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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Emerging pollutants in the environment:A challenge for water resource management显示文摘A significant number of emerging pollutants(EPs)resulting from point and diffuse pollution is present in the aquatic environment.These are chemicals that are not commonly monitored but have the potential to enter the environment and cause adverse ecological and human health effects.According to the NORMAN network,at least 700 substances categorized into 20 classes,have been identified in the European aquatic environment.In light of their potential impact action is urgently required.In this study,we present a concept that shows the current state of art and challenges for monitoring programs,fate and risk assessment tools and requirements for policies with respect to emerging pollutants as a base for sustainable water resource management.Currently,methods for sampling and analysis are not harmonized,being typically focused on certain EP classes.For a number of known highly hazardous EPs detection limits are too high to allow proper risk assessment.For other EPs such as microplastics method development is in its infancy.Advanced ultra-sensitive instrumental techniques should be used for quantitative determination of prioritized EPs in water,suspended matter,soil and biota.Data on EPs'and their metabolites'properties that determine their fate in the environment are often not available.National surveys on water quality often use different parameters for water quality assessment and often do not include EPs.A harmonized monitoring of surface and groundwater is not yet achieved and urgently required.Specific component integrated into models assessing the fate of EPs in a multi compartment environmental approach are missing and must be developed.The main goal of risk assessment is the overall protection of ecological communities in the aquatic environment and human health.New methods for assessing the cumulative risks from combined exposures to several stressors,including mixtures of EPs in a multi-scale approach are required.A combination of regulations and management measures with respect to use/emissions of EPs into the environment,as well as to their occurrence in the environment are fundamental to reach an efficient water resource management. | Violette Geissen Hans Mol Erwin Klumpp Günter Umlauf Marti Nadal Martine van der Ploeg Sjoerd E.A.T.M.van de Zee Coen J.Ritsema | 2015 | International Soil and Water Conservation Research2015，3，1： | 3 |
| 3 | Retroperitoneal Adrenalectomy: Open or Endoscopic?显示文摘 | H. Jaap Bonjer Erwin van der Harst Ewout W. Steyerberg Wouter W. de Herder Geert Kazemier Robert S.A. Mohammedamin Hajo A. Bruining | 1998 | World Journal of Surgery1998，，12： | 1 |
| 4 | The metagenome of the marine anammox bacterium ‘ Candidatus Scalindua profunda’ illustrates the versatility of this globally important nitrogen cycle bacterium显示文摘 | Jack van de Vossenberg Dagmar Woebken Wouter J. Maalcke Hans J. C. T. Wessels Bas E. Dutilh Boran Kartal Eva M. Janssen‐Megens Guus Roeselers Jia Yan Daan Speth Jolein Gloerich Wim Geerts Erwin van der Biezen Wendy Pluk Kees‐Jan Francoijs Lina Russ Phylli | 2012 | Environmental Microbiology2012，，5： | 1 |
| 5 | Antibody repertoire development in camelids显示文摘 | Erwin De Genst Dirk Saerens Serge Muyldermans | 2006 | Dev Comp Immunol2006，30，12： | 1 |
