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| 1 | Two new triterpenoid saponins from Lonicera macranthoides显示文摘二新 triterpenoid saponins 把 lonimacranthoide 称为 IV (1 ) , lonimacranthoide V (2 ) 从忍冬 macranthoides Hand.-Mazz 的花芽被孤立。(Caprifoliaceae ) 。他们作为 aglycone 有 hederagenin。Lonimacranthoide IV (1 ) 是 hederagenin 的 C-23 上的稀罕 chlorogenic 酸酉旨 acylated。Lonimacranthoide IV 是新 sulfated triterpenoid saponin。saponins 的结构被化学、光谱的方法建立。 | Yu Chen Yu Shan You Yi Zhao Qi Zhi Wang Ming Wang Xu Feng Jing Yu Liang | 2012 | Chinese Chemical Letters2012，23，3： | 14 |
| 2 | Prevalence and Genotypes of Rotavirus A and Human Adenovirus among Hospitalized Children with Acute Gastroenteritis in Fujian, China, 2009-2017显示文摘Gastroenteritis is an infectious diarrhea that has been considered as an important cause of hospitalizations and death in children aged < 5 years, particularly in developing countries. Unsanitary water, contaminated food, poor hygiene, and inadequate disposal of waste and feces are all risk factors for gastroenteritis, resulting in the higher incidence in developing countries. Gastroenteritis is generally caused by viral infections, among which rotavirus (RV) infections have been reported to be the most common, especially among young children aged < 5 years with acute gastroenteritis in Asia and Africa[1]. Other viruses associated with acute gastroenteritis include human Adenovirus (HAdV), Norovirus, Sapovirus (SaV), human Astrovirus (HAstV), and Aichi virus. Recent research has reported that adenovirus types 40 and 41, belonging to species F, cause gastroenteritis and were therefore termed as enteric adenoviruses. In addition, non-enteric HAdV species such as A, B, C, and D have been associated with diarrheal. | WU Bing Shan HUANG Zhi Miao WENG Yu Wei CHEN Feng Qin ZHANG Yun Lin LIN Wei Dong YU Ting Ting | 2019 | Biomedical and Environmental Sciences2019，32，3： | 10 |
| 3 | Effects of Outdoor Temperature on Blood Pressure in a Prospective Cohort of Northwest China显示文摘Objective The relationship between outdoor temperature and blood pressure(BP) has been inconclusive. We analyzed data from a prospective cohort study in northwestern China to investigate the effect of outdoor temperature on BP and effect modification by season.Methods A total of 32,710 individuals who participated in both the baseline survey and the first follow-up in 2011–2015 were included in the study. A linear mixed-effect model and generalized additive mixed model(GAMM) were applied to estimate the association between outdoor temperature and BP after adjusting for confounding variables.Results The mean differences in systolic blood pressure(SBP) and diastolic blood pressure(DBP)between summer and winter were 3.5 mm Hg and 2.75 mm Hg, respectively. After adjusting for individual characteristics, meteorological factors and air pollutants, a significant increase in SBP and DBP was observed for lag 06 day and lag 04 day, a 0.28 mm Hg(95% CI: 0.27–0.30) per 1 °C decrease in average temperature for SBP and a 0.16 mm Hg(95% CI: 0.15–0.17) per 1 °C decrease in average temperature for DBP, respectively. The effects of the average temperature on both SBP and DBP were stronger in summer than in other seasons. The effects of the average temperature on BP were also greater if individuals were older, male, overweight or obese, a smoker or drinker, or had cardiovascular diseases(CVDs), hypertension, and diabetes.Conclusions This study demonstrated a significant negative association between outdoor temperature and BP in a high-altitude environment of northwest China. Moreover, BP showed a significant seasonal variation. The association between BP and temperature differed by season and individuals' demographic characteristics(age, gender, BMI), unhealthy behaviors(smoking and alcohol consumption), and chronic disease status(CVDs, hypertension, and diabetes). | ZHENG Shan WANG Min Zhen CHENG Zhi Yuan KANG Feng NIE Yong Hong MI Xiu Ying LI Hai Yan JIN Lan ZHANG Ya Wei BAI Ya Na | 2021 | Biomedical and Environmental Sciences2021，34，2： | 5 |
