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| 1 | Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis显示文摘Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis. The minipig model of periodontitis was established. Icariin was injected locally. The periodontal clinical assessment index, a computed tomography(CT) scan, histopathology and enzyme-linked immune sorbent assay(ELISA)were used to evaluate the effects of icariin. Quantitative analysis results 12 weeks post-injection demonstrated that probing depth,gingival recession, attachment loss and alveolar bone regeneration values were(3.72 ± 1.18) mm vs.(6.56 ± 1.47) mm,(1.67 ± 0.59)mm vs.(2.38 ± 0.61) mm,(5.56 ± 1.29) mm vs.(8.61 ± 1.72) mm, and(25.65 ± 5.13) mm3 vs.(9.48 ± 1.78) mm3 in the icariin group and0.9% NaCl group, respectively. The clinical assessment, CT scan, and histopathology results demonstrated significant enhancement of periodontal tissue regeneration in the icariin group compared to the 0.9% NaCl group. The ELISA results suggested that the concentration of interleukin-1 beta(IL-1β) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis. Local injection of icariin promoted periodontal tissue regeneration and exerted anti-inflammatory and immunomodulatory function. These results support the application of icariin for the clinical treatment of periodontitis. | Xiuli Zhang Nannan Han Guoqing Li Haoqing Yang Yangyang Cao Zhipeng Fan Fengqiu Zhang | 2018 | International Journal of Oral Science2018，10，3： | 9 |
| 2 | Fate of mercury in flue gas desulfurization gypsum determined by Temperature Programmed Decomposition and Sequential Chemical Extraction显示文摘A considerable amount of Hg is retained in flue gas desulfurization(FGD) gypsum from Wet Flue Gas Desulfurization(WFGD) systems. For this reason, it is important to determine the species of Hg in FGD gypsum not only to understand the mechanism of Hg removal by WFGD systems but also to determine the final fate of Hg when FGD gypsum is disposed. In this study, Temperature Programmed Decomposition(TPD) and Sequential Chemical Extraction(SCE) were applied to FGD gypsum to identify the Hg species in it. The FGD gypsum samples were collected from seven coal-fired power plants in China, with Hg concentrations ranging from 0.19 to 3.27 μg/g. A series of pure Hg compounds were used as reference materials in TPD experiments and the results revealed that the decomposition temperatures of different Hg compounds increase in the order of Hg_2Cl_2< HgCl_2< black HgS < Hg_2SO_4< red HgS < HgO < HgSO_4. The Hg compounds existing in FGD gypsums identified by TPD included HgCl_2, Hg_2Cl_2, Hg_2SO_4, black HgS and red HgS, of which mercury sulfides were the primary compounds. The results of SCE indicated that Hg was mainly distributed in the strongly complexed phase. The low Hg content in FGD gypsum increases the ambiguity of assigning extraction fractions to certain Hg species by SCE. The fact that the primary compounds in FGD gypsum are HgS phases leads the leaching of Hg in the natural environment to be quite low, but a considerable amount of Hg may be released during the industrial heating process. | Zhenwu Zhu Yuqun Zhuo Yaming Fan Zhipeng Wang | 2016 | Journal of Environmental Sciences2016，28，5： | 8 |
| 3 | Identification and molecular mechanism of angiotensin-converting enzyme inhibitory peptides from Larimichthys crocea titin显示文摘This study aimed to identify novel ACEI peptides from Larimichthys crocea titin using in silico approaches and to clarify the molecular interaction mechanism.The hydrolyzed peptides of titin were compared with known ACEI peptides in the AHTPDB and BIOPEP-UWM database.Furthermore,peptides were evaluated for their solubility,ADMET properties,ΔG(kcal/mol)values,and in vitro ACEI activity.Molecular mechanism of ACE-peptide was performed by molecular interactions and binding orientation study.The results revealed that IC50 values of Trp-Ala-Arg(WAR)and Trp-Gln-Arg(WQR)were(31.2±0.8)and(231.33±0.02)mol/L,respectively.The docking interactions result suggested that ACE-WAR and ACEWQR complexes have same binding site,including the residues LYS511,TYR520,TYR523,HIS353,and HIS513.Molecular docking of two tripeptides WAR and WQR with ACE studies predicted their binding site and clarified the interaction between ACE and its inhibitors.The molecular docking data are consistent with the ACE inhibitory activity of the studied peptides.The results showed that Larimichthys crocea titin may be a valuable source for developing nutraceutical food. | Yue Fan Zhipeng Yu Wenzhu Zhao Long Ding Fuping Zheng Jianrong Li Jingbo Liu | 2020 | Food Science and Human Wellness2020，9，3： | 5 |
