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| 1 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 2 | Pulse-compression down to 20fs using a photonic crystal fiber seeded by a diode-pumped Yb∶ SYS laser at 1070nm显示文摘 | DRUON F GEORGES P | 2004 | Optics Express2004，12，15： | 1 |
| 3 | Direct and absolute temperature mapping and heat transfer measurements in diode-end-pumped Yb: YAG显示文摘 | Chenais S Forget S Druon F | 2004 | Applied Physics B : Lasers and Optics2004，79，2： | 1 |
| 4 | Efficient, tunable, zero- line diode-pumped, continuous-wave Yb^3+ : Ca4LnO ( BOa )a (Ln=Gd, Y) lasers at room temperature and application to miniature lasers显示文摘 | F Druon F Aug6 F Balembois | 2000 | J Opt Soc Am B2000，17，1： | 1 |
| 5 | Passively mode-locked diode-pumped Nd : YVO4 oscillator operat- ing at an uhralow repetition rate 显示文摘 | Papadopoulos D N Delaigue M Druon F | 2003 | Optics letters2003，28，19： | 1 |
| 6 | Multiwatt, tunable, diode-pumped CW Yb:GdCOB laser显示文摘 | S Chfinais F Druon F Balembois | 2001 | Appl Phys B2001，72，4： | 1 |
| 7 | Second-harmonic generation and wave-front correction of a terawatt laser system显示文摘 | QUENEUILLE J DRUON F MAKSIMCHUK A | 2000 | Optics Letters2000，25，： | 1 |
| 8 | Diode-pumped Passively Mode-locked Nd:YVO,laser at 914 nm显示文摘 | BLANDIN P DRUON F GEORGS P | 2006 | Optics Letters2006，31，2： | 1 |
| 9 | Thermal lensing in diode-pumped ytterbium lasers-part I: theoretical analysis and wavefront measurements 显示文摘 | Chenais S Balembois F Druon F | 2004 | IEEE Journal of Quantum Electronics2004，40，9： | 1 |
| 10 | Distributed nonlinear fiber chirped - pulse amplifier system 显示文摘 | Marc Hanna Dimitris Papadopoulos Frederic Druon | 2009 | Optics Express2009，17，10： | 1 |
| 11 | Diode-pumped Yb:GGG Laser:Comparison with Yb:YAG显示文摘 | Chenais S Druon F Balembois F | 2003 | Optical Materials2003，22，： | 1 |
| 12 | Diode-pumped Yb:GGG laser comparison withYb:YAG显示文摘 | CHENAIS S DRUON F BALEMBOIS F | 2003 | Opt Mater2003，22，： | 1 |
| 13 | Diode-pumped Yb;Sr3 Y(BO3 )3 femtosecond laser显示文摘 | F Druon S Chénais P Raybaut et ol | 2002 | Optics Letters2002，27，： | 1 |
| 14 | Thermal lensing in diode-pumped ytterbium lasers-part Ⅰ:theoretical analysis and wavefront measurements显示文摘 | CHENAIS S BALEMBOIS F DRUON F | 2004 | IEEE J Q E2004，40，9： | 1 |
| 15 | Diode-pumped Yb:GGG laser: comparison with Yb:YAG显示文摘 | S. Chénais F. Druon F. Balembois P. Georges A. Brenier G. Boulon | 2002 | Optical Materials2002，，2： | 1 |
| 16 | Power Density Control in Microwave Assisted Air Drying to Improve Quality of Food显示文摘 | Kone K Y Druon C Gnimpieba EZ | 2013 | Journal of Food Engineering2013，119，4： | 1 |
| 17 | Passively Q switched diode-pumped Cr^4+ : YAG/Nd^3+ : GdVO4 monolithic microchip laser显示文摘 | FORGET S DRUON F BALEMBOIS F | 2006 | Opt Commun2006，259，2： | 1 |
| 18 | Diode-pumped Yb∶GGG laser:comparision with Yb∶YAG显示文摘 | Druon F Balembois F | 2003 | Optical Materials2003，22，： | 1 |
| 19 | Considerations about pure proportional navigation显示文摘 | Druon E | 1994 | IEEE 0-7803-2129-41994，，： | 1 |
| 20 | Second-Harmonic Generation and Wave-Front Correction of a Terawatt Laser System显示文摘 | Druon F Maksimchuk A | 2000 | OPTICS LETTERS2000，25，7： | 1 |
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