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| 1 | Lamivudine resistance in children with chronic hepatitis B显示文摘Currently, although lamivudine(LAM) has a low genetic barrier, only interferon-alpha and LAM are available as a first-line treatment in children with chronic hepatitis B(CHB). LAM is a potent inhibitor of hepatitis B virusdeoxyribonucleic acid(HBV-DNA) polymerase replication by termination of the proviral HBV-DNA chain. LAM has a good safety and tolerability profile in CHB patients with hepatic decompensation. However, the main disadvantages of this HBV reverse transcriptase inhibitor are:(1) pre-existing covalently closed circular DNA cannot be eradicated by LAM, thus relapse after therapy withdrawal is frequent; and(2) although the longer LAMtreatment induced the higher seroconversion rate, the risk of viral resistance increased through the selection of YMDD(tyrosine, methionine, aspartate, aspartate) motif. Insufficient suppression of viral replication leads to the emergence of resistant strains that could result in virological breakthrough which is usually followed by biochemical breakthrough. Mutant strains affects additional resistance and cross resistance, leading to drug resistance in a significant number of CHB patients. In this case, efficacy of more powerful anti-viral agents with higher genetic barrier against development of resistance is diminished. Furthermore, strains that are resistant to LAM could bring about vaccine escape mutants, decreasing the efficacy of HBV vaccine. A more potent drug with a high genetic barrier to resistance needs to be approved as the first-line treatment option for CHB in children. | Erhun Kasirga | 2015 | World Journal of Hepatology2015，7，6： | 9 |
| 2 | Robust nonlinear control strategy to maximize energy capture in a variable speed wind turbine with an internal induction generator显示文摘This paper proposes a control strategy to maximize the wind energy captured in a variable speed wind turbine, with an internal induction generator, at low to medium wind speeds. The proposed strategy controls the tip-speed ratio, via the rotor angular speed, to an optimum point at which the efficiency constant (or power coefficient) is maximum for a particular blade pitch angle and wind speed. This control method allows for aerodynamic rotor power maximization without exact wind turbine model knowledge. Representative numerical results demonstrate that the wind turbine can be controlled to achieve near maximum energy capture. | Erhun IYASERE Mohammed H. SALAH Darren M. DAWSON John R. WAGNER Enver TATLICIOGLU | 2012 | 控制理论与应用(英文版)2012，10，2： | 6 |
| 3 | Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3显示文摘AIM:To evaluate the effects of growth hormone(GH) on the histology of small intestines which might be related to the role of insulin like growth factor(IGF)-I, IGF-binding protein 3(IGFBP-3)and its receptors. METHODS:Twelve week-old adult male Wistar albino rats were divided into two groups.The study group(n =10),received recombinant human growth hormone (rGH)at a dose of 2 mg/kg per day subcutaneously for 14 d and the control group(n=10)received physiologic serum.Paraffin sections of jejunum were stained with periodic acid shift(PAS)and hematoxylin and eosin(HE) for light microscopy.They were also examined for IGF-I, IGFBP-3 and IGF-receptor immunoreactivities.Staining intensity was graded semi-quantitatively using the HS- CORE. RESULTS:Goblet cells and the cells in crypt epitheliawere significantly increased in the study group compared to that of the control group.We have demonstrated an increase of IGF-I and IGFBP-3 immunoreactivities in surface epithelium of the small intestine by GH application.IGF-I receptor immunoreactivities of crypt,villous columnar cells,enteroendocrine cells and muscularis mucosae were also more strongly positive in the study group compared to those of in the control group. CONCLUSION:These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine.The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. | Betul Ersoy Kemal Ozbilgin Erhun Kasirga Sevinc Inan Senol Coskun Ibrahim Tuglu | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 4 | Contract complexity and performance under asymmetric demand information: an experimental evaluation 显示文摘 | Kalkanci B Chen K Y Erhun F | 2011 | Management Science2011，57，4： | 1 |
| 5 | The art of managing new product transitions显示文摘 | Erhun F Goncalves P Hopman J | 2007 | Mit Sloan Management Review2007，48，3： | 1 |
| 6 | Relating the multiple supply problem to quantity flexibility contracts 显示文摘 | ozgur Yazlali Feryal Erhun | 2007 | Operations Research Letters2007，35，6： | 1 |
| 7 | Quantity discounts under demand uncertainty显示文摘 | Altintas N Erhun F Tayur S | 2008 | Management Science2008，54，4： | 1 |
| 8 | Quantity discounts under demand uncertainty显示文摘 | Altintas N Erhun F Tayur S | 2008 | Management Science2008，54，4： | 1 |
| 9 | Quantity discounts under demand uncertainty显示文摘 | Nihat Altintas Feryal Erhun Sridhar Tayur | 2008 | Management Science2008，54，4： | 1 |
| 10 | Assessment of the knowledge and attitudes of intern doctors to medication prescribing errors in a Nigeria tertiary hospital显示文摘 | Adetutu Ajemigbitse Moses Omole Nnamdi Ezike Wilson Erhun | 2014 | Journal of Basic and Clinical Pharmacy2014，，1： | 1 |
| 11 | Quantity discounts under demand uncertainty显示文摘 | Altintas Erhun F Tayur S | 2008 | Management Science2008，54，4： | 1 |
| 12 | Robust support vector machines for multiple instance learning 显示文摘 | Poursaeidi Mohammad H Kundakcioglu 0 Erhun | 2014 | Annals of Operations Research2014，216，1： | 1 |
| 13 | Contract complexity and performance under asymmetric demand information显示文摘 | Kalkanci B Chen K Y Erhun F | 2011 | Manage- ment Science2011，57，4： | 1 |
| 14 | Designing supply contracts for perishable goods with two periods of shelf life 显示文摘 | Chung Y T Erhun F | 2013 | IIE Transactions2013，45，1： | 1 |
| 15 | Quality and Entry Deterrence显示文摘 | Karer Erhun F | 2015 | European Journal of Operational Research2015，240，1： | 1 |
| 16 | Dynamie Procurement in a Capacitated Supply Chain Facing Uncertain Demand显示文摘 | Feryal Erhun Pinar Keskinocak Sridhar Tayur | 2008 | IIE Transactions2008，8，： | 1 |
| 17 | Quantity discount under demand uncer- tainty显示文摘 | Ahintas N Erhun F Tayur S | 2008 | Managemnet Science2008，54，4： | 1 |
| 18 | Diagnostic Yield of Upper Gastrointestinal Endoscopy in the Evaluation of Iron Deficiency Anemia in Older Children and Adolescents显示文摘 | Huseyin Gulen Erhun Kasirga Sule Aslan Yildirim Sebnem Kader Gulseren Sahin Semin Ayhan | 2011 | Pediatric Hematology-Oncology2011，，8： | 1 |
| 19 | Optimal control of a two-server queueing system with failures显示文摘 | OKAN Erhun KUAROUFEH J P | 2014 | Probability in the Engineering and Informational Science2014，28，： | 1 |
| 20 | Bottom-up construction of minimum-cost AND/OR trees for sequential fault diagnosis显示文摘 | KUNDAKCIOGLU O ERHUN (U)NL(U)YURT TONGUC | 2007 | IEEE Trans on Systems Man and Cybernetics2007，37，5： | 1 |
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