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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | The flux-E_p relation within GRB060218 in comparison with typical GRB pulses显示文摘The prompt gamma-ray/X-ray emission of gamma-ray burst(GRB) 060218 was simultaneously observed by the Burst Alert Telescope(BAT) and X-ray Telescope(XRT) onboard Swift.Its peak energy of the joint νfν spectrum(Ep) clearly evolves with time from tens of keV to-1 keV,crossing both the BAT and XRT bands.The best fit yields log Ep=(4.61± 0.23)+(-1.29±0.08) log t,with a correlation coefficient of 0.98 and a chance probability of p<10-4.We derive its bolometric flux(F)in the 0.01-10 4 keV band,and find that its F-Ep relation,with a power-law index of 0.37,is much shallower than that observed in typical GRB pulses.Discussion of this shallowness is presented. | DONG Wei,LIANG EnWei & LU RuiJing Physical Science & Technology College,Guangxi University,Nanning 530004,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，S1： | 3 |
| 3 | Luminosity-peak energy relation in the decay phases of gamma-ray burst pulses显示文摘Using time-resolved spectral data for a sample of 30 pulses in 27 bright GRBs detected with CGRO/BATSE, we investigate the luminosity-peak energy relation (L-E p relation) in the decay phases of these pulses. A tight L-E p relation is found for most of the pulses, but its power law index is various among pulses, which is normally distributed at 1.84±0.60(1σ) for the pulses in our sample, roughly consistent with the L-E p relation within a GRB and the isotropic gamma-ray energy-E p relation among GRBs. The large scatter of the power law index cannot be explained with both the statistical or observational effects and it may be an intrinsic feature, indicating that no universal L-E p relation would be expected among GRBs/pulses. This may strongly weaken the cosmological use of this relation. | LU RuiJing & LIANG EnWei Physical Science & Technology College, Guangxi University, Nanning 530004, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 1 |
| 4 | Preliminary study on heat flux measurement data of TT-0 flight test显示文摘With the explosive development of aerospace science,the design of the new generation airliner at higher speeds is attracting more attentions.To achieve this goal,it is necessary to achieve accurate prediction of the aerodynamic heating/force loads and successful reduction of drag and heat flux.As a remedy for the existing studies which are based upon the CFD and wind tunnel tests,this study presents a flight test for the drag and heat reduction spike technology.The principal goals of this flight test were to provide reference for verifying the accuracy of the prediction technology on ground and promote the development of the drag and heat reduction technology.By adopting the OS-X rocket,the TT-0 test vehicle designed by Shenyang Aircraft Design&Research Institute reached a maximum Mach number of 5.8 and a maximum altitude of 38 km.Hypersonic and supersonic pressure data by pressure scanning valves and heat fluxes by gauges at different locations were obtained successfully.Also,heat fluxes obtained by in-house CFD code are illustrated in comparison with the flight data.The results indicate that the numerical errors are large in most cases.More technologies,such as more CFD codes and more numerical procedures,should be adopted to conduct studies on this issue in the future. | Enwei LU Linxuan ZUO Zheng GUO Honggang ZENG Wei ZHU Feng QU | 2021 | Chinese Journal of Aeronautics2021，34，5： | 0 |
| 5 | Author Correction:Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prog nosis in esophageal squamous cell carcinoma显示文摘Correction to:Cell Research https://doi.org/10.1038/s41422-020-0333-6,published online 12 May 2020 In the initial published version of this article,there was an error in the Supplementary information,Table S1.Row 463 and row 80 have the same sample id BDESCC-01-838.After checking the original id of these two samples,we found that they were actually two different samples.This error was caused by Excel random numbering when we assigned the external id to each sample.Thus,we re-assigned a new id BDESCC-01-839 to the row 4P3 sample to fix this issue. | Yongping Cui Hongyan Chen Ruibin Xie Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qi min Zhan Yanhong Li Zhihua Liu | 2022 | Cell Research2022，32，4： | 0 |
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