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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes显示文摘 | Eric J. Kunkel Judie Boisvert Kristine Murphy Mark A. Vierra Mark C. Genovese Andrew J. Wardlaw Harry B. Greenberg Martin R. Hodge Lijun Wu Eugene C. Butcher James J. Campbell | 2002 | The American Journal of Pathology2002，，1： | 2 |
| 3 | Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses显示文摘 | Christopher J. Weight Benjamin T. Larson Amr F. Fergany Tianming Gao Brian R. Lane Steven C. Campbell Jihad H. Kaouk Eric A. Klein Andrew C. Novick | 2010 | The Journal of Urology2010，，： | 2 |
| 4 | Nanofabrication with proximal probes显示文摘 | Campbell Paul M Perkins F Keith | 1997 | Proceedings of the IEEE1997，85，4： | 1 |
| 5 | Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults显示文摘 | Peter T. Campbell Christina C. Newton Alpa V. Patel Eric J. Jacobs Susan M. Gapstur | 2012 | Diabetes Care2012，，9： | 1 |
| 6 | Prospective Study Reveals Associations Between Colorectal Cancer and Type 2 Diabetes Mellitus or Insulin Use in Men显示文摘 | Peter T. Campbell Anusila Deka Eric J. Jacobs Christina C. Newton Janet S. Hildebrand Marjorie L. McCullough Paul J. Limburg Susan M. Gapstur | 2010 | Gastroenterology2010，，4： | 1 |
| 7 | Functionalization of eleetrospun TiO2 nanofibers with Ptnanoparticels and nanowires for catalytic applications显示文摘 | Eric Formo Eric Lee Dean Campbell Younan Xia | 2008 | Nano Letters2008，8，： | 1 |
| 8 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Benjamin A. Corl Robert J. Harrell Hong Kil Moon Oulayvahn Phillips Eric M. Weaver Joy M. Campbell John D. Arthington Jack Odle | 2007 | The Journal of Nutritional Biochemistry2007，，12： | 1 |
| 9 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Benjamin A. Corl Robert J. Harrell Hong Kil Moon Oulayvahn Phillips Eric M. Weaver Joy M. Campbell John D. Arthington Jack Odle | 2007 | The Journal of Nutritional Biochemistry2007，，12： | 1 |
| 10 | Data with Holding in Academic Genetics Vidence from a National Survey显示文摘 | Eric G Campbell | 2002 | The Journal of the Ameri- can Medical Association2002，287，4： | 1 |
| 11 | 标准水质取样法与取样器法的对比研究显示文摘:美国环境保护局 (EPA)和美国地质调查局 (USGS)要求 ,如果水质样品未按USGS标准过滤或按EPA标准在pH低于 2的条件下酸化 ,则必须于 2 4h内在田间或实验室内分析 ,而不能保存更长时间。这一采样和分析标准有时由于诸种原因而难以实现。为评价时间对分析精度的影响 ,通过改变保存样品和保存时间来研究这些因素是否影响水样的分析结果。未经过滤的水样来自塞拉山坡发展中心的 9条小河 ,一些样品在2 4h内分析 ,其它重复采集的样品则用 6种冷冻和保存时间来进行处理 ,大多数处理模拟样品由田间送往实验室的时间或自动水样取样器的保存时间。对测试结果进行比较 ,发现立即测定的样品结果与未经过滤而放 1周的样品结果在化学组成上没有显著的统计学差异。 | Barbara Allen-Diaz Eric Hammerling Chris Campbell 杜振宇 | 2000 | 水土保持科技情报2000，18，1： | 1 |