| 4 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 5 | Digital high-efficiency print forming method and device for multi-material casting molds显示文摘Sand mold 3D printing technology based on the principle of droplet ejection has undergone rapid development in recent years and has elicited increasing attention from engineers and technicians.However,current sand mold 3D printing technology exhibits several problems,such as single-material printing molds,low manufacturing efficiency,and necessary post-process drying and heating for the manufacture of sand molds.This study proposes a novel high-efficiency print forming method and device for multi-material casting molds.The proposed method is specifically related to the integrated forming of two-way coating and printing and the shortflow manufacture of roller compaction and layered heating.These processes can realize the high-efficiency print forming of high-performance sand molds.Experimental results demonstrate that the efficiency of sand mold fabrication can be increased by 200%using the proposed two-way coating and printing method.The integrated forming method for layered heating and roller compaction presented in this study effectively shortens the manufacturing process for 3D-printed sand molds,increases sand mold strength by 63.8%,and reduces resin usage by approximately 30%.The manufacture of multi-material casting molds is demonstrated on typical wheeled cast-iron parts.This research provides theoretical guidance for the engineering application of sand mold 3D printing. | Zhongde SHAN Zhi GUO Dong DU Feng LIU Wenjiang LI | 2020 | Frontiers of Mechanical Engineering2020，15，2： | 5 |
| 6 | Coating process of multi-material composite sand mold 3D printing显示文摘Sand mold 3 D printing technology is an advanced manufacturing technology which has great flexible manufacturing ability. A multi-material composite sand mold can control the temperature field of metallic parts during the pouring process, while the current sand mold 3 D printing technology can only fabricate a single material sand mold. The casting temperature field can not be adjusted by using single sand mold material with isotropous heat exchange ability during the pouring process. In this work, a kind of novel coating device was designed. Multi-material composite sand molds could be manufactured using the coating device according to the casting process demands of the final parts. The influences of curing agent content, coating velocity and scraper shape on compactness and surface roughness of the sand layer(silica sand and zircon sand) were studied. The shapes and sizes of transition intervals of two kinds of sand granules were also tested. The results show that, with the increase of the added volume of curing agent, the compactness of sand layer reduces and the surface roughness value rises. With the increase of the velocity of the coating device, the compactness of sand layer reduces and the surface roughness value rises similarly. In addition, the scraper with a dip angle of 72 degrees could increase the compactness value of the sand layer. The criteria of quality parmeters of the coating procedure are obtained. That is, the surface roughness(δ) of sand layer should be equal to or lesser than half of main size of the sand particles(Dm). The parameter H of the coating device which is the distance between the base of hopper and the surface of sand layer impacts the size of transition zone. The width of the transition zone is in direct proportion to the parameter H, qualitatively. Through the optimization of the coating device, high quality of multi-material sand layers can be obtained. This will provide a solution in manufacturing the multi-material composite sand mold. | Zhong-de Shan Zhi Guo Dong Du Feng Liu | 2017 | China Foundry2017，14，6： | 4 |