| 4 | Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis显示文摘Signal transduction between different organs is crucial in the normal development of the human body. As an important medium for signal communication, exosomes can transfer important information, such as microRNAs(miRNAs), from donors to receptors.MiRNAs are known to fine-tune a variety of biological processes, including maxillofacial development; however, the underlying mechanism remains largely unknown. In the present study, transient apoptosis was found to be due to the expression of a miniature swine maxillofacial-specific miRNA, ssc-mir-133b. Upregulation of ssc-mir-133b resulted in robust apoptosis in primary dental mesenchymal cells in the maxillofacial region. Cell leukemia myeloid 1(Mcl-1) was verified as the functional target, which triggered further downstream activation of endogenous mitochondria-related apoptotic processes during tooth development.More importantly, mandible exosomes were responsible for the initial apoptosis signal. An animal study demonstrated that ectopic expression of ssc-mir-133 b resulted in failed tooth formation after 12 weeks of subcutaneous transplantation in nude mice. The tooth germ developed abnormally without the indispensable exosomal signals from the mandible. | Ye Li Xinxin Wang Jiali Ren Xiaoshan Wu Guoqing Li Zhipeng Fan Chunmei Zhang Ang Li Songlin Wang | 2018 | Bone Research2018，6，4： | 5 |
| 5 | Study on pneumatic-fuel hybrid system based on waste heat recovery from cooling water of internal combustion engine显示文摘The paper proposes a novel pneumatic-fuel hybrid system,which combines a traditional internal combustion engine(ICE)and a pneumatic engine.One important merit of this concept is that the system can recover waste from cooling water of internal combustion engine to optimize the working process of pneumatic engine,and thus to improve the entire efficiency of the hybrid system.Meanwhile,energy-saving effect due to lower cooling fan power can be achieved on ICE by waste heat recovery of pneumatic engine.Based on thermodynamic analysis,an experimental system is designed and established for verification.The experimental results show that the performance of pneumatic engine is improved when the waste heat recovery concept of the hybrid system is applied.Then an application example on a 4-cylinder engine is analyzed and discussed using numerical simulation.The results show that the fan power of the ICE cooling system can be saved up to 50%by applying the hybrid system.Considering the appreciable improvements on the energy efficiency with only limited system modifications when the concept is applied to traditional ICE based power systems,the proposed hybrid concept has the potential to serve as an alternative technology aiming for energy saving and emission reduction. | FANG YiDong LI DaoFei FAN ZhiPeng XU HuanXiang WANG Lei YU XiaoLi | 2013 | Science China(Technological Sciences)2013，56，12： | 5 |
| 6 | Inorganic nitrate alleviates the senescence-related decline in liver function显示文摘Senescence-related decline in liver function is a common complication in the elderly that can lead to impaired health in older individuals.Dietary nitrate supplements have physiological and therapeutic effects on organ function by nitrate(NO_3^-)-nitrite(NO_2^-)-nitric oxide(NO)pathway.However,the role of dietary nitrate on the senescence-related decline in liver function is unclear.The findings of the present study showed that nitrate levels in the serum and liver decreased,whereas the levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in serum increased in ageing mice.Consistently,cell