|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 2 | A framework for equipment systems-of-systems effectiveness evaluation using parallel experiments approach显示文摘Equipment systems-of-systems(So S) effectiveness evaluation can provide important reference for construction and optimization of the equipment So S. After discussing the basic theory and methods of parallel experiments, we depict an So S effectiveness analysis and evaluation method using parallel experiments theory in detail. A case study is carried out which takes the missile defense system as an example. An artificial system of the missile defense system is constructed with the multi-agent modeling method. Then, single factor, multiple factors and defense position deployment computational experiments are carried out and evaluated with the statistical analysis method. Experiment results show that the altitude of the secondary interception missile is not the key factor which affects So S effectiveness and putting the defense position ahead will increase defense effectiveness. The case study demonstrates the feasibility of the proposed method. | Zilong Cheng Li Fan Yulin Zhang | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 7 |
| 3 | Multi-agent decision support system for missile defense based on improved PSO algorithm显示文摘Ballistic missile defense system(BMDS) is important for its special role in ensuring national security and maintaining strategic balance. Research on modeling and simulation of the BMDS beforehand is essential as developing a real one requires lots of manpower and resources. BMDS is a typical complex system for its nonlinear, adaptive and uncertainty characteristics.The agent-based modeling method is well suited for the complex system whose overall behaviors are determined by interactions among individual elements. A multi-agent decision support system(DSS), which includes missile agent, radar agent and command center agent, is established based on the studies of structure and function of BMDS. Considering the constraints brought by radar,intercept missile, offensive missile and commander, the objective function of DSS is established. In order to dynamically generate the optimal interception plan, the variable neighborhood negative selection particle swarm optimization(VNNSPSO) algorithm is proposed to support the decision making of DSS. The proposed algorithm is compared with the standard PSO, constriction factor PSO(CFPSO), inertia weight linear decrease PSO(LDPSO),variable neighborhood PSO(VNPSO) algorithm from the aspects of convergence rate, iteration number, average fitness value and standard deviation. The simulation results verify the efficiency of the proposed algorithm. The multi-agent DSS is developed through the Repast simulation platform and the constructed DSS can generate intercept plans automatically and support three-dimensional dynamic display of missile defense process. | Zilong Cheng Li Fan Yulin Zhang | 2017 | Journal of Systems Engineering and Electronics2017，28，3： | 5 |
| 4 | Effect of fluoride on the corrosion behavior of nanostructured Ti-24Nb-4Zr-8Sn alloy in acidulated artificial saliva显示文摘The surface of titanium dental implants is highly susceptible to aggressive fluoride ions in the oral environment. Nanotechnology has proven an effective approach to improve the stability and corrosion resistance of titanium by applying a passive film. In this study, we investigated the effects of fluoride on the corrosion behavior of nanostructured(NS) Ti-24 Nb-4 Zr-8 Sn(Ti2448) alloy in acidulated artificial saliva(AAS)at 37 ℃, and then conducted comparisons with its coarse grained(CG) counterpart. Electrochemical techniques, such as potentiodynamic polarization and electrochemical impedance spectroscopy(EIS), as well as surface analysis including X-ray photoelectron spectroscopy(XPS) with argon ion sputtering, and scanning electronic microscopy(SEM) were employed to evaluate the effects of fluoride on sensitivity to pitting and the tolerance of Ti2448 to fluoride in AAS solution. The results demonstrate that corrosion current density increased with F-concentration. In all respects, the NS Ti2448 alloy presented corrosion