| 7 | Hyperbaric oxygen treatment on keloid tumor immune gene expression显示文摘Background:Hyperbaric oxygen treatment(HBOT)has been demonstrated to influence the keloid recurrence rate after surgery and to relieve keloid symptoms and other pathological processes in keloids.To explore the mechanism of the effect of HBOT on keloids,tumor immune gene expression and immune cell infiltration were studied in this work.Methods:From February 2021 to April 2021,HBOT was carried out on keloid patients four times before surgery.Keloid tissue samples were collected and divided into an HBOT group(keloid with HBOT before surgery[HK]group,n=6)and a non-HBOT group(K group,n=6).Tumor gene expression was analyzed with an Oncomine Immune Response Research Assay kit.Data were mined with R package.The differentially expressed genes between the groups were compared.Hub genes between the groups were determined and verified with Quantitative Real-time PCR.Immune cell infiltration was analyzed based on CIBERSORT deconvolution algorithm analysis of gene expression and verified with immunohistochemistry(IHC).Results:Inflammatory cell infiltration was reduced in the HK group.There were 178 upregulated genes and 217 downregulated genes.Ten hub genes were identified,including Integrin Subunit Alpha M(ITGAM),interleukin(IL)-4,IL-6,IL-2,Protein Tyrosine Phosphatase Receptor Type C(PTPRC),CD86,transforming growth factor(TGF),CD80,CTLA4,and IL-10.CD80,ITGAM,IL-4,and PTPRC with significantly downregulated expression were identified.IL-10 and IL-2 were upregulated in the HK group but without a significant difference.Infiltration differences of CD8 lymphocyte T cells,CD4 lymphocyte T-activated memory cells,and dendritic resting cells were identified with gene CIBERSORT deconvolution algorithm analysis.Infiltration levels of CD4 lymphocyte T cell in the HK group were significantly higher than those of the K group in IHC verification.Conclusion:HBOT affected tumor gene expression and immune cell infiltration in keloids.CD4 lymphocyte T cell,especially activated memory CD4+T,might be the key regulatory immune cell,and its related gene expression needs further study. | Chun-Hu Wang Meng-Jie Shan Hao Liu Yan Hao Ke-Xin Song Huan-Wen Wu Tian Meng Cheng Feng Zheng Qi Zhi Wang You-Bin Wang | 2021 | Chinese Medical Journal2021，，18： | 4 |
| 8 | Rapid Internal Control Reference Recombinase-Aided Amplification Assays for EBV and CMV Detection显示文摘Epstein-Barr virus(EBV)and cytomegalovirus(CMV),two of the most prevalent human herpesviruses,cause a wide spectrum of diseases and symptoms and are associated with serious health problem.In this study,we developed an internal control reference recombinase-aided amplification(ICR-RAA)assay for the rapid detection of EBV and CMV within 30 min.The assay had a sensitivity of 5 and 1 copies/test for EBV and CMV,respectively,with no cross reaction with other pathogens.In comparison with those of the commercial quantitative polymerase chain reaction(qPCR),the sensitivity of the EBV and CMV ICR-RAAs using extracted DNA was 93.33%and 84.84%,respectively;the specificity was 98.75%and 100.00%,respectively;and the Kappa values were 0.930 and 0.892(P<0.05),respectively.In comparison with those of qPCR,the sensitivity of the EBV and CMV ICR-RAAs using the DNA by thermal lysis was 72.22%and 80.00%,respectively;the specificity was 100.00%。 | GAO Yuan TIE Yan Qing ZHAO Lin Qing TAN He DING Nan DING Ya Xin GUO Qi ZHANG Rui Qing WANG Jin Rong CHEN Zi Wei FAN Guo Hao SHEN Xin Xin FENG Zhi Shan MA Xue Jun | 2021 | Biomedical and Environmental Sciences2021，34，8： | 3 |
| 9 | pH-sensitive polymer-assisted refolding of urea-denatured fibroblast growth factor显示文摘pH 应答的聚合物 Eudragit S-100 被发现了在 FGF-2 (成纤维细胞生长 factor-2 ) 的正确合拢帮助的 A 在 pH 与 8 mol/L 脲和 10 mmol/L dithiothreitol 使中毒 7.2。FGF-2 的 refolding 被直接冲淡执行使中毒的 FGF-2 进包含 Eudragit S-100 的一个 refolding 缓冲区。Eudragit S-100 的能力用 MTT 方法,荧光排放光谱学和反向的阶段 HPLC 被调查提高蛋白质 refolding 水平。在另一方面,结果显示出提高蛋白质的 refolding 水平的 S-100 由于在 Eudragit S-100 之间的相互作用并且断然控告 FGF-2 的 Eudragit 的能力。 | Zhi Feng Huang Shan Shan Wang Chun Yan Ni Shu Lin Yang Xiao Kun Li Susanna S.J. Leong | 2009 | Chinese Chemical Letters2009，20，4： | 2 |
