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| 1 | Comparative analysis of upper ureteral stones (>15 mm) treated with retroperitoneoscopic ureterolithotomy and ureteroscopic pneumatic lithotripsy显示文摘 | YunYan Wang JianQuan Hou DuanGai Wen Jun OuYang JunSong Meng HaiJun Zhuang | 2010 | International Urology and Nephrology2010，，： | 2 |
| 2 | Prostate cancer in the senior men from rural areas in east district of China: Contemporary management and 5-year outcomes at multi-institutional collaboration显示文摘 | Qiang Shao Jun Ouyang Youzhang Fan Jianjun Xie Jundong Zhou Jingchang Wu A. Karim Kader Jianfeng Xu Guihua Liu Yuxi Shan Duangai Wen Yuanyuan Zhang | 2011 | Cancer Letters2011，，2： | 1 |
| 3 | 血清白细胞介素18在前列腺癌患者中的临床价值(英文)显示文摘Objective: To determine serum interleukin-18 (IL-18) levels and their clinical significance in patients with prostate cancer. Methods: Peripheral blood samples were obtained from 38 nonmetastatic and 18 metastatic prostate cancer patients who underwent curative surgery and from 25 healthy volunteers. The serum IL-18 level was determined in each sample with the enzyme-linked immunosorbent assay. Results: The levels of serum IL-18 were increased significantly in prostate cancer patients compared with control subjects (P < 0.05). Serum IL-18 levels were significantly higher in the metastatic patients compared with the nonmetastatic patients (P < 0.01). Patients with bone metastasis had higher serum IL-18 levels compared with patients with liver and lung metastasis (P < 0.01). When the patients were subdivided into groups, it was found that the serum IL-18 levels in patients with T2, T3 and T4 stage were significantly higher than that of T1 stage patients (P < 0.01). Pa- tients with IL-18 levels ≥ 316 pg/mL experienced a significantly lower survival rate compared with the patients who had IL-18 levels < 316 pg/mL after undergoing surgery (P < 0.05). The serum IL-18 level was identified as an independent postopera- tive prognostic factor in multivariate survival analysis using a Cox proportional hazards model (hazard ratio, 4.21; P = 0.02). Conclusion: The serum IL-18 level may be a useful marker in monitoring prostate cancer patients. IL-18 activity in prostate cancer patients with bone metastasis may be more valuable in the follow-up. | Shaojun Nong Duangai Wen Caibin Fan Jun Ouyang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，6： | 0 |
| 4 | 膀胱癌组织中MMP-2与TIMP-2 mRNA的表达及临床意义(英文)显示文摘Objective:The aim of the study was to investigate the expressions of matrix metalloproteinase-2(MMP-2) and tissue inhibitor of MMP-2(TIMP-2) mRNA in transitional cell carcinomas of bladder and discuss their clinical significances.Methods:Using RT-PCR and real time quantitative PCR(RQ-PCR) technique,the expressions of MMP-2 and TIMP-2 mRNA of 45 cases of bladder carcinoma(tumor group) and 10 cases of normal bladder tissue(control group) were analyzed.Results:MMP-2 and TIMP-2 were not expressed in control group.MMP-2 was expressed in 30 cases tumor samples and TIMP-2 was expressed in 26 cases.The expression of MMP-2 mRNA in non-muscle invasive bladder cancers and grade I cancers was lower than that in muscle invasive bladder cancers and grades II-III cancers respectively.The differences were statistically significant(P<0.05).The expression of MMP-2 in recurrent patients was higher than that in incipient patients.TIMP-2 mRNA expression decreased with grades and stage.The expression of TIMP-2 in non-muscle invasive bladder cancers and grade I cancers was higher than that in muscle invasive bladder cancers and grades II-III cancers respectively.There was statistical difference between two groups(P < 0.05).TIMP-2 expression in incipient patients was higher than that in recurrent patients,but the difference was not significant(P>0.05).Conclusion:These results suggest that MMP-2 and TIMP-2 play an important role in the invasion step of transitional cell carcinoma of bladder.MMP-2 may become a new approach to the diagnosis of bladder carcinoma. | Yunyan Wang Junsong Meng Haijun Zhuang Jianquan Hou Duangai Wen | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，5： | 0 |
| 5 | Establishment of orthotopic transplantation model of human bladder cancer and detection by MRI显示文摘Objective: To establish an orthotopic bladder cancer model bearing human bladder cancer for experimental research, and monitor tumor progression by magnetic resonance imaging (MRI). Methods: The mucosa was mechanically damaged transurethrally under direct vision, and then human bladder cancer cell line T24 was inoculated into the bladders of BALB/c nude mice to establish orthotopic bladder cancer model. To find a suitable concentration of Gd-DTPA for this re- search. MRI was performed weekly to assess tumor growth, using Gd-DTPA as contrast agent. The pathologic morphology of the bladders and other specimens were observed with HE stain. Results: All the 25 mice developed bladder cancer after inoculation. The best concentration of Gd-DTPA was 1.408 mg/mL. On MRI, no change in the bladders was observed on day 7 after inoculation, filling defect in the bladders, accordant to actual tumor size, was detected on days 14, 21 and 28. Pathologic examination showed that tumor grew in the mucosa or superficial muscle of bladder on day 7, confined in muscle layer on days 14–28, and invaded serosa on day 35. Conclusion: Transurethrally damaged bladder mucosa under direct vision and instilled bladder cancer cell T24, we successfully established an orthotopic bladder cancer model. Tumor growth simulated the progression of human bladder cancer approximately. MRI was a reliable way for dynamic detection of murine orthotopic bladder tumor. | Shenmin Yang Duangai Wen Jianquan Hou Jun He Jianhua Chen | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，1： | 0 |
| 6 | The Relationship of PSA,PSAD and Clinicopathological Stage in Patients with Prostate Cancer显示文摘OBJECTIVE To investigate the relationship between the clinicopatho- logical stage and serum prostate specific antigen(PSA)concentration and PSAdensity(PSAD)in patients with prostate cancer. METHODS The clinicopathological stage was determined on the basis of a pathological examination and clinical data in 65 prostate cancer patients treated by radical prostatectomy.PSA and PSAD were measured before the operation.The Spearman rank correlation was applied to evaluate the relationship between the clinicopathological stage,serum PSAconcentration and PSAD. RESULTS Patients with higher PSA and PSAD were significantly more likely to have higher clinical stages,a higher Gleason score,positive surgical margins,capsular penetration,and seminal vesicle invasion(each P<0.05). But there was no significant association between PSA and lymph node metastasis(P=0.053).The levels of serum PSA concentration and PSAD were significantly correlated with the clinical stage(P<0.05)in the prostate cancer patients. CONCLUSION The level of both PSA and PSAD were significantly correlated with the clinical stage(P<0.05)in the prostate cancer patients.But PSAD may be a more powerful predictor of clinical stage and prognosis than PSA. | Shaojun Nong Duangai Wen Caibin Fan | 2007 | Chinese Journal of Clinical Oncology2007，4，5： | 0 |
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