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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 3 | Charring of fire retarded ethylene vinyl acetate copolymer-magnesium hydroxide/zinc borate formulations显示文摘 | FABIEN C SERGE B MICHEL L B | 2000 | Polymer Degradation and Stability2000，69，1： | 1 |
| 4 | Regularizing common spatial patterns to improve BCI designs: unified theory and new algorithms显示文摘 | Fabien Lotte Guan C | 2011 | IEEE Transactions on Biomeflieal Engineering2011，58，2： | 1 |
| 5 | Heavy metal contamination along a soil transect in the vicinity of the iron smelter of Kremikovtzi (Bulgaria) 显示文摘 | Rainer S Fabien C Margarita M | 2007 | Geoderma2007，140，： | 1 |
| 6 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 1 |
| 7 | Regulation of flavonoid biosynthesis involves an unexpected complex transcriptional regulation of TT 8 expression, in A rabidopsis显示文摘 | Wenjia Xu Damaris Grain José Gourrierec Erwana Harsco?t Adeline Berger Vincent Jauvion Aurélie Scagnelli Nathalie Berger Przemyslaw Bidzinski Zsolt Kelemen Fabien Salsac Antoine Baudry Jean‐Marc Routaboul Lo?c Lepiniec Christian Dubos | 2013 | New Phytol2013，，1： | 1 |
| 8 | High-level secrctory production of recombinant porcine follicle-stimulating hormone by Pichia pastoris显示文摘 | Boze H Laborde C Chemardin P Fabien R Venturin C Combarnous Y Moulin G | | 0，，： | 1 |
| 9 | Including multiple differing stakeholder values into vulnerability assessments of social- ecological systems显示文摘 | Jacqueline D C Fabien Q Sandra L | 2008 | Global Environmental Change2008，，18： | 1 |
| 10 | C-myc boxⅡ mutations in burkitt's iymphoma-derived alleles reduce cell-transformation activity and lower response to broad apoptotic stimul显示文摘 | Fabien K Patricia A Helen C | 2001 | Oncogene2001，20，42： | 1 |
| 11 | TrkB inhibition as a therapeutic target for CNS-related disorders显示文摘 | Fabien B Gunter K Maxime C | | 0，，02： | 1 |
| 12 | Charring of Re- tarded Ethylene Vinyl Acetate Copolymermagnesium Hy- droxide/zinc Borate Formulations显示文摘 | Fabien C Serge B Michel L B | 2000 | Polymer Degrada- tion and Stability2000，69，： | 1 |
| 13 | Optimal control of a flywheel energy storage system with a radial flux hybrid magnetic bearing显示文摘 | Jr-Yi Shen Fabien B C | 2002 | J of the Franklin Institute2002，339，2： | 1 |
| 14 | Quantitative metabolic profiles of tomato flesh and seeds during fruit development: complementary analysis with ANN and PCA显示文摘 | Fabien Mounet Martine Lemaire-Chamley Micka?l Maucourt Cécile Cabasson Jean-Luc Giraudel Catherine Deborde René Lessire Philippe Gallusci Anne Bertrand Monique Gaudillère Christophe Rothan Dominique Rolin Annick Moing | 2007 | Metabolomics2007，，3： | 1 |
| 15 | Guided shear horizontal surface acoustic wave sensors for chemical and biochemical detection in liquids 显示文摘 | FABIEN J FLORIAN B RICHARD W C | 2001 | Analytical Chemistry2001，73，： | 1 |
| 16 | Generation of electrically induced stimuli for MEMS self-test 显示文摘 | Benoit C Salvador M Fabien P | 2001 | Journal of Elctronic: Theory and Application2001，17，： | 1 |
| 17 | A Two-phase heuristic for the two-dimensional cutting-stock problem 显示文摘 | Fabien C | 1991 | Operational Research Society1991，42，： | 1 |
| 18 | Some tools for the direct solution of optimal control problems显示文摘 | Fabien Brian C | 1998 | Advances in Engineering Software1998，29，1： | 1 |
| 19 | Detection of transient signals in lung sounds: local approach using a mark- ovian tree with frequency selectivity 显示文摘 | LE CAM S CHRISTOPHE C FABIEN S | 2011 | J Signal Process Syst2011，65，3： | 1 |
| 20 | Sulfonimidamides: efficient chiral iminoiodane precursors for diastereoselective copper-catalyzed aziridination of olefins 显示文摘 | Pablo H D C Fabien R P Philippe D | 2004 | Org Lett2004，6，24： | 1 |
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