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| 1 | Elevated plasma von Willebrand factor levels in patients with active ulcerative colitis reflect endothelial perturbation due to systemic inflammation显示文摘AIM: To evaluate the plasma von Willebrand factor (vWF) levels in patients with ulcerative colitis (UC) and to investigate their relationship with disease activity,systemic inflammation and coagulation activation.METHODS: In 46 patients with ulcerative colitis (active in 34 patients), clinical data were gathered and plasma vWF levels, markers of inflammation (ESR, CRP, and fibrinogen) and thrombin generation (TAT, F1+2, and D-dimers) were measured at baseline and after 12 wk of treatment. Plasma vWF levels were also determined in 52 healthy controls (HC). The relationship of plasma vWF levels with disease activity, disease extent, response to therapy, acute-phase reactants (APRs) and coagulation markers (COAGs) was assessed.RESULTS: The mean plasma vWF concentrations were significantly higher in active UC patients (143.38±63.73%) than in HC (100.75±29.65%, P = 0.001)and inactive UC patients (98.92±43.6%, P = 0.031).ESR, CRP and fibrinogen mean levels were significantly higher in active UC patients than in inactive UC patients,whereas there were no significant differences in plasma levels of D-dimers, F1+2, and TAT. UC patients with raised APRs had significantly higher mean plasma vWF levels than those with normal APRs (144.3% vs 96.2%,P = 0.019), regardless of disease activity. Although the mean plasma vWF levels were higher in UC patients with raised COAGs than in those with normal COAGs,irrespective of disease activity, the difference was not significant (141.3% vs 118.2%, P = 0.216). No correlation was noted between plasma vWF levels and disease extent. After 12 wk of treatment, significant decreases of fibrinogen, ESR, F1+2, D-dimers and vWF levels were noted only in UC patients with clinical and endoscopic improvement.CONCLUSION: Our data indicate that increased plasma vWF levels correlate with active ulcerative colitis and increased acute-phase proteins. Elevated plasma vWF levels in ulcerative colitis possibly reflect an acutephase response of the perturbed endothelium due to inflammation. In UC patients, plasma vWF levels may be another useful marker of disease activity or response to therapy. | Petros Zezos Georgia Papaioannou Nikolaos Nikolaidis Themistoclis Vasiliadis Olga Giouleme Nikolaos Evgenidis | 2005 | World Journal of Gastroenterology2005，11，48： | 4 |
| 2 | Hyperhomocysteinemia in ulcerative colitis is related to folate levels显示文摘AIM: To study the prevalence and clinical significance of hyperhomocysteinemia (hHcys), an independent factor for arterial and venous thrombosis, in a group of patients with ulcerative colitis (UC).METHODS: Fasting homocysteine (Hcys), folate, and vitamin B12 serum levels were measured in 40 UC patients and 50 healthy controls. Clinical data regarding UC were gathered.RESULTS: Median serum Hcys levels in UC patients were similar to those in controls (12.26 μmol/L vs 12.32 μmol/L), but the prevalence of hHcys was higher in UC patients than in controls (30% vs 10%, P= 0.028). UC significantly increased the risk of hHcys (adjusted odds ratio: 4.125;95% CI: 1.26-13.44). Multivariate regression analysis showed that male sex, folate and vitamin B12 deficiency or lower serum values were significant independent predictors of higher Hcys levels in UC patients (r2 = 0.4; P<0.001).CONCLUSION: hHcys is common in UC patients and it is related to folate and vitamin B12 deficiency or lower serum values. It would be reasonable for patients with UC to receive folate and vitamin B complex supplements as a prophylactic measure. | Petros Zezos Georgia Papaioannou Nikolaos Nikolaidis Themistoclis Vasiliadis Olga Giouleme Nikolaos Evgenidis | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | Inflammatory pseudotumor of the liver successfully treated with nonsteroidal anti-inflammatory drugs: A challenge diagnosis for one not so rare entity显示文摘 | Themistoklis Vassiliadis Nikolaos Vougiouklis Kalliopi Patsiaoura Alexander Mpoumponaris Nikolaos Nikolaidis Olga Giouleme Nikolaos Evgenidis | 2007 | European Journal of Gastroenterology & Hepatology2007，，11： | 1 |
| 4 | Malignant peripheral nerve sheath tumor in neurobifromatosis type-1:two case reports显示文摘 | Koasmas C Tsakonas G Evgenidi K | | 0，，： | 1 |
| 5 | Maize hybrids less dependent on high plant densities improve resource-use efficiency in rainfed and irrigated conditions显示文摘 | I.S. Tokatlidis V. Has V. Melidis I. Has I. Mylonas G. Evgenidis A. Copandean E. Ninou V.A. Fasoula | 2010 | Field Crops Research2010，，3： | 1 |
| 6 | Bubbly flow characteristics during decompression sickness:effect of surfactant and electrolyte on bubble size distribution显示文摘 | Evgenidis S P Kazakis N A Karapantsios T D | 2010 | Colloids and Surfaces A:Physicochemical Engineering Aspects2010，365，123： | 1 |
| 7 | Effect of bubble size on void fraction fluctuations in dispersed bubble flows显示文摘 | EVGENIDIS S P KARAPANTSIOS T D | 2015 | International Journal of Multiphase Flow2015，75，： | 1 |
| 8 | Malignanet peripheral nerve sheath tumor in neurobifromatosis type-1 :two case reports显示文摘 | Kosmas C Tsakonas G Evgenidi K | 2009 | Cases J2009，2，： | 1 |
| 9 | Malignant peripheral nerve sheath tumor in neurobifromatosis type-1:two case reports显示文摘 | Kosmas C Tsakonas G Evgenidi K | 2009 | Cases J2009，2，： | 1 |
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