|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Mass production of 2D materials by intermediate-assisted grinding exfoliation显示文摘The scalable and high-efficiency production of 2D materials is a prerequisite to their commercial use.Currently,only graphene and graphene oxide can be produced on a ton scale,and the inability to produce other 2D materials on such a large scale hinders their technological applications.Here we report a grinding exfoliation method that uses micro-particles as force intermediates to resolve applied compressive forces into a multitude of small shear forces,inducing the highly efficient exfoliation of layer materials.The method;referred to as intermediate-assisted grinding exfoliation(iMAGE);can be used for the large-scale production of many 2D materials.As an example;we have exfoliated bulk h-BN into 2D h-BN with large flake sizes;high quality and structural integrity,with a high exfoliation yield of 67%,a high production rate of 0.3 g h^-1 and a low energy consumption of 3.01 x 106 J g^-1.The production rate and energy consumption are one to two orders of magnitude better than previous results.Besides h-BN,this iMAGE technology has been used to exfoliate various layer materials such as graphite,black phosphorus,transition metal dichalcogenides;and metal oxides;provings universality.Molybdenite concentrate,a natural low-cost and abundant mineral;was used as a demo for the large-scale exfoliation production of 2D M0S2 flakes.Our work indicates the huge potential of the iMAGE method to produce large amounts of various 2D materials;which paves the way for their commercial application. | Chi Zhang Junyang Tan Yikun Pan Xingke Cai Xiaolong Zou Hui-Ming Cheng Bilu Liu | 2020 | National Science Review2020，7，2： | 10 |
| 3 | Changing Rural Development Inequality in Jilin Province, Northeast China显示文摘Rural development inequality is an important practical issue during the course of full establishment of a ′moderately well-off society′ in modern China,and the objective understanding and evaluation of the status and regional inequality of rural development can provide scientific basis for ′building a new countryside′ and coordination development of rural-urban regions.Based on the county-level data of 2000,2005 and 2009,this paper examines the rural development inequality of Jilin Province in Northeast China by establishing a rural development index.The spatio-temporal dynamic patterns and domain factors are discussed by using the method of exploratory spatial data analysis and multi-regression model.The results are shown as follows.Firstly,most of the counties were in lower development level,which accounted for 58.3%,62.5% and 66.7% of the total counties in 2000,2005 and 2009,respectively.The characteristics of spatial inequality were very obvious at county level.For example,rural development level of Changchun Proper and the proper of seven prefecture-level cities were much higher than that of the surrounding regions.The counties in the eastern and northern Jilin Province were the lowest regions of rural development level,while the middle counties were the rapid growth areas in rural economy.Secondly,Moran′s I of rural development index(RDI) was 0.01,–0.16 and –0.06 in 2000,2005 and 2009,respectively,which indicated that spatial agglomeration of RDI was not obvious in Jilin Province,and took on the characteristic of random distribution.The counties of both the units and its adjacent units have higher development level(HH) were transferred from the western areas to the eastern areas,while the countries of both the units and its adjacent units have lower development level(LL) were diffused from the eastern to middle and western Jilin Province.Finally,the result of multi-regression analysis showed that the improvement of agricultural production condition,development of agricultural economics and the adjustment of industrial structure were the domain factors affecting rural development inequality of Jilin Province in the later ten years. | CHENG Yeqing WANG Yanfei WANG Zheye LUO Xiaolong | 2013 | Chinese Geographical Science2013，23，5： | 9 |