| 6 | Pillars of virtual enterprise: leveraging physical assets in the new economy显示文摘 | Charles Steinfield Dirk de Wit Thomas Adelaar Arnout Bruins Erwin Fielt Markus Hoefsloot Alko Smit Harry Bouwman | 2001 | info2001，，3： | 1 |
| 7 | Data mining in the US Vaccine Adverse Event Reporting System (VAERS): eraly detecion of intussusception and other events after rotavirus vaccination 显示文摘 | Niu MT Erwin DE Braun MM | 2001 | Vaccine2001，19，46： | 1 |
| 8 | Deinterlaeing-An Overview显示文摘 | Gerard de Haan Erwin B Bellers | 1998 | Proceedings of the IEEE1998，86，9： | 1 |
| 9 | Applicability of an in Vitro Digestion Model in Assessing the Bioaccessibility of Mycotoxins from Food 显示文摘 | Carolien H M Versantvoort Agnes G Oomen Erwin Van de Kamp | 2005 | Food and Chemical Toxicology2005，43，： | 1 |
| 10 | Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation显示文摘 | Erwin Geuken Dorien Visser Folkert Kuipers Hans Blokzijl Henri G.D. Leuvenink Koert P. de Jong Paul M.J.G. Peeters Peter L.M. Jansen Maarten J.H. Slooff Annette S.H. Gouw Robert J. Porte | 2004 | Journal of Hepatology2004，，6： | 1 |
| 11 | Losses of Chromosomes 1p and 3q Are Early Genetic Events in the Development of Sporadic Pheochromocytomas显示文摘 | Hilde Dannenberg Ernst J.M. Speel Jianming Zhao Parvin Saremaslani Erwin van der Harst Jürgen Roth Philipp U. Heitz H. Jaap Bonjer Winand N.M. Dinjens Wolter J. Mooi Paul Komminoth Ronald R. de Krijger | 2000 | The American Journal of Pathology2000，，2： | 1 |
| 12 | Spine Update: Prevention of Postoperative Infection in Patients Undergoing Spinal Surgery显示文摘 | Erwin M. Brown Ian K. Pople John de Louvois Alan Hedges Roger Bayston Stephen M. Eisenstein Peter Lees | 2004 | Spine2004，，8： | 1 |
| 13 | Deinterlacing-An Overview显示文摘 | Gerard de Haan Erwin B Bellers | 1998 | Proceedings of the IEEE1998，86，9： | 1 |
| 14 | Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis显示文摘 | Noortje G. Rossen Susana Fuentes Mirjam J. van der Spek Jan G. Tijssen Jorn H.A. Hartman Ann Duflou Mark L?wenberg Gijs R. van den Brink Elisabeth M.H. Mathus-Vliegen Willem M. de Vos Erwin G. Zoetendal Geert R. D’Haens Cyriel Y. Ponsioen | 2015 | Gastroenterology2015，，： | 1 |
| 15 | Coronary leukocyte activation in relation to progression of coronary artery disease显示文摘白血球激活被连接了到 atherogenesis,但是在为它在动脉粥样硬化的前进的角色的 vivo 证据有很少。我们在冠的发行量为白血球激活标记的冠的动脉疾病(CAD ) 的前进评估了预兆的值。在冠的动脉的单核白血球和嗜中性的 CD11b,嗜中性的 CD66b 表示和细胞内部的嗜中性的 myeloperoxidase (军邮局) 被流动 cytometry 在经历冠的 angiography 的病人决定。主要结果由于不稳定的心绞痛包括了致命、非致命的心肌的梗塞或动脉的脉管的干预。在被包括的总数 99 题目, 70 在包括有 CAD (26 个病人有单个容器的疾病, 18 个病人把 twovessel 疾病和 26 个病人有三容器的疾病) 。中部的后续持续时间是 2242 天(interquartile 范围:2142-2358 ) 。在后续期间, 13 个病人(13%) 开发了 CAD 的前进。在从冠的动脉获得的血测量的单核白血球 CD11b,嗜中性的 CD11b 和 CD66b 表示和细胞内部的军邮局没与 CAD 的前进被联系。这些数据显示冠的单核白血球 CD11b,嗜中性的 CD11b 和 CD66b 表示和细胞内部的军邮局不预言 CAD 的前进的风险。 | Marijke A. de Vries Arash Alipour Erwin Bimie Andrew Westzaan Selvetta van Santen Ellen van der Zwan Anho H. Liem Noelle van der Meulen Manuel Castro Cabezas | 2016 | Frontiers of Medicine2016，10，1： | 0 |
| 16 | Mitigation of municipal solid waste leachate contamination at Payatas, Metro Manila, Philippines: A technical proposal显示文摘 | Marvin Joseph Montefrio Kai Scene Ng Lee Yih Koh Erwin Torio Mark Hansley Chua Louernie de Sales-Papa Jeffrey Philip Obbard | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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