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| 1 | New flexible endoscopic controlled stapler technique for the treatment of Zenker's diverticulum:A case series显示文摘AIM To report about the combination and advantages of a tapler-assisted diverticulotomy performed by flexible endoscopy.METHODS From November 2014 till December 2015 17 patients(8 female, 9 male, average age 69.8 years) with a symptomatic Zenker diverticulum(mean size 3.5 cm) were treated by inserting a new 5 mm fully rotatable surgical stapler(Micro Cutter30 Xchange, Cardica Inc.) next to an ultrathin flexible endoscope through an overtube. The Patients were under conscious sedation with the head reclined in left position, the stapler placed centrally and pushed forward to the bottom of the diverticulum. The septum was divided by the staple rows under flexible endoscopic control.RESULTS In eleven patients(64.7%) the stapler successfully divided the septum completely. Mean procedure time was 21 min, medium size of the septum was 2.8 cm(range 1.5 cm to 4 cm). In four patients the septum was shorter than 3 cm, in seven longer than 3 cm. To divide the septum, averagely 1.3 stapler cartridges were used. Two minor bleedings occurred. Major adverse events like perforation or secondary haemorrhage did not occur. After an average time of two days patients were discharged from the hospital. In 6 patients(35.3%) the stapler failed due to a thick septum or insufficient reclination of the head. Follow up endoscopy was performed after an average of two months in 9 patients; 4 patients(44.4%) were free of symptoms, 5 patients(55.6%) stated an improvement. A relapse of symptoms did not occur. CONCLUSION Flexible endoscopic Zenker diverticulotomy by using a surgical stapler is a new, safe and efficient treatment modality. A simultaneously tissue opening and occlusion prevents major complications. | Johanna Wilmsen Robert Baumbach Dietmar Stüker Vincens Weingart Frank Neser Stefan Karl Golder Christof Pfundstein Ellen Claudia Notzel Thomas Rosch Siegbert Faiss | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 2 | Major depressive disorder: new clinical, neurobiological, and treatment perspecti- ves 显示文摘 | David J Kupfer Ellen Frank Mary L Phillips | 2012 | The Lancet2012，379，： | 1 |
| 3 | Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains显示文摘 | Johannes V Swinnen Paul P Van Veldhoven Leen Timmermans Ellen De Schrijver Koen Brusselmans Frank Vanderhoydonc Tine Van de Sande Hannelore Heemers Walter Heyns Guido Verhoeven | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 4 | Which chronic conditions are associated with better or poorer quality of life?显示文摘 | Mirjam A.G. Sprangers Ellen B. de Regt Frank Andries Heleen M.E. van Agt Rob V. Bijl Josien B. de Boer Marleen Foets Nancy Hoeymans Annelies E. Jacobs Gertrudis I.J.M. Kempen Harold S. Miedema Marja A.R. Tijhuis Hanneke C.J.M. de Haes | 2000 | Journal of Clinical Epidemiology2000，，9： | 1 |
| 5 | The antral follicle count is a better marker than basal follicle-stimulating hormone for the selection of older patients with acceptable pregnancy prospects after in vitro fertilization显示文摘 | Ellen RK Frank JMB Caspar WNL | 2005 | Fertil Steril2005，83，3： | 1 |
| 6 | Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People显示文摘 | Diana G Redwood Elvin D Asay Ian D Blake Pamela E Sacco Claudia M Christensen Frank D Sacco James J Tiesinga Mary E Devens Steven R Alberts Douglas W Mahoney Tracy C Yab Patrick H Foote Thomas C Smyrk Ellen M Provost David A Ahlquist | 2016 | Mayo Clinic Proceedings2016，，： | 1 |
| 7 | Dissociated cerebral vasoparalysis in acute liver failure显示文摘 | Fin Stolze Larsen Bent Adel Hansen Frank Pott Ellen Ejlersen Niels H. Secher Olaf B. Paulson Gitte Moos Knudsen | 1996 | Journal of Hepatology1996，，2： | 1 |
| 8 | Nonsteroidal anti‐inflammatory drugs and the risk of skin cancer显示文摘 | Sigrun Alba Johannesdottir Ellen T. Chang Frank Mehnert Morten Schmidt Anne Braae Olesen Henrik Toft S?rensen | 2012 | Cancer2012，，19： | 1 |
| 9 | Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections显示文摘BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human diseases.Short-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)resections.We hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk factors.AIM To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection samples.METHODS Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from 2010-2020.The 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on gDNA.RNA sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥6.RESULTS PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach significance.Linear mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level taxa.QPCR confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics group.Principal coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor samples.Differentially expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race groups.CONCLUSION Recent adoption of additional preoperative antibiotics as standard of care,has a measurable impact on-omics analysis of resected specimens.This study still confirmed increased Fusobacterium nucleatum in tumor. | Sarah A Malik Chencan Zhu Jinyu Li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen Li | 2021 | World Journal of Gastroenterology2021，27，14： | 0 |
| 10 | 气候变化下维管植物对大气碳同化和泥炭碳分解的调控作用显示文摘气候变化可以通过促进维管植物的生长来改变泥炭地植物群落的组成。然而,这种植被变化如何影响泥炭地碳动态仍然不清楚。为了评估植被变化对碳吸收和释放的影响,我们在两处以泥炭藓为主的泥炭地上进行了维管植物去除实验,这两处泥炭地代表了沿气候梯度下自然植被演替的不同阶段。对净生态系统CO_(2)交换量的周期性测量表明,维管植物在确保净碳吸收潜力方面发挥着关键作用,尤其是在气候变暖的情况下。然而,维管植物的存在也增强了生态系统呼吸量,通过利用呼吸作用产生的CO_(2)中放射性碳(bomb-^(14)C)特征的季节变化,我们证明根际激发效应增强了泥炭碳的异养分解。观察到的泥炭碳分解的根际激发效应与溶解有机物的更高度腐殖化相匹配,在植物的生长季之后仍然很明显。我们的研究结果强调了根际激发效应在泥炭地中的相关性,特别是在评估与气候变化相关的植被群落组成发生变化的泥炭地未来碳汇功能时。 | Konstantin Gavazov Remy Albrecht Alexandre Buttler Ellen Dorrepaal Mark H.Garnett Sebastien Gogo Frank Hagedorn Robert T.E.Mills Bjorn J.M.Robroek Luca Bragazza 鲁蕴哲(译) 徐汇遥(译) 胡雅琴(译) 谭薇(译) 赵红艳(译) | 2023 | 腐植酸2023，，1： | 0 |
| 11 | 流体-固体相互作用、碰撞和起飞的建模显示文摘本文是流体-固体相互作用机制方面的最新进展综述,主要研究固体物体自身的运动与其周围流体运动之间的相互影响.非稳态相互作用的数学模型是对两个空间维度和时间尺度的内部通道和外部近壁流的描述.本文重点描述伴随计算量减少的分析发展过程.文章讨论无黏性流中掠过和下沉、物体的起飞、飞离或弹跳,以及黏性效应,特别是黏性和无黏性之间的相互作用和影响.主要研究结果涉及撞击时间、起飞条件、撞击和飞离之间的边界、主要参数及其范围以及物体形状和质量对物理及力学机制的影响. | Frank T.Smith Ellen M.Jolley Ryan A.Palmer | 2023 | Acta Mechanica Sinica2023，39，5： | 0 |
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