| 4 | Pigsties near dwellings as a potential risk factor for the prevalence of Japanese encephalitis virus in adult in Shanxi,China显示文摘Background:The increasing trend of adult cases of Japanese encephalitis(JE)in China,particularly in northern China,has become an important public health issue.We conducted an epidemiological investigation in the south of Shanxi Province to examine the relationships between mosquitoes,Japanese encephalitis virus(JEV),and adult JE cases.Methods:Mosquito specimens were collected from the courtyards of farmers’households and pig farms in Shanxi Province.Mosquitoes were pooled,homogenized,and centrifuged.Reverse transcription-polymerase chain reaction(RT-PCR)was used to detect mosquito-borne arbovirus genes in homogenates.Specimens positive for these genes were inoculated into the baby hamster kidney cell line(BHK-21)to isolate virus.Minimum infection rate was calculated and phylogenetic analyses were performed.Results:A total of 7943 mosquitoes belonging to six species in four genera were collected;Culex tritaeniorhynchus accounted for 73.08%(5805/7943),C.pipiens pallens for 24.75%(1966/7943),and the remaining 3%(104/7943)consisted of Anopheles sinensis,Aedes vexans,Ae.dorsalis,and Armigeres subalbatus.Sixteen pools were positive for JEV based on RT-PCR using JEV pre-membrane gene nested primers.Phylogenetic analyses showed that all JEVs belonged to genotype I;two pools were positive using Getah Virus(GETV)gene primers.In addition,one JEV strain(SXYC1523)was isolated from C.pipiens pallens specimens.These results indicate that the minimum infection rate of JEV in mosquito specimens collected from the courtyards of farmers’households with pigsties was 7.39/1000;the rate for pig farms was 2.68/1000;and the rate for farmers’courtyards without pigsties was zero.Conclusions:The high-prevalence regions of adult JE investigated in this study are still the natural epidemic focus of JEV.Having pigsties near dwellings is a potential risk factor contributing to the prevalence of adult JE.To prevent the occurrence of local adult JE cases,a recommendation was raised that,besides continuing to implement the Expanded Program on Immunization for children,the government should urge local farmers to cease raising pigs in their own courtyards to reduce the probability of infection with JEV. | Xiaojie Ren Shihong Fu Peifang Dai Huanyu Wang Yuanyuan Li Xiaolong Li Wenwen Lei Xiaoyan Gao Ying He Zhi Lv Jingxia Cheng Guiqin Wang Guodong Liang | 2017 | Infectious Diseases of Poverty2017，6，1： | 6 |
| 5 | The grapevine kinome:annotation,classification and expression patterns in developmental processes and stress responses显示文摘Protein kinases(PKs)have evolved as the largest family of molecular switches that regulate protein activities associated with almost all essential cellular functions.Only a fraction of plant PKs,however,have been functionally characterized even in model plant species.In the present study,the entire grapevine kinome was identified and annotated using the most recent version of the grapevine genome.A total of 1168 PK-encoding genes were identified and classified into 20 groups and 121 families,with the RLK-Pelle group being the largest,with 872 members.The 1168 kinase genes were unevenly distributed over all 19 chromosomes,and both tandem and segmental duplications contributed to the expansion of the grapevine kinome,especially of the RLK-Pelle group.Ka/Ks values indicated that most of the tandem and segmental duplication events were under purifying selection.The grapevine kinome families exhibited different expression patterns during plant development and in response to various stress treatments,with many being coexpressed.The comprehensive annotation of grapevine kinase genes,their patterns of expression and coexpression,and the related information facilitate a more complete understanding of the roles of various grapevine kinases in growth and development,responses to abiotic stress,and evolutionary history. | Kaikai Zhu Xiaolong Wang Jinyi Liu Jun Tang Qunkang Cheng Jin-Gui Chen Zong-Ming(Max)Cheng | 2018 | Horticulture Research2018，5，1： | 5 |
| 6 | Spinel LiNi0.5Mn1.5O4 cathode ion batteries: Nano vs micro, disordered phase (F4332) for rechargeable lithium- ordered phase (P433m)显示文摘 | Jingang Yang Xiaopeng Han Xiaolong Zhang Fangyi Cheng Jun Chen | 2013 | Nano Research2013，6，9： | 5 |
| 7 | Effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on excisional wound healing in a rat's model显示文摘OBJEVTIVE: To investigate the effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on the excisional wound healing in a rat's model.METHODS: Rats were performed a surgical lesion with a 2.0 cm resected tissue in the dorsal fascia.Following, animals were randomly divided into model group, YNB group and APE group those were respectively treated with saline, 1 mg/mL of Yunnan Baiyao and 1 mg/mL of Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) extracts. Wound contractions in days 0, 3, 7, 14 and 21 were calculated by an image analyzer. Histological analysis was analyzed using hematoxilin and eosin.Levels of tumor necrosis factor-2(IL-2), IL-4, IL-10, transformαin(TNF-g growα), interleukinth factor-1(TGF-nd basic fibroblast growth factor(bFββ1) a-GF) were determined by real-time quantitative PCR.RESULTS: Compared with that of YNB group and APE gtoup, the skin of