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| 1 | Antimicrobial and antispasmodic activity of leaf extract and fractions of Stachytarpheta cayennensis显示文摘Objective:To investigate the antimicrobial activity of the methanol leaf extract(ME),n-hexane fraction(HF),ethylacetate fraction(EF) and methanol fraction(MF),of Stachytarpheta cayennensis C.Rich(verbenaceae) as well as to ascertain the antispasmodic effects of the ME and the various fractions(HF,EF and MF) on acetylcholine(Ach) and histamine(H) induced contractions on isolated guinea pig ileum.Methods:The in vitro agar well diffusion method was used for the antimicrobial studies while the isolated tissue method was employed for the antispasmodic test. Organisms used were all clinical isolates of Bacillus subtilis,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella paratyphi,Candida albicans and Aspergillus niger.Results:The extract and fractions exhibited dose dependent inhibition against all the bacteria tested and also exhibited insignificant antifungal activity against Candida albicans and Aspergillus niger.The minimum inhibitory concentration(MIC) of the extract and fractions(mg/mL) on Bacillus subtilis, Staphylococcus aureus,Pseudomonas aeruginosa and Salmonella paratyphi respectively were ME 5.62,14.12,22.38,2.11;EF 1.25,6.30,9.40,9.40 and MF 3.98,8.81,39.80,21.13.The n-hexane fraction exhibited MIC of 1.07 mg/mL against only Bacillus subtilis.The extract and fractions exhibited significant(P< 0.05) dose dependent attenuation of contractions induced by acetylcholine and histamine on isolated guinea pig ileum.Concentrations of the extract and fractions(μg/mL) which evoked 50%inhibition of maximal response exhibited by Ach were ME 0.64,HF 0.16,EF 0.08 and MF 0.15,while that of histamine included ME 5.12,HF 0.16,EF 0.04 and MF 0.64.Preliminary phytochemical studies on the extract and fractions indicated the presence of carbohydrates,alkaloids,saponins,flavonoids,steroids and terpenoids.Conclusions: The extract and fractions of Stachytarpheta cayennensis possessed both antibacterial and antispasmodic effects confirming the claimed use in folkloric medicine for wound healing and gastrointestinal ulceration. | Okoye TC Akah PA Okoli CO Ezike AC Mbaoji FN | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 3 |
| 2 | Antibacterial resistance显示文摘 | Ang JY Ezike E Asmar BI | 2004 | Indian J Pediator2004，71，： | 1 |
| 3 | Assessment of the knowledge and attitudes of intern doctors to medication prescribing errors in a Nigeria tertiary hospital显示文摘 | Adetutu Ajemigbitse Moses Omole Nnamdi Ezike Wilson Erhun | 2014 | Journal of Basic and Clinical Pharmacy2014，，1： | 1 |
| 4 | Antibacterial resistance显示文摘 | Ang J Y Ezike E Asmar BI | 2004 | Indian J Pediatr2004，71，： | 1 |
| 5 | Carieapapaya (paw paw) unripe fruit may be benefieial in ulcer 显示文摘 | AC Ezike P Akah C Okoli | 2009 | J Med Food2009，12，6： | 1 |
| 6 | Pre-operative anaesthesia visit:Problems and prospeets in a university teaching hospital in Enugu,South East Nigeria显示文摘 | Ezike H Amucheazi A Ajuzieoegu V | 2011 | Ann Med Health Sci Res2011，1，1： | 1 |
| 7 | Antibacterial resistance显示文摘 | Ang JY Ezike E Asmar BI | 2004 | Indian J Pediaetr2004，71，： | 1 |
| 8 | Evaluation of the acute and sub acute toxicity of Annona senegalensis root bark extracts显示文摘Objective:To investigate the safety profile of Annona senegalensis(A.senegalensis).Methods: Dried powdered root-bark of A.senegalensis was prepared by Sohxlet extraction using methanolmethylene chloride(1:1) solution and concentrated to obtain the methanol-methylene chloride extract(MME).MME was fractionated to obtain the n-hexane(HF),ethylacetate(EF) and methanol(MF) fractions.Acute toxicity(LD50) test was performed with MME,HF,EF and MF in mice by oral route.The sub acute toxicity studies were performed in rats after 14 days of MME administration while haemalological and biochemical parameters were monitored.Results: Medium lethal(LD-(50)) values of 1 296.3 808.1 265 and 2 154 mg/kg were obtained for the MME.MF, HF and EF,respectively.The sub-acute toxicity studies indicated a significant(P<0.05) increase in the body weight of both the treated rats and the control.The haematological tests indicated no change in the packed cell volume values but a significant(P<0.05) increase in the total WBC count at 100 and 400 mg/kg doses.The differential analysis showed a decrease in the nutrophils and a non-significant increase in the lymphocyte counts.The liver transaminase enzymes, alanin transaminase and aspartate transaminase showed no significant increase compared to the control.Histopathological examination of the liver sections also indicted no obvious signs of hepatotoxicity except with the 400 mg/kg dose that showed degeneration and necrosis of the hepatocytes.Conclusions:These results indicated that the root bark extracts of A.Senegalensis are safe at the lower doses tested,and calls for caution in use at higher doses in treatment. | Theophine C Okoye Peter A Akah Adaobi C Ezike Maureen O Okoye Collins A Onyeto Frankline Ndukwu Ejike Ohaegbulam Lovelyn Ikele | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 1 |
| 9 | Plasma glucose and liver glycogen of African catfish (Clarias gariepinus) exposed to petrol显示文摘 | Ezike C Ufodike E B C | 2008 | Journal of Fisheries International2008，3，2： | 1 |
| 10 | Pre - operative anaesthesia visit:problems and prospects in a university teaching hospital in Enugu,South East Nigeria显示文摘 | Ezike H Amuzcheazi A Ajuzieoegu V | 2011 | Ann Med Health Sci Res2011，1，1： | 1 |
| 11 | Antibacterial resistance 显示文摘 | Ang JY Ezike E Asmar BI | 2004 | Indian J Pediatr2004，71，： | 1 |
| 12 | Pendergraft, MSPH, Improving Access to Diabetes Care in an Inner-City, Communily-Based Outpatient Health Center with a Monthly Open-Access, Multistation Group Visit Program显示文摘 | Gregory C Vachon MD Ngozi Ezike MD | 2007 | Journal Of The Natiolal Medical Association2007，99，： | 1 |
| 13 | Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri显示文摘 | C.O. Okoli I.C. Obidike A.C. Ezike P.A. Akah O.A. Salawu | 2011 | Pharmaceutical Biology2011，，3： | 1 |
| 14 | A retrospective study of the outcome of cesarean section for women with severe pre-eclampsia in a third world setting显示文摘 | AJUZIEOGU OV EZIKE HA AMUCHEAZI AO | 2011 | Saudi J Anaesth2011，5，1： | 1 |
| 15 | Antibacterial resistance 显示文摘 | Ang JY Ezike E Asmar BI | 2004 | Indian J Pediatr2004，71，3： | 1 |
| 16 | Antibacterial resistance显示文摘 | Ang JY Ezike E Asmar BI | 2004 | In dian J Pediaetr2004，71，： | 1 |
| 17 | 快速抗原检测中2次与1次咽拭子检测A型链球菌的效果比较 | Ezike E.N. Rongkavilit C. Fairfax M.R. 平智广 | 2005 | 世界核心医学期刊文摘(儿科学分册)2005，0，10： | 0 |
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