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| 1 | Measurement of earth crust tilt tides with a folded pendulum显示文摘A new method for detecting the crust tilt tides with a folded pendulum is presented. The principle of the folded pendulum and the displacement transducer together with the recording system are introduced. The preliminary experimental result shows that the folded pendulum is very sensitive to the tilt tides. | Shuhua Fan Shuchao Wu Yunxia Cai Jun Luo | 1999 | Chinese Science Bulletin1999，44，1： | 4 |
| 2 | Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion显示文摘Osteocytes are mechanosensitive bone cells, but little is known about their effects on tumor cells in response to mechanical stimulation. We treated breast cancer cells with osteocyte-derived conditioned medium(CM) and fluid flow-treated conditioned medium(FFCM) with 0.25 Pa and 1 Pa shear stress. Notably, CM and FFCM at 0.25 Pa induced the mesenchymal-to-epithelial transition(MET), but FFCM at 1 Pa induced the epithelial-to-mesenchymal transition(EMT). This suggested that the effects of fluid flow on conditioned media depend on flow intensity. Fluorescence resonance energy transfer(FRET)-based evaluation of Src activity and vinculin molecular force showed that osteopontin was involved in EMT and MET switching. A mouse model of tumorinduced osteolysis was tested using dynamic tibia loadings of 1, 2, and 5 N. The low 1 N loading suppressed tumor-induced osteolysis, but this beneficial effect was lost and reversed with loads at 2 and 5 N, respectively. Changing the loading intensities in vivo also led to changes in serum TGFβ levels and the composition of tumor-associated volatile organic compounds in the urine.Collectively, this study demonstrated the critical role of intensity-dependent mechanotransduction and osteopontin in tumorosteocyte communication, indicating that a biophysical factor can tangibly alter the behaviors of tumor cells in the bone microenvironment. | Yao Fan Aydin Jalali Andy Chen Xinyu Zhao Shengzhi Liu Meghana Teli Yunxia Guo Fangjia Li Junrui Li Amanda Siegel Lianxiang Yang Jing Liu Sungsoo Na Mangilal Agarwal Alexander G.Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota | 2020 | Bone Research2020，8，2： | 4 |
| 3 | Response of a folded pendulum to tilt tides 显示文摘 | Fan Shuhua Cai yunxia Wu Shuchao | 1999 | Physics Letters A1999，256，： | 1 |
| 4 | Long - term exposure to hexavalent chromium inhibits expression of tumor suppres- sor genes in cultured cells and in mice显示文摘 | Fan Yunxia Ovesen Jerald L Puga Alvaro | 2012 | Jour- nal of Trace Elements in Medicine and Biology2012，26，23： | 1 |
| 5 | Early onset se- nescence occurs when fibroblasts lack glutamate eysteine ligase modifier subunit显示文摘 | Ying Chen Elisabet Johansson Yunxia Fan | 2009 | Free Radic Biol Med2009，47，4： | 1 |
| 6 | Smoothing effect in the broadband laser through a dispersive wedge显示文摘 | Runwu Peng Yunxia Ye Zhixiang Tang Chujun Zhao Shuangchun Wen Dianyuan Fan | 2006 | Optics Communications2006，，1： | 1 |
| 7 | 巴曲酶灌注联合肝动脉化疗栓塞治疗原发性肝癌的临床初步研究(英文)显示文摘Objective:The aim of the study was to explore the therapeutic efficacy and safety of batroxobin in patients with primary hepatic carcinoma(PHC) and the advantages of transcatheter arterial perfusion of batroxobin combined with transcatheter arterial chemoembolization(TACE).Methods:Forty patients with PHC were randomized into experimental group(transcatheter arterial perfusion of batroxobin combined with TACE treatment,20 patients) and control group(TACE alone group,20 patients).The patients were followed up and the data were recorded,compared and analyzed.Results:(1) Compared with the control group,the FIB level in the experimental group was significantly decreased at the first month after treatment(P < 0.05).(2) The baseline of the tumor was shortened in both groups after the treatment.There was a significant difference between the two groups at different time intervals(P < 0.05).