resistance superior to that of its coarse grained(CG) counterpart at low F-concentrations(<0.1%).Furthermore, a high content of F-(1%) was shown to promote the active dissolution of both alloys by increasing the rate of corrosion. Following immersion in the fluoridated AAS solution for 60 days, a tissuefriendly compound, Ca_3(PO_4)_2, was detected on the surface of the NS when F-= 0.01% and Na_2 TiF_6 was identified as the main component in the corrosion products of the CG as well as NS Ti2448 alloys when F-= 1%. High concentrations of F-produced pitting corrosion on the CG alloy, whereas NS Ti2448 alloy presented general corrosion in the form of lamellar separation under the same conditions. These findings demonstrate the superior corrosion resistance of the NS Ti2448 alloy as well as lower pitting sensitivity and higher tolerance to fluoride due mainly to grain refinement. | Ji Li Yun Bai Zhidong Fan Shujun Li Yulin Hao Rui Yang Yongbo Gao | 2018 | Journal of Materials Science & Technology2018，34，9： | 3 |
| 5 | Heterojunction Incorporating Perovskite and Microporous Metal–Organic Framework Nanocrystals for Efficient and Stable Solar Cells显示文摘In this paper,we present a facile approach to enhance the efficiency and stability of perovskite solar cells(PSCs)by incorporating perovskite with microporous indium-based metal–organic framework[In12O(OH)16(H2O)5(btc)6]n(In-BTC)nanocrystals and forming heterojunction light-harvesting layer.The interconnected micropores and terminal oxygen sites of In-BTC allow the preferential crystallization of perovskite inside the regular cavities,endowing the derived films with improved morphology/crystallinity and reduced grain boundaries/defects.Consequently,the In-BTC-modified PSC yields enhanced fill factor of 0.79 and power conversion efficiency(PCE)of 20.87%,surpassing the pristine device(0.76 and 19.52%,respectively).More importantly,over 80%of the original PCE is retained after 12 days of exposure to ambient environment(25°C and relative humidity of^65%)without encapsulation,while only about 35%is left to the pristine device. | Xuesong Zhou Lele Qiu Ruiqing Fan Jian Zhang Sue Hao Yulin Yang | 2020 | Nano-Micro Letters2020，12，6： | 3 |
| 6 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 7 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 8 | Oxygen vacancies enriched nickel cobalt based nanoflower cathodes: Mechanism and application of the enhanced energy storage显示文摘The rational design of oxygen vacancies and electronic microstructures of electrode materials for energy storage devices still remains a challenge. Herein, we synthesize nickel cobalt-based oxides nanoflower arrays assembled with nanowires grown on Ni foam via the hydrothermal process followed annealing process in air and argon atmospheres respectively. It is found that the annealing atmosphere has a vital influence on the oxygen vacancies and electronic microstructures of resulting NiCo_(2)O_(4) (NCO-Air) and CoNiO_(2) (NCO-Ar) products, which NCO-Ar has more oxygen vacancies and larger specific surface area of 163.48 m^(2)/g. The density functional theory calculation reveals that more oxygen vacancies can provide more electrons to adsorb –OH free anions resulting in superior electrochemical energy storage performance. Therefore, the assembled asymmetric supercapacitor of NCO-Ar//active carbon delivers an excellent energy density of 112.52 Wh/kg at a power density of 558.73 W/kg and the fabricated NCO-Ar//Zn battery presents the specific capacity of 180.20 mAh/g and energy density of 308.14 Wh/kg. The experimental measurement and theoretical calculation not only provide a facile strategy to construct flower-like mesoporous architectures with massive oxygen vacancies, but also demonstrate that NCO-Ar is an ideal electrode material for the next generation of energy storage devices. | Jiahui Ye Xingwu Zhai Long Chen Wen Guo Tiantian Gu Yulin Shi Juan Hou Fei Han Yi Liu Changchun Fan Gang Wang Shanglong Peng Xuhong Guo | 2021 | Journal of Energy Chemistry2021，30，11： | 2 |