rats showed poor re-modeling and re-epithelization characterized by a significant decrease of neovascularization, epithelialization and fibroblast in the model group. In the APE group, levels of TNF-α-and IL-2 were significantly down-regulated and IL4 and IL-10 significantly upregulated in contrasted with that of model group.In addition, levels of TGF-roup were significantly iβ1 and bFGF in the APE gnduced compared with that of model group.CONCLUSION: The results suggest that the extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) promote wound healing in the rats, which is associated with enhancing antiinflammatory ability and inducing fibroblast formation. | Xia Xichao Ma Yuhong Wang Fuan Zheng Xinhua Liu Yang Zhang Junfeng Cui Juan Shi Bingqin Li Hongwen Liu Rongzhi Zhang Yaping Cheng Zhaofei Han Xiaolong | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 8 | RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy显示文摘Semiconducting conjugated polymer nanoparticles(SPNs)represent an emerging class of phototheranostic materi-als with great promise for cancer treatment.In this report,low-bandgap electron donoracceptor(DA)-conjugated SPNs with sur-face cloaked by red blood cell membrane(RBCM)are developed for highly e ective photoacoustic imaging and photothermal therapy.The resulting RBCM-coated SPN(SPN@RBCM)displays remarkable near-infrared light absorption and good photosta-bility,as well as high photothermal conver-sion e ciency for photoacoustic imaging and photothermal therapy.Particularly,due to the small size(<5 nm),SPN@RBCM has the advantages of deep tumor penetration and rapid clearance from the body with no appreciable toxicity.The RBCM endows the SPNs with prolonged systematic circulation time,less reticuloendothelial system uptake and reduced immune-recognition,hence improving tumor accumulation after intravenous injection,which provides strong photoacoustic signals and exerts excellent photothermal therapeutic e ects.Thus,this work provides a valuable paradigm for safe and highly e cient tumor pho-toacoustic imaging and photothermal therapy for further clinical translation. | Dongye Zheng Peiwen Yu Zuwu Wei Cheng Zhong Ming Wu Xiaolong Liu | 2020 | Nano-Micro Letters2020，12，7： | 3 |
| 9 | Black phosphorus-based van der Waals heterostructures for mid-infrared light-emission applications显示文摘Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications. | Xinrong Zong Huamin Hu Gang Ouyang Jingwei Wang Run Shi Le Zhang Qingsheng Zeng Chao Zhu Shouheng Chen Chun Cheng Bing Wang Han Zhang Zheng Liu Wei Huang Taihong Wang Lin Wang Xiaolong Chen | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 10 | Isolation and application of effective nitrogen fixation rhizobial strains on low-phosphorus acid soils in South China显示文摘Soybean (Glycine max L.) is a very important food and oil crop in China. Legume-rhizobium symbiotic nitrogen (N) fixation is an important biological character and also the base of improving soil fertility of soybean. However, soybean production and development is severely limited in tropical and subtropical areas in China due to a lack of effective rhizobial inoculants adapting to low-phosphorus (P) acid soils. In the present study, 12 soybean rhizobial strains were isolated and purified from the nodules of two soybean genotypes contrasting in P efficiency, which were grown on different low-P acid soils with different soybean cultivation histories. Results from 16S rDNA sequence analysis showed that these 12 rhizobial strains belonged to the genus of Bradyrhizobium, which had higher nitrogenase activities compared to the control strain, Bradyrhizboium japonicum USDA110. A field experiment was carried out by applying rhizobial inoculants, a mixture of three rhizobial strains that showed the highest ni- trogenase activity, on a typical low-P acid soil in South China. The results showed that, without inocu- lation, no nodules were formed in the three soybean genotypes tested; with inoculation, the nodulation rates in all were 100%. Inoculation with rhizobial inoculants not only made many nodules formed, but also increased soybean shoot biomass and yield, and improved nitrogen (N) and P nutrient status. Among which, shoot dry weight, N and P content of a soybean genotype, Huachun 3, inoculated with rhizobium were increased 154.3%, 152.4% and 163.2% compared to that without inoculation, respec- tively. We concluded that: (i) The effective indigenous rhizobial strains isolated in this study from soybeans on low-P acid soils in South China have the characters of broad host range, high nodulation efficiency, efficient N fixation, great low pH and low P tolerance. (ii) Soil environment and host types are the key factors to screen the effective