(3) After the treatment,there was a significant difference of progression-free survival(PFS) levels between the two groups(t =2.877,P < 0.05).(4) The incidence of metastasis were 5.0%(1/20) in both groups at 6 months after treatment,and that after one year was 10.0%(2/20) in the experimental group and 25.0%(5/20) in the control group.However,the difference was not significant(χ2 = 0.693,P > 0.05).Conclusion:Batroxobin can rapidly and effectively decrease the FIB level of the PHC cases.Therefore it may be used as an effective and safe adjuvant drug for the treatment of primary hepatic carcinomas.Transcatheter arterial perfusion of batroxobin combined with TACE therapy has advantages in comparison with TACE alone therapy.It could be taken as a new therapeutic regimen in the PHC treatment. | Tianjun Gao Mingwu Lou Hui Wang Yi Fan Yunxia Shen Jiyin Ruan Hongguang Zhang | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 1 |
| 8 | Investigation of damage threshold to TiO2 coatings at different laser wavelength and pulse duration 显示文摘 | YAO Jianke FAN Zhengxiu JIN Yunxia | 2008 | Thin Solid Films(S0040-6090)2008，516，6： | 1 |
| 9 | Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicin显示文摘Apoptosis 在卵巢的开发和功能起一个突出的作用[1-4 ].During 滤泡开发,绝大多数滤泡作为成分卵母细胞或小囊的房间的后果 ofapoptosis 经历闭锁,或,没能完成成熟进程。闭锁发生根本在滤泡的生长和发展期间小囊的开发上演。初发、主要的滤泡的闭锁被卵母细胞 apoptosis 开始,由 granulosa 房间的死亡列在后面[1-4 ] 。在比较,种滤泡到一个单个 ovulatory 滤泡的大数字的减小首先被房间死亡 ofgranulosa 房间完成[1-4 ] 。Bcl-2 和 caspase 家庭的成员在卵巢的房间死亡的规定起重要作用,在滤泡开发并且响应化学疗法的代理人[5 ] 。 | Mei Dong Yunxia Fan Nicholas J Toepfer Jianhua Zhang | 2007 | Cell Research2007，17，8： | 0 |
| 10 | A mechanistic study of selective propane dehydrogenations on MoS_(2) supported single Fe atoms显示文摘On-purpose propane dehydrogenation(PDH) has emerged as a profitable alternative to the traditional cracking of oil products for propylene production. By means of density functional theory(DFT) calculations, the present work demonstrates that Fe atoms may atomically disperse on MoS_(2)(Fe_(1)/MoS_(2)) and serve as a promising single-atom catalyst(SAC) for PDH. The catalytic activity of Fe_(1)/MoS_(2)is attributed to the highly exposed d orbitals of single Fe atoms, while the propylene selectivity is originated from the kinetic inhibition of propylene dehydrogenation resulting from fast propenyl hydrogenation. The unique catalytic selectivity of Fe_(1)/MoS_(2)may inspire further investigations of on-purpose dehydrogenations of propane on SACs. | Yingke Yang Ruru Song Xing Fan Yunxia Liu Ningning Kong Haiping Lin Youyong Li | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 11 | Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex显示文摘Dear Editor,The outbreak of human monkeypox in May 2022 across nonendemic countries is unusual compared to previous reports.A recent study indicates that the basic reproduction number(R_(0))of monkeypoxvirus(MPxV)is>1 in populations of men who have sex with men,and MPxV is reported to be transmitted via close contact and airborne droplets,suggesting that monkeypox poses a great threat to the global health. | Yunxia Xu Yaqi Wu Yuanyuan Zhang Ruixin Fan Yaxue Yang Danyang Li Shimin Zhu Biao Yang Zhengyu Zhang Changjiang Dong | 2023 | Cell Research2023，33，6： | 0 |
| 12 | The aging behavior,microstructure and mechanical properties of AlN/AZ91 composite显示文摘Microstructure evolution and mechanical properties of the aging treated AlN/AZ91 composites were systematically investigated by optical microscopy(OM),high resolution scanning electron microscopy(HRSEM)with an energy dispersive spectrum(EDS),and high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM).The results show that the higher fracture elongation(14±1%)and ultimate tensile strength(275±6 MPa)were simultaneously obtained in the peak-aged AlN/AZ91 composites.Comparied with AZ91 matrix alloy,the strength was increased by about 44%and the elongation was approximately five times