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| 1 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 2 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 2 |
| 3 | A two dimensional numerical study of the stick-slip extrusion instability显示文摘 | ELENI T GEORGIOS C G ANDREAS N A | 2007 | J Non-Newton Fluid Mech2007，146，： | 1 |
| 4 | Impact of high cadmium and nickel soil concentration on selected physiological pa- rameters of Amndo donax L 显示文摘 | ELENI G PAPAZOGLOU | 2007 | European Journal of Soil Biology2007，，3： | 1 |
| 5 | Statistical methods for detecting nonlinearity and non-stationarity in univariate short-term time-series of traffic volume 显示文摘 | Eleni I Vlahogianni Matthew G Karlaftis John C Golias | 2006 | Transportation Research Part C2006，14，5： | 1 |
| 6 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 1 |
| 7 | Microbiological,chemical and sensory changes of whole and filleted Mediterranean aquacultured sea bass(Dicentrarchus labrax)stored in ice显示文摘 | Dimitra Taliadourou Vassilios Papadopoulos Eleni Domvridou Ioannis N Savvaidis Michael G Kontominas | 2003 | Journal of the Science of Food and Agriculture2003，83，： | 1 |
| 8 | Quality of life: it's never too late 显示文摘 | CHRISTOPHER BS GAVINM M ELENI G | 2002 | J Clin Oncol2002，20，13： | 1 |
| 9 | Idiotypeantiidiotype circuit in non-autoimmune mice after immunization with the epitope and complementary epitope 289-308aa of La/SSB:implications for the maintenance and perpetuation of the anti-La/SSB response显示文摘 | John G Routsiasa Eleni Dotsikab Eugenia Touloupia | 2003 | Journal of Autoimmunity2003，21，： | 1 |
| 10 | Metal tetraphosphonate ' wires ' and their corrosion inhibiting passive films 显示文摘 | Konstantinos D D Eleni B Raphael G R | 2009 | lnorg Chem2009，48，： | 1 |
| 11 | Characterization and compar ison of thermostabihty of purified 13-glucosidases form a mesophilic Aureo basidium pullulans and a thermophilic Thermoascus aurant/acus 显示文摘 | RODRIGO S R L ELENI G ROBERTO D S | 2007 | Process Biochemistry2007，42，6： | 1 |
| 12 | Control charts for the toxicity ot finished water-Modeling the structure of toxicity显示文摘 | Eleni M S Demetrios E K Spyridon K G | 2007 | Water Research2007，41，12： | 1 |
| 13 | A wind-hydro-pumped storage station leading to high RES penetration in the autono- mous island system of ikaria显示文摘 | Stefanos V Papaeflhymiou Eleni G Karamanou Stavros A Papathanassiou | 2010 | IEEE Transactions on Sustainable Energy2010，1，3： | 1 |
| 14 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | 2010 (9756)2010，，9756： | 1 |
| 15 | Optimized and metaoptimized neural networks for short-term traffic flow prediction:a genetic approach显示文摘 | Eleni I V Matthew G K John C G | | 0，，： | 1 |
| 16 | A study on pitting behavior of AA2024/SiCp composites using the double cycle polarization technique显示文摘 | Grigoris E K Stefanos M S Eleni G P | 1999 | Corrosion Sci- ence1999，41，： | 1 |
| 17 | Growth hormone and insulin-like growth factor I protect intestinal cells from radiation induced apoptosis显示文摘 | Panagiotis G Mylonas Panagiota T Matsouka Eleni V Papandoniou Constantine Vagianos Fotis Kalfarentzos Theodore K Alexandrides | 2000 | Molecular and Cellular Endocrinology2000，，1： | 1 |
| 18 | Partial characterization of protease from a thermophilic fungus,Thermoascus aurantiacus,and its hydrolytic activity on bovine casein显示文摘 | Merheb C W Cabral H Eleni G | 2007 | Food Chemistry2007，104，1： | 1 |
| 19 | The transmembrane form of tumor necrosis factor is the prime activating hgand of the 80kD tumor necrosis factor receptor 显示文摘 | Matthias G Eleni D Harald W | 1995 | Cell1995，83，12： | 1 |
| 20 | Impact of high cadmium and nickel soil concentration on selectedphysiological parameters of Arundo donax L 显示文摘 | Eleni G P Konstantinos G S Dimitris L B | 2007 | European Journal of Soil Biology?2007，43，4： | 1 |
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