rhizobial strains. Considering soil pH values and P efficiency of the host genotypes might increase the screening efficiency. (iii) Improving N status and facilitating root growth might be the mechanisms of increasing the P uptake in soybean plants inoculated with the ef- fective rhizobial strains on low-P acid soils. (iv) Inoculation with the effective rhizobial inoculants could significantly improve growth, N and P content of soybean on low-P acid soils, which might be an effec- tive approach to enhance soybean cultivation and development in these areas. Therefore, application and extension of inoculation techniques with effective rhizobial inoculants in legumes would result in great economical, environmental and ecological benefits. | CHENG FengXiant CAO GuiQin WANG XiuRong ZHAO Jing YAN XiaoLong LIAO Hong | 2009 | Chinese Science Bulletin2009，54，3： | 3 |
| 11 | Superconducting nanowire single-photon detectors:recent progress显示文摘Research of superconducting nanowire singlephoton detectors(SNSPDs) has been progressing rapidly in recent years. The combined properties of high efficiency,low noise, and fast speed of SNSPDs permit its applications ranging from long-distance quantum teleportation to moonto-earth optical communications. Here we briefly discussed recent progress of SNSPDs, in particular(1) tungstensilicide SNSPDs,(2) waveguide-integrated SNSPDs, and(3) a few applied demonstrations. | Xiaolong Hu Yuhao Cheng Chao Gu Xiaotian Zhu Haiyi Liu | 2015 | Science Bulletin2015，60，23： | 2 |
| 12 | Punicalagin Inhibits Inflammation in LPS-Induced RAW264.7 Macrophages via the Suppression of TLR4-Mediated MAPKs and NF-κB Activation显示文摘 | Xiaolong Xu Peng Yin Changrong Wan Xinlu Chong Mingjiang Liu Peng Cheng Jiajia Chen Fenghua Liu Jianqin Xu | 2014 | Inflammation2014，，3： | 2 |
| 13 | Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration显示文摘The circadian clock participates in maintaining homeostasis in peripheral tissues,including intervertebral discs(IVDs).Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration(IDD).Based on the rhythmic daily loading pattern of rest and activity,we hypothesized that abnormal mechanical loading could dampen the IVD clock,contributing to IDD.Here,we investigated the effects of abnormal loading on the IVD clock and aimed to inhibit compression-induced IDD by targeting the core clock molecule brain and muscle Arnt-like protein-1(BMAL1).In this study,we showed that BMAL1 KO mice exhibit radiographic features similar to those of human IDD and that BMAL1 expression was negatively correlated with IDD severity by systematic analysis based on 149 human IVD samples.The intrinsic circadian clock in the IVD was dampened by excessive loading,and BMAL1 overexpression by lentivirus attenuated compression-induced IDD.Inhibition of the RhoA/ROCK pathway by Y-27632 or melatonin attenuated the compression-induced decrease in BMAL1 expression.Finally,the two drugs partially restored BMAL1 expression and alleviated IDD in a diurnal compression model.Our results first show that excessive loading dampens the circadian clock of nucleus pulposus tissues via the RhoA/ROCK pathway,the inhibition of which potentially protects against compression-induced IDD by preserving BMAL1 expression.These findings underline the importance of the circadian clock for IVD homeostasis and provide a potentially effective therapeutic strategy for IDD. | Dong Wang Pandi Peng Michal Dudek Xueyu Hu Xiaolong Xu Qiliang Shang Di Wang Haoruo Jia Han Wang Bo Gao Chao Zheng Jianxin Mao Chu Gao Xin He Pengzhen Cheng Huanbo Wang Jianmin Zheng Judith A.Hoyland Qing-Jun Meng Zhuojing Luo Liu Yang | 2022 | Bone Research2022，10，2： | 2 |
| 14 | Human obstructive(postvasectomy)and nonobstructive azoospermia-Insights from scRNA-Seq and transcriptome analysis显示文摘A substantial number of male infertility is caused by azoospermia.However,the underlying etiology and the molecular basis remain largely unknown.Through single-cell(sc)RNA sequencing,we had analyzed testis biopsy samples from two patients with obstructive azoospermia(OA)and nonobstructive azoospermia(NOA).We found only somatic cells in the NOA samples and explored the transcriptional changes in Sertoli cells in response to a loss of interactions with germ cells.Moreover,we observed a germ cell population discrepancy between an OA(postvasectomy)patient and a healthy individual.We confirmed this observation in a secondary study with two datasets at GSM3526588 and GSE124263 for detailed analysis wherein the regulatory mechanisms at the transcriptional level were identified.These findings thus provide valuable information on huma n spermatoge nesis,and we also ide ntified in sightful info rmation for further research on reproducti on-related diseases. | Shitao Chen Geng An Hanshu Wang Xiaolong Wu Ping Ping Longfei Hu Yunmei Chen Jue Fan C.Yan Cheng Fei Sun | 2022 | Genes & Diseases2022，9，3： | 2 |
