wang Baojing Zhang Lei Feng Shanshan Huang Xiaochi Ma | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 14 | High-throughput fluorescent screening of thioredoxin reductase inhibitors to inhibit Mycobacterium tuberculosis显示文摘Tuberculosis(TB)is a chronic infectious disease,which is caused by the pathogen Mycobacterium tuberculosis(Mtb)and reemerged as a global health risk with a significant proportion of multi-drug resistant and extensively drug resistant TB cases.It is very urgent to find some novel high-confidence drug targets in Mtb for discovering the effective anti-TB agents.Thioredoxin reductase(TrxR)has been identified to be a highly viable target for anti-TB drugs for its important role in protecting the pathogen from thiol-specific oxidizing stress,regulating intracellular dithiol/disulfide homeostasis and DNA replication and repair.In the present work,a near-infrared(NIR)fluorescent probe DDAT was developed for the detection of TrxR activity and used to high-throughput screen the TrxR inhibitors from natural products.Two screened TrxR inhibitors from Sappan Lignum and microbial metabolites that were further used to inhibit Mycobacterium tuberculosis.All the results indicate that DDAT is a practical fluorescent molecular tool for the discovery of potential anti-TB drugs. | Fei Yan Xin Zhao Ruibo Li Xiuyan Han Qiulong Yan Lei Feng Xiulan Xin Jingnan Cui Xiaochi Ma | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 15 | Insertion of pillar[5]arene into Troger’s base-derived porous organic polymer for promoted heterogeneous catalytic performance in Knoevenagel condensation and CO_(2)fixation显示文摘Development of new metal-free heterogeneous catalysts has long been the focus of intense research interest.The integration of multifunctional monomers into the skeletons of porous organic polymers(POPs)provides an efficient pathway to achieve this goal.Herein,we rationally designed and successfully prepared a new Troger’s base(TB)-derived POPs by insertion of pillar[5]arene macrocycle as a positively auxiliary group.Combined the both merits of pillar[5]arene macrocycle and TB moiety,the as-prepared polymer was further explored as an effective metal-free heterogeneous catalyst and exhibited promoted catalytic performance in Knoevenagel condensation and CO_(2)conversion.This work provides a new strategy to fabricate metal-free heterogeneous catalysts based on macrocyclic POPs. | Lu Liu Ziyi Liu Jingnan Cui Guiling Ning Weitao Gong | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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