| 9 | Graphene-nickel nitride hybrids supporting palladium nanoparticles for enhanced ethanol electrooxidation显示文摘Electrocatalysts for ethanol oxidation reaction(EOR)are generally limited by their poor durability because of the catalyst poisoning induced by the reaction intermediate carbon monoxide(CO).Therefore,the rapid oxidation removal of CO intermediates is crucial to the durability of EOR-based catalysts.Herein,in order to effectively avoiding the catalyst CO poisoning and improve the durability,the graphene-nickel nitride hybrids(AG-Ni_(3)N)were designed for supporting palladium nanoparticles(Pd/AG-Ni_(3)N)and then used for ethanol electrooxidation.The density functional theory(DFT)calculations demonstrated the introduction of AG-Ni_(3)N depresses the CO absorption and simultaneously promotes the adsorption of OH species for CO oxidation removal.The fabricated Pd/AG-Ni_(3)N catalyst distinctively exhibits excellent electroactivity with the mass catalytic activity of 3499.5 m A mg^(-1) on EOR in alkaline media,which is around 5.24 times higher than Pd/C(commercial catalyst).Notably,the Pd/AG-Ni_(3)N hybrids display excellent stability and durability after chronoamperometric measurements with a total operation time of 150,000 s. | Tong Wu Xiao Wang Ahmet Emrehan Emre Jinchen Fan Yulin Min Qunjie Xu Shigang Sun | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 10 | Er3+ and Yb3+ co doped TiO2 xFx up-conversion luminescence powder as a light scatte layer with enhanced performance in dye sensitized solar cells显示文摘 | Jia Yu Yulin Yang Ruiqing Fan | 2013 | Journal of Power Sources2013，243，： | 1 |
| 11 | Enhanced Near Infrared to Visible Upconversion Nanoparticles of Ho3+ Yb3 F Tri-Doped TiO2 and Its Application in Dye-Sensitized Solar Cells with 37% Improvement in Power Conversion Efficiency显示文摘 | Jia Yu Yulin Yang Ruiqing Fan | 2014 | Inorganic Chemistry2014，53，： | 1 |
| 12 | Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats显示文摘 | Ruchun Dai Yulin Ma Zhifeng Sheng Yan Jin Yuhai Zhang Lingna Fang Huijie Fan Eryuan Liao | 2008 | Journal of Bone and Mineral Metabolism2008，，4： | 1 |
| 13 | Torsional Design of Hybrid Concrete Box Girders显示文摘 | Mo Y L Fan Yulin | 2006 | Journal of Bridge Engineering2006，，6： | 1 |
| 14 | Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats显示文摘 | Ruchun Dai Yulin Ma Zhifeng Sheng Yan Jin Yuhai Zhang Lingna Fang Huijie Fan Eryuan Liao | 2008 | Journal of Bone and Mineral Metabolism2008，，4： | 1 |
| 15 | Influence of equiatomic Zr/Nb substitution on superelastic behavior of Ti–Nb–Zr alloy显示文摘 | Jinyong Zhang Fan Sun Yulin Hao Nicolas Gozdecki Emilie Lebrun Philippe Vermaut Richard Portier Thierry Gloriant Pascal Laheurte Frédéric Prima | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 16 | Characterization and auto-restoration mechanism of nanoscale serpentine powder as lubricating oil additive under high temperature显示文摘 | Xiaowen Qi Zhining Jia Yulin Yang Bingli Fan | 2011 | Tribology International2011，，7： | 1 |
| 17 | The effects of state-dependent time delay on a stage-structured population growth model显示文摘 | Gao Yulin Fan Jiangqing Thomas C G | 1992 | Non Anal Theory Met and Apple1992，19，： | 1 |
| 18 | An integrated geospatial information service system for disaster management in China显示文摘The Chinese Government and citizens face enormous challenges of disaster management as widespread devastation,economic damages,and loss of human lives caused by increasing natural disasters.Disaster management requires a complicated iterative process that includes disaster monitoring,early detection,forecasting,loss assessment,and efficient analysis of disaster reduction.Each task typically involves the use of technologists and multiple geospatial information resources,including sensors,data sources,models,geo-tools,software packages,and computing resources.However,most existing disaster management systems operate in a typical passive data-centric mode,where resources cannot be fully utilized.This impediment is partially being addressed by the increasingly complex application requirements and the growing availability of diverse resources.In this paper,we summarize and analyze the practical problems experienced by the National Disaster Reduction Application System of China.To address the issues of data-centric,centralized,isolated solutions,we