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	题名	作者	年代	出处	被引量
1	Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer显示文摘AIM To characterize the expression of toll-like receptors(TLR) 2 and 4 in colorectal cancer(CRC) and in normal colorectal mucosa.METHODS We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present. Expression levels in different locations were compared and their associations with clinicopathological features including TNM-stage and the grade of the tumour and 5-year follow-up observations were analysed.RESULTS Normal colorectal epithelium showed a gradient of expression of both TLR2 and TLR4 with low levels in the crypt bases and high levels in the surface. In CRC, expression of both TLRs was present in all cases and in the major proportion of tumour cells. Compared to normal epithelium, TLR4 expression was significantly weaker but TLR2 expression stronger in carcinoma cells. Weak TLR4 expression in the invasive front was associated with distant metastases and worse cancerspecific survival at 5 years. In tumours of the proximal colon the cancer-specific survival at 5 years was 36.9% better with strong TLR4 expression as compared with those with weak expression(P = 0.044). In contrast, TLR2 expression levels were not associated with prognosis. Tumour cells in the lymph node metastases showed higher TLR4 expression and lower TLR2 expression than cells in primary tumours.CONCLUSION Tumour cells in CRC show downregulation of TLR4 and upregulation of TLR2. Low expression of TLR4 in the invasive front predicts poor prognosis and metastatic disease.	Karoliina Paarnio Sara Vayrynen Kai Klintrup Pasi Ohtonen Markus J Makinen Jyrki Makela Tuomo J Karttunen	2017	World Journal of Gastroenterology2017，23，26：	8
2	HIF-1α and VEGF are Associated with Disease Progression in Esophageal Carcinoma显示文摘	Heikki Takala Juha Saarnio Heikki Wiik Pasi Ohtonen Ylermi Soini	2011	Journal of Surgical Research2011，，1：	2
3	Characterization of ‘safe sites’ for pioneers in primary succession on recently deglaciated terrain 显示文摘	Jumpponen A V?re H Mattson KG Ohtonen R Trappe JM	1999	J Ecol1999，87，1：	1
4	Rerupture and deep infection following treatment of Achilles tendon rupture 显示文摘	Pajala A Kangas J Ohtonen P	2002	J Bone Joint Surg Am2002，84，11：	1
5	Endovenous obliteration versus conventional stripping operation in the treatment of primary varicose veins : a randomized controlled trial with comparison of costs 显示文摘	Rautio T Ohiunta A Ohtonen P	2002	J Vasc Surg2002，35，5：	1
6	Arthroscopic Bankart repair: results and risk factors of recurrence of instability显示文摘	Flinkkila T Hyvonen P Ohtonen P	2010	Knee Surg Sports Traumatol Arthrosc2010，18，12：	1
7	(Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis显示文摘	Peltonen T N(a)p(a)nkangas J Ohtonen P		0，，01：	1
8	Neurogenic Pulmonary Edema in Patients with Nontraumatic Intracerebral Hemorrhage: Predictors and Association with Outcome显示文摘	Eija Junttila Tero Ala-Kokko Pasi Ohtonen Anne Vaarala Ari Karttunen Olli Vuolteenaho Tuula Salo Meeri Sutinen Toni Karhu Karl-Heinz Herzig Juha Koskenkari	2013	Anesthesia & Analgesia2013，，4：	1
9	Point prevalence and risk factors for healthcare-associated infections in primary healthcare wards显示文摘	Puhto T Ylipalosaari P Ohtonen P	2011	Infection2011，39，3：	1
10	Incidence of osteo- tomies around the knee for the treatment of knee osteoarthritis : a 22-year population-based study显示文摘	Niinimaki TF Eskelinen A Ohtonen P	2012	Int Orthop2012，36，7：	1
11	Rerupture and deep infection following treatment of Achilles tendon rupture 显示文摘	Pajala A Kangas J Ohtonen P	2002	J Bone Joint Surg Am2002，84，11：	1
12	Rerupture and deep infection following treatment of total Achilles tendon rupture 显示文摘	Pajala A Kangas J Ohtonen P	2002	J Bone Joint Surg( Am )2002，11，：	1
13	Five ~ year outcome of laparoscopic and Lichtenstein hernioplasties显示文摘	Bringman S Ohtonen P	2004	Surg Endosc2004，18，3：	1
14	Stability criteria for nonoperative ankle fracture management 显示文摘	Pakarinen HJ Flinkkil TE Ohtonen PP	2011	Foot Ankle Int2011，32，2：	1
15	Ecosystem properties and microbial community changes in primary succession on a g lacier forefront 显示文摘	Ohtonen R Fritze H Pennanen T	1999	O ecologia1999，119，：	1
16	Effect of monomer composition ofpolymer matrix on flexural properties of glass fibre-reinforced or-thodontic archwire 显示文摘	Ohtonen J Vallittu PK Lassila LV	2013	Eur J Orthod2013，35，1：	1
17	Neurogenic pulmonary edema in patients with nontraumatic intracerebral hemorrhage:predictors and association with outcome显示文摘	Junttila E Ala-Kokko T Ohtonen P	2013	Anesth Analg2013，116，4：	1
18	Rerupture and deep infection following treatment of Achilles tendon rupture 显示文摘	Pajala A Kangas J Ohtonen P	2002	J Bone Joint Surg(Am)2002，84，11：	1
19	Point prevalence and risk factors for healthcare-associated infections in primary healthcare wards显示文摘	Puhto T Ylipalosaari P Ohtonen P	2011	Infection2011，39，3：	1
20	Surgical treatment of extra-articular or simple intra-articular distal tibial fractures:external fixation versus intramedullary nailing显示文摘	Ristiniemi J Lunkinen P Ohtonen P	2011	J Orthop Trauma2011，25，2：	1

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