| 10 | Synthesis and thermal properties of shape-stabilized lauric acid/ activated carbon composites as phase change materials for thermal energy storage 显示文摘 | CHEN Zhi SHAN Feng CAO Lei | 2012 | Solar Energy Materials & Solar Cells2012，102，： | 1 |
| 11 | High Damping Capacity of a Binary TiNi Shape Memory Alloy显示文摘 | Yuan Zhi Shan Feng Zhao Wei Miao Wei Dong Wang Jiang Bo Zhou Jin Zhu Ming | 2011 | Materials Science Forum2011，，687： | 1 |
| 12 | Carbon sequestration and emissions mitigation in paddy fields based on the DNDC model: A review显示文摘The DeNitrification–DeComposition(DNDC)model is a process model with a series of carbon and nitrogen biogeochemistry in agro-ecosystems.It incorporates the driving factors of the ecological environment and aims to simulate the carbon and nitrogen cycle in the terrestrial ecosystem.Furthermore,the model can be applied effectively in a paddy ecosystem.Based on an investigation and literature review,this study summarized and analyzed the impact of agricultural practices such aswatermanagement,fertilizer application,and strawincorporation on greenhouse gas emissions and soil carbon storage.After years of improvement,the DNDC model can presently be used effectively to evaluate the carbon sequestration and emissions mitigation potential of various agricultural practices.However,the related details of scientific processes of agricultural management,such as biochar incorporation and plastic mulching in paddy fields,should be added or modified and combined with experimental cases of actual agricultural practices to complete the calibration of the model,provide theoretical support for its promotion,and establish a reliable method of evaluating carbon sequestration and emissions mitigation in paddy fields. | Shan Yin Xianxian Zhang Junyao Lyu Yuee Zhi Feng Chen Longqin Wang Chunjiang Liu Sheng Zhou | 2020 | Artificial Intelligence in Agriculture2020，，1： | 1 |
| 13 | Preparation and characteristics of microencapsulated stearic acid as composite thermal energy storage material in buildings显示文摘 | Zhi Chen Lei Cao Feng Shan Guiyin Fang | 2013 | Energy & Buildings2013，，： | 1 |
| 14 | Tracking the algal origin of the Ulva bloom in the Yellow Sea by a combination of molecular, morphological and physiological analyses显示文摘 | Shao Jun Pang Feng Liu Ti Feng Shan Na Xu Zhi Huai Zhang Su Qin Gao Thierry Chopin Song Sun | 2009 | Marine Environmental Research2009，，4： | 1 |
| 15 | Study on a New Low-Voltage Residual Current Protective System显示文摘 | Yue Jing Zhao Feng Shan Huang Zhi Lin Zhao | 2013 | Advanced Materials Research2013，，694： | 1 |
| 16 | Synthesis and thermal properties of shape-stabilized lauric acid/activated carbon composites as phase change materials for thermal energy storage显示文摘 | Zhi Chen Feng Shan Lei Cao Guiyin Fang | 2012 | Solar Energy Materials and Solar Cells2012，，： | 1 |
| 17 | Synthesis and thermal properties of shape-stabilized lauric acid/ activated carbon composites as phase change materials for thermal energy stoarge 显示文摘 | Chen Zhi Shan Feng Cao Lei | 2012 | Solar Energy Materials and Solar Cells2012，102，： | 1 |
| 18 | Synthesis and thermal properties of shape-stabilized lauric acid/activa- ted carbon composites as phase change materials for ther- mal energy storage 显示文摘 | CHEN Zhi SHAN Feng CAO Lei | 2012 | Solar Energy Materials and Solar Cells2012，102，7： | 1 |
| 19 | Cultivation of the brown alga Sargassum horneri: sexual reproduction and seedling production in tank culture under reduced solar irradiance in ambient temperature显示文摘 | Shao Jun Pang Feng Liu Ti Feng Shan Su Qin Gao Zhi Huai Zhang | 2009 | Journal of Applied Phycology2009，，4： | 1 |
| 20 | Synthesis and thermal properties of shape-stabilized lauric acid/activated carbon composites as phase change materials for thermal energy storage显示文摘 | CHEN Zhi SHAN Feng CAO Lei | 2012 | Solar Energy Materials & Solar Cells2012，102，： | 1 |
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