propose a novel Focusing Service Mechanism,which is capable of scheduling and allocating for optimum utilization of multiple resources,to dynamically generate collaborative and on-demand disaster information services.We also demonstrate the design and implementation of the Integrated Disaster Information Service System(IDISS).Through the service strategies of Virtualizing,Wrapping,and Integrating,disasterrelated resources are constructed into services in the IDISS.These services are dynamically aggregated into focusing service chains,for diverse disaster management tasks.Actual applications illustrate that the proposed service system can significantly improve the capability of disaster management in China. | Yulin Ding Yida Fan Zhiqiang Du Qing Zhu Wei Wang Sanchao Liu Hui Lin | 2015 | International Journal of Digital Earth2015，8，11： | 1 |
| 19 | Soil bacterial communities interact with silicon fraction transformation and promote rice yield after long-term straw return显示文摘Returning crop straw into the soil is an important practice to balance biogenic and bioavailable silicon(Si)pool in paddy,which is crucial for the healthy growth of rice.However,owing to little knowledge about soil microbial communities responsible for straw degradation,how straw return affects Si bioavailability,its uptake,and rice yield remains elusive.Herein,we investigate the change of soil Si fractions and microbial community in a 39-year-old paddy field amended by a long-term straw return.Results show that rice straw return significantly increased soil bioavailable Si and rice yield from 29.9%to 61.6%and from 14.5%to 23.6%,respectively,when compared to NPK fertilization alone.Straw return significantly altered soil microbial community abundance.Acidobacteria was positively and significantly related to amorphous Si,while Rokubacteria at phylum level,Deltaproteobacteria,and Holophagae at class level was negatively and significantly related to organic matter adsorbed and Fe/Mn-oxide-combined Si in soils.Redundancy analysis of their correlations further demonstrated that Si status significantly explained 12%of soil bacterial community variation.These findings suggest that soil bacteria community and diversity interact with Si mobility by altering its transformation,thus resulting in the balance of various nutrient sources to drive biological Si cycle in agroecosystem. | Alin Song Zimin Li Yulin Liao Yongchao Liang Enzhao Wang Sai Wang Xu Li Jingjing Bi Zhiyuan Si Yanhong Lu Jun Nie Fenliang Fan | 2021 | Soil Ecology Letters2021，3，4： | 0 |
| 20 | Metal-organic frameworks with mixed-ligands strategy as heterogeneous nucleation center to assist crystallization for efficient and stable perovskite solar cells显示文摘Deep-level defects and random oriented configuration in perovskite crystallization process would cause the nonradiative recombination and further affect the performance of perovskite solar cells(PSCs).Herein,two metal-organic frameworks(MOFs)with tunable Lewis-base passivation sites have been constructed(Cd-Httb and Cd-Httb-BDC,Httb=5-(4-(1H-1,2,4-triazole-1-yl)benzyl)-1h-tetrazole,BDC=1,4-dicarboxybenzene)to eliminate deep-level defects and simultaneously as nanostructured heterogeneous nucleation seed to assist the growth of large-grained perovskite films.Compared with the control and Cd-Httb,Cd-Httb-BDC designed with mix-ligands strategy exhibited the enhanced inducted effect on the crystallization and nucleation of high-quality perovskite films during annealing process.Consequently,the resultant Cd-Httb-BDC-modified device achieved higher power conversion efficiency(PCE)(22.18%)than the control(20.89%)and Cd-Httb(21.56%).Meanwhile,the unencapsulated Cd-Httb-BDC-modified device still maintained 90%of initial PCE after 1500 h in ambient conditions and exhibited enhanced thermal stability(85℃ in N_(2) atmosphere).This work presented a successful example of mixligands strategy on construction of high-quality MOF-assisted perovskite films for high-efficient and stable PSCs. | Yayu Dong Shuang Gai Jian Zhang Ruiqing Fan Boyuan Hu Wei Wang Wei Cao Jiaqi Wang Ke Zhu Debin Xia Lin Geng Yulin Yang | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员