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| 1 | Hepatic abscess induced by foreign body:Case report and literature review显示文摘Hepatic abscess due to perforation of the gastrointestinal tract caused by ingested foreign bodies is uncommon. Pre-operative diagnosis is difficult as patients are often unaware of the foreign body ingestion and symptoms and imagiology are usually non-specific. The authors report a case of 62-year-old woman who was admitted with fever and abdominal pain. Further investigation revealed hepatic abscess, without resolution despite antibiotic therapy. A liver abscess resulting from perforation and intra-hepatic migration of a bone coming from the pilorum was diagnosed by surgery. The literature concerning foreign body-induced perforation of the gastrointestinal tract complicated by liver abscess is reviewed. | Sofia A Santos Sara CF Alberto Elsa Cruz Eduardo Pires Tomás Figueira lia Coimbra José Estevez Mário Oliveira Luís Novais Joo R Deus | 2007 | World Journal of Gastroenterology2007，13，9： | 10 |
| 2 | S-adenosyl-L-methionine modifies antioxidant-enzymes,glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells显示文摘AIM: To elucidate the mechanism(s) by which S-adenosyl-L-methionine(SAM) decreases hepatitis C virus(HCV) expression.METHODS: We examined the effects of SAM on viral expression using an HCV subgenomic replicon cell culture system. Huh7 HCV-replicon cells were treated with 1 mmol/L SAM for different times(24-72 h), then total RNA and proteins were isolated. c DNA was synthesized and real time-PCR was achieved to quantify HCV-RNA, superoxide dismutase 1 and 2(SOD-1, SOD-2) catalase, thioredoxin 1, methionine adenosyltransferase 1A and 2A(MAT1A, MAT2A) expression, and GAPDH and RPS18 as endogenous genes. Expression of cellular and viral protein was evaluated by western-blot analysis using antibodies vs HCV-NS5 A, SOD-1, SOD-2, catalase, thioredoxin-1, MAT1 A, MAT2 A, GAPDH and actin. Total glutathione levels were measured at different times by Ellman's recycling method(0-24 h). Reactive oxidative species(ROS) levels were quantified by the dichlorofluorescein assay(0-48 h); Pyrrolidin dithiocarbamate(PDTC) was tested as an antioxidant control and H2O2 as a positive oxidant agent.RESULTS: SAM exposition decreased HCV-RNA levels 50%-70% compared to non-treated controls(24-72 h). SAM induced a synergic antiviral effect with standard IFN treatment but it was independent of IFN signaling. In addition, 1 mmol/L SAM exposition did not modify viral RNA stability, but it needs cellular translation machinery in order to decrease HCV expression. Total glutathione levels increased upon SAM treatment in HCV-replicon cells. Transcriptional antioxidant enzyme expression(SOD-1, SOD-2 and thioredoxin-1) was increased at different times but interestingly, there was no significant change in ROS levels upon SAM treatment, contrary to what was detected with PDTC treatment, where an average 40% reduction was observed in exposed cells. There was a turnover from MAT1A/MAT2 A, since MAT1 A expression was increased(2.5 fold-times at 48 h) and MAT2 A was diminished(from 24 h) upon SAM treatment at both the transcriptional and translational level. CONCLUSION: A likely mechanism(s) by which SAM diminish HCV expression could involve modulating antioxidant enzymes, restoring biosynthesis of glutathione and switching MAT1/MAT2 turnover in HCV expressing cells. | Sonia Amelia Lozano-Sepulveda Eduardo Bautista-Osorio Jose Angel Merino-Mascorro Marta Varela-Rey Linda Elsa Munoz-Espinosa Paula Cordero-Perez María Luz Martinez-Chantar Ana Maria Rivas-Estilla | 2016 | World Journal of Gastroenterology2016，22，14： | 2 |
| 3 | Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies显示文摘 | Nora M A P Carlos A P Elsa B D | 2003 | Carbohyd Res2003，338，2： | 1 |
| 4 | EHects of grazing on commu- nity structure and productivity o{ a Uruguayan Grassland显示文摘 | Alice A Mart O Elsa L etal | 2005 | Plant Ecology2005，179，1： | 1 |
