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| 1 | Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system显示文摘In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine(TMP) is enhanced when combined with borneol(BN) in a microemulsionbased transdermal therapeutic system(ME-TTS). The formulation of the TMP and BN microemulsion(TEM-BN-ME) was optimized in skin permeation studies in vitro following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher( P < 0.05) C max and AUC of TMP than the TMP-ME-TTS treated rats, indicating that BN improves the rate and extent of TMP percutaneous absorption. In the tissue distribution study, the AUC of TMP in brain was significantly higher in the TMP-BN-ME-TTS group( P < 0.05), indicating that BN facilitates the distribution of TMP in brain. In summary, BN enhanced the percutaneous absorption and brain distribution of TMP in a microemulsion-based transdermal therapeutic system. | Xiaoge Hu Ning Cheng Jihui Zhao Xianghua Piao Yulu Yan Qibo Zhang Kuan Zhou Yongtai Zhang Nianping Feng | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 4 |
| 2 | Strain Transfer Mechanism of Grating Ends Fiber Bragg Grating for Structural Health Monitoring显示文摘The grating ends bonding fiber Bragg grating(FBG)sensor has been widely used in sensor packages such as substrate type and clamp type for health monitoring of large structures.However,owing to the shear deformation of the adhesive layer of FBG,the strain measured by FBG is often different from the strain of actual matrix,which causes strain measurement errors.This investigation aims at improving the measurement accuracy of strain for the grating ends surface-bonded FBG.To fulfill this objective,a strain transfer equation of the grating ends bonding FBG is derived,and a theoretical model of the average strain transfer from the matrix to the optical fiber is developed.Moreover,parameters that influence the average strain transfer rate from the matrix to the optical fiber are analyzed.A selection scheme of bonding parameters by numerical simulation is provided,which is significantly advantageous over that of the grating bonding FBG.The theoretical equation is verified by finite element method(FEM).Compared with the existing model,the proposed model has higher measurement accuracy.Experimental tests are performed to validate the effectiveness of the proposed model on the equalintensity cantilever beam,whose surface is attached to the bare FBG with grating ends bonding and strain gauge by using epoxy glue.The results show that there is a great agreement between the outcome of the bare FBG and that of the strain gauge,and the corrected strain is closer to the true strain.The proposed model provides a theoretical basis for the design of the grating ends surface-bonded FBG strain sensor for health monitoring of large structures. | Guang Chen Keqin Ding Qibo Feng Xinran Yin Fangxiong Tang | 2019 | Structural Durability & Health Monitoring2019，13，3： | 4 |
| 3 | A new laser displacement sensor based on triangulation for gauge real-time measurement显示文摘 | Zhang Zhifeng Feng Qibo Gao Zhan | 2008 | Optics and Laser Technology2008，40，2： | 1 |
| 4 | A simple me~hod for dynami~ cally measuring the diameters of train wheels using a one-dimen- sional laser displacement transducer 显示文摘 | Yah Gao Feng Qibo Cui Jianying | 2014 | Optics and Lasers in Engineering2014，53，： | 1 |
| 5 | A new method for measuring subgrade settlement in high-speed railway by using a linear CCD 显示文摘 | Yang Jing Feng Qibo | 2013 | Measure- ment:Journal of the International Measurement Confederation2013，46，5： | 1 |
| 6 | A new laser displacement sensor based on triangulation for gauge real time measurement 显示文摘 | Zhang Zhifeng Feng Qibo | 2008 | Optics & Laser Technology2008，40，： | 1 |
| 7 | A straight-ness measurement system using a single-mode fiber-coup led laser module显示文摘 | Feng Qibo Zhang Bin Kuang Cuifang | 2004 | Optics and Laser Technol-ogy2004，36，： | 1 |
| 8 | Development of equipment for simultaneously measuring two-dimensional rotation angles of the linear guide track显示文摘 | Kuang Cuifang Feng Qibo Liu Bin | 2005 | Journal of Optoelectronics·Lasers2005，，08： | 1 |
| 9 | A new laser displacement sensor based on triangulation for gauge real-time measurement显示文摘 | Zhifeng Zhang Qibo Feng Zhan Gao | 2008 | Optics & laser technology2008，，40： | 1 |
| 10 | A four-degree-of freedom laser measurement system (FDMS) using a single-mode fiber-coupled laser module 显示文摘 | Cuifang Kuang Qibo Feng Bin Zhang | 2005 | Sensors and Actuators A: Physical2005，125，： | 1 |
| 11 | A straight-ness measurement system using a single-mode fiber-coup led laser module显示文摘 | Feng Qibo Zhang Bin Kuang Cuifang | 2004 | Optics and Laser Tech-nology2004，36，： | 1 |
| 12 | Theoretical analysis of the gauge laser sensor and several design parameters显示文摘 | Zhifeng Zhang Qibo Feng Shiqian Chen | 2005 | 6th International Symposium on Test and Measurement2005，，4： | 1 |
| 13 | A straightness measurement system using a single-modle fiber coupled laser module显示文摘 | FENG Qibo ZHANG Bin KUANG Cuifang | 2004 | Optics & Laser Technology2004，36，： | 1 |
| 14 | Digital shearography with insitu phase shift calibration显示文摘 | Wu Sijin Zhu Lianqing Feng Qibo | 2012 | OPTICS AND LASERS IN ENGI-NEERING2012，50，9： | 1 |
| 15 | A straightness measuremnt system using asingle-mode fiber-coupled laser module显示文摘 | Qibo Feng Bin Zhang Cuifang Kuang | 2004 | Optics & Laser Technology2004，36，： | 1 |
| 16 | Track irregularity inspection trolley based on fiber-optic gym显示文摘 | GAO Zhan FENG Qibo WU Sijin | 2010 | Journal of Micro-Nanolithography MEMS and MOEMS2010，9，1： | 1 |
| 17 | A Straightness Measurement System Using A Single-model Fiber Coupled Laser Module 显示文摘 | FENG Qibo ZHANG Bin KUANG Cuifang | 2004 | Optics & Laser Technology2004，36，： | 1 |
| 18 | A straightness measurement system using a single-mode fiber-coupled laser module 显示文摘 | Feng Qibo Zhang Bin Kuang Cuifang | 2004 | Optics & Laser Technology2004，36，： | 1 |
| 19 | Chemical characterization of rice straw-derived biochar for soil amendment显示文摘 | Weixiang Wu Min Yang Qibo Feng Kim McGrouther Hailong Wang Haohao Lu Yingxu Chen | 2012 | Biomass and Bioenergy2012，，： | 1 |
| 20 | A New Laser Displacement Sensor Based on Triangulation for Gauge Real-time Measurement显示文摘 | Zhifeng Zhang Qibo Feng Zhan Gao | 2008 | Optics and Laser Technology2008，40，： | 1 |
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