senescence,decreased glycogen levels and increased lipid deposition were found in the liver of aged mice,both glucokinase(GCK)and phosphoenolpyruvate carboxykinase(PCK)were down-regulated(n=10).Daily nitrate intake(0.5 mmol L^(-1))restored nitrate levels,decreased ALT and AST levels,and prevented cell senescence and structural and glucose and lipid metabolism degeneration in liver tissue both in D-galactose(D-gal)-induced ageing mice(n=10)and in natural aged mice(n=10).In conclusion,the present study demonstrated that the reduction of nitrate levels was correlated with liver degeneration in ageing individuals and that dietary supplement of nitrate could restore the nitrate levels in serum and the liver and prevent ageing-related liver degeneration. | Haifeng Wang Lei Hu Le Li Xiaoshan Wu Zhipeng Fan Chunmei Zhang Jinsong Wang Jidong Jia Songlin Wang | 2018 | Science China(Life Sciences)2018，61，1： | 5 |
| 7 | Topological domain states and magnetoelectric properties in multiferroic nanostructures显示文摘Multiferroic nanostructures have been attracting tremendous attention over the past decade, due to their rich cross-coupling effects and prospective electronic applications. In particular, the emergence of some exotic phenomena in size-confined multiferroic systems, including topological domain states such as vortices, center domains, and skyrmion bubble domains, has opened a new avenue to a number of intriguing physical properties and functionalities, and thus underpins a wide range of applications in future nanoelectronic devices. It is also highly appreciated that nano-domain engineering provides a pathway to control the magnetoelectric properties, which is promising for future energy-efficient spintronic devices. In recent years, this field, still in its infancy, has witnessed a rapid development and a number of challenges too.In this article, we shall review the recent advances in the emergent domain-related exotic phenomena in multiferroic nanostructures. Specific attention is paid to the topological domain structures and related novel physical behaviors as well as the electric-field-driven magnetic switching via domain engineering. This review will end with a discussion of future challenges and potential directions. | Guo Tian Wenda Yang Deyang Chen Zhen Fan Zhipeng Hou Marin Alexe Xingsen Gao | 2019 | National Science Review2019，6，4： | 4 |
| 8 | miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition显示文摘Human dental pulp stem cells(DPSCs)have emerged as an important source of stem cells in the tissue engineering,and hypoxia will change various innate characteristics of DPSCs and then affect dental tissue regeneration.Nevertheless,little is known about the complicated molecular mechanisms.In this study,we aimed to investigate the influence and mechanism of miR-140-3p on DPSCs under hypoxia condition.Hypoxia was induced in DPSCs by Cobalt chloride(CoCl_(2))treatment.The osteo/dentinogenic differentiation capacity of DPSCs was assessed by alkaline phosphatase(ALP)activity,Alizarin Red S staining and main osteo/dentinogenic markers.A luciferase reporter gene assay was performed to verify the downstream target gene of miR-140-3p.This research exhibited that miR-140-3p promoted osteo/dentinogenic differentiation of DPSCs under normoxia environment.Furthermore,miR-140-3p rescued the CoCl_(2)-induced decreased osteo/odontogenic differentiation potentials in DPSCs.Besides,we investigated that miR-140-3p directly targeted lysine methyltransferase 5B(KMT5B).Surprisingly,we found inhibition of KMT5B obviously enhanced osteo/dentinogenic differentiation of DPSCs both under normoxia and hypoxia conditions.In conclusion,our study revealed the role and mechanism of miR-140-3p for regulating osteo/dentinogenic differentiation of DPSCs under hypoxia,and discovered that miR-140-3p and KMT5B might be important targets for DPSC-mediated tooth or bone tissue regeneration. | Han Zheng Ning Wang Le Li Lihua Ge Haichao Jia Zhipeng Fan | 2021 | International Journal of Oral Science2021，13，4： | 2 |