| 5 | Platelet glycoprotein IIIA PIA1/A2 polymorphism in young patients with ST elevation myocardial infarction and idiopathic ischemic stroke显示文摘 | Blanca Elsa Rivera-García Juan Carlos Esparza-García Jose Luis Aceves-Chimal Alfredo Lea?os-Miranda Abraham Majluf-Cruz Irma Isordia-Salas | 2013 | Molecular and Cellular Biochemistry (-)2013，，1： | 1 |
| 6 | Xylans from scinaia hatei: structural features, sulfation and anti-HSV activity 显示文摘 | Pinaki M Carlos A P Elsa B D et a | 2010 | Int J Biol Macromol2010，46，2： | 1 |
| 7 | Analysis of the dynamics of bacterial communities in the rhizophere of the chrysanthemum via denaturing gradient gel electrophoresis and substrate utilization 显示文摘 | Duineveld B M Rosado A Elsas J D | 1998 | Appl Environ Microbiol1998，64，12： | 1 |
| 8 | Induced natural transformation of A cinetobaeter calcoaeeticus in soil microcosms 显示文摘 | N ielsen KM Bones A M van Elsas J D | 1997 | App Environ Microbiol1997，63，： | 1 |
| 9 | Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitu- mor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses显示文摘 | Sutmuller RP van Duivenvoorde LM van Elsas A | 2001 | J Exp Med2001，194，82： | 1 |
| 10 | Synergism f cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cyto toxic T lymphocyte responses显示文摘 | Sutmuller R P M Van duivenvoorde L M van Elsas A | 2001 | J Exp Med2001，194，： | 1 |
| 11 | Effect of grazing on community structure and productivity of a Uruguayan grassland显示文摘 | ALICE A MARTIN O ELSA L | 2005 | Plant Ecology2005，179，： | 1 |
| 12 | Microbiological and molecular biological methods for monitoring microbial inoculants and their effects in the soil environment显示文摘 | Elsas J D van Duarte G F Rosado A S | | 0，，32： | 1 |
| 13 | Microbialdiversity in soil:selection of microbial populations by plant and soil type and implications for disease suppressiveness显示文摘 | Garbeva P van Veen J A van Elsas J D | 2004 | Annu Rev Phytopathol2004，，42： | 1 |
| 14 | Effect of a Chronic GSM 900 MHz Exposure on Glia in the Rat Brain显示文摘 | Mohamed A Elsa B Christelle G | 2008 | Bio medicine & Pharmacotherapv2008，62，： | 1 |
| 15 | Physicochemical, morphological, and pasting properties of nixtamalized flours from quality protein maize and its particle distribution显示文摘 | María de los ángeles Cornejo-Villegas Elsa Gutiérrez-Cortez Isela Rojas-Molina Alicia Del Real-López María de la Luz Zambrano-Zaragoza Viridiana Martínez-Vega Mario E. Rodríguez-García | 2013 | LWT - Food Science and Technology2013，，1： | 1 |
| 16 | Synergismof cy-totoxic T lymphoxyte-associated antigen 4 blockade and depleteon of CD25^+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte response显示文摘 | Sutmuller R P Van Duivenvoorde L M Van Elsas A | 2001 | J Exp Med2001，194，6： | 1 |
| 17 | Risk factors for premature ovarian failure in females with galactosemia显示文摘 | Guerrero NV Singh RH Manatunga A Berry GT Steiner RD Elsas LJ 2nd | 2000 | J Pediatr2000，137，6： | 1 |
| 18 | Analysis of the dynamics of fungal communities in soil via fungal-specific PCR of soil DNA followed by denaturing gradient gel electrophoresis显示文摘 | van Elsas JD Duarte GF Keijzer-Wolters A | 2000 | Journal of Microbio- logical Methods2000，43，2： | 1 |
| 19 | Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta)显示文摘 | Sutapa Mazumder Prodyut K Ghosal Carlos A Pujol Mar??a J Carlucci Elsa B Damonte Bimalendu Ray | 2002 | International Journal of Biological Macromolecules2002，，1： | 1 |
| 20 | Use of chitosan-based edible coatings in combination with other natural compounds, to control Rhizopus stolonifer and Escherichia coli DH5α in fresh tomatoes显示文摘 | Margarita Ramos-García Elsa Bosquez-Molina Jesús Hernández-Romano Guadalupe Zavala-Padilla Eduardo Terrés-Rojas Irán Alia-Tejacal Laura Barrera-Necha Mónica Hernández-López Silvia Bautista-Ba?os | 2012 | Crop Protection2012，，： | 1 |
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