| 15 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 16 | A comparison on the phytoremediation ability of triazophos by different macrophytes显示文摘The strategy of choosing suitable plants should receive great performance in phytoremediation of surface water polluted by triazophos(O,O-diethyl-O-(1-phenyl-1,2,4-triazol-3-base) sulfur phosphate, TAP), which is an organophosphorus pesticide widespread applied for agriculture in China and moderately toxic to higher animal and fish. The tolerance, uptake, transformation and removal of TAP by twelve species of macrophytes were examined in a hydroponic system and a comprehensive score(CS) of five parameters(relative growth rate(RGR), biomass, root/shoot ratio, removal capacity(RC), and bio-concentration factor(BCF)) by factor analysis was employed to screen the potential macrophyte species for TAP phytoremediation. The results showed that Thalia dealbata, Cyperus alternifolius, Canna indica and Acorus calamus had higher RGR values, indicating these four species having stronger growth capacity under TAP stress. The higher RC loading in Iris pseudacorus and Cyperus rotundus were 42.11 and 24.63 μg/(g fw·day), respectively. The highest values of BCF occurred in A. calamus(1.17), and TF occurred in Eichhornia crassipes(2.14). Biomass and root/shoot ratio of plant showed significant positive correlation with first-order kinetic constant of TAP removal in the hydroponic system, indicating that plant biomass and root system play important roles in remediation of TAP. Five plant species including C. alternifolius, A. calamus, T. dealbata, C. indica and Typha orientalis, which owned higher CS, would be potential species for TAP phytoremediation of contaminated water bodies. | Zhu Li Huiping Xiao Shuiping Cheng Liping Zhang Xiaolong Xie Zhenbin Wu | 2014 | Journal of Environmental Sciences2014，26，2： | 2 |
| 17 | A generalization of LSB matching显示文摘 | LI XIAOLONG YANG BIN CHENG DAOFANG | 2009 | IEEE Signal Processing Letters2009，16，2： | 1 |
| 18 | Correlation Analysis of X-Band Sea Clutter in Complex Domain显示文摘The correlation analysis of sea clutter data in a complex domain is conducted in this study. Specific to X-band sea clutter, the statistical characteristics of the complex correlation, particularly the phase characteristics which are closely related to the phase difference of the sea clutter and the Doppler properties, are analyzed in detail based on the experimental data, recorded by the Mc Master University IPIX radar in 1993. That the phase term of the complex correlation presents linear change means that there exists the linearity of phase differences between different time intervals in the X-band sea clutter. This investigation explores the regularities about the effect of wind on the complex correlation with similar patterns for different polarization modes. The regularities indicate that the wind direction can be inferred from the distribution pattern of the complex correlation. Moreover, a model describing the relationships between the statistics of the complex correlation and wind parameters is proposed. The application for target detection based on the differences of characteristics of complex correlations between the sea clutter and the target are also investigated and the proposed features have been confirmed. The principle of the method is fundamental for broader future applications. | CHENG Xiaolong JI Tingting WANG Guoyu JI Guangrong | 2016 | Journal of Ocean University of China2016，15，4： | 1 |
| 19 | High-energy wave-breaking free pulse from all-fiber mode-locked laser system显示文摘 | Tian Xiaolong Tang Ming Cheng Xueping | 2009 | Opt Ex- press2009，17，： | 1 |
| 20 | New insights from the widening homogeneity perspective to target intratumor heterogeneity显示文摘Precision medicine has shed new light on the treatment of heterogeneous cancer patients.However,intratumor heterogeneity strongly constrains the clinical benefit of precision medicine.Thus,rethinking therapeutic strategies from a different facet within the precision medicine framework will not only diversify clinical interventions,but also provide an avenue for precision medicine.Here,we explore the current approaches for targeting intratumor hetero-geneity and their limitations.Furthermore,we propose a theoretical strategy with a“homogenization”feature based on iatrogenic evolutionary selection to target intratumor heterogeneity. | Mengying Tong Ziqian Deng Xiaolong Zhang Bin He Mengying Yang Wei Cheng Quentin Liu | 2018 | Cancer Communications2018，38，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员