| 12 | Prospective Study Reveals Associations Between Colorectal Cancer and Type 2 Diabetes Mellitus or Insulin Use in Men显示文摘 | Peter T. Campbell Anusila Deka Eric J. Jacobs Christina C. Newton Janet S. Hildebrand Marjorie L. McCullough Paul J. Limburg Susan M. Gapstur | 2010 | Gastroenterology2010，，4： | 1 |
| 13 | Effect of pH and Ca^2 +-induced associationa of soybean proteins 显示文摘 | Yong J Yuan Orlin D Velev Ken Chen Bruce E Campbell Eric W Kaler Abraham Mlenhoff | 2002 | J Agric Food Chem2002，50，： | 1 |
| 14 | A national survey of physician-industry relationships显示文摘 | Eric G Campbell | 2007 | N Engl J Med2007，356，17： | 1 |
| 15 | Targeting T cell responses by selective chemokine receptor expression显示文摘 | Daniel J Campbell Gudrun F Debes Brent Johnston Eric Wilson Eugene C Butcher | 2003 | Seminars in Immunology2003，，5： | 1 |
| 16 | 清洁能源研究领域科学计量分析(2005-2009) 加拿大-美国的国际合作显示文摘加拿大清洁能源研发合作推广工作组当前正重新评价加拿大与美国之间的合作伙伴关系,旨在为清洁能源研发长期合作计划筛选出合适的科学领域作为清洁能源对话行动方案框架的一部分。根据该科学计量分析结果,工作组将进一步探索清洁能源研发领域以及三个子领域(新一代生物燃料、清洁能源车辆与绿色建筑)的科学产出与合作前景。科学计量结果表明,2005-2009年间,清洁能源研发及其三个子领域的美加合作科学产出增长迅速。美加两国都是清洁能源研发15强成员,尤其美国更是该领域及三个子领域中的领头羊。科学影响力、质量与专业化指标反映出各强国在三个子领域的表现存在差异,但总体上,瑞典与土耳其的影响力与专业化程度超出世界水平。加拿大、德国、荷兰、美国与英国虽然在影响力的排位上超过世界平均水平,但专业化程度表现低迷。提请注意的是,由于绿色建筑领域内的论文数量较少,不适合作深入的计量指标分析。就合作模式而言,分析结果表明超过60%的被调查对象与科研强国同仁的合作低于预期。在清洁能源研发及三个子领域,加拿大的最大合作伙伴是美国、土耳其、中国。总体而言,合作论文的平均被引频次要高于非合作论文,虽然有些意外,但事实上,这是加拿大在清洁能源研发领域的整体表现。除提供国家层面上的数据外,该文也分析了此领域内美国与加拿大的优秀科研机构。对两国机构层面合作模式的研究表明,加拿大研究机构比美国研究机构更倾向于二者的合作,考虑到科研规模与水平,这个结论并无意外之处。 | Trina Foster Michelle Picard-Aitken Olivier Hillman-Beauchesne David Campbell Eric Archambault 朱海峰(翻译) 马建华(审校) | 2011 | 科学观察2011，6，3： | 1 |
| 17 | Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses显示文摘 | Christopher J. Weight Benjamin T. Larson Amr F. Fergany Tianming Gao Brian R. Lane Steven C. Campbell Jihad H. Kaouk Eric A. Klein Andrew C. Novick | 2010 | The Journal of Urology2010，，4： | 1 |
| 18 | Association of the platelet GPIIb/IIIa polymorphism with atherosclerotic plaque morphology显示文摘 | Anna M. Kucharska-Newton Keri L. Monda Stephen Campbell Patrick T. Bradshaw Lynne E. Wagenknecht Eric Boerwinkle Bruce A. Wasserman Gerardo Heiss | 2011 | Atherosclerosis2011，，1： | 1 |
| 19 | Garlic consumption and colorectal cancer risk in the CPS-II Nutrition Cohort显示文摘 | Marjorie McCullough Eric Jacobs Roma Shah Peter Campbell Susan Gapstur | 2012 | Cancer Causes & Control2012，，10： | 1 |
| 20 | A National Survey of Physician-Industry Relationships显示文摘 | Eric Campbell | 2007 | NEJM2007，356，17： | 1 |
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