higher,which mainly attributed to the precipitation of nano-sizedγ-Mg_(17)Al_(12)phase and the activation of non-basal slip systems induced by in-situ AlN particles at room temperature.However,the in-situ formation of AlN reinforcements consumed part of Al element in the matrix alloy,which resulted into the volume fraction decreasing ofγ-Mg_(17)Al_(12)precipitates,and then the age hardening and strengthening efficiency were reduced in the AlN/AZ91 composites.On the other hand,the mismatch of thermal expansion coefficient between AlN particles and AZ91 matrix generated high density dislocations around AlN particles,which promoted the precipitation ofγ-Mg_(17)Al_(12)phase,and then the peak aging time and temperature were decreased. | Yunxia Sun Changlin Yang Bin Zhang Jianfeng Fan Hongxiang Li Tianhao Zhao Jing Li | 2023 | Journal of Magnesium and Alloys2023，11，7： | 0 |
| 13 | Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness显示文摘Facial and cranial variation represent a multidimensional set of highly correlated and heritable phenotypes.Little is known about the genetic basis explaining this correlation.We develop a software package ALo SFL for simultaneous localization of facial and cranial landmarks from head computed tomography(CT)images,apply it in the analysis of head CT images of 777 Han Chinese women,and obtain a set of phenotypes representing variation in face,skull and facial soft tissue thickness(FSTT).Association analysis of 301 single nucleotide polymorphisms(SNPs)from 191 distinct genomic loci previously associated with facial variation reveals an unexpected larger number of loci showing significant associations(P<1e-3)with cranial phenotypes than expected under the null(O/E=3.39),suggesting facial and cranial phenotypes share a substantial proportion of genetic components.Adding FSTT to a SNP-only model shows a large impact in explaining facial variance.A gene ontology analysis reveals that bone morphogenesis and osteoblast differentiation likely underlie our cranial-significant findings.Overall,this study simultaneously investigates the genetic effects on both facial and cranial variation of the same sample,supporting that facial variation is a composite phenotype of cranial variation and FSTT. | Wei Qian Manfei Zhang Kaiwen Wan Yunxia Xie Siyuan Du Jiarui Li Xiongzheng Mu Jiange Qiu Xiangyang Xue Xiahai Zhuang Yingzhi Wu Fan Liu Sijia Wang | 2022 | Journal of Genetics and Genomics2022，49，10： | 0 |
| 14 | The triggering of catalysis via structural engineering at atomic level: Direct propane dehydrogenation on Fe-N_(3)P-C显示文摘The on-purpose direct propane dehydrogenation(PDH) has received extensive attention to meet the everincreasing demand of propylene.In this work,by means of density functional theory(DFT) calculations,we systematically studied the intrinsic coordinating effect of Fe single-atom catalysts in PDH.Interestingly,the N and P dual-coordinated single Fe(Fe-N_(3)P-C) significantly outperform the Fe-N_(4-)C site in catalysis and exhibit desired activity and selectivity at industrial PDH temperatures.The mechanistic origin of different performance on Fe-N_(3)P-C and Fe-N_(4-)C has been ascribed to the geometric effect.To be specific,the in-plane configuration of Fe-N_(4) site exhibits low H affinity,which results in poor activity in C-H bond activations.By contrast,the out-of-plane structure of Fe-N_(3)P-C site exhibits moderate H affinity,which not only promote the C-H bond scission but also offer a platform for obtaining appropriate H diffusion rate which ensures the high selectivity of propylene and the regeneration of catalysts.This work demonstrates promising applications of dual-coordinated single-atom catalysts for highly selective propane dehydrogenation. | Wenyi Bian Xueli Shen Huang Tan Xing Fan Yunxia Liu Haiping Lin Youyong Li | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
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