| 9 | miR-4651 inhibits cell proliferation of gingival mesenchymal stem cells by inhibiting HMGA2 under nifedipine treatment显示文摘Drug-induced gingival overgrowth(DIGO) is recognized as a side effect of nifedipine(NIF);however, the underlying molecular mechanisms remain unknown. In this study, we found that overexpressed mi R-4651 inhibits cell proliferation and induces G0/G1-phase arrest in gingival mesenchymal stem cells(GMSCs) with or without NIF treatment. Furthermore, sequential window acquisition of all theoretical mass spectra(SWATH-MS) analysis, bioinformatics analysis, and dual-luciferase report assay results confirmed that high-mobility group AT-hook 2(HMGA2) is the downstream target gene of mi R-4651. Overexpression of HMGA2 enhanced GMSC proliferation and accelerated the cell cycle with or without NIF treatment. The present study demonstrates that mi R-4651 inhibits the proliferation of GMSCs and arrests the cell cycle at the G0/G1 phase by upregulating cyclin D and CDK2 while downregulating cyclin E through inhibition of HMGA2 under NIF stimulation. These findings reveal a novel mechanism regulating DIGO progression and suggest the potential of mi R-4651 and HMGA2 as therapeutic targets. | Xiao Han Ruzhuang Yang Haoqing Yang Yangyang Cao Nannan Han Chen Zhang Ruitang Shi Zhengting Zhang Zhipeng Fan | 2020 | International Journal of Oral Science2020，12，2： | 2 |
| 10 | Automatic Identification of Clear-Air Echoes Based on Millimeter-wave Cloud Radar Measurements显示文摘Millimeter-wave cloud radar(MMCR)provides the capability of detecting the features of micro particles inside clouds and describing the internal microphysical structure of the clouds.Therefore,MMCR has been widely applied in cloud observations.However,due to the influence of non-meteorological factors such as insects,the cloud observations are often contaminated by non-meteorological echoes in the clear air,known as clear-air echoes.It is of great significance to automatically identify the clear-air echoes in order to extract effective meteorological information from the complex weather background.The characteristics of clear-air echoes are studied here by combining data from four devices:an MMCR,a laser-ceilometer,an L-band radiosonde,and an all-sky camera.In addition,a new algorithm,which includes feature extraction,feature selection,and classification,is proposed to achieve the automatic identification of clear-air echoes.The results show that the recognition algorithm is fairly satisfied in both simple and complex weather conditions.The recognition accuracy can reach up to 95.86%for the simple cases when cloud echoes and clear-air echoes are separate,and 88.38%for the complicated cases when low cloud echoes and clear-air echoes are mixed. | Ling YANG Yun WANG Zhongke WANG Qian YANG Xingang FAN Fa TAO Xiaoqiong ZHEN Zhipeng YANG | 2020 | Advances in Atmospheric Sciences2020，37，8： | 2 |
| 11 | Development of new solid phase extraction techniques in the last ten years 显示文摘 | Fan Huixia Deng Zhipeng Zhong Hao | 2013 | Journal of Chinese Pharmaceutical Science2013，22，4： | 1 |
| 12 | A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a Chinese fami lv显示文摘 | Fan Zhipeng Li Jingyuan Du Juan | | 0，，05： | 1 |
| 13 | Nanofibers and Nanoribbons:Preparation by electrospinning and their formaldehyde gas-sensing properties 显示文摘 | Zhipeng Li Yingju Fan Jinhua Zhan | 2010 | Chem2010，3，33： | 1 |
| 14 | A missense mutation in PTCH2 underlies dominantly inherited NBCCS in a Chinese family 显示文摘 | Fan Zhipeng Li Jingyuan Du Juan | 2008 | J Med Genet2008，45，5： | 1 |
| 15 | Estrogen deficiency inhibits the odonto/osteogenic differentiation of dental pulp stem cells via activation of the NF-κB pathway显示文摘 | Yanping Wang Ming Yan Yan Yu Jintao Wu Jinhua Yu Zhipeng Fan | 2013 | Cell and Tissue Research2013，，3： | 1 |
| 16 | Detection of telomerase activity in biopsy samples for predicting prognosis in cirrhotic patients with hepatocellular carcinoma after laparoscopic radiofrequency ablation therapy显示文摘Objective: To explore the role of telomerase activity detected in biopsy samples for evaluating the efficacy of lapa- roscopic radiofrequency ablation (RFA) therapy in patients with hepatocellular carcinoma (HCC) and liver cirrhosis. Methods: From August 2001 to October 2004, 34 cirrhotic patients with HCC were treated by laparoscopic RFA under general anesthe- sia. A total of 34 tumors, with a mean maximum tumor diameter of 4.0 ± 1.0 cm, were all located on the liver surface or adja- cent to the gallbladder. Laparoscopic ultrasound-guided core biopsy for liver lesions was performed before and immediately after RFA therapy. In these biopsy samples, telomerase activity was detected by the ELISA-based telomeric repeat amplifica- tion protocol (ELISA-TRAP) assay, and pathological examination was routinely performed. Results: Laparoscopic RFA was successfully performed in all the 34 patients. A complete tumor necrosis was achieved in all patients on the contrast-enhanced helical CT scanning one month after laparoscopic RFA. The positive rates of telomerase activity and histopathologic diagnosis in biopsy samples were 91.2% (31/34) and 100% (34/34) respectively before RFA, and 26.5% (9/34) and 0% respectively after RFA. During a median follow-up period of 35 months (range, 18–51 months), the rates of local tumor recurrence at the ablation sites in post-RFA telomerase-positive and negative patients were 88.9% (8/9) and 4% (1/25) respectively (P < 0.01), and the rates of distant recurrence within the livers were 0% (0/9) and 12% (3/25) respectively (P > 0.05). Conclusion: For cirrhotic patients with HCC treated by laparoscopic RFA, detection of telomerase activity in biopsy samples may be useful for evaluating the therapeutic efficacy of RFA and predicting postoperative local tumor recurrence. | Ruifang Fan Fulu Chai Zhipeng Han Chenyang Wang Xianling Guo Xinxin Bu Lixin Wei | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 1 |
| 17 | In2O3 nanofibers and nanoribbons:preparation by electrospinning and their formaldehyde gas-sensing properties显示文摘 | LI Zhipeng FAN Yingju ZHAN Jinhua | 2010 | European Journal of Inorganic Chemistry2010，2010，21： | 1 |
| 18 | Por-ous SnO2 nanospheres as sensitive gas sensors for volatile organic compounds detection 显示文摘 | LI Zhipeng ZHAO Quanqin FAN Weiliu | 2011 | Nanoscale2011，3，： | 1 |
| 19 | Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes显示文摘 | Anuradha Budhu Stephanie Roessler Xuelian Zhao Zhipeng Yu Marshonna Forgues Junfang Ji Edward Karoly Lun–Xiu Qin Qing–Hai Ye Hu–Liang Jia Jia Fan Hui–Chuan Sun Zhao–You Tang Xin Wei Wang | 2013 | Gastroenterology2013，，5： | 1 |
| 20 | Holey graphene oxide-templated construction of nano nickel-based metal–organic framework for highly efficient asymmetric supercapacitor显示文摘Metal–organic frameworks(MOFs)with redox-active metal sites and controllable crystalline structures make it possible to access the merits of highly-efficient electrode materials in electrochemical energy storage systems.However,most MOFs suffer from low capacitance and poor cycling stability that largely thwart their application.Herein,we present the holey graphene oxide(HGO)template strategy to prepare nano two-dimensional Ni(BDC)with HGO as both template and capping agent(denoted as Ni(BDC)-HGOx,x=10,20,30,and 40 according to the added HGO amount).Structural analyses reveal that HGO can significantly inhibit the Ni(BDC)agglomeration,thus offering a high ion-accessible surface area.Ni(BDC)-HGO30 with well-exposed active sites exhibits a high capacitance of 1,115.6 F·g^(−1) at 1 A·g^(−1) in 6 M KOH aqueous,1.8 times that of bulk Ni(BDC).An asymmetric supercapacitor with Ni(BDC)-HGO30 as a positive electrode and activated carbon as the opposing electrode delivers an energy density of 52.5 W·h·kg^(−1) and a power density up to 18.0 kW·kg−1,with 92.5%capacitance retention after 10,000 cycles.Galvanostatic intermittent titration technique and in situ electrochemical–Raman measurements were exploited to elucidate the electrochemical behavior of Ni(BDC)-HGO30.These results pave the way for the development of rationally tuned MOF materials for enhancing supercapacitor performances. | Hang Wang Pengfei Zhao Xingmao Zhang Su Zhang Xiaolong Lu Zhipeng Qiu Kang Ren Zheng Xu Ruxin Yao Tong Wei Zhuangjun Fan | 2022 | Nano Research2